Clinical Practice and Epidemiology in Mental Health最新文献

{"title":"Cost-Effectiveness of Transcranial Magnetic Stimulation and Virtual Reality-Based Cognitive Remediation for Depressive Symptoms among Cancer Patients: Protocol for a Three-Arm Randomized Controlled Trial.","authors":"Federica Sancassiani, Martino Belvederi Murri, Clelia Madeddu, Michela Atzeni, Goce Kalcev, Barbara Zaccagnino, Anna Francesca Olivetti, Danila Azzolina, Marco Cruciata, Maria Giulia Nanni, Giulia Cossu, Alessandra Perra, Lorenzo di Natale, Diego Primavera, Massimo Tusconi, Rosangela Caruso, Mauro Giovanni Carta, Luigi Grassi","doi":"10.2174/0117450179376750250925051532","DOIUrl":"https://doi.org/10.2174/0117450179376750250925051532","url":null,"abstract":"<p><strong>Introduction: </strong>This paper presents a research protocol of a randomized controlled trial aimed to evaluate the feasibility and the cost-effectiveness of non-pharmacological interventions for depressive symptoms, quality of life, depression-related conditions, and cognitive function among patients with cancer. Specifically, repetitive transcranial magnetic stimulation (rTMS) and virtual reality-based cognitive remediation (VR-COG) will be analyzed, alongside standard treatment as usual (TAU), in comparison to TAU alone.</p><p><strong>Methods: </strong>100 participants will be enrolled: 60 from the Health Trust of Ferrara randomized 1:1:1 to (a) TAU, (b) rTMS + TAU, and (c) VR-COG + TAU, and 40 from the University Hospital of Cagliari randomized 1:1 to (a) TAU and (b) VR-COG + TAU. The inclusion criteria will be as follows: patients aged 18 years and older, both sexes, a diagnosis of oncological disease within the last 5 years in a non-advanced stage, a diagnosis of major depressive disorder according to DSM-5 criteria, and a score of≥14 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17). The VR-COG program will include a series of exercises in virtual sailing scenarios using the software CEREBRUM. The rTMS program will be delivered at 50% of the resting motor threshold. Personalized targets created for each individual will be located at various cortical depths. TAU will include psychiatric visits and psychological counseling. All the interventions will last 3 months, with pre-post evaluation for outcomes of interest and 3-6 months of follow-up.</p><p><strong>Results: </strong>The results of the trial will be published in international peer-reviewed journals and will be disseminated at international meetings and congresses.</p><p><strong>Discussion: </strong>The results of this study will be useful for obtaining knowledge for clinical practice regarding the feasibility and cost-effectiveness of innovative therapeutic approaches aimed at treating depression in individuals suffering from oncological pathologies.</p><p><strong>Conclusion: </strong>The monitoring of the program's cost-effectiveness, encompassing both the screening and intervention phases, will enable policymakers to inform the implementation of this evidence in routine clinical practice.</p><p><strong>Clinical trial registration number: </strong>The study has been registered on the ClinicalTrials.gov website with ID no. NCT06589544.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"22 ","pages":"e17450179376750"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Stress and Rhythm Dysregulation among Health Workers in the Post-Pandemic Context: An Italian Study and a Proposal for a Preventive Psychoeducational Intervention.","authors":"Elisa Cantone, Antonio Urban, Cesar Aviles Gonzales, Alessandra Perra, Stefano Lorrai, Michela Atzeni, Stocchino Serena, Rober Romero Ramírez, Adalberto Rangel Restrepo, Mauro Giovanni Carta, Giulia Cossu","doi":"10.2174/0117450179449051260114063307","DOIUrl":"https://doi.org/10.2174/0117450179449051260114063307","url":null,"abstract":"<p><strong>Introduction: </strong>During the COVID-19 pandemic, healthcare workers (HCWs) faced intense and prolonged stress. This exposure increased their risk of burnout and mood disorders. The <i>Dysregulation of Mood, Energy, and Social Rhythms (DYMERS) hypothesis</i> suggests that instability in biological and social rhythms may precede the onset of mood dysregulation. This study examined rhythm disturbances among HCWs and explored the potential role of a rhythm-focused psychoeducational intervention.</p><p><strong>Methods: </strong>Ninety-seven HCWs from the University Hospital of Cagliari, Italy, participated in a cross-sectional study. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and rhythm regulation was evaluated through the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Data were compared with published findings from mood disorders, psychotic disorders, and community samples.</p><p><strong>Results: </strong>A current depressive episode with PHQ-9 score was identified in 35.1% of HCWs participants, with significantly higher prevalence (<i>p</i>= 0.01) among women (42.7%) than men (14.7%). Mean BRIAN scores were 46.1 ± 11.0, significantly higher than those observed in psychotic disorder (<i>p</i> = 0.04) and community samples (<i>p</i>< 0.0001). Rhythm dysregulation scores approached values reported in bipolar disorder samples. Elevated BRIAN scores were also observed among non-depressed participants.</p><p><strong>Discussion: </strong>The elevated rhythm dysregulation scores observed in healthcare workers support the hypothesis that chronic occupational stress may disrupt biological and social rhythms, potentially increasing vulnerability to mood disorders.