2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)最新文献_第3页

An Implantable Wireless Network of Distributed Microscale Sensors for Neural Applications 一种用于神经应用的分布式微型传感器可植入无线网络

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717023

Jihun Lee, Ethan Mok, Jiannan Huang, Lingxiao Cui, Ah-Hyoung Lee, V. Leung, P. Mercier, Steven Shellhammer, L. Larson, P. Asbeck, Ramesh R. Rao, Yoon-Kyu Song, A. Nurmikko, F. Laiwalla

{"title":"An Implantable Wireless Network of Distributed Microscale Sensors for Neural Applications","authors":"Jihun Lee, Ethan Mok, Jiannan Huang, Lingxiao Cui, Ah-Hyoung Lee, V. Leung, P. Mercier, Steven Shellhammer, L. Larson, P. Asbeck, Ramesh R. Rao, Yoon-Kyu Song, A. Nurmikko, F. Laiwalla","doi":"10.1109/NER.2019.8717023","DOIUrl":"https://doi.org/10.1109/NER.2019.8717023","url":null,"abstract":"A vastly enhanced capability to bi-directionally interface with cortical microcircuits in a clinically viable way is the ultimate aspiration in neuroengineering. This necessitates a paradigm shift in neural interface system design beyond current bulky, monolithic constructs which are challenging to scale past 100-200 channels due to anatomic and engineering design constraints. A neural interface system relying on a spatially-distributed network of wireless microscale implantable sensors offers a highly scalable, robust and adaptive architecture for next-generation neural interfaces. We describe the development of a wireless network of sub-mm, untethered, individually addressable, fully wireless \"Neurograin\" sensors, in the context of an epicortical implant. Individual neurograin chiplets integrate a ~ 1 GHz wireless link for energy harvesting and telemetry with analog and digital electronics for neural signal amplification, on-chip storage, and networked communications via a TDMA protocol. Each neurograin thus forms a completely self-contained single channel of neural access and is implantable after post-process atomic layer deposition of thin-film (100 nm thick) barriers for hermetic sealing. Finally, ensembles of implantable neurograins form a fully wireless cortico-computer communication network (utilizing their unique device IDs). The implanted network is coordinated by a compact external \"Epidermal Skinpatch\" RF transceiver and data processing hub, which is implemented as a wearable module in order to be compatible with clinical implant considerations. We describe neurograin performance specifications and proof-of-concept in bench top and ex vivo and in vivo rodent platforms.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123342412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Simple Quasi-Static Control of Functional Electrical Stimulation-Driven Reaching Motions 功能电刺激驱动到达运动的简单准静态控制

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8716955

D. Wolf, Eric M. Schearer

引用次数: 5

Neural based assessment of mind wandering during a fatigueinducing motor task: Is task failure due to fatigue or distraction? 疲劳诱发运动任务中走神的神经评估:任务失败是由于疲劳还是注意力分散?

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717037

Surbhi Hablani, Ciara Marie OrHiggins, D. Walsh, R. Reilly

{"title":"Neural based assessment of mind wandering during a fatigueinducing motor task: Is task failure due to fatigue or distraction?","authors":"Surbhi Hablani, Ciara Marie OrHiggins, D. Walsh, R. Reilly","doi":"10.1109/NER.2019.8717037","DOIUrl":"https://doi.org/10.1109/NER.2019.8717037","url":null,"abstract":"This study developed a method for investigating mind wandering (MW) in a fatigue-inducing motor task. To develop research protocols to assess fatigue in clinical cohorts, it is important that participants perform the task at hand to the best of their ability and with their complete attention. Therefore, it is important to know if the participant fails in the task due to fatigue or lack of sustained attention as a result of MW. Two cohorts of 12 healthy controls and Chronic Fatigue Syndrome (CFS) subjects performed a hand-grip fatigue-inducing motor task while EMG and EEG were simultaneously recorded. Frontal midline theta (FMT) and parietal alpha power were calculated throughout the task. While no significant differences were obtained in the FMT power for both cohorts, significant differences in parietal alpha power for the healthy subjects across the task shows they may have experienced MW unlike CFS subjects, who had to put in consistent effort to sustain attention during the task, which could imply fewer MW events. Assessing MW using EEG can serve as an objective marker for evaluating performance in a task and, for assessing the impact of fatigue on the ability to sustain attention.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132629354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2 环孢素免疫抑制和rAAV2-retro介导的ChR2表达后非人灵长类运动神经延长的功能性光学敏感性

