Reema Karasneh, Sayer Al-Azzam, Karem H Alzoubi, Mohammad B Nusair, Sahar Hawamdeh, Amal T Nusir
{"title":"Patterns and Predictors of Internet Gaming Disorder: An Observational Study from Jordan.","authors":"Reema Karasneh, Sayer Al-Azzam, Karem H Alzoubi, Mohammad B Nusair, Sahar Hawamdeh, Amal T Nusir","doi":"10.2174/1745017902117010217","DOIUrl":"https://doi.org/10.2174/1745017902117010217","url":null,"abstract":"<p><strong>Objective: </strong>Internet Gaming Disorder (IGD) is a rapidly growing public health problem that may have detrimental effects. The purpose of this study is to identify factors associated with IGD status.</p><p><strong>Methods: </strong>In this cross-sectional observational study, a convenient sample of gamers in Jordan was recruited and asked to participate in an online survey based on the nine criteria of the 20-item Internet Gaming Disorder (IGD-20) used to assess gaming disorder. Sociodemographic and psychosocial data were also obtained.</p><p><strong>Results: </strong>A total of 504 gamers participated in this study. The mean age of respondents was 21.6 ± 3.90 years. Using the standard IGD-20 scale, 96 participants (19%) were classified as potential IGD cases, compared to 408 (80.9%) non-disordered gamers. Males were dominant among the population, constituting 348 (69%) of gamers. Males also played significantly more hours per week [17.8 ±16.75] compared to females [13 ± 17.65]. The majority of gamers (411 (81.5%)) were students, although unemployed adults played for the highest total time [23.9 ± 30.84 hours/week]. Device type used for gaming also significantly (p <0.05) affected the time spent playing. Predictors of IGD included educational level (p< 0.05) and playing hours/week (p< 005). Conversely, no significant associations were found between IGD and gender, age, employment, or sleeping hours. IGD is increasingly being diagnosed among both genders and presents a health challenge for internet users.</p><p><strong>Conclusion: </strong>Establishing gamer profiles and recognizing predictors of IGD is therefore vital for guiding clinical classification and diagnosis of the disease.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabela A Melca, Antonio E Nardi, Lucio L Gonçalves, Rachel M Ferreira, Mariana S K Lins de Padua, Anna L S King
{"title":"Sex, Digital Devices, Social Media, and Social Isolation: A Study on Sexual Behavioral During COVID -19 Pandemic.","authors":"Isabela A Melca, Antonio E Nardi, Lucio L Gonçalves, Rachel M Ferreira, Mariana S K Lins de Padua, Anna L S King","doi":"10.2174/1745017902117010235","DOIUrl":"https://doi.org/10.2174/1745017902117010235","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus (COVID-19) pandemic has caused social and economic damages. People have adapted to a new reality of physical distance.</p><p><strong>Objective: </strong>The study aimed to assess the use of digital devices and social media, focusing on psychosocial and demographic factors of people´s sexual behavior during the pandemic.</p><p><strong>Methods: </strong>A total of 1,357 Brazilian adults participated in a cross-sectional online survey. They were recruited through social media to obtain information regarding sexual behavior and the use of digital devices and social media.</p><p><strong>Results: </strong>Digital devices and social media were used by 38.8% of the participants. Among the group that used technological devices, most claimed to have changed their sexual behavior, with 76.9% consuming more sexual content through movies or series.</p><p><strong>Conclusion: </strong>In a smaller group, technological resources appeared as an alternative for safer sex, reducing the risks of COVID-19 transmission.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship Between Gender and Clinician's Subjective Experience during the Interaction with Psychiatric Patients.","authors":"Federico Dazzi, Laura Fonzi, Mauro Pallagrosi, Marina Duro, Massimo Biondi, Angelo Picardi","doi":"10.2174/1745017902117010190","DOIUrl":"https://doi.org/10.2174/1745017902117010190","url":null,"abstract":"<p><strong>Introduction: </strong>The clinician's subjective experience can be a valuable element for diagnosis and treatment. A few factors have been recognized that affect it, such as the patient's personality, the severity of psychopathology, and diagnosis. Other factors, such as patient's and clinician's gender, have not been specifically investigated. The aim of this study is to explore the impact of gender differences on the clinician's subjective experience in a large sample of psychiatric patients.</p><p><strong>Methods: </strong>The study involved 61 psychiatrists and 960 patients attending several inpatient and outpatient psychiatric settings. The clinicians completed the Assessment of Clinician's Subjective Experience (ACSE) questionnaire after observing each patient for the first time.</p><p><strong>Results: </strong>In multivariate analysis, higher scores on the Difficulty in Attunement (p < 0.001), Engagement (p<0.05), and Impotence (p<0.01) scales were significantly associated with female clinician gender, whereas higher scores on the Tension and Disconfirmation scales were significantly associated with male clinician gender. The scores on all ACSE dimensions were also associated with the severity of psychopathology.</p><p><strong>Conclusion: </strong>The findings suggest that clinician's gender might affect a clinician's emotional response toward patients. Specific attention to this issue might be useful in clinical situations, not only in terms of promoting gender-balanced teams but also in terms of enhancing self-observation in clinicians evaluating patients for the first time.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Miin Lau, Kai Samuel Sim, Qian Hui Chew, Kang Sim