</p><p><strong>Conclusion: </strong>HCWs displayed pronounced rhythm dysregulation and high rates of depressive symptoms, highlighting occupational stress as a potential major risk factor and further supporting the DYMERS hypothesis. From both clinical and research perspectives, it could be essential to promote psychoeducational programs that target rhythm regulation, such as adaptations of Interpersonal and Social Rhythm Therapy, which may offer effective preventive strategies to enhance resilience and mental well-being in this population. However, the cross-sectional design, convenience sampling, limited socio-demographic data, and reliance on self-reported measures constrain generalizability and causal inference, underscoring the need for larger longitudinal studies to validate and extend these findings.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"22 ","pages":"e17450179449051"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive Daytime Sleepiness and Risk of Sleep Apnea: A Retrospective Analysis of Peruvian Adults.","authors":"Víctor Juárez-Chunga, Aurora Calderón-Valentín, Doris Hancco-Huillca, Tania Betsy Rios-Tuanama, Andre Nelson Sotomayor-Serruno, Juan Morales","doi":"10.2174/0117450179442008251205104706","DOIUrl":"https://doi.org/10.2174/0117450179442008251205104706","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep apnea is a highly prevalent chronic disorder and a leading causal factor of excessive daytime sleepiness (EDS).</p><p><strong>Objectives: </strong>This study aimed: (1) To evaluate the presence of EDS and the type of sleep apnea in the adult population assessed; (2) to identify factors associated with the type of sleep apnea; and (3) to evaluate the ability of EDS to predict the type of sleep apnea.</p><p><strong>Materials and methods: </strong>This study employed an observational, descriptive, and cross-sectional design, utilizing a retrospective analysis of secondary data. A total of 350 adults evaluated at a specialized sleep center in Lima, Peru, were included. EDS was assessed using the Epworth Sleepiness Scale (ESS), while the type of sleep apnea was determined through overnight polysomnography.</p><p><strong>Results: </strong>EDS was present in 84.6% (n= 296) of participants, with a predominance of ESS levels II and III. According to the polysomnographic diagnosis, 8.0% (n = 28) showed no evidence of sleep apnea, 49.1% (n = 172) were diagnosed with central sleep apnea, and 42.9% (n = 150) with obstructive sleep apnea. Male sex (OR = 5.32; 95% CI: 2.01-14.06) and symptoms, such as daytime sleepiness (OR = 3.51; 95% CI: 1.52-8.10), difficulty falling asleep (OR = 5.20; 95% CI: 2.32-11.64), awakening with sleepiness (OR = 35.11; 95% CI: 8.16-151.07), and choking sensation upon awakening (OR = 15.62; 95% CI: 2.10-116.42), were significantly associated with sleep apnea. EDS emerged as the main predictor in the decision tree model, which achieved an overall accuracy of 58.5%.</p><p><strong>Discussion: </strong>Daytime sleepiness is associated with sleep apnea, underscoring its clinical relevance. However, the model´s moderate predictive accuracy reinforces the importance of polysomnography as the gold standard diagnosis.</p><p><strong>Conclusion: </strong>EDS was found to be highly prevalent and significantly associated with both central and obstructive sleep apnea. These findings highlight the clinical importance of screening for EDS in primary care as a practical approach to identifying individuals at higher risk of sleep apnea, supporting timely referral for polysomnography.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"22 ","pages":"e17450179442008"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Internet Gaming Addiction among School Children: A Cross-Sectional Study.","authors":"Suzie Rababa'h, Karem H Alzoubi, Rania Mahafdeh, Iman Basheti, Zahra A Sayed, Ahmed Alhusban","doi":"10.2174/0117450179451710260206215203","DOIUrl":"https://doi.org/10.2174/0117450179451710260206215203","url":null,"abstract":"<p><strong>Introduction: </strong>Targeting the younger generation and growing appeal among older users, video games have become an important and timely source of entertainment for teenagers and preteens. The study aims to assess the relationship between Jordanian schoolchildren's academic success and online gaming addiction.</p><p><strong>Methods: </strong>A sample of 458 children, whose ages were 9 to 17, were randomly chosen from five private schools to participate in this cross-sectional survey, which was carried out in Jordan between May and July 2024. Pre-teens (9-12 years old) and adolescents (13-17 years old) were the two groups of participants. The Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) in Arabic was used to measure the severity of gaming. Self-reported academic achievement, gaming habits, and sociodemographic information were all covered <i>via</i> a standardized questionnaire. The t-test and chi-square test were used to analyse group differences; <i>p</i> < 0.05 was deemed statistically significant.