Japanese Journal of Leprosy最新文献_第10页

[Novel type of antimicrobial mechanism in host macrophages against mycobacterial infections]. 宿主巨噬细胞抗分枝杆菌感染的新型抗菌机制。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.283

Toshiaki Shimizu, Haruaki Tomioka

{"title":"[Novel type of antimicrobial mechanism in host macrophages against mycobacterial infections].","authors":"Toshiaki Shimizu, Haruaki Tomioka","doi":"10.5025/hansen.78.283","DOIUrl":"https://doi.org/10.5025/hansen.78.283","url":null,"abstract":"Macrophages (M(phi)s) play a central role as anti-microbial effector cells in the expression of host resistance to mycobacterial infections. With respect to antimicrobial effector molecules of host M(phi) against mycobacterial pathogens, recent studies suggest the possibility that the reactive nitrogen intermediates (RNI)--and reactive oxygen intermediates-independent antimycobacterial mechanism(s) may be crucial for the antimycobacterial function of host M(phi). In this context, we previously found that free fatty acids (FFAs) such as arachidonic acid (AA) and linolenic acid exhibited potent antimicrobial activity against mycobacterial organisms, including Mycobacterium tuberculosis (MTB) and Mycobacterium avium complex (MAC). In addition, FFAs in combination with RNI played critical roles in manifestation of the activity of M(phi) against mycobacterial organisms. Moreover, our recent studies have shown the following findings. First, anti-MTB activity of IFN-gamma-activated M(phi)s was specifically blocked by arachidonyl trifluoromethylketone (aTFMK), an inhibitor of cytosolic phospholipase A2 (cPLA2). Second, ATP potentiated the anti-MAC bactericidal activity of M(phi)s cultivated in the presence of clarithromycin and rifamycin. This effect of ATP was closely related to intracellular Ca2+ mobilization and was specifically blocked by aTFMK. Third, intramacrophage translocation of membranous AA molecules to MAC-containing phagosomes was also specifically blocked by aTFMK. In the confocal microscopic observation of MAC-infected M(phi)s, ATP enhanced the intracellular translocation of cPLA2 into MAC-containing phagosomes. These findings suggest that FFAs (especially AA) produced by the enzymatic action of cPLA2 play important roles as antimycobacterial effectors in the expression of M(phi) antimicrobial activity against mycobacterial pathogens.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Report of leprosy elimination commemorative day in Myanmar]. [缅甸消灭麻风病纪念日报告]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.251

Y Nagaoka

引用次数: 0

[Genetic involvement of bacterial sensor molecules in Japanese leprosy]. [日本麻风病细菌传感器分子的遗传参与]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.255

Nobuo Kanazawa, Naoya Mikita, Hong-Jin Li, Yumi Nakatani, Motoaki Ozaki, Maki Kosaka, Norihisa Ishii, Hiroyuki Nishimura, Fukumi Furukawa

{"title":"[Genetic involvement of bacterial sensor molecules in Japanese leprosy].","authors":"Nobuo Kanazawa, Naoya Mikita, Hong-Jin Li, Yumi Nakatani, Motoaki Ozaki, Maki Kosaka, Norihisa Ishii, Hiroyuki Nishimura, Fukumi Furukawa","doi":"10.5025/hansen.78.255","DOIUrl":"https://doi.org/10.5025/hansen.78.255","url":null,"abstract":"Occurrence of new patients of leprosy, caused by Mycobacterium leprae infection, is now almost absent in Japan but is still uncontrolled in developing countries. As one factor affecting the disease development, genetic predisposition of a host has been considered to be associated. Actually, various gene mutations have been reported to be associated at two stages of the disease progression, not only establishment of the disease but also determination of the phenotype, such as lepromatous (L)-type, tuberculoid (T)-type and reversal reaction. On the basis of recent progress of the research on innate immunity, here we analyzed single nucleotide polymorphisms (SNPs) of the genes of major bacterial sensor molecules expressed in antigen-presenting cells, TLR2, DC-SIGN, NOD1 and NOD2, in Japanese leprosy patients. As a result, frequency of polymorphisms in DC-SIGN -336 showed significant difference between the leprosy patients and the healthy controls, reflecting its role in establishment of the disease. Especially, among those with a particular TLR2 -16934 genotype, frequency of the polymorphisms in DC-SIGN -336 showed significant difference between the patients and the controls, suggesting any cooperation of these SNPs.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Prevalence of disability among leprosy patients and effectiveness of leprosy reaction services with standard prednisolone treatment at field level in an endemic country--some data from joint leprosy research collaboration in Myanmar]. [在一个麻风病流行国家，麻风病患者的致残率和麻风病反应服务中标准泼尼松龙治疗的有效性——部分数据来自缅甸麻风病联合研究合作]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.277

