Alkaloids: Chemistry and Biology最新文献_第3页

Preface. 前言。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/S1099-4831(20)30023-7

Hans-Joachim Knölker

引用次数: 0

The indole-based subincanadine alkaloids and their biogenetic congeners. 吲哚类琥珀碱生物碱及其生物同系物。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-27 DOI: 10.1016/bs.alkal.2019.12.001

Manojkumar Gulabrao Kalshetti, Narshinha Panditrao Argade

{"title":"The indole-based subincanadine alkaloids and their biogenetic congeners.","authors":"Manojkumar Gulabrao Kalshetti, Narshinha Panditrao Argade","doi":"10.1016/bs.alkal.2019.12.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2019.12.001","url":null,"abstract":"The tryptamine-derived polycyclic bridged bioactive indole alkaloids subincanadines A-G were isolated in 2002 by Ohsaki and coworkers from the bark of the Brazilian medicinal plant Aspidosperma subincanum. Kobayashi proposed that subincanadines D-F could be biosynthetically resulting from stemmadenine via two different pathways and, furthermore, that the subincanadines A-C could be biogenetically resulting from subincanadines D and E. Kam and coworkers, in their focused efforts, isolated five indole alkaloids from Malaysian Kopsia arborea species, namely valparicine, apparicine, arboridinine, arborisidine, and arbornamine in combination with subincanadine E. On the basis of structural features, it has been proposed and proved in some examples that subincanadine E is a biogenetic precursor of these five different bioactive indole alkaloids bearing complex structural architectures. All important information on isolation, characterization, bioactivity, probable biogenetic pathways, and more specifically racemic and enantioselective total synthesis of subincanadine alkaloids and their biogenetic congeners are summarized in the present chapter. Special importance is given to the total synthesis and the synthetic strategies intended therein, comprising a set of main reactions.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"83 ","pages":"187-223"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2019.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37676659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The manzamine alkaloids. 曼扎胺类生物碱。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-04-23 DOI: 10.1016/bs.alkal.2020.03.001

Takaaki Kubota, Shin-Ichiro Kurimoto, Jun'ichi Kobayashi

{"title":"The manzamine alkaloids.","authors":"Takaaki Kubota, Shin-Ichiro Kurimoto, Jun'ichi Kobayashi","doi":"10.1016/bs.alkal.2020.03.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.03.001","url":null,"abstract":"The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"84 ","pages":"1-124"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37944348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Index 指数

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/s1099-4831(20)30012-2

引用次数: 0

Preface. 前言。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/S1099-4831(20)30010-9

Hans-Joachim Knölker

引用次数: 0

Chemodiversity, chemotaxonomy and chemoecology of Amaryllidaceae alkaloids. 朱顶菊科生物碱的化学多样性、化学分类学和化学生态学。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-23 DOI: 10.1016/bs.alkal.2019.10.002

Strahil Berkov, Edison Osorio, Francesc Viladomat, Jaume Bastida

引用次数: 57

Biosynthesis, synthetic studies, and biological activities of the jadomycin alkaloids and related analogues. jadomycin生物碱及其类似物的生物合成、合成研究及生物活性。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-03-09 DOI: 10.1016/bs.alkal.2020.02.001

Charles B de Koning, Kennedy J Ngwira, Amanda L Rousseau

{"title":"Biosynthesis, synthetic studies, and biological activities of the jadomycin alkaloids and related analogues.","authors":"Charles B de Koning, Kennedy J Ngwira, Amanda L Rousseau","doi":"10.1016/bs.alkal.2020.02.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.02.001","url":null,"abstract":"The jadomycins are an expanding class of compounds produced from Streptomyces venezuelae, by diverting the normal biosynthesis which provides the antibiotic chloramphenicol. In the presence of amino acids, and either by heat shock, supplementation with ethanol, or when phage SV1 is added to the culture, the formation of substituted jadomycins and benzo[b]phenanthridines can be achieved. The first part of this review provides details of intermediates involved in the biosynthesis of the jadomycins and the related benzo[b]phenanthridines. Both the jadomycins and the benzo[b]phenanthridines share biosynthetic pathways with a large class of naturally occurring compounds known as the angucyclines. The biosynthetic pathways diverge when it is postulated that an intermediate quinone, such as 3-(2-formyl-6-hydroxy-4-methylphenyl)-8-hydroxy-1,4-naphthoquinone-2-carboxylic acid is formed. The quinone then undergoes reactions with amino acids and derivatives in the culture medium to ultimately afford a library of jadomycins and a few benzo[b]phenanthridines. The second part of the review initially details synthetic efforts toward the synthesis of the naturally occurring benzo[b]phenanthridine, phenanthroviridin, and then outlines methods that have been used to assemble a selection of jadomycins. Total syntheses of jadomycin A and B, derived from l-isoleucine, are described. In addition, the synthesis of the aglycon of jadomycins M, W, S, and T is outlined. These four jadomycins were derived from l-methionine, l-tryptophan, l-serine and l-threonine respectively. As a result of these synthetic efforts, the structures of jadomycin S and T have been revised. The third part of the review describes the reported antibacterial and anticancer activities of both the jadomycins and some naturally occurring benzo[b]phenanthridines.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"84 ","pages":"125-199"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37944349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Recent applications of the Wittig reaction in alkaloid synthesis. Wittig反应在生物碱合成中的最新应用。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-03-25 DOI: 10.1016/bs.alkal.2020.02.002

Majid M Heravi, Vahideh Zadsirjan, Hoda Hamidi, Mansoureh Daraie, Tayebeh Momeni

引用次数: 5

Contributors 贡献者

Alkaloids: Chemistry and Biology Pub Date : 2019-01-01 DOI: 10.1016/s1099-4831(19)30029-x

引用次数: 0

The Chemical Synthesis and Applications of Tropane Alkaloids. Tropane生物碱的化学合成及应用。

Alkaloids: Chemistry and Biology Pub Date : 2019-01-01 Epub Date: 2018-09-07 DOI: 10.1016/bs.alkal.2018.06.001

Samson Afewerki, Jia-Xin Wang, Wei-Wei Liao, Armando Córdova

引用次数: 18