</p><p><strong>Results: </strong>The findings indicated that adolescents' excessive gaming was more severe than that of preteens. Teens reported a poor correlation with their academic performance, were more likely to use gaming apps during class, and had trouble focusing. Teens, who made up 63.5% of the participants, reported a higher perceived negative impact of gaming applications on their overall GPA that did not reach statistical significance. The overall effect of gaming on meeting deadlines and exam preparation did not differ significantly between age groups. Internet gaming scores were high among teenagers (<i>p</i> < 0.05). Furthermore, compared to pre-teens, teenagers reported using the internet for gaming more frequently in class (<i>p</i>= 0.049). Teens also claimed that using gaming applications negatively affected their ability to focus in class (<i>p</i><0.05).</p><p><strong>Discussion: </strong>The findings showed that excessive usage of gaming apps in class has a more detrimental effect on students' ability to concentrate, but it has no significant effect on missing deadlines or preparing for exams. These findings highlight the significance of keeping an eye on gaming behaviour in order to reduce the negative effects of IGD on concentration in the classroom.</p><p><strong>Conclusion: </strong>Video game disorder is quite prevalent among Jordanian private school students.These results underscore the need for more long-term studies using objective academic indicators and larger samples to elucidate the educational implications of internet gaming in this population. They also show that attention during class and difficulty focusing during lessons are regarded as potential areas of concern in the context of intensive gaming.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"22 ","pages":"e17450179451710"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-selected Recovery in High-intensity Interval Training Promotes Positive Responses in Affect, Pleasure, and Mood in Young People.","authors":"Leandro Sant'Ana, Jeferson Macedo Vianna, Bruno Travassos, Fábio Yuzo Nakamura, Diogo Teixeira, Fabiana Rodrigues Scartoni, Amandio Dias, Raul Antunes, Filipe Rodrigues, Rui Matos, Sérgio Machado, Diogo Monteiro","doi":"10.2174/0117450179378796260109054752","DOIUrl":"https://doi.org/10.2174/0117450179378796260109054752","url":null,"abstract":"<p><strong>Introduction: </strong>High-Intensity Interval Training (HIIT) with self-selected recovery can promote positive emotional responses. This study aimed to verify the acute responses to HIIT with fixed recovery and to select high scorers on the state of affect, enjoyment, and mood in healthy young people.</p><p><strong>Methods: </strong>Nineteen participants took part in the study (19.0±1.0 years, 64.0±9.2 kg, 169.1±8.5, and 22.0±2.0 BMI). They performed 10 x 30 s (95% V_peak) with 1 min recovery (HIIT_RecA - active - 40% V_peak) and self-selected (HIIT_Rec-B). Affect, enjoyment, and mood were assessed before and after HIIT (both conditions).</p><p><strong>Results: </strong>In both conditions, for time 1 and 2 were positive in positive (<i>p</i>=.170, EF: .102) and negative (<i>p</i>=.0.90, EF: .151) affect, pleasure (<i>p</i>=.010, EF: .315), and mood domains (tension: <i>p</i><.001, EF: .673; depression: <i>p</i>=.015, EF: .286), anger: <i>p</i>=.033, EF: .230, and mental confusion: <i>p</i><.001, EF: .451). In contrast, there was a reduction in the vigor domain and an increase in fatigue, with no differences in all emotional variables for condition and time*condition (<i>p</i>>.05).</p><p><strong>Conclusion: </strong>Thus, selected self-recovery may be a strategy in prescribing HIIT with possibilities of not interfering with the emotional aspects, researched here.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"22 ","pages":"e17450179378796"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Gaming Behavior between Teens and Preteens and its Association with Depression, Anxiety, Stress, and Academic Performance in Children.","authors":"Suzie Rababa'h, Karem H Alzoubi, Rania Mahafdeh, Iman Basheti, Laiali T Alquraan, Bayan Mahafdeh, Ahmed Alhusban","doi":"10.2174/0117450179393523251022062235","DOIUrl":"10.2174/0117450179393523251022062235","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Video games have emerged as a significant and timely source of entertainment among teens and preteens, primarily targeting the younger generation while also gaining popularity among the older population. Numerous studies have demonstrated that symptoms of stress, anxiety, and depression can impact children's academic performance and may result in school dropout. However, to date, no research has examined these three conditions specifically in Jordanian high school students. Therefore, this study aims to compare the gaming behavior of teens and preteens and its relationship to memory, depression, anxiety, and stress in Jordanian schoolchildren. Additionally, it seeks to define the prevalence of anxiety, depression, and stress among high school students in Northern Jordan and identify factors associated with these conditions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional study, conducted between May and July 2024, involved a sample of 388 children aged 12 to 17 years, randomly selected from public and private schools. Validated versions of the Arabic versions of the Patient Health Questionnaire-9 (PHQ-9), the seven-item Generalized Anxiety Disorder Scale (GAD-7), the Perceived Stress Scale (PSS), and the Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) were used to assess depression, anxiety, perceived stress, and internet gaming disorder, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among the 388 students included in the study, 25 students (6.44%) reported using gaming