Yutaka Ishida

{"title":"[Prevalence of disability among leprosy patients and effectiveness of leprosy reaction services with standard prednisolone treatment at field level in an endemic country--some data from joint leprosy research collaboration in Myanmar].","authors":"Yutaka Ishida","doi":"10.5025/hansen.78.277","DOIUrl":"https://doi.org/10.5025/hansen.78.277","url":null,"abstract":"Prevalence of disability among leprosy patients and effectiveness of standard predonisolone treatment for leprosy reaction at field level in some place of Myanmar are shown in this paper as results of joint leprosy research collaboration. WHO disability grading was measured for all newly registered leprosy patients through 2007 in 5 selected townships of Ayeyarwaddy Division, with the results of G0 = 66.3%, GI = 18.9%, GII = 14.7% (N = 95). The cross-sectional disability survey at selected 9 townships in Mandalay, Sagaing and Magway Division for all registered patients who had completed WHO/MDT done by JICA project in 2003/4 showed G0 = 62.5%, GI = 2.4%, GII = 35.1% (N = 10,528). From these two data, it is supposed that considerable number of patients with G1 at registered time developed worsening of disability from G1 to G2. Proportion of G0 also reduced a little bit in patients who completed WHO/MDT. Early detection and proper treatment of leprosy reaction are one of the main issues of prevention of disability. Effectiveness of leprosy reaction services were evaluated at Mandalay Special Skin Clinic, where WHO fixed regimen of prednisolone were given as routine service. 100 cases were evaluated who developed leprosy reactions from 1st December 2007 to 31st December 2008 and identified severe reaction who needed oral prednisolone treatment. Evaluation criteria of \"effective\" was defined as \"no more signs and symptoms of reactions were present after treatment. And \"less effective\" was defined as \"more than one of signs and symptoms were still remained after treatment\". Over all \"effective\" was 36 (36%) and \"less effective\" was 64 (64%). It was also found that rates of improvement of nerve functions, either in sensory or in motor, were little after the standard treatment.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.78.277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Forefront of vaccine development: tuberculosis and leprosy]. [疫苗发展的前沿:结核病和麻风病]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.271

Toshiki Tamura, Yasuo Fukutomi, Masahiko Makino

{"title":"[Forefront of vaccine development: tuberculosis and leprosy].","authors":"Toshiki Tamura, Yasuo Fukutomi, Masahiko Makino","doi":"10.5025/hansen.78.271","DOIUrl":"https://doi.org/10.5025/hansen.78.271","url":null,"abstract":"The role of vaccines to tuberculosis and leprosy is to induce a cellular immunity, and as a result to induce the differentiation of memory CD8+ cytotoxic T cells. 'Help' from CD4+ T cells is important for the differentiation of naive CD8+ T cells to effector and memory CD8+ cytotoxic T cells. However, how CD4+ T cell 'help' is involved in the steps instructing T helper (Th) polarization is not yet clear. Peptide-25, a major Th epitope of Ag85B from Mycobacterium tuberculosis, preferentially induced development of Th1 cells. In contrast, altered peptide ligands (APL) that have a substitution of glycine for alanine at position 248 of Peptide-25 induced solely Th2 development. To elucidate the role of Th polarization on the 'Help' function of CD4+ T cells, we established an in vitro culture system using OVA specific CD8+ T cells, Peptide-25 specific CD4+ T cells and splenic dendritic cells (DCs). The DCs that were pre-cultured with Peptide-25 specific CD4+ T cells together with OVA and Peptide-25 induced the proliferation and granzyme B production of OVA specific CD8+ T cells. On the other hand, the DCs that were pre-cultured with Peptide-25 specific CD4+ T cells together with OVA and APL induced only proliferation of OVA specific CD8+ T cells. These results suggest that Th1 immune response induced by Peptide-25 plays an important role in the induction of functional activation of CD8+ cytotoxic T cells.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Tendencies of prescriptions for neuralgic pain in National Suruga Sanatorium (leprosy), Japan during last 11 years]. [日本国立骏河疗养院(麻风病)近11年神经痛处方趋势分析]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.293

Akatsuki Yamada, Munekatsu Horita, Kazuaki Shindo, Yutaka Ishida, Mitsuyoshi Maeda

