Archive of Oncology最新文献

{"title":"Expression of epidermal growth factor receptor in advance stage nonkeratinizing nasopharyngeal carcinoma in west Sumatra, Indonesia","authors":"Sukri Rahman, Histawara Subroto, J. Budiman, Aswiyanti Asri, Hafni Bachtiar","doi":"10.2298/AOO180401005R","DOIUrl":"https://doi.org/10.2298/AOO180401005R","url":null,"abstract":"subcellular mechanism of the nasopharyngeal confirmed, but in several studies overexpression of the epidermal growth factor receptor was found. Based on histopathological classification, nonkeratinizing subtypes consisting of differentiated (WHO II) and undifferentiated (WHO III) are the most frequent types in endemic areas, whereas in non-endemic areas the majority of cases are keratinizing subtype (WHO I). The objective of this study was to evaluate the expression of epidermal growth factor receptor in advanced stage nonkeratinizing nasopharyngeal carcinoma as well as to evaluate difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated (WHO III) nasopharyngeal carcinoma that may affect the anti-epidermal growth factor receptor therapy for nasopharyngeal carcinoma. Biopsies from 34 advance stage (stage III and stage IV) nonkeratinizing carcinoma consisting of 17 differentiated nonkeratinizing and 17 undifferentiated carcinomas of epidermal factor in investigated Our results demonstrated that epidermal growth factor receptor in 23 out of 34 subjects in differentiated nonkeratinizing carcinoma of in carcinoma histopathological subtypes (p=0.465). Conclusions: The epidermal growth factor receptor was expressed in most cases of advance stage nonkeratinizing nasopharyngeal carcinoma, and there was no difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated nonkeratinizing nasopharyngeal carcinoma (WHO III).","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality traits as predictors of the affective state in patients after breast cancer surgery","authors":"I. Novakov, S. Popović-Petrović","doi":"10.2298/AOO1701003N","DOIUrl":"https://doi.org/10.2298/AOO1701003N","url":null,"abstract":"as well as with maladaptive coping strategies (11-13). Those individuals high in negative affect generally manifest elevated levels of distress, anxiety, dissatisfaction, and a tendency toward focusing on the unpleasant aspects of themselves, other people, the world / life and the future (14). On the other hand, positive affect reflects the degree to which a person feels enthusiastic, active, confident and energetic (10). Positive affect is traditionally associated with subjective well-being and personal resources such as a supportive social network, optimism, adaptive coping strategies (15) and resilience in general. Negative and positive affect can be measured as both trait and state (16). is studies compared psychosocial outcomes of mastectomy and breast-conserving surgery found little differences in the presence of affective disorders between these two groups 18). Background. Breast cancer diagnosis is an extremely stressful life event that brings a number of physical and psychological challenges. Studies show that there is a high prevalence of psychological distress and symptoms of anxiety and depression among the diagnosed individuals. Although it is known that personality traits are strong predisposing factors for elevated experience of distress, research in oncology continues to be more focused on disease-related variables. In order to explore the role of personality traits in the experience of distress, the aim of our study was to examine the predictive value of personality characteristics such as neuroticism, hope, and optimism regarding the affective state of the patients after breast cancer surgery. Methods. The study was conducted on 40 women who had undergone breast cancer surgery, aged from 33 to 69 years (Mean = 55.02, SD = 9.18). The participants completed the following measures: Basic Demographic Data Questionnaire, The Positive and Negative Affect Schedule (PANAS), Life Orientation Test – Revised (LOT-R), Adult Hope Scale (AHS) and Neuroticism subscale from Big Five Inventory (BFI). Results. Two multiple regression analysis were performed, with the participants' age, level of hope, optimism and neuroticism as predictors and positive/negative affect as the criteria variables. In the first analysis, a statistically significant model was obtained (F 4, 35 = 3.05, p = 0.03), with optimism being the only significant predictor of positive affect. The second analysis also yields a statistically significant model (F 4, 35 = 3.32, p = 0.02), where neuroticism, and, marginally, optimism turned out to be significant predictors of negative affect. Conclusion. Our study showed that optimism and neuroticism may be important predictors of the affective state after breast cancer surgery. Therefore, it is important to include these factors in the screening batteries for early detection of vulnerable individuals and to take them into account when planning psychological interventions.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated primary echinococcosis of breast: A rare case report","authors":"R. Liubota, M. Anikusko, O. Zotov, R. Vereshchako, I. Liubota","doi":"10.2298/AOO1701015L","DOIUrl":"https://doi.org/10.2298/AOO1701015L","url":null,"abstract":"Isolated echinococcosis or hydatid cyst of breast is very rare disease especially in non-endemic areas. Even in endemic areas, hydatid cysts detects only for 0.27% of all cases of hydatidosis. Diagnosis of hydatid disease is difficult and it is diagnosed after surgical excision in majority cases. We report a case of 39 year old female with isolated hydatid cyst of the left breast that appeared as a painless breast lump without any specific symptoms.