{"title":"Quality of Life and Clinical Correlates in Adults with Social Phobia: A Scoping Review.","authors":"Hui Miin Lau, Kai Samuel Sim, Qian Hui Chew, Kang Sim","doi":"10.2174/1745017902117010224","DOIUrl":"https://doi.org/10.2174/1745017902117010224","url":null,"abstract":"<p><strong>Objective: </strong>In light of the substantial clinical and societal burden of social phobia (SP) and impact on the sense of well-being of affected individuals, we sought to summarise extant data related to quality of life and relevant correlates in adults with SP to distill clinical profiles for earlier identification and appropriate management.</p><p><strong>Methods: </strong>A scoping review was carried out on studies examining quality of life in adults with SP and clinical correlates within different settings. PubMed/Medline and Web of Science databases were searched for relevant articles beginning from database inception until May 2021.</p><p><strong>Results: </strong>A total of 25 papers were included. Most of the studies (92%) were cross sectional in nature (80%), conducted in the West (92%), and within clinic or community settings (88%). Patients with comorbid psychiatric conditions, and undergraduate students reported higher rates of SP compared with community population. Significant correlates of SP included demographic (such as females, younger age, living alone, fewer years of education, unemployment) and clinical factors (such as family history of anxiety disorders, suicidal ideas, avoidant personality features). SP was widely associated with decreased QoL involving several domains and especially related to complexity, greater number of feared or trigger situations, and comorbid medical and psychiatric conditions.</p><p><strong>Conclusion: </strong>SP is not uncommon within clinical, and undergraduate populations, and has a significantly negative impact on quality of life. Awareness of its associated clinical profiles allows better identification and overall management of this condition including improvement in QoL.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduardo Lattari, Andreza Jesus Costa Pascouto, Bruno Ribeiro Ramalho Oliveira, Livia Soares Silva, Aldair José Oliveira, Sérgio Machado, Geraldo Albuquerque Maranhao Neto
{"title":"Association between Estimated Cardiorespiratory Fitness and Depression among Middle-income Country Adults: Evidence from National Health Survey.","authors":"Eduardo Lattari, Andreza Jesus Costa Pascouto, Bruno Ribeiro Ramalho Oliveira, Livia Soares Silva, Aldair José Oliveira, Sérgio Machado, Geraldo Albuquerque Maranhao Neto","doi":"10.2174/1745017902117010198","DOIUrl":"10.2174/1745017902117010198","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed the relationship between cardiorespiratory fitness (CRF) and depression in adults.</p><p><strong>Methods: </strong>A total of 52,611 individuals aged between 18-59 years old were evaluated for symptoms of depression and CRF. The presence of depressive symptoms was self-report through the Patient Health Questionnaire (PHQ-9), and the CRF was predicted from a non-exercise equation. The association between CRF and the presence of depression was determined by crude and multivariable-adjusted logistic regressions.</p><p><strong>Results: </strong>The associations were identified between symptoms of depression and CRF in both unadjusted and adjusted models. After adjusting for age categories, sex, body mass index categories, educational level, marital status, smoking, and alcohol use, the individuals with moderate CRF had 18% lower odds of depression (OR: 0.82, CI 95%: 0.71 - 0.95) compared to individuals with low CRF.</p><p><strong>Conclusion: </strong>Depressive symptoms are inversely related to CRF levels in adults.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa
{"title":"Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia Underwent Hematopoietic Stem Cell Transplantation","authors":"O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa","doi":"10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","url":null,"abstract":"\u0000 \u0000 β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy, based on blood transfusions and iron chelation, and nowadays this approach is capable to assure a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). The aim of this paper was to evaluate with a systematic review and meta-analysis the role of HRQoL in transplanted β-TM patients.\u0000 \u0000 \u0000 \u0000 PubMed database, Web of Science and Scopus were systematically searched for studies published between January 1st, 2000 to September, 2020; the following terms were entered in the database queries: β-thalassemia, HRQoL and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement.\u0000 \u0000 \u0000 \u0000 We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with a conventional therapy in Physical an Emotional Function dimension, with a medium effect size (d=0.65, (95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75% and d=0.59, (95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0% respectively).\u0000 \u0000 \u0000 \u0000 HRQoL is generally good in β-TM transplanted patients and may give a significant contribute the difficult choice whether transplant or not a β-TM patient treated with conventional therapy.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aiswarya L Varghese, Chinnu Thomas, Megha Mohan, Sudhin Karuppali
