Alkaloids: Chemistry and Biology最新文献_第3页

Cumulative Index of Titles 职称累积索引

Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/S0065-2725(08)60118-X

A. Katritzky

引用次数: 0

Contributors 贡献者

Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 DOI: 10.1016/s1099-4831(21)00028-6

引用次数: 0

Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids. 麦角生物碱的生物合成、全合成及生物学特性。

Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2020-09-30 DOI: 10.1016/bs.alkal.2020.08.001

Nikhil R Tasker, Peter Wipf

{"title":"Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids.","authors":"Nikhil R Tasker, Peter Wipf","doi":"10.1016/bs.alkal.2020.08.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.08.001","url":null,"abstract":"While the use of ergot alkaloids in folk medicine has been practiced for millennia, systematic investigations on their therapeutic potential began about 100 years ago. Subsequently, Albert Hofmann's discovery of lysergic acid diethylamide (LSD) and its intense psychedelic properties garnered worldwide attention and prompted further studies of this compound class. As a result, several natural ergot alkaloids were discovered and unnatural analogs were synthesized, and some were used to treat an array of maladies, including Alzheimer's and Parkinson's disease. While LSD was never commercially approved, recent clinical studies have found it can be an innovative and effective treatment option for several psychiatric disorders. Ongoing biosynthetic and total synthetic investigations aim to understand the natural origins of ergot alkaloids, help develop facile means to produce these natural products and enable their continued use as medicinal chemistry lead structures. This review recounts major developments over the past 20 years in biosynthetic, total synthetic, and pharmaceutical studies. Many ergot alkaloid biosynthetic pathways have been elucidated, with some of them subsequently applied toward \"green\" syntheses. New chemical methodologies have fostered a fast and efficient access to the ergoline scaffold, prompting some groups to investigate biological properties of natural product-like ergot alkaloids. Limited pharmaceutical applications have yet to completely bypass the undesirable side effects of ergotism, suggesting further studies of this drug class are likely needed and will potentially harness major therapeutic significance.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"85 ","pages":"1-112"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25430901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Lamellarin alkaloids: Isolation, synthesis, and biological activity. 薄层藻素生物碱:分离、合成及生物活性。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-23 DOI: 10.1016/bs.alkal.2019.10.001

Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao

引用次数: 22

Preface. 前言。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/S1099-4831(20)30023-7

Hans-Joachim Knölker

引用次数: 0

The manzamine alkaloids. 曼扎胺类生物碱。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-04-23 DOI: 10.1016/bs.alkal.2020.03.001

Takaaki Kubota, Shin-Ichiro Kurimoto, Jun'ichi Kobayashi

{"title":"The manzamine alkaloids.","authors":"Takaaki Kubota, Shin-Ichiro Kurimoto, Jun'ichi Kobayashi","doi":"10.1016/bs.alkal.2020.03.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2020.03.001","url":null,"abstract":"The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"84 ","pages":"1-124"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2020.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37944348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The indole-based subincanadine alkaloids and their biogenetic congeners. 吲哚类琥珀碱生物碱及其生物同系物。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-27 DOI: 10.1016/bs.alkal.2019.12.001

Manojkumar Gulabrao Kalshetti, Narshinha Panditrao Argade

{"title":"The indole-based subincanadine alkaloids and their biogenetic congeners.","authors":"Manojkumar Gulabrao Kalshetti, Narshinha Panditrao Argade","doi":"10.1016/bs.alkal.2019.12.001","DOIUrl":"https://doi.org/10.1016/bs.alkal.2019.12.001","url":null,"abstract":"The tryptamine-derived polycyclic bridged bioactive indole alkaloids subincanadines A-G were isolated in 2002 by Ohsaki and coworkers from the bark of the Brazilian medicinal plant Aspidosperma subincanum. Kobayashi proposed that subincanadines D-F could be biosynthetically resulting from stemmadenine via two different pathways and, furthermore, that the subincanadines A-C could be biogenetically resulting from subincanadines D and E. Kam and coworkers, in their focused efforts, isolated five indole alkaloids from Malaysian Kopsia arborea species, namely valparicine, apparicine, arboridinine, arborisidine, and arbornamine in combination with subincanadine E. On the basis of structural features, it has been proposed and proved in some examples that subincanadine E is a biogenetic precursor of these five different bioactive indole alkaloids bearing complex structural architectures. All important information on isolation, characterization, bioactivity, probable biogenetic pathways, and more specifically racemic and enantioselective total synthesis of subincanadine alkaloids and their biogenetic congeners are summarized in the present chapter. Special importance is given to the total synthesis and the synthetic strategies intended therein, comprising a set of main reactions.","PeriodicalId":35785,"journal":{"name":"Alkaloids: Chemistry and Biology","volume":"83 ","pages":"187-223"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.alkal.2019.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37676659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Index 指数

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/s1099-4831(20)30012-2

引用次数: 0

Preface. 前言。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 DOI: 10.1016/S1099-4831(20)30010-9

Hans-Joachim Knölker

引用次数: 0

Chemodiversity, chemotaxonomy and chemoecology of Amaryllidaceae alkaloids. 朱顶菊科生物碱的化学多样性、化学分类学和化学生态学。

Alkaloids: Chemistry and Biology Pub Date : 2020-01-01 Epub Date: 2020-01-23 DOI: 10.1016/bs.alkal.2019.10.002

Strahil Berkov, Edison Osorio, Francesc Viladomat, Jaume Bastida

引用次数: 57