Clinical Practice and Epidemiology in Mental Health最新文献

{"title":"Virtual Reality in the Treatment of Panic Disorder in the Last Decade: A Systematic Review.","authors":"Lucio Gonçalves, Rafael Garcia, Laiana Quagliato, Jose Carlos Appolinario, Antonio Nardi","doi":"10.2174/0117450179358928250123064503","DOIUrl":"10.2174/0117450179358928250123064503","url":null,"abstract":"<p><strong>Introduction: </strong>Virtual Reality (VR) is an interactive, three-dimensional computing environment that enables individuals to experience a sense of presence as if they are immersed in a real-world setting. VR is currently being implemented in therapeutic interventions for individuals with certain mental disorders.</p><p><strong>Objective: </strong>To illustrate the implementation and evolution of VR in the treatment of panic disorder, agoraphobia, and panic disorder with or without agoraphobia over the past decade.</p><p><strong>Method: </strong>A systematic literature review was conducted based on articles retrieved from PubMed, Cochrane, and Web of Science, covering the period from 2013 to 2023. A total of 21 studies were selected after analyzing the titles, abstracts, and content in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.</p><p><strong>Results: </strong>A total of 153 articles were initially selected and included in the study. The results demonstrated the evolution and increasing use of VR-based technologies for the treatment of mental disorders, including panic disorder and PDA.</p><p><strong>Discussion: </strong>The utilization of VR exposure therapy (VRET) for patients with panic disorder, agoraphobia, or PDA yielded measurable outcomes, including the evolution of VRET applications, an increase in the number of scientific articles and patients in recent years, as well as advancements in hardware devices, software, and other application methods, such as self-guided applications.</p><p><strong>Conclusions: </strong>The implementation of VRET is increasing in several regions worldwide, and its evolution is indisputable for the treatment of panic disorder, agarophobia, and PDA. Comparisons with traditional <i>in vivo</i> methods revealed that VRET yields satisfactory and promising outcomes. The continued evolution of VR technology is expected to expand its potential application in patients with these disorders.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179358928"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pre-lockdown Hyper-energy on Mood and Rhythm Dysregulation in Older Adults During the COVID-19 Pandemic.","authors":"Diego Primavera, Goce Kalcev, Fabrizio Bert, Elisa Cantone, Alessandra Perra, Massimo Tusconi, Samantha Pinna, Germano Orrù, Alessandra Scano, Enzo Tramontano, Ivan Barbov, Marcello Nonnis, Antonio Egidio Nardi, Giulia Cossu, Federica Sancassiani, Mauro Giovanni Carta","doi":"10.2174/0117450179344148250206065104","DOIUrl":"https://doi.org/10.2174/0117450179344148250206065104","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this work is to verify whether a cohort of elderly people with hyper-energy tended to increase depressive symptoms and misaligned social and personal rhythms during the lockdown compared to a cohort of older adults without hyper-energy one year before the lockdown.</p><p><strong>Methods: </strong>The two cohorts were evaluated in April 2019 (T0) and in April 2020 (T1). Hyper-energy, cognitive performance, depressive symptoms, and social and personal rhythms were evaluated at T0 and T1.</p><p><strong>Results: </strong>In the measure of the Brief Social Rhythm Scale (BSRS) score, the differences between groups in the two observation times reach statistical significance. The sub-group with previous hyper-energy at T0 but no longer having hyper-energy at T1 increases the score by more than 5 points (a higher score indicates greater rhythm dysregulation, thus having a worse regulation of rhythms at T1), while in those individuals who didn't have hyper-energy, the score remains substantially unchanged (+0.06). However, if the increase in the score from T0 and T1 is measured, both groups with hyper-energy at T0 presented a greater mean increase compared to people who did not have hyper-energy at T1. In the total of the eleven elderly people with hyper-energy at T0, the mean increase in BSRS score was 1.05±1.19 versus 0.06±0.98 (F=9.407, P=0.003), and in people who no longer had hyper-energy at T1, it was 1.05±1.19 versus 5.50±3.83 (F=105.0, P<0.0001). In people with hyper-energy at T0, the mean increase in the Patient Health Questionnaire-9 (PHQ-9) score was 0.72±0.75 versus 0.01±0.28 (F=37.153, P<0.0001). The gain was even higher in people who no longer had hyper-energy at T1, 1.38±1.03 <i>vs</i>. 0.01±0.28 (F=87.386, P<0.0001). An inverse linear correlation was found between energy perception (measured as the score of Item 10 of SF-12) and the score of PHQ-9 measuring depressive symptoms both at T0 and, more strongly, at T1, as well as with the BSRS scores, but only at T1.