{"title":"A Comparative Study of the Communication Profile of Typically Developing Children and Children with Receptive-Expressive Language Disorders: A Parental Perceptive.","authors":"Aiswarya L Varghese, Chinnu Thomas, Megha Mohan, Sudhin Karuppali","doi":"10.2174/1745017902117010177","DOIUrl":"https://doi.org/10.2174/1745017902117010177","url":null,"abstract":"<p><strong>Background: </strong>Parental concerns pertaining to communication abilities are essential as it does aid in the identification of the children at risk of physical and mental health problems.</p><p><strong>Objectives: </strong>The current study followed a cross sectional study design. The study focussed on developing a questionnaire targeting the parental concerns in Typically developing (TD) children and children with Receptive-Expressive Language Disorders (CWRELD) between 3.7 and 6.6 years of age; to administer the developed questionnaire on parents of TD children and CWRELD; and to analyse and compare the concerns faced by parents of TD children and CWRELD across 3.7 and 6.6 years of age.</p><p><strong>Methods: </strong>Fifty-one parents of TD children and 51 parents of CWRELD participated in the study. The study was carried out in three phases- Phase I included the development and validation of questionnaire; Phase II included data collection using the developed questionnaire; and Phase III included performing statistical analysis. Descriptive statistics was done to determine the mean and standard deviation (SD) for both the TD and CWRELD groups.</p><p><strong>Results: </strong>The results revealed that the concerns exhibited by parents of CWRELD were significantly higher than that of parents of TD children. Chi square results indicated statistically significant findings across all the domains between TD children and CWRELD (p<0.05).</p><p><strong>Conclusion: </strong>The developed questionnaire can be used in clinical settings to help track parental concerns which may aid in the early identification of children at risk of various communication disorders. Additionally, this questionnaire may be considered for monitoring parental concerns throughout the course of the intervention program.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39763481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angelo Picardi, Marco Miniotti, Paolo Leombruni, Antonella Gigantesco
{"title":"A Qualitative Study Regarding COVID-19 Inpatient Family Caregivers' Need for Supportive Care.","authors":"Angelo Picardi, Marco Miniotti, Paolo Leombruni, Antonella Gigantesco","doi":"10.2174/1745017902117010161","DOIUrl":"https://doi.org/10.2174/1745017902117010161","url":null,"abstract":"<p><strong>Background: </strong>Family caregivers of COVID-19 inpatients are exposed to multiple sources of distress. These include not only losing friends, colleagues and members of the family, but also the fear of possible losses in sociality, finances and, impoverished communication with sick family members and health care providers.</p><p><strong>Objective: </strong>This study describes the psychological experience of COVID-19 inpatient family caregivers to highlight the main sources of distress, issues, concerns and unmet needs.</p><p><strong>Methods: </strong>Two focus groups were independently organized with COVID-19 inpatient family caregivers and health care personnel of COVID-19 wards in order to highlight family caregivers' practical and psychological burden and related needs. A thematic analysis was conducted to analyze the data.</p><p><strong>Results: </strong>Family caregivers mentioned they needed more information about the patient's condition with more attention being paid to their own emotional state. Feelings of impotence, concerns about how to deal with patient's discharge, significant psychological distress, and anxiety were frequently reported by study participants.</p><p><strong>Conclusion: </strong>Study findings suggest the need to strengthen the assistance of COVID-19 patient family caregivers. In the pandemic scenario, family caregivers might represent a crucial resource, which can guarantee rapid discharges, support home health care and thus relieve pressure on hospital systems.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Prevalence of Addiction to Social Network Among Students in Iran and its Factors Related: A Study Conducted in 2020.","authors":"Hoorieh Rahiminia, Hamid Soori, Mahdi Jafari, Soheila Khodakarim","doi":"10.2174/1745017902117010170","DOIUrl":"10.2174/1745017902117010170","url":null,"abstract":"<p><strong>Background: </strong>In the present era, the prevalence of addiction to social networks has shown that many users, including students, are detaching from the real world. Therefore, this study aims to estimate the prevalence of addiction to the social networks among students in Iran and its related factors.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted in 2020 on 1000 students in Shahid Beheshti University of Medical Sciences, Tehran, Iran. The data collection tool was a standardized questionnaire about addiction to the social networks distributed online among students. Statistical data were analyzed using Stata software version 14.</p><p><strong>Results: </strong>Generally, 462 students (44%) had addiction to social networks, of which 449 (90.04%) had slight addiction and 13 (9.96%) had severe addiction. The results showed that age (p = 0.001), type of disciplines in the treatment-related subgroup (p = 0.03) and using nerve medicine (p = 0.0001) had significant relationships with addiction to social networks.</p><p><strong>Conclusion: </strong>Considering that a high number of students in the present study are at high risk of addiction, it is suggested that educational programs should be implemented to improve the knowledge of parents and students for optimal use of social networks and raise awareness of the harmful consequences of addiction.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. E. Nardi, F. Sancassiani, Vanessa Barrui, G. Kalcev, V. Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, M. Carta
{"title":"The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials.","authors":"A. E. Nardi, F. Sancassiani, Vanessa Barrui, G. Kalcev, V. Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, M. Carta","doi":"10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12","url":null,"abstract":"\u0000 \u0000 The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment.\u0000 \u0000 \u0000 \u0000 Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020.\u0000 \u0000 \u0000 \u0000 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed.\u0000 \u0000 \u0000 \u0000 All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91336408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}