{"title":"Late dislodgement of left bundle branch pacing lead and failure of left ventricle capture management algorithm","authors":"Pugazhendhi Vijayaraman","doi":"10.1016/j.ipej.2025.04.004","DOIUrl":"10.1016/j.ipej.2025.04.004","url":null,"abstract":"<div><div>A 74-year-old man with nonischemic cardiomyopathy, LV ejection fraction (LVEF) of 20 % and left bundle branch block (LBBB) underwent successful cardiac resynchronization therapy defibrillator (CRT-D) implantation utilizing LBBP lead in the LV port. Despite normalization of LVEF at 6 months, patient presented with late lead dislodgment at 10 months post-implant and decline in LV function. LV capture management algorithm was inactive due to sensing of conducted beat as ventricular fibrillation sensed event. Removal and replacement of LBBP lead resulted in recovery of LV function.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 167-170"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina J. Beelen , Jitendra Vohra , Job A.J. Verdonschot
{"title":"Basic principles of genetics and genetic counselling","authors":"Nina J. Beelen , Jitendra Vohra , Job A.J. Verdonschot","doi":"10.1016/j.ipej.2025.05.002","DOIUrl":"10.1016/j.ipej.2025.05.002","url":null,"abstract":"<div><div>Genetic counselling and testing is a fast growing field in modern medicine. Genetic analysis can aid in the diagnosis, treatment, management and prevention of (genetic) diseases in patients. This review provides an overview of the fundamental principles of genetics from a clinical perspective, focusing on the practical application and interpretation of genetic testing. Key concepts, including genetic expression and inheritance patterns, are discussed to give a better understanding of the subject. There is a large variety of genetic testing methodologies, from single gene testing to whole genome sequencing (WGS) that have their respective advantages, disadvantages and clinical implications. Interpretation of genetic results is performed on different levels: from the molecular level (variant interpretation and classification) to the clinical level (association of genetic variants with disease and phenotype). The correct interpretation of the results is essential to use genetics for clinical decision making. Challenges in the field include, but are not limited to, variants of unknown significance, incidental findings, and the familial forms of disease that remain gene-elusive with the current technologies. Pre- and post-test genetic counselling is essential to ensure that patients and their family members are aware of the options and implications of genetic testing, which will significantly benefit patients with coping. This review is based on the latest European and American guidelines, to give an up-to-date overview of rapid advancements of genetic testing and counselling. A dedicated follow-up article in this series will explore the Indian perspective in greater depth.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 177-184"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ree Lu , Devin Skoll , Ahmed Y. Gasmelseed , Geoffrey A. Rubin , Elaine Y. Wan , Amardeep S. Saluja , Jose M. Dizon , Angelo B. Biviano , Hasan Garan , Hirad Yarmohammadi
{"title":"Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation","authors":"Ree Lu , Devin Skoll , Ahmed Y. Gasmelseed , Geoffrey A. Rubin , Elaine Y. Wan , Amardeep S. Saluja , Jose M. Dizon , Angelo B. Biviano , Hasan Garan , Hirad Yarmohammadi","doi":"10.1016/j.ipej.2025.05.004","DOIUrl":"10.1016/j.ipej.2025.05.004","url":null,"abstract":"<div><h3>Background</h3><div>Patients with atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular mortality compared to patients with AF alone. Consequently, employing rhythm control strategies such as AF catheter ablation could offer substantial benefits to patients with COPD. However, the impact of COPD on AF ablation outcomes is not well established.</div></div><div><h3>Methods</h3><div>In this single-center case control study, we retrospectively analyzed 200 patients with AF and COPD, 52 of whom underwent AF catheter ablation. Those who underwent ablation were matched with a control group of patients with AF but without COPD who underwent ablation. Ablation outcomes were compared between the groups. Univariate and multivariable analysis were conducted for prediction of AF recurrence.</div></div><div><h3>Results</h3><div>Compared to the controls, cases with COPD were more likely to have AF recurrence following catheter ablation (OR 13.42, P-value = 0.0001). Multivariable analysis revealed predictors of AF recurrence following catheter ablation included decreased use of loop diuretics and amiodarone. Patients with severe or very severe COPD were more likely to have left atrial enlargement than patients with mild or moderate COPD (OR 2.28, P-value = 0.026).</div></div><div><h3>Conclusion</h3><div>Patients with AF and COPD were more likely than patients with AF but without COPD to experience AF recurrence following catheter ablation. Predictors of AF recurrence included decreased use of loop diuretics and amiodarone. Our study demonstrates that while ablation in patients with COPD is safe, ablation in patients with COPD is associated with higher AF recurrence rates.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 148-156"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonid Maizels MD, PhD , Jonathan M. Kalman MBBS, PhD