</p><p><strong>Conclusion: </strong>The study, despite the limitations of a small sample, seems to confirm a greater vulnerability to the lockdown situation in people with hyperactivity, even in the absence of psychopathology (i.e., part of the bipolar spectrum).</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179344148"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Tunisian Arabic Functioning Assessment Short Test (FAST) and Functional Outcome Factors in a Sample of Patients with Bipolar Disorder.","authors":"Hend Jemli, Uta Ouali, Ons Maatouk, Ahlem Hajri, Azza Ben Cheikh Ahmed, Amina Aissa, Rabaa Jomli","doi":"10.2174/0117450179361739250203043410","DOIUrl":"https://doi.org/10.2174/0117450179361739250203043410","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorders negatively impact functional outcomes and, consequently, prognosis. The Functioning Assessment Short Test is a reliable tool to evaluate functional outcomes in people with bipolar disorders.</p><p><strong>Aim: </strong>The aim of the study was to conduct a cross-cultural validation of the Functioning Assessment Short Test (FAST) and to explore correlations between functional impairment and sociodemographic and clinical variables.</p><p><strong>Methods: </strong>A cross-sectional study was carried out in a population of 60 bipolar patients and 60 healthy controls. The scales administered were the Global Functioning Assessment (GAF), the World Health Organization Quality Of Life-Bref (WHOQOL-BREF), the FAST, and a questionnaire containing sociodemographic and clinical variables. The validation study was based on face and content validity, reliability, and construct validity.</p><p><strong>Results: </strong>The face and content validity were satisfactory. The internal consistency obtained was high, with a Cronbach's alpha of 0.785. All six FAST domains had significant correlations with each other and with the total score. The FAST assessment at baseline and week 2 were highly correlated (<i>p</i>>0.05), and the intraclass correlation coefficient was 0.998, indicating high test-retest reliability. The FAST total score was negatively and significantly associated with GAF (rho=-0.788, <i>p</i><0.001) and WHOQOL-BREF scores, suggesting good concurrent validity. The total FAST scores were significantly lower in controls as compared with bipolar patients (<i>p</i><0.001), with a cut-off at 26. Functional impairment was significantly associated with the following variables: low educational level, living alone, early age at onset, number of depressive episodes, and treatment associations (mood stabilizers and antipsychotics).</p><p><strong>Conclusion: </strong>The Tunisian Arabic version of the FAST demonstrated satisfactory psychometric properties and could be used to assess specific domains of functional impairment in people living with bipolar disorders and may be instrumental in implementing psychosocial and rehabilitation interventions.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179361739"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Data for Objective ADHD Smartphone Application in a General Population.","authors":"Urban Gustafsson, Robert Nolen, Nuria Casals, Simon Larsson, Ragini Sanyal, Mikkel Hansen","doi":"10.2174/0117450179377329250131072308","DOIUrl":"https://doi.org/10.2174/0117450179377329250131072308","url":null,"abstract":"<p><strong>Background: </strong>Normative data for objective measures in the clinical assessment of Attention Deficit Hyperactivity Disorder (ADHD) are crucial for enhancing the accuracy, reliability, and clinical utility of diagnostic tools. This observational study aimed to establish normative demographic data in a representative population for an investigational version of QbMobile (QbMobile), a software application for the administration of a performance test to provide objective measurements of hyperactivity, inattention, and impulsivity in the clinical assessment of ADHD.</p><p><strong>Methods: </strong>This study was conducted in the United Kingdom, The Netherlands, Germany, and the United States. Participants between 6-60 years were included. The QbMobile application was pre-installed on the smart device/iPhone. Participants were instructed to sit holding the smartphone with both hands and tap the screen each time a target stimulus appeared on-screen and withhold tapping to all other stimuli. The smartphone tracked the participants' movements with the camera and movements from the smartphone to measure activity.</p><p><strong>Results: </strong>A total of 2541 participants completed the study, n=326 aged 6-11 years and n=2215 aged 12-60 years. There were more females (55.7%) than males (44.3%). Demographic and characteristics variables had no impact on the data collected. Household income and educational levels were investigated to ensure sufficient spread across countries. The basic parameters of QbMobile were captured and evaluated during the assessment. There was a high degree of acceptance of the test, and 94% reported that the application was easy to use.