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8716978

Jordan J. Williams, A. Vazquez, A. Schwartz

{"title":"Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2","authors":"Jordan J. Williams, A. Vazquez, A. Schwartz","doi":"10.1109/NER.2019.8716978","DOIUrl":"https://doi.org/10.1109/NER.2019.8716978","url":null,"abstract":"Peripheral optogenetic stimulation of motor activity offers enticing advantages over traditional functional electrical stimulation for the purposes of reanimating paralyzed muscles. When facilitated by intramuscular injection of viral gene therapy constructs, however, the process of transducing light sensitive ion channels along motor nerves faces several challenges including uptake of the virus at the neuromuscular junction as well as evasion of both virus and expressed gene products from the immune system. These hurdles to successful peripheral motor gene therapy are often amplified when attempting to translate these techniques to non-human primates. In this study, we examined the efficacy of a systemic immunosuppression regimen and use of a designer adeno-associated virus in prolonging functional opsin expression in targeted peripheral nerves of a macaque. Using a regimen of daily cyclosporine and either an intramuscular or intraneural injection of an rAAV2-retro based vector, we observed functional nerve expression of ChR2 via EMG activity locked to optical stimulation of a targeted nerve for up to 24 weeks post-injection. Throughout this experiment, we observed a gross timeline of expression including an initial increase of ChR2 expression over 9-13 weeks followed by an eventual decline after cessation of the immunosuppression regimen. These results suggest a potential strategy for successful translation of peripheral motor gene therapy to human subjects.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114823753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An Intraoral Closed-Loop Monitoring and Stimulation System for Treatment of Swallowing Problems 一种治疗吞咽问题的口内闭环监测和刺激系统

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717139

Siddarth Biyani, Saurabh Biswas, Hangue Park

{"title":"An Intraoral Closed-Loop Monitoring and Stimulation System for Treatment of Swallowing Problems","authors":"Siddarth Biyani, Saurabh Biswas, Hangue Park","doi":"10.1109/NER.2019.8717139","DOIUrl":"https://doi.org/10.1109/NER.2019.8717139","url":null,"abstract":"One in every 25 Americans suffer from swallowing disorders, referred to as Dysphagia. Problems in the pharyngeal phase of swallowing are hard to treat because of the neuromuscular complexity in the region and the quick passage of food (< 1 s) through the pharyngeal region. This paper proposes a new closed-loop neural stimulation approach for treating swallowing problems. This approach monitors the start of involuntary phase of swallowing by detecting the tongue-tip pressure and stimulating the soft palatal area inside the 2nd molar, potentially lesser palatine nerve, as a closed-loop. We hypothesize that the closed-loop stimulation on the soft palatal area inside the 2nd molar, timed with the onset of the pharyngeal swallowing, augments the sensory feedback and promotes triggering of the pharyngeal swallowing phase. Two experiments were performed to test the hypothesis. In the first experiment, the swallowing time and acceleration of laryngeal excursion was recorded without any stimulation. In the second experiment, stimulation was provided to the lesser palatine nerve for 500 ms when tongue tip was detached from the incisors, and the swallowing time and acceleration of laryngeal excursion was recorded. Two human subjects participated in the study. Without stimulation, both subjects showed consistent swallowing in both duration and amplitude. Stimulation reduced the peak-to-peak duration of laryngeal excursion, but the peak-to-peak amplitude of laryngeal excursion was not changed by stimulation. This study found that closed-loop stimulation onto the palatal area inside the 2nd molar, timed with the onset of the pharyngeal swallowing, can reduce the duration of the pharyngeal swallowing.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123225555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Correlates of error processing during grasping with invasive brain-machine interfaces* 有创脑机接口抓取过程中错误处理的神经关联研究*

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717020

Miri Benyamini, Samuel R. Nason, C. Chestek, M. Zacksenhouse

{"title":"Neural Correlates of error processing during grasping with invasive brain-machine interfaces*","authors":"Miri Benyamini, Samuel R. Nason, C. Chestek, M. Zacksenhouse","doi":"10.1109/NER.2019.8717020","DOIUrl":"https://doi.org/10.1109/NER.2019.8717020","url":null,"abstract":"Brain-machine interfaces (BMIs) may generate more errors than those encountered during normal motor control. Thus, they provide an opportunity to investigate neural correlates of error processing. Characterizing neural correlates of error processing may, in turn, provide a tool for on-line correction of the errors that are made by the interface. We investigated neural correlates of error processing during BMI experiments in which monkeys controlled an animated hand on the screen to touch a ball by moving their own fingers. Short movement segments that were consistently toward or away from the target were labeled accordingly and used to train a classifier to differentiate between correct and erroneous movements based on the neural activity. The results indicate that despite the limited number of labeled segments and active neurons in the studied data, the classifier achieved a classification rate of 68% on testing. The full receiver operating curve (ROC) has been estimated and indicates that even when the false alarm is restricted to 5%, the classifier can detect 36% of the erroneous movements. Better results are expected when using more data, especially as more challenging grasping tasks are performed. Such a classifier could be used to improve the performance of BMIs by detecting and correcting erroneous movements.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126409548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Closed-Loop Bladder Neuromodulation Therapy in Spinal Cord Injury Rat Model 闭环膀胱神经调节疗法在脊髓损伤大鼠模型中的应用

