Family Medicine and Medical Science Research最新文献_第5页

Triploidy/Diploidy Mosaisizm, Diandry and Uniparental Isodisomy: Fetus with Omphalocele and Contracted Finger 三倍体/二倍体嵌合、二代和单代同染色体:脐膨出和手指收缩的胎儿

Family Medicine and Medical Science Research Pub Date : 2015-07-21 DOI: 10.4172/2327-4972.1000I180

F. Sılan, A. Gungor, Mine Urfali, A. Uludağ, E. Çavuş, E. Koç, O. Ozdemır

{"title":"Triploidy/Diploidy Mosaisizm, Diandry and Uniparental Isodisomy: Fetus with Omphalocele and Contracted Finger","authors":"F. Sılan, A. Gungor, Mine Urfali, A. Uludağ, E. Çavuş, E. Koç, O. Ozdemır","doi":"10.4172/2327-4972.1000I180","DOIUrl":"https://doi.org/10.4172/2327-4972.1000I180","url":null,"abstract":"Omphalocele is an abdominal wall defect that bowel and/or other visceral organs herniate from umbical ring, which is covered by peritoneal sac. Omphalocele pathogenesis is not clear but familial and genetical factors plays important role to development of omphalocele. Twenty years old, 19 weeks 4 days pregnant, primigravid patient presented. In her ultrasonographic assessment omphalocele was detected and fetus was death. Pregnancy was terminated and genetic studies were performed from fetal blood and tissue biopsy. Karyotype from intracardiac blood sample was found 46, XX. QF-PCR analysis performed from the DNA obtained from fetal skin biopsy; 4:1 peak ratio observed in all the STR regions. This is the first case shows 4:1 peaks at QF-PCR. This finding was incompatible with karyotype. So mosaicism doubt occurred. FISH from skin biopsy showed diploid/triploid mosaicism. Fetuses with omphalocele must be evaluated for additional anomalies and genetic consultation. Our case indicates high frequency of mosaicism and the importance of examination from different tissues with different types of genetic methods. Triploid cell line is found only in fibroblasts in about 70% of cases, so this mixoploidy syndrome is likely underdiagnosed. Performing genetic analysis from different tissues and using different techniques are very important for detecting mosaicism and not to miss the genetic etiology of stillbirths and anomalous fetuses.","PeriodicalId":356612,"journal":{"name":"Family Medicine and Medical Science Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131326660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Xenoestrogen Exposure and Early Puberty among Young Females Living in Jeddah, Saudi Arabia 居住在沙特阿拉伯吉达的年轻女性中异雌激素暴露与青春期提前的关系

Family Medicine and Medical Science Research Pub Date : 2015-07-16 DOI: 10.4172/2327-4972.1000I179

A. Al-Agha, Duaa A Aiash, Bara’ah O Tatwany

{"title":"The Relationship between Xenoestrogen Exposure and Early Puberty among Young Females Living in Jeddah, Saudi Arabia","authors":"A. Al-Agha, Duaa A Aiash, Bara’ah O Tatwany","doi":"10.4172/2327-4972.1000I179","DOIUrl":"https://doi.org/10.4172/2327-4972.1000I179","url":null,"abstract":"Background: Xenoestrogen (estrogen disruptors) are artificial estrogen compounds, which are found in the environment and in various synthetic chemical products. Xenoestrogen have been claimed to affect the process of puberty among young females. \u0000Purpose: This study aimed to investigate the relationship between exposure to various xenoestrogen products and the factor of early puberty among younger females in Jeddah, Saudi Arabia. \u0000Method: This cross-sectional study was conducted in Jeddah for the time frame of one month. The study selected 568 younger females from different areas of Jeddah. Pubertal staging was done using the Tanner staging. The relevant data was collected through a questionnaire. Pearson’s Correlation Coefficient did data analysis. \u0000Results: There was a significant association among the use of children toys, age of breast (p-value = 0.040), and pubic hair development (p-value=0.028). The consumption of children plastic bottles also showed a significant correlation with early pubic hair development (p-value=0.048). The increased frequency usage of water plastic bottles, plastic packaging materials, women cosmetics and food preservations showed an inverse effect on pubertal signs. \u0000Conclusion: This study confirmed the association between using xenoestrogen products and early puberty in young females living in Jeddah, Saudi Arabia. The study has evaluated that different association between the use of xenoestrogen products and the occurrence of early puberty was observed among the selected population. Therefore, it is advised to decrease the use of products that contain xenoestrogen in the daily life.","PeriodicalId":356612,"journal":{"name":"Family Medicine and Medical Science Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130211801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Assessment of the Awareness of Lifestyle Changes in Patients withHypertension 高血压患者生活方式改变意识的评估