</p><p><strong>Conclusion: </strong>Representative normative data for QbMobile was established from a multinational general population and should provide a useful basis as a comparator for other datasets, such as people with ADHD.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179377329"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Preliminary Validation of a Questionnaire to Assess Perceptions on the Implementation of UN CRPD Principles Concerning Social Inclusion and Participation of Persons with Disabilities in Municipalities.","authors":"Samantha Pinna, Massimo Tusconi, Michela Atzeni, Alessandra Perra, Valerio Leonetti, Giulia Cossu, Diego Primavera, Noemi Maria Mereu, Donatella Rita Petretto, Antonio Preti, Elisa Pelosin, Mehmet Eskin, Gian Mario Migliaccio, Mauro Giovanni Carta, Federica Sancassiani","doi":"10.2174/0117450179360265250113081501","DOIUrl":"https://doi.org/10.2174/0117450179360265250113081501","url":null,"abstract":"<p><strong>Background: </strong>The present study aims to evaluate the preliminary content and face validity of the <b>\"</b>Perceptions on the Implementation of the CRPD in muniCIpalities Questionnaire (PICI-Q),\" a self-report questionnaire built to assess the perceptions on how effectively municipalities implement the CRPD principles concerning social inclusion and participation of persons with disabilities in municipalities.</p><p><strong>Methods: </strong>A two-step Delphi methodology was used to build the questionnaire and assess its content and face validity. A group including health professionals, academics, experts in psychometrics, persons with disabilities and local policymakers was involved in building the questionnaire according to the CRPD articles regarding social inclusion and active participation of persons with disabilities. Two pools of experts assessed the content and face validity and lay stakeholders, respectively.</p><p><strong>Results: </strong>An average content validity index of 0.95 was obtained, with no items removed. Regarding face validity, all items achieved high scores, ranging from 17 to 21, with a face validity index of 0.95.</p><p><strong>Conclusion: </strong>The PICI-Q is a promising tool for assessing perceptions of CRPD implementation in municipalities. Its robust preliminary validation suggests it could support local authorities in designing and improving policies and interventions aligned with the CRPD principles of social inclusion and participation for persons with disabilities.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179360265"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for Coping with Burnout among Palestinian Mental Health Practitioners throughout Wartimes: A Cross-sectional Study.","authors":"Muna Ahmead, Ahmad A Daqqa, Samah Abu Lail, Raba Hadeed, Ikhlass Ghafari","doi":"10.2174/0117450179350988241224114712","DOIUrl":"https://doi.org/10.2174/0117450179350988241224114712","url":null,"abstract":"<p><strong>Background: </strong>During wartime, mental health professionals are more prone to mental health problems, such as burnout. Currently, there is less knowledge of the coping strategies employed by Palestinian mental health professionals to manage the consequences of wars and conflicts. In light of the ongoing political violence in Palestine, this study sought to investigate the prevalence of burnout and coping methods among mental health professionals.</p><p><strong>Methods: </strong>The research design was cross-sectional. We used self-reported questionnaires to gather data, including the abbreviated Maslach Burnout Questionnaire and Brief COPE Scale. Multiple regression, Pearson correlation, and a Chi-square test were used to examine the association between the study variables and burn symptoms.</p><p><strong>Results: </strong>Out of 514 participants, who were surveyed, there was a prevalence of high burnout (75.4%), emotional exhaustion (24.7%), depersonalization (11.9%), and inadequate personal accomplishment (19.6%). Professionals who reported struggling or being unable to interact with their clients during the political violence and those whose psychological state was negatively impacted by it were more likely to feel emotional exhaustion. Also, self-blame was found to raise the chance of emotional exhaustion, whereas planning decreased it. Depersonalization was more common in 31-40-year-olds. Humor and behavioral disengagement increased depersonalization, but religious coping lowered it. Furthermore, treating patients affected by political conflict, being male, not being single, and using substances decreased personal accomplishment, whereas venting increased it.</p><p><strong>Conclusion: </strong>The results showed an elevated prevalence of burnout among mental health personnel during conflict and political violence. Therefore, it is critical to immediately provide mental health workers with stress management training and psychological support to enhance their psychological well-being. Additionally, they need help in learning how to effectively organize their time, manage activities, and distribute duties during political conflict.