抗酸菌，使人长寿长寿;从抗酸菌缓慢生存、频繁睡眠的机制出发，思考如何开发药物

Q4 Medicine

Japanese Journal of Leprosy Pub Date : 2023-01-01 DOI:10.5025/hansen.92.41

Sohkichi Matsumoto

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引用次数: 0

摘要

人们渴望活得更久、更健康，研究发现通过限制卡路里可以延长寿命。有趣的是，这种机制从线虫到老鼠再到灵长类动物都是保守的。这种长寿效应的重要分子机制是通过上调sirtuin基因和抑制mTOR信号传导来抑制基因表达和代谢，包括呼吸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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人の長寿と長生きの抗酸菌；抗酸菌がゆっくりと生きて頻繁に眠るしくみから、薬剤開発への展開を考える

Research that responds to the desire to live longer and be healthier has led to the discovery of life extention through calorie restriction. Interestingly, this mechanism is conserved from nematodes to mice to primates. Important molecular mechanisms for this longevity effect is the suppression of gene expression and metabolism, including respiration, through upregulation of sirtuin genes and suppression of mTOR signaling.

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来源期刊

Japanese Journal of Leprosy Medicine-Dermatology

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