Japanese Journal of Leprosy最新文献

人の長寿と長生きの抗酸菌；抗酸菌がゆっくりと生きて頻繁に眠るしくみから、薬剤開発への展開を考える抗酸菌，使人长寿长寿;从抗酸菌缓慢生存、频繁睡眠的机制出发，思考如何开发药物

Japanese Journal of Leprosy Pub Date : 2023-01-01 DOI: 10.5025/hansen.92.41

Sohkichi Matsumoto

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次世代シーケンシング解析を併用したNested Multiplex PCR法による、らい菌の薬剤耐性および型別の新規同時同定法同时使用新一代测序分析的Nested Multiplex PCR法，对赖氏菌的耐药性和型别进行新的同时鉴定法

Japanese Journal of Leprosy Pub Date : 2023-01-01 DOI: 10.5025/hansen.92.47

Yasuhisa Iwao, Shuichi Mori, Manabu Ato, Noboru Nakata

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1. Current situation of leprosy learned from one case 2. Skin diseases to watch out for in elderly care facilities 1. 从一例了解麻风现状2。长者护理机构应注意的皮肤病

Japanese Journal of Leprosy Pub Date : 2022-01-01 DOI: 10.5025/hansen.91.45

T. Fukuda

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Decrease of newly registered leprosy patients in Japan in the second half of the 20th century 20世纪下半叶日本新登记麻风病患者的减少

Japanese Journal of Leprosy Pub Date : 2022-01-01 DOI: 10.5025/hansen.91.75

M. Ozaki, S. Hazama

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(Part 2) Molecular characterization of Mycobacterium ulcerans DNA gyrase and identification of mutations reduced susceptibility to quinolones in vitro (第二部分)溃疡分枝杆菌DNA旋切酶的分子特征及体外喹诺酮类药物敏感性降低突变的鉴定

Japanese Journal of Leprosy Pub Date : 2022-01-01 DOI: 10.5025/hansen.91.55

Hyun Kim, S. Mori, T. Kenri, Yasuhiko Suzuki

{"title":"(Part 2) Molecular characterization of Mycobacterium ulcerans DNA gyrase and identification of mutations reduced susceptibility to quinolones in vitro","authors":"Hyun Kim, S. Mori, T. Kenri, Yasuhiko Suzuki","doi":"10.5025/hansen.91.55","DOIUrl":"https://doi.org/10.5025/hansen.91.55","url":null,"abstract":"Buruli ulcer disease (BU) is an emerging chronic ulcerating illness caused by the environmental mycobacterium, as Mycobacterium ulcerans (Mul), which primarily affects the skin, subcutaneous tissue, and occasionally bones. It is recognized by the WHO as a neglected tropical disease1). BU is gradually increasing with approximately 2,000 to 5,000 new annual reported cases2). However, the reasons for increases in the past few years have not been understood3). Recently, drug therapy against Mul has been administered through anti-mycobacterial antibiotics, including rifampicinbased combinations with either streptomycin, amikacin, or clarithromycin4). Early and non-severe stages of BU can be treated with an 8-week regimen of rifampicin (10 mg/kg orally, once daily) combined with clarithromycin (7.5 mg/kg per body weight, twice daily), streptomycin (15 mg/kg intramuscularly, once daily), fluoroquinolone (FQ) or other antibiotics. FQ is effective antibiotics against Mul in vitro and in vivo5). Evidence exists that DNA topoisomerase II is the therapeutic target of the drug. Remarkably, Mul expresses only DNA gyrase from a gyrB-gyrA contig in the complete genome and this enzyme is the sole target of FQs. However, the detailed molecular mechanism of Mul DNA gyrase and the mechanisms of FQ resistance were not determined. Our study aimed to determine the functional analysis of Mul DNA gyrase activities in vitro from Mul shinshuense and Agy99 strains. DNA gyrase subunits of both strains were Jpn J Lepr 91, 55-57(2022)","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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近現代ハンセン病資料アーカイブス事業近现代麻风病档案事业

Japanese Journal of Leprosy Pub Date : 2021-01-01 DOI: 10.5025/HANSEN.89.27

修一森, 学阿戸

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Leprosy research and United States-Japan Cooperative Medical Science Program 麻风病研究和美日合作医学项目

Japanese Journal of Leprosy Pub Date : 2021-01-01 DOI: 10.5025/hansen.90.77

M. Goto, Yasuhiko Suzuki

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WHOのハンセン病診断治療予防ガイドライン2018年について关于2018年世界卫生组织麻风病诊断、治疗和预防指南

Japanese Journal of Leprosy Pub Date : 2021-01-01 DOI: 10.5025/hansen.90.35

正道後藤, 里英四津

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Survey report on autopsies of residents of Kyushu Sanatorium/National Sanatorium Kikuchi Keifuen 九州疗养院/菊地庆恩国立疗养院居民尸体解剖调查报告

Japanese Journal of Leprosy Pub Date : 2021-01-01 DOI: 10.5025/hansen.90.67

R. Nogami

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QoL of ex-leprosy patients’ children in Vietnam 越南麻风病前患者子女的生活质量

Japanese Journal of Leprosy Pub Date : 2020-01-01 DOI: 10.5025/hansen.89.1

Hiroyuki Watanabe, V. Anh, Huynh Cong Ai, Tran Xuan Vy, Tran Sy Duy, Tran Quang Tien, Ho Thu Linh

{"title":"QoL of ex-leprosy patients’ children in Vietnam","authors":"Hiroyuki Watanabe, V. Anh, Huynh Cong Ai, Tran Xuan Vy, Tran Sy Duy, Tran Quang Tien, Ho Thu Linh","doi":"10.5025/hansen.89.1","DOIUrl":"https://doi.org/10.5025/hansen.89.1","url":null,"abstract":"In Vietnam, ex-leprosy patients and their families are housed in villages called leprosy villages. The aim of this study was to measure the quality of life (QoL) of ex-leprosy patients’ children who live in these leprosy villages with their families, using the Kid-KINDL R (Vietnamese version). We collected and analyzed data from 105 individuals (58 ex-leprosy patients’ children and 47 control group children). The results showed that the scores of the ex-leprosy patients’ children in terms of physical health and having friends, as well as their total scores, were significantly lower than those of the control group. However, no significant differences were in the scores for primary school, self-esteem, and family relationships though ex-leprosy patients’ children scored significantly lower in the secondary school category. Moreo -ver, the male children in the ex-leprosy patients’ children group in secondary schools had significantly lower scores in the self-esteem and family relationship categories than their female counterparts. The results also showed that the QoL of ex-leprosy patients’ children diminished after secondary school, which necessitates support for their physical health, self-esteem, and family relationships. Meanwhile, the academic achievement of ex-leprosy patients’ children was higher than that of those in the control group in upper secondary school, who therefore required socioeconomic support to foster motivation of ex-leprosy patients’ children to study and to move on to higher education.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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