切平类/地平类/曲诺卡平类吲哚类生物碱的化学性质。

Q1 Biochemistry, Genetics and Molecular Biology

Alkaloids: Chemistry and Biology Pub Date : 2021-01-01 Epub Date: 2020-09-02 DOI:10.1016/bs.alkal.2020.07.001

Steven C Taylor, Steven M Weinreb

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引用次数: 1

摘要

chippiines/dippinines/tronocarpine是一类从Tabernaemontana属植物的叶子和树皮提取物中分离出来的多环色胺衍生的吲哚生物碱。迄今为止，该家族的14名成员已被分离和鉴定。本文综述了这些代谢物的分离、结构测定、生物活性和拟议的生物合成。此外，还介绍了生物碱的合成研究，包括特罗诺卡平和地平B核心中间体的合成方法以及(+)-地平B和(+)-特罗诺卡平的全合成方法。

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Chemistry of the chippiine/dippinine/tronocarpine class of indole alkaloids.

The chippiines/dippinines/tronocarpine are a family of biologically and structurally interesting polycyclic tryptamine-derived indole alkaloids isolated from the leaf and bark extracts of plants belonging to the Tabernaemontana genus. To date, 14 members of this family have been isolated and characterized. This review discusses the isolation, structure determination, biological activity, and proposed biosynthesis of these metabolites. In addition, synthetic studies on the alkaloids are described including approaches to tronocarpine and dippinine B core intermediates and total syntheses of (+)-dippinine B and (+)-tronocarpine.

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来源期刊

Alkaloids: Chemistry and Biology Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

13.70

自引率

0.00%

发文量