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of smad4 gene promoter methylation in pancreatic and endometrial cancers","authors":"A. Nikolić, Filip Opincal, M. Ristanović, J. Trifunovic, S. Knežević, D. Radojkovic","doi":"10.2298/AOO1702017N","DOIUrl":"https://doi.org/10.2298/AOO1702017N","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orofacial complaints and complications of chemotherapy","authors":"C. Novaes, Rafaela Tristão e Silva, Ângela Mello Coelho, G. Fabri, Maria das Graças Afonso Miranda Chaves","doi":"10.2298/aoo1701009n","DOIUrl":"https://doi.org/10.2298/aoo1701009n","url":null,"abstract":"effects, involving paraneoplastic mechanisms. Pain secondary to cancer therapy varies with the treatment modalities used: chemo-radiotherapy protocols are typically associated with painful mucositis and neurotoxicity. Surgical therapies often result in nerve and ABSTRACT Background: Oral complications of chemotherapy are sometimes unnoticed and if not treated, they can compromise patients’ health and quality of life. Methods: This study aimed to assess and characterize orofacial complaints and complications, and their impact on the oral-health-related quality of life in patients undergoing cancer chemotherapy. Results: We evaluated 28 patients with solid tumors undergoing chemotherapy, through a systematic orofacial evaluation. Eighteen patients (64.2%) developed oral complications during chemotherapy and xerostomia scored the highest incidence n = 14 (50%). About oral health data, gingival index revealed greater part of patients classified with moderate or severe gingival inflammation. The mean plaque index was 25.6%. The mean CPOD index was 15.48 and was worse in patients without oral complications. The patients presented higher plaque index and the oral health impact profile showed higher mean index in the patients group that developed oral complications. Conclusion: These data reinforce the crucial role of the dentist in the multidisciplinary team, with crucial suport in the diagnosis of oral complications. Thus, a specific assistance and relieve of patient’s complaints could impact positively on quality of life.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical, morphological and pathohistological characteristics of thymomas - our ten year experience","authors":"A. Lovrenski, D. Tegeltija, I. Jeličić, Milorad Bijelović, D. Ðuric, Milana Panjković","doi":"10.2298/AOO1702020L","DOIUrl":"https://doi.org/10.2298/AOO1702020L","url":null,"abstract":"Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014. Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with 24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype B2 and type AB presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor diameter between 5 and 10 cm. Five patients had malignant thymoma, and the most common types of thymoma that showed signs of capsula invasion or pleural and pericardial implants were type AB (60%) and subtype B2 (50%). Biopsies of suspected tissue were obtained through a sternotomy, video-assisted thoracoscopy surgery, and video-assisted mini thoracotomy, and after setting a diagnosis on ex tempore analysis, the lesions were removed by thymectomy or extirpation of the tumor mass. Conclusion: Thymomas have variable clinical presentations. Clinical outcome correlates with histological type, size and clinical stage, as well as the ability to achieve complete tumor resection.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Values of alkaline phosphathase and their isoenzyme profiles in patients with cancer in respect to bone and liver metastasis","authors":"Marina Ðokic-Lisanin, V. Pantović, Z. Jovanović, G. Samardžić, V. Jurišić","doi":"10.2298/AOO1301014D","DOIUrl":"https://doi.org/10.2298/AOO1301014D","url":null,"abstract":"Background: Alkaline phosphatase is a glycoprotein that catalyzes two kinds of chemical reactions: hydrolysis of phosphorus ester breaking P-O bonds and phospho-transfer reactions in which phosphoric group is transferred to an acceptor molecule. In the human body, ALP exists in multiple molecular forms whose heterogeneity is partly due to genetic factors and partly to posttranslational modifications. The aim was to evaluate a total ALP activity and its isoforms in cancer patients with bone and liver metastasis in comparison to healthy controls. Methods: Human serum was collected from 20 healthy individuals, and 20 cancer patients with bone and liver metastases, with metastases confirmed by ultrasound, computerized tomography and a radiology scan. Determination of ALP was done by the endpoint spectrophotometric method. Isoenzymes were determined by heat inactivation method. Results: In cancer patients, the total ALP activity was significantly higher (p< 0.05) compared to healthy controls. In the sera of cancer patients with liver metastases, the remaining ALP activity was two-fold higher in comparison to bone metastases. Conclusion: Determination of ALP isoenzymes is important but a correct clinical interpretation in the context of other analyses is vital for a proper diagnosis of a disease. [Projekat Ministarstva nauke Republike Srbije, br.175056]","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301014D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard therapy of HER2-positive and triple negative metastatic breast cancer - present and future","authors":"J. Trifunović, J. Pešić","doi":"10.2298/AOO1304163T","DOIUrl":"https://doi.org/10.2298/AOO1304163T","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerosing hemangioma of the lung","authors":"D. Tegeltija, A. Lovrenski, M. Milić, Miloš Koledin, Milana Panjković","doi":"10.2298/aoo1304133t","DOIUrl":"https://doi.org/10.2298/aoo1304133t","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eight years after introducing liver resection at the Oncology Institute of Vojvodina","authors":"I. Majdevac, N. Budišin, M. Ranisavljevic, D. Lukić, Imre Lovas, N. Šolajić","doi":"10.2298/AOO1304101M","DOIUrl":"https://doi.org/10.2298/AOO1304101M","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}