Family Medicine and Medical Science Research Pub Date : 2015-07-05 DOI: 10.4172/2327-4972.1000178

Yusuf Ozdag, Y. DidemSuna, B. Yavuz

{"title":"An Assessment of the Awareness of Lifestyle Changes in Patients withHypertension","authors":"Yusuf Ozdag, Y. DidemSuna, B. Yavuz","doi":"10.4172/2327-4972.1000178","DOIUrl":"https://doi.org/10.4172/2327-4972.1000178","url":null,"abstract":"Aim: In this study it was aimed to evaluate the awareness of lifestyle changes (LC) of patients with hypertension (HT). \u0000Method: The study included patients who were diagnosed with HT in the cardiology and family medicine polyclinics between September- December 2013. A questionnaire consisted of 63 items in 4 sections was used to assess sociodemographic properties, cardiovascular risk factor analysis, LC awareness, effects of HT. \u0000Results: A total of 301 patients with a mean age of 59.6 ± 10.9 years were included. The rate of blood pressure (BP) under control was 48%. Awareness rates of 6 basic LC were diet at 18%, alcohol at 48%, cigarette smoking at 50%, exercise at 45%, obesity at 65%, salt restriction at 91%. From the total patient group 44% were aware of 4 or more LC, frequency of LC awareness was greater in males (54%) than females (40%) (p=0.02). LC awareness was seen not to affect BP control (p=0.4). The patients were found to have a high level of awareness about target organ damage in HT. While patients were aware of the necessity of a salt-free diet, they did not know how much salt should be restricted each day and while they were aware that they should exercise, they did not know what kind of exercise or for what duration. Patients who applied 4 or more of LC were determined at a rate of 71%. No significant difference was determined in respect of the application of LC between those who were aware or not aware of 4 or more LC. \u0000Conclusion: The results of this study have shown the necessity for patients to be as willing to implement LC as to be aware of them and for healthcare personnel to give more detailed explanations when recommending LC to patients.","PeriodicalId":356612,"journal":{"name":"Family Medicine and Medical Science Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127813965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Sleep Patterns and Health Status in Homeschool Children 在家上学儿童的睡眠模式与健康状况

Family Medicine and Medical Science Research Pub Date : 2015-06-28 DOI: 10.4172/2327-4972.1000177

David Wachob

引用次数: 0

Secular Trends in Thyroid Disease and Self-Perceived Mental StressAmong Swedish Women: A Comparative Cross-Sectional Study of theTwo Cohorts 1980-1981 and 2004-2005 from the Population Study ofWomen in Gothenburg, Sweden 瑞典妇女甲状腺疾病和自我感觉精神压力的长期趋势:1980-1981年和2004-2005年瑞典哥德堡妇女人口研究的两个队列的比较横断面研究

Family Medicine and Medical Science Research Pub Date : 2015-06-25 DOI: 10.4172/2327-4972.1000176

S. Linda, V. Sundh, D. Hange

{"title":"Secular Trends in Thyroid Disease and Self-Perceived Mental StressAmong Swedish Women: A Comparative Cross-Sectional Study of theTwo Cohorts 1980-1981 and 2004-2005 from the Population Study ofWomen in Gothenburg, Sweden","authors":"S. Linda, V. Sundh, D. Hange","doi":"10.4172/2327-4972.1000176","DOIUrl":"https://doi.org/10.4172/2327-4972.1000176","url":null,"abstract":"Objective: The aim of this study was to investigate the prevalence of thyroid disease among 38- and 50-year-old Swedish women in 1980-1981 and in 2004-2005. A second aim was to study whether there is any connection between deviant levels of TSH and mental stress or between diagnosed thyroid disease with normalized levels of TSH and mental stress. Design: Prospective study. Setting: Goteborg, Sweden, population about 4,30,000. Subjects: This study is based on material from the Population Study of Women in Gothenburg. The participants are two representative samples of 38- and 50-year-old women who took part in examinations 1980-1981 and 2004-2005. Main outcome measures: Prevalence of thyroid disease as well associations between mental stress and thyroid disease, studied cross-sectionally. Results: The prevalence of thyroid disease has increased in both 38- (with 39%) and 50-year-old (with 56%) women between 1980-1982 and 2004-2005. There was a significant increase in the prevalence, from 0.9% (CI 0.2-2.6) to 3.4% (CI 1.7-6.2) of 50-year-old women with suppressed TSH. No connection was found between high mental stress and deviant levels of TSH. In the 38-year-old women there was a significant connection between high mental stress and diagnosed thyroid disease. Conclusion: The results indicate that the prevalence of suppressed TSH in Swedish women has increased since the early eighties, and that mental symptoms can exist also in successfully treated thyroid disease. However, all of the changes observed consist of relatively few individuals and no certain conclusions can therefore be drawn from the results.","PeriodicalId":356612,"journal":{"name":"Family Medicine and Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134084719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic Central Pontine Myelinolysis: A Case Report 医源性桥脑中央髓鞘溶解1例报告