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179350988"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive Symptoms Prevalence among Medical Students in Four Major Universities, Saudi Arabia: A Cross-Sectional Study.","authors":"Feras A Al-Awad, Kawther Hadhiah, Ahmad Albik, Ahmed Abdulwahab, Ali Almatiq, Ali Alhumran, Husain Alsaffar, Mohammed Alomar, Mohammed A BuSaad","doi":"10.2174/0117450179360311241216053222","DOIUrl":"10.2174/0117450179360311241216053222","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder is recognized by the World Health Organization as one of the top 10 most disabling disorders globally. Characterized by recurrent and persistent thoughts (obsessions) and/or repetitive behaviors (compulsions), it significantly disrupts an individual's daily life, impacting routine, education, career development, and social relationships. The disorder's prevalence varies worldwide, with studies in Saudi Arabia showing a higher rate of obsessive-compulsive symptoms among medical students.</p><p><strong>Objective: </strong>This study aimed to determine the prevalence of obsessive-compulsive symptoms among undergraduate medical students in four major universities in Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional, web-based survey was administered between April and June 2023 to medical students from Imam Abdulrahman Bin Faisal University, King Faisal University, King Saud University, and King Abdulaziz University. The survey assessed obsessive-compulsive symptoms using the OCI-R scale.</p><p><strong>Results: </strong>Out of 886 medical students, 411 (46.4%) scored 21 or more on the OCI-R, indicating probable obsessive-compulsive disorder. Females had significantly higher OCI-R scores compared to males. Younger students, those with a family or personal history of psychiatric disorders, particularly depression, and those with lower academic satisfaction exhibited higher scores.</p><p><strong>Conclusion: </strong>This study emphasizes the importance of incorporating mental health awareness programs into educational curricula due to the high prevalence of obsessive-compulsive symptoms among medical students. Implementing such programs can help reduce stress and improve both academic performance and overall well-being.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"20 ","pages":"e17450179360311"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Nurses Working in Mental Health in a Time of Changing Approaches More Exposed to Stress than other Professionals? Job Satisfaction and Perception of Respect for the Rights of Users in Seven Different Countries Worldwide.","authors":"Cesar Ivan Aviles Gonzalez, Sara De Matteis, Yessika Madelaine Abarca Arias, Doris Marina Cerchiaro Fernandez, Martha Esther Guerra Munoz, Goce Kalcev, Maura Galletta, Maria Rita Pinna, Rober Romero Ramirez, Maria Veronica Brasesco, Uta Ouali, Fabrizio Bert, Mehmet Eskin, Massimo Tusconi, Mauro Giovanni Carta","doi":"10.2174/0117450179349117241211094816","DOIUrl":"10.2174/0117450179349117241211094816","url":null,"abstract":"<p><strong>Background: </strong>The perception of respect for users' rights is fundamental for organizational well-being in mental health services. This cross-sectional observational study examined the job satisfaction and perception of user rights among nursing staff compared to other health professionals across seven countries in the Mediterranean and Latin American regions. This research measures this perception among nursing staff in different countries, with a particular focus on regional differences and professional roles.</p><p><strong>Methods: </strong>Data were collected from mental health services in four Mediterranean and three Latin American countries <i>via</i> a structured questionnaire (Well-Being at Work and Respect Rights Questionnaire - WWRR), administered both online and on paper. Using multivariable logistic regression, the study analyzed associations between job satisfaction, respect for rights, and various socio-demographic and professional factors.</p><p><strong>Results: </strong>Among 408 nurses and 492 other health professionals, findings revealed significant cross-country variability. Nurses in North Macedonia reported higher job satisfaction and perceived respect for user rights than other professionals (<i>p</i><0.0001 in all items of the questionnaire), while Tunisian nurses showed lower organizational satisfaction but higher respect for user rights (<i>p</i>=0.033 for respect for rights). However, in general, no significant differences were found between nurses and other professionals across all items.