{"title":"[Tendencies of prescriptions for neuralgic pain in National Suruga Sanatorium (leprosy), Japan during last 11 years].","authors":"Akatsuki Yamada, Munekatsu Horita, Kazuaki Shindo, Yutaka Ishida, Mitsuyoshi Maeda","doi":"10.5025/hansen.78.293","DOIUrl":"https://doi.org/10.5025/hansen.78.293","url":null,"abstract":"The number of ex-leprosy patients has reduced rapidly who were forced to be admitted under leprosy prevention/segregation law and are staying at national sanatoriums with different disabilities due to different physical and social reasons for long time in Japan. Most of them have been of clinically cured status for decades after effective chemotherapy. Some have still been suffering from acute or chronic neuralgic pains which are supposed to be long standing consequences of nerve damage of leprosy and getting medications for long period. Pharmacy department of National Suruga Sanatorium has studied the amount of prescriptions of some medicines for last 11 years, which were thought to be prescribed for pain including neuralgic pain. There seem to be some tendencies of medications during last decade. VitaminB12 (Mecobalamine) is one of the commonest drugs for neuralgic pain at this sanatorium and the amount of prescription had almost been unchanged through the years. Prescription of non-steroid anti-inflammatory drugs (NSAIDs) increased year by year, which may reflect the increasing age of ex-patients who need more pain killers for their painful joints or back. Loxoprofen is the most popular pain killer here and increased by ten times for last decade. The number of prescription for Pentazocine and Hydroxyzine Hydrochloride injection increased for last several years, which reflects a few patients who were still suffering from severe chronic neuralgia for years. It is desirable that a standard regimen for chronic neuralgic pain as a consequence of nerve impairment in leprosy will be developed as soon as possible.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.78.293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why does tuberculosis lead to specific inflammation? 为什么肺结核会导致特定的炎症?

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.263

Isamu Sugawara

引用次数: 9

[Children born to Hansen's disease patients in Amami-Oshima, Kagoshima, Japan]. [日本鹿儿岛奄美大岛麻风病患者所生的孩子]。

Japanese Journal of Leprosy Pub Date : 2009-09-01 DOI: 10.5025/hansen.78.231

Kazutaka Moriyama, Ichiro Kikuch, Norihisa Ishii

{"title":"[Children born to Hansen's disease patients in Amami-Oshima, Kagoshima, Japan].","authors":"Kazutaka Moriyama, Ichiro Kikuch, Norihisa Ishii","doi":"10.5025/hansen.78.231","DOIUrl":"https://doi.org/10.5025/hansen.78.231","url":null,"abstract":"In the Japanese leprosaria, it was very difficult or almost impossible for leprosy patients to give birth to their children. There were various reasons for this situation. Leprosy in the women mostly worsened in pregnancy and some of the children developed leprosy. Because of the chronic nature of the disease, marriage was encouraged in Japanese leprosaria, so that vasectomy was usually enforced in men who were wed, while artificial abortion was enforced in pregnant women. The only one exception was the situation of the Amami Wako-en Leprosarium. The Wako-en Leprosarium was started in 1943, and between 1946 and 1953, it was under American rule. Later it was transferred to Japanese rule. Religions such as Buddhism, Christianity and other religions greatly helped with leprosy patients, and in the Wakoen, it was Catholicism which prevailed. Catholic believer Joan Matsubara (later the secretary of Wako-en), Father Patrick Finn, Kaoru Ohira (director) outlined how children born to Hansen's disease patients would be grown up and made the internal rules of the couples' dormitory, while this was impossible in other leprosaria. Between 1953 and 1954, children were brought up by Matsubara's family or nurses. And since November 1954, children were brought up at nurseries (firstly named \"Children's House\" and later at \"Naze Engel House\" and children between 2 and 3 years went to \"White Lily House\". The children could meet their parents at times and now they are full-fledged grown-up citizens.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Abstracts of the 82nd General Meeting of the Japanese Leprosy Association of the 21st Co-Medical Meeting. May 13-15, 2009. Izumo, Japan]. [摘要]日本麻风病协会第82届全体会议第21届联合医学会议。2009年5月13日至15日。出云国,日本]。

Japanese Journal of Leprosy Pub Date : 2009-04-01

引用次数: 0

[In memory of Dr. Tonetarou Itou]. [纪念Tonetarou Itou博士]。

Japanese Journal of Leprosy Pub Date : 2009-02-01

Masanao Makino

引用次数: 0