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Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/s1099-4831(21)00026-2
{"title":"Copyright","authors":"","doi":"10.1016/s1099-4831(21)00026-2","DOIUrl":"https://doi.org/10.1016/s1099-4831(21)00026-2","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56577182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphine alkaloids: History, biology, and synthesis. 吗啡生物碱:历史、生物学和合成。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2021-09-21 DOI: 10.1016/bs.alkal.2021.04.001
Christopher Wicks, Tomas Hudlicky, Uwe Rinner
{"title":"Morphine alkaloids: History, biology, and synthesis.","authors":"Christopher Wicks,&nbsp;Tomas Hudlicky,&nbsp;Uwe Rinner","doi":"10.1016/bs.alkal.2021.04.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2021.04.001","url":null,"abstract":"<p><p>This chapter provides a short overview of the history of morphine since it's isolation by Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"86 ","pages":"145-342"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39450729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Preface. 前言。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/S1099-4831(21)00029-8
Hans-Joachim Knölker
{"title":"Preface.","authors":"Hans-Joachim Knölker","doi":"10.1016/S1099-4831(21)00029-8","DOIUrl":"https://doi.org/10.1016/S1099-4831(21)00029-8","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"86 ","pages":"ix"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39450731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemistry of the chippiine/dippinine/tronocarpine class of indole alkaloids. 切平类/地平类/曲诺卡平类吲哚类生物碱的化学性质。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2020-09-02 DOI: 10.1016/bs.alkal.2020.07.001
Steven C Taylor, Steven M Weinreb
{"title":"Chemistry of the chippiine/dippinine/tronocarpine class of indole alkaloids.","authors":"Steven C Taylor,&nbsp;Steven M Weinreb","doi":"10.1016/bs.alkal.2020.07.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.07.001","url":null,"abstract":"<p><p>The chippiines/dippinines/tronocarpine are a family of biologically and structurally interesting polycyclic tryptamine-derived indole alkaloids isolated from the leaf and bark extracts of plants belonging to the Tabernaemontana genus. To date, 14 members of this family have been isolated and characterized. This review discusses the isolation, structure determination, biological activity, and proposed biosynthesis of these metabolites. In addition, synthetic studies on the alkaloids are described including approaches to tronocarpine and dippinine B core intermediates and total syntheses of (+)-dippinine B and (+)-tronocarpine.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"85 ","pages":"177-222"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25430903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Aspidosperma and Strychnos alkaloids: Chemistry and biology. 藤属植物和马钱子生物碱:化学和生物学。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2021-09-21 DOI: 10.1016/bs.alkal.2021.05.001
Senzhi Zhao, Gopal Sirasani, Rodrigo B Andrade
{"title":"Aspidosperma and Strychnos alkaloids: Chemistry and biology.","authors":"Senzhi Zhao,&nbsp;Gopal Sirasani,&nbsp;Rodrigo B Andrade","doi":"10.1016/bs.alkal.2021.05.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2021.05.001","url":null,"abstract":"<p><p>Of Nature's nearly 3000 unique monoterpene indole alkaloids derived from tryptophan, those members belonging to the Aspidosperma and Strychnos families continue to impact the fields of natural products (i.e., isolation, structure determination, biosynthesis) and organic chemistry (i.e., chemical synthesis, methodology development) among others. This review covers the biological activity (Section 2), biosynthesis (Section 3), and synthesis of both classical and novel Aspidosperma (Section 4), Strychnos (Section 5), and selected bis-indole (Section 6) alkaloids. Technological advancements in genetic sequencing and bioinformatics have deepened our understanding of how Nature assembles these intriguing molecules. The proliferation of innovative synthetic strategies and tactics for the synthesis of the alkaloids covered in this review, which include contributions from over fifty research groups from around the world, are a testament to the creative power and technical skills of synthetic organic chemists. To be sure, Nature-the Supreme molecular architect and source of a dazzling array of irresistible chemical logic puzzles-continues to inspire scientists across multiple disciplines and will certainly continue to do so for the foreseeable future.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"86 ","pages":"1-143"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39450728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Preface. 前言。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/S1099-4831(21)00009-2
Hans-Joachim Knölker
