印尼西苏门答腊晚期非角化性鼻咽癌中表皮生长因子受体的表达

Q4 Medicine
Sukri Rahman, Histawara Subroto, J. Budiman, Aswiyanti Asri, Hafni Bachtiar
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引用次数: 4

摘要

鼻咽部的亚细胞机制得到证实,但在一些研究中发现表皮生长因子受体过表达。根据组织病理学分类,由分化型(WHO II)和未分化型(WHO III)组成的非角化亚型是流行地区最常见的类型。而在非流行地区,大多数病例为角化亚型(WHO I)。本研究的目的是评估晚期非角化鼻咽癌中表皮生长因子受体的表达,并评估分化非角化鼻咽癌(WHO II)和未分化鼻咽癌(WHO III)之间表达的差异,这可能影响抗表皮生长因子受体治疗鼻咽癌。34例晚期(III期和IV期)非角化癌的活检,包括17例分化的非角化癌和17例未分化的表皮因子癌。我们的研究结果表明,34例分化的非角化癌的组织病理学亚型中有23例存在表皮生长因子受体(p=0.465)。结论:表皮生长因子受体在大多数晚期非角化鼻咽癌中均有表达,分化型非角化鼻咽癌(WHO II)与未分化型非角化鼻咽癌(WHO III)的表达无差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of epidermal growth factor receptor in advance stage nonkeratinizing nasopharyngeal carcinoma in west Sumatra, Indonesia
subcellular mechanism of the nasopharyngeal confirmed, but in several studies overexpression of the epidermal growth factor receptor was found. Based on histopathological classification, nonkeratinizing subtypes consisting of differentiated (WHO II) and undifferentiated (WHO III) are the most frequent types in endemic areas, whereas in non-endemic areas the majority of cases are keratinizing subtype (WHO I). The objective of this study was to evaluate the expression of epidermal growth factor receptor in advanced stage nonkeratinizing nasopharyngeal carcinoma as well as to evaluate difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated (WHO III) nasopharyngeal carcinoma that may affect the anti-epidermal growth factor receptor therapy for nasopharyngeal carcinoma. Biopsies from 34 advance stage (stage III and stage IV) nonkeratinizing carcinoma consisting of 17 differentiated nonkeratinizing and 17 undifferentiated carcinomas of epidermal factor in investigated Our results demonstrated that epidermal growth factor receptor in 23 out of 34 subjects in differentiated nonkeratinizing carcinoma of in carcinoma histopathological subtypes (p=0.465). Conclusions: The epidermal growth factor receptor was expressed in most cases of advance stage nonkeratinizing nasopharyngeal carcinoma, and there was no difference in the expression between differentiated nonkeratinizing (WHO II) and undifferentiated nonkeratinizing nasopharyngeal carcinoma (WHO III).
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来源期刊
Archive of Oncology
Archive of Oncology Medicine-Oncology
CiteScore
0.60
自引率
0.00%
发文量
5
审稿时长
12 weeks
期刊介绍: Archive of Oncology is an international oncology journal that publishes original research, editorials, review articles, case (clinical) reports, and news from oncology (medical, surgical, radiation), experimental oncology, cancer epidemiology, and prevention. Letters are also welcomed. Archive of Oncology is covered by Biomedicina Vojvodina, Biomedicina Serbica, Biomedicina Oncologica, EMBASE/Excerpta Medica, ExtraMED and SCOPUS.
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