{"title":"The hotter and shorter the better? Strategy comparison for atrial fibrillation ablation using high power short duration settings","authors":"Leonid Maizels MD, PhD , Jonathan M. Kalman MBBS, PhD","doi":"10.1016/j.ipej.2025.05.009","DOIUrl":"10.1016/j.ipej.2025.05.009","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 146-147"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajaz A. Lone , Mohd Iqbal Dar , Jan Mohd Sheikh , Sheikh Mohamad Tahir , Waseem Rashid , Imran Hafeez , Hilal A. Rather , Syed Bilal
{"title":"Corrigendum to“Transvenous lead extraction: Experience from a Northern State of India - The Srinagar extraction registry” [Indian Pacing and Electrophysiology Journal (25), Issue 2, March–April 2025, Pages 58–66]","authors":"Ajaz A. Lone , Mohd Iqbal Dar , Jan Mohd Sheikh , Sheikh Mohamad Tahir , Waseem Rashid , Imran Hafeez , Hilal A. Rather , Syed Bilal","doi":"10.1016/j.ipej.2025.06.007","DOIUrl":"10.1016/j.ipej.2025.06.007","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Page 196"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Failure to pace identified by a smartwatch: what is your diagnosis?","authors":"Valérian Valiton, Samuel Stempfel, Haran Burri","doi":"10.1016/j.ipej.2025.06.002","DOIUrl":"10.1016/j.ipej.2025.06.002","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 187-190"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanie A. Gunawardene , Melissa E. Middeldorp , Prashanthan Sanders
{"title":"Obstructive path to sinus rhythm: When COPD undermines AF ablation success","authors":"Melanie A. Gunawardene , Melissa E. Middeldorp , Prashanthan Sanders","doi":"10.1016/j.ipej.2025.06.001","DOIUrl":"10.1016/j.ipej.2025.06.001","url":null,"abstract":"","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 3","pages":"Pages 157-158"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine Hermanto, Raymond Pranata, Hawani Sasmaya Prameswari, Giky Karwiky, Chaerul Achmad, Mohammad Iqbal
{"title":"Early rhythm control compared to rate control in atrial fibrillation – A systematic review, meta-analysis, and meta-regression","authors":"Katherine Hermanto, Raymond Pranata, Hawani Sasmaya Prameswari, Giky Karwiky, Chaerul Achmad, Mohammad Iqbal","doi":"10.1016/j.ipej.2025.02.003","DOIUrl":"10.1016/j.ipej.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>This meta-analysis aimed to compare the effectiveness of early rhythm control to rate control, and whether catheter ablation derived more benefit compared to other methods of rhythm control.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted on PubMed, SCOPUS, and EuropePMC up to July 2, 2024. The primary outcome of this study was major adverse cardio-cerebrovascular events (MACCE), defined as a composite of mortality, stroke/systemic embolism, heart failure hospitalization (HFH), and acute coronary syndrome (ACS) during the follow-up period. Outcome measures were adjusted hazard ratios (aHR).</div></div><div><h3>Results</h3><div>A total of 504,124 patients from 11 studies were included in this systematic review and meta-analysis. Early rhythm control was significantly associated with reduction in MACCE (aHR 0.85 [95 % CI 0.80, 0.90], p < 0.001; I<sup>2</sup>: 23 %), stroke (aHR 0.79 [95 % CI 0.72, 0.86], p < 0.001; I<sup>2</sup>: 25 %), HFH (aHR 0.87 [95 % CI 0.78, 0.96], p = 0.008; I<sup>2</sup>: 48 %), and ACS (aHR 0.80 [95 % CI 0.66, 0.96], p = 0.018; I<sup>2</sup>: 40 %). No mortality benefit (aHR 0.93 [95 % CI 0.85, 1.01], p = 0.066; I<sup>2</sup>: 67 %) was observed; however, mortality benefit became evident (aHR 0.87 [95 % CI 0.85, 0.89], p < 0.001) upon removal of a study during a leave-one-out sensitivity analysis. Meta-regression analysis showed that the benefits of early rhythm control in terms of MACCE were more pronounced with ablation (coefficient −0.004, p = 0.010, R<sup>2</sup>: 100 %).</div></div><div><h3>Conclusion</h3><div>Early rhythm control was associated with better outcomes compared to rate control in AF, with a more pronounced benefit observed for ablation.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 2","pages":"Pages 82-90"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tachycardia induced cardiomyopathy due to ectopic atrial tachycardia originating from the atrial appendage: A case series and review of literature","authors":"Abhinav Aggarwal, Anil Yadav, Ankit Jain, Anunay Gupta","doi":"10.1016/j.ipej.2025.03.001","DOIUrl":"10.1016/j.ipej.2025.03.001","url":null,"abstract":"<div><div>This case series describes four cases of tachycardia-induced cardiomyopathy due to incessant ectopic atrial tachycardias from the atrial appendage (three from the right atrial appendage, one from the left). P wave morphology changes on surface 12-lead electrocardiogram can be used to diagnose this relatively rare subset of tachycardias and localise the site of origin. Tachycardia induced cardiomyopathy is relatively more common in atrial tachycardias from the atrial appendage as compared to tachycardia from other sites<sup>1,2</sup>. Radiofrequency ablation is the treatment of choice and is associated with a high success rate. Oral ivabradine is another treatment option for cases where ablation is unsuccessful or if the patient is unwilling for ablation. For rare cases refractory to other treatment measures, surgical excision of the atrial appendage may be needed.</div></div>","PeriodicalId":35900,"journal":{"name":"Indian Pacing and Electrophysiology Journal","volume":"25 2","pages":"Pages 112-117"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}