{"title":"Preface.","authors":"Hans-Joachim Knölker","doi":"10.1016/S1099-4831(21)00009-2","DOIUrl":"https://doi.org/10.1016/S1099-4831(21)00009-2","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"85 ","pages":"ix"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1099-4831(21)00009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25430904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cumulative Index of Titles 职称累积索引
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/S0065-2725(08)60118-X
A. Katritzky
{"title":"Cumulative Index of Titles","authors":"A. Katritzky","doi":"10.1016/S0065-2725(08)60118-X","DOIUrl":"https://doi.org/10.1016/S0065-2725(08)60118-X","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0065-2725(08)60118-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55879955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/s1099-4831(21)00028-6
{"title":"Contributors","authors":"","doi":"10.1016/s1099-4831(21)00028-6","DOIUrl":"https://doi.org/10.1016/s1099-4831(21)00028-6","url":null,"abstract":"","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56577216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids. 麦角生物碱的生物合成、全合成及生物学特性。
Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2020-09-30 DOI: 10.1016/bs.alkal.2020.08.001
Nikhil R Tasker, Peter Wipf
{"title":"Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids.","authors":"Nikhil R Tasker,&nbsp;Peter Wipf","doi":"10.1016/bs.alkal.2020.08.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.08.001","url":null,"abstract":"<p><p>While the use of ergot alkaloids in folk medicine has been practiced for millennia, systematic investigations on their therapeutic potential began about 100 years ago. Subsequently, Albert Hofmann's discovery of lysergic acid diethylamide (LSD) and its intense psychedelic properties garnered worldwide attention and prompted further studies of this compound class. As a result, several natural ergot alkaloids were discovered and unnatural analogs were synthesized, and some were used to treat an array of maladies, including Alzheimer's and Parkinson's disease. While LSD was never commercially approved, recent clinical studies have found it can be an innovative and effective treatment option for several psychiatric disorders. Ongoing biosynthetic and total synthetic investigations aim to understand the natural origins of ergot alkaloids, help develop facile means to produce these natural products and enable their continued use as medicinal chemistry lead structures. This review recounts major developments over the past 20 years in biosynthetic, total synthetic, and pharmaceutical studies. Many ergot alkaloid biosynthetic pathways have been elucidated, with some of them subsequently applied toward \"green\" syntheses. New chemical methodologies have fostered a fast and efficient access to the ergoline scaffold, prompting some groups to investigate biological properties of natural product-like ergot alkaloids. Limited pharmaceutical applications have yet to completely bypass the undesirable side effects of ergotism, suggesting further studies of this drug class are likely needed and will potentially harness major therapeutic significance.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"85 ","pages":"1-112"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25430901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Lamellarin alkaloids: Isolation, synthesis, and biological activity. 薄层藻素生物碱:分离、合成及生物活性。
Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-23 DOI: 10.1016/bs.alkal.2019.10.001
Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao
{"title":"Lamellarin alkaloids: Isolation, synthesis, and biological activity.","authors":"Tsutomu Fukuda,&nbsp;Fumito Ishibashi,&nbsp;Masatomo Iwao","doi":"10.1016/bs.alkal.2019.10.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2019.10.001","url":null,"abstract":"<p><p>Lamellarins are marine alkaloids containing fused 14-phenyl-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinoline or non-fused 3,4-diarylpyrrole-2-carboxylate ring systems. To date, more than 50 lamellarins have been isolated from a variety of marine organisms, such as mollusks, tunicates, and sponges. Many of them, especially fused type I lamellarins, exhibit impressive biological activity, such as potent cytotoxicity, topoisomerase I inhibition, protein kinases inhibition, and anti-HIV-1 activity. Due to their useful biological activity and limited availability from natural sources, a number of synthetic methods have been developed. In this chapter, we present an updated and comprehensive review on lamellarin alkaloids summarizing their isolation, synthesis, and biological activity.</p>","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"83 ","pages":"1-112"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2019.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37676657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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