Family Medicine and Medical Science Research Pub Date : 2015-06-17 DOI: 10.4172/2327-4972.1000175

D. Joshi, P. Sinha, Ranveer Yadav, A. Singh, Vivek Sharda

引用次数: 0

Suicide and Its Public Health Importance in India 印度自杀及其对公共卫生的重要性

Family Medicine and Medical Science Research Pub Date : 2015-06-15 DOI: 10.4172/2327-4972.1000174

Gupta Sn, G. Naveen, A. Nesar, G. Shivani

引用次数: 4

Obsessive-Compulsive Disorder cases with a Good Prognosis which Underwent CBT and Morita Therapy 接受CBT和森田治疗后预后良好的强迫症病例

Family Medicine and Medical Science Research Pub Date : 2015-05-02 DOI: 10.4172/2327-4972.1000172

Ayumu Tateno, K. Yano, M. Kawakami, Y. Imamura, Kei Nakamura

引用次数: 0

Repeated Pregnancy with Delivery of Full Term Baby in a Dialysis Woman:Case Report and Review of Literature 透析妇女反复妊娠并发足月婴儿:病例报告及文献回顾

Family Medicine and Medical Science Research Pub Date : 2015-04-29 DOI: 10.4172/2327-4972.1000170

W. El-Reshaid, Hanan El-Desawy

引用次数: 2

Oral Sildenafil has No Acute Effect on Diffusion Capacity Measurements inPatients with Diffuse Parenchymal Lung Disease and Pulmonary Hypertension 口服西地那非对弥漫性肺实质疾病和肺动脉高压患者弥漫性扩散能力测量无急性影响

Family Medicine and Medical Science Research Pub Date : 2015-04-27 DOI: 10.4172/2327-4972.1000173

I. Mira-Avendano, U. Hatipoğlu, Catherine A. Sant, D. Laskowski, R. Yadav, R. Dweik

{"title":"Oral Sildenafil has No Acute Effect on Diffusion Capacity Measurements inPatients with Diffuse Parenchymal Lung Disease and Pulmonary Hypertension","authors":"I. Mira-Avendano, U. Hatipoğlu, Catherine A. Sant, D. Laskowski, R. Yadav, R. Dweik","doi":"10.4172/2327-4972.1000173","DOIUrl":"https://doi.org/10.4172/2327-4972.1000173","url":null,"abstract":"Diffuse parenchymal lung diseases have diverse etiology and treatment often requires individualization taking into consideration comorbidities. Pulmonary hypertension represents one such comorbidity which, when present, worsens prognosis and confounds approach to treatment. Sildenafil is a pulmonary vasodilator, which has recently generated considerable interest for use in patients with diffuse parenchymal lung disease and concomitant pulmonary hypertension. We wondered whether acute administration of oral sildenafil affects the diffusion capacity measurement, which is a tool for serially monitoring patients with diffuse parenchymal lung diseases. \u0000Methods: 15 patients with diffuse parenchymal lung disease and pulmonary hypertension (WHO Class III) had diffusion capacity measurements and 6 minute walk test performed before and after receiving sildenafil 20 mg orally. CT scans of the chest were scored to determine burden of interstitial lung disease. \u0000Results: The mean change in DLCO after administration of oral sildenafil was -0.26 ± 0.94 ml/min/mmHg (p=0.30) and -0.41 ± 2.84 % predicted (p=0.58). The average 6 minute walk distance at baseline was 363.28 ± 141 meters. After oral administration of sildenafil, 6 minute walk distance was 369 ± 116 meters (p=0.63). No correlation was observed between composite radiology scores and DLCO measurements or change in DLCO and radiology scores (p=0.43 and p=0.17 respectively). \u0000Conclusion: We found no acute change in diffusion capacity after a single dose of oral sildenafil in patients with diffuse parenchymal lung disease and pulmonary hypertension.","PeriodicalId":356612,"journal":{"name":"Family Medicine and Medical Science Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128424303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3