</p><p><strong>Conclusion: </strong>The perception of respect for users' rights is fundamental for organizational well-being in mental health services. The study highlights differences in organizational well-being perceptions across various contexts, emphasizing the need for culturally and economically adapted policies to improve mental health service environments globally. The results indicate the variability in the perception of respect for rights and job satisfaction between different geographical and professional contexts. This indicates the need for policies adapted to specific cultural and economic realities to improve organizational well-being in mental health services.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"20 ","pages":"e17450179349117"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis.","authors":"Marcos Fidry, Morena Mourao Zugliani, Mariana Costa do Cabo, Renan Machado Martins, Manuella Assad Gomez, Clara Gitahy Falcão Faria, Antonio Egidio Nardi, Rafael C Freire","doi":"10.2174/0117450179337258241031035148","DOIUrl":"10.2174/0117450179337258241031035148","url":null,"abstract":"<p><strong>Background: </strong>Many pharmacological treatments are considered effective in the treatment of panic disorder (PD), however, about 20 to 40% of the patients have treatment-resistant PD. Pharmacogenetics could explain why some patients are treatment-resistant.</p><p><strong>Objective: </strong>Our objective was to gather preliminary data on the clinical usefulness of pharmacogenetic testing in this disorder.</p><p><strong>Methods: </strong>Twenty patients with treatment-resistant PD were included in this observational study and submitted to commercial pharmacogenetic testing. Testing panel included gene polymorphisms related to CYP, genes <i>EPHX1</i>, <i>UGT1A4</i>, <i>UGT2B15</i>, <i>ABCB1</i>, <i>ADRA2A</i>, <i>ANKK1</i>, <i>COMT</i>, <i>DRD2</i>, <i>FKBP5</i>, <i>GRIK4</i>, <i>GSK3B</i>, <i>HTR1A</i>, <i>HTR2A</i>, <i>HTR2C</i>, <i>MC4R</i>, <i>OPRM1</i>, <i>SCN1A</i>, <i>SLC6A4</i> and <i>MTHFR</i>. Participants received treatment-as-usual for PD before being enrolled in this study, including first-line and second-line medications for PD.</p><p><strong>Results: </strong>In 30% of the patients, the tests indicated reduced chance of response to the prescribed drug, while they indicated very low serum levels of the prescribed drug in 20% of the subjects. The pharmacogenetic tests predicted reduction of MTHFR enzyme activity in 74% of the patients. ABCB1 gene alleles associated to drug resistance were found in 90% of the samples.</p><p><strong>Conclusion: </strong>Commercial pharmacogenetic testing failed to predict negative treatment outcome in most patients with PD. The association between treatment-resistance in PD and the genes CYP2C19, MTHFR and ABCB1 deserves further study.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"20 ","pages":"e17450179337258"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Mental Health Issues and Priorities in Indonesia Through Qualitative Expert Consensus.","authors":"Ray Wagiu Basrowi, Tjhin Wiguna, Kristin Samah, Nila Djuwita F Moeloek, Mudji Soetrisno, Semiarto Aji Purwanto, Maria Ekowati, Adriana Elisabeth, Andre Rahadian, Bacelius Ruru, Bunga Pelangi","doi":"10.2174/0117450179331951241022175443","DOIUrl":"10.2174/0117450179331951241022175443","url":null,"abstract":"<p><strong>Background: </strong>Mental health well-being is a fundamental human right. However, mental health awareness is not yet considered as a main priority for the government and public in Indonesia. Thus, there is an urgent need for Indonesians to fully comprehend the importance of raising mental health awareness.</p><p><strong>Methods: </strong>A discussion among 45 experts in September until October 2023 was conducted by the Community Caucus Caring for Mental Health to raise an awareness of the importance of mental health in Indonesia. The results were reported as an expert consensus.</p><p><strong>Results: </strong>The discussion acknowledged the urgency of managing mental health issue along with its five key drivers and three essences. It identified nine specific themes of mental health issues in Indonesia by focusing on four high-risk population groups. The consensus proposed multi-pronged recommendations, <i>i.e</i>., developing personalized mental health-related campaigns and movements, conducting mental health-relevant studies at clinical and community settings, incorporating of mental health awareness in teaching curriculum and family's discussion, innovating technology for screening and diagnosing mental health issues, as well as an providing mental health first-aid with wide access to all population.</p><p><strong>Conclusion: </strong>The expert consensus concluded that Indonesians must start to prioritize mental health awareness and to provide sufficient resources to screen, diagnose and treat individuals with mental health disorders. The expert consensus identified nine specific themes of mental health issues in Indonesia and subsequently proposed multi-pronged recommendations with an aim to improve mental health awareness in Indonesia.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"20 ","pages":"e17450179331951"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}