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717001

M. Raczkowska, W. Y. Peh, Yuni Teh, Monzurul Alam, S. Yen, N. Thakor

引用次数: 0

Pupillary Correlates of Emotion and Cognition: A Computational Model 瞳孔相关的情绪和认知:一个计算模型

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717091

C. Balkenius, Christine Fawcett, T. Falck-Ytter, G. Gredebäck, B. Johansson

引用次数: 6

Employing an entropy-based measure of sway to probe postural stability in Fragile X Premutation carriers* 采用基于熵的摇摆测量来探测脆性X预突变携带者的姿势稳定性*

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717071

Clodagh O’Keeffe, Laura P. Taboada, Niamh Feerick, L. Gallagher, T. Lynch, R. Reilly

{"title":"Employing an entropy-based measure of sway to probe postural stability in Fragile X Premutation carriers*","authors":"Clodagh O’Keeffe, Laura P. Taboada, Niamh Feerick, L. Gallagher, T. Lynch, R. Reilly","doi":"10.1109/NER.2019.8717071","DOIUrl":"https://doi.org/10.1109/NER.2019.8717071","url":null,"abstract":"Carriers of the fragile X premutation are at risk of developing the late-onset neurodegenerative movement disorder Fragile X associated tremor/ataxia Syndrome. (FXTAS). Although only recently discovered, emerging research has revealed that premutation carriers exhibit various subtle deficits in certain aspects of cognition and stability well before the typical age of onset of FXTAS. This study aimed to characterize the premutation phenotype in terms of cognition and postural stability as well as investigating the relationship between these two faculties with the aim of identifying preclinical symptoms of FXTAS. Methods: A group of 12 female premutation carriers and 15 healthy controls had postural stability recorded while standing with their eyes open, closed, as well as during working memory and attention based dual-tasks. Postural sway was characterized through traditional parameters (area, path length, and velocity) as well as through entropy-based measures such as the Complexity Index. Results: There were no differences observed in terms of traditional parameters between groups. The control group exhibited higher complexity indices than carrier in both dual-task conditions. Similarly, the complexity index of the control group was significantly higher during both dual-tasks, compared to the baseline eyes open condition, while premutation carriers remained consistent across tasks. This may reflect a reduction in adaptive capacity in premutation carriers. Conclusion: A combination of traditional and entropy-based measures of sway may serve as an objective measure of dual-task interference in premutation carrier and reveal subtle changes in stability and postural control when under increased cognitive load.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133986469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Simultaneous impedance measurements of the Utah electrodes array : A finite element method analysis 犹他电极阵列的同步阻抗测量:一种有限元分析方法

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Pub Date : 2019-03-20 DOI: 10.1109/NER.2019.8717172

Elena della Valle, J. Weiland

{"title":"Simultaneous impedance measurements of the Utah electrodes array : A finite element method analysis","authors":"Elena della Valle, J. Weiland","doi":"10.1109/NER.2019.8717172","DOIUrl":"https://doi.org/10.1109/NER.2019.8717172","url":null,"abstract":"High-count micro-electrode arrays for the recording or stimulation of the nervous system have the potential to restore function lost to disease or injury. The tracking of the electrode characteristics and changes over time becomes crucial for reliability evaluation and human implementation. Current approaches to impedance measurement are manual and often restricted to a single frequency (1 kHz). Channels are evaluated serially. When 100 or more channels are present, the process can become time-consuming. In this paper, we use finite element method (FEM) modeling for studying the impact of simultaneous impedance measurement of 100 electrodes of a Utah Electrode Array (UEA). We simulate potentiostatic impedance spectroscopy of a UEA implanted in the brain. The simulations have been performed using a 25 mV excitation voltage, applied to a common reference, at frequency range from 1 Hz to 10 MHz. Each individual electrode channel is held at ground potential and the current through each channel is measured to determine impedance. Higher impedance has been found when measuring the electrodes simultaneously versus measurement of a single electrode, due to crowding of electric field lines near the electrode tissue interface.","PeriodicalId":356177,"journal":{"name":"2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124479355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0