apps during classes on a frequent and daily basis. The findings reported that gaming during class was significantly linked to higher depression scores (p &lt; 0.0001). Additionally, students with high GPAs were more likely to experience severe depression (p = 0.02), suggesting that academic pressure contributes to mental health struggles. Anxiety was a strong predictor of depression severity, while excessive gaming also emerged as a significant factor in both mild and severe depression. Older students had higher intermediate GPAs, suggesting that maturity and time management skills may positively impact academic performance. These findings highlighted the complex relationship between gaming, academic performance, and mental health, emphasizing the need for responsible gaming habits and mental health support in educational settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;A comparison of gaming behavior between teens and preteens indicates that teens exhibit higher levels of depression, anxiety, and gaming habits than preteens. This study highlights the complex interplay between gaming behavior and academic performance. While gaming itself does not directly lower GPA, it may contribute to psychological health issues. Additionally, high-achieving students may be at greater risk of depression, emphasizing the need for mental health support programs in educational settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Current findings stress the importance of r","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179393523"},"PeriodicalIF":0.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Assessment of Attention Deficit Hyperactivity Disorder with QbMobile: A Smartphone Application for Clinical Use.","authors":"Urban Gustafsson, Simon Larsson, Núria Casals, Robert Nolen, Ragini Yallampalli Sanyal, Mikkel Hansen","doi":"10.2174/0117450179444324251118134538","DOIUrl":"10.2174/0117450179444324251118134538","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Digital mental health interventions such as web or mobile applications have become more prominent in the last years to improve the clinical assessment and workflow in mental health disorders while also being potentially more accessible than laptops. QbMobile is a software application that provides objective assessments of hyperactivity, impulsivity, and inattention to aid in the clinical evaluation of attention deficit hyperactivity disorder (ADHD). The purpose was to examine whether QbMobile could objectively quantify symptoms and reveal significant clinical differences between an ADHD population and a normative population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data were acquired from two low-intervention/observational studies (conducted in Europe and US), involving participants aged 6 to 60 years. The application (QbMobile) was configured on the smartphone (iPhone) with embedded instructions to ensure a consistent experience. Participants were seated at a desk in a stabilized chair and instructed to hold the smartphone with both hands and to tap the screen whenever an infrequent target stimulus appeared, while withholding a response to non-target stimuli. Concurrently, to measure activity, the camera of the smartphone captured the physical activity of the participant as well as the movements from holding the device. Approximately 20% of the complete dataset for each study was combined as a pooled dataset for a model validation of output parameters from QbMobile. A Total Score between 0 and 100 was calculated, where lower scores indicate a lower likelihood of ADHD symptoms and higher scores indicate a higher likelihood.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The ADHD cohort (n=63) demonstrated a higher mean Total Score of 83.0 (Standard deviation=17.5) compared to 48.9 (Standard deviation=18.8) in the normative population (n=354), a difference that was statistically significant (p&lt;0.001). Significant domain-specific differences in SD-scores (movement pattern, activity, impulsivity, inattention) were identified between the ADHD cohort and the normative comparison group (p&lt;0.001). A sensitivity of 0.86 and specificity of 0.75 were seen overall, though a low specificity was found in children, which was likely due to a smaller sample size and high activity levels in younger children in general.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This investigation demonstrates that QbMobile can generate objective symptom measurements that distinguish clinically relevant differences between individuals with ADHD and a normative population. A smartphone application of quantified behavioral psychometric testing of the core symptoms could streamline a faster diagnostic evaluation and treatment titration in the ADHD clinical workflow. The authors are employed by the manufacturer of QbMobile, which is discussed in this manuscript. This affiliation is disclosed to ensure transparency and does not affect the objectivity or scientific integrity of the wo","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179444324"},"PeriodicalIF":0.0,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Mild to Moderate Mental Illness, Correlates of Treatment Patterns, and Perceived Unmet Need among U.S. Adults: Results from the National Survey on Drug Use and Health, 2021.","authors":"Valerie L Forman-Hoffman, Megan Flom, Andre Williams, Timothy Mariano","doi":"10.2174/0117450179394114251013063017","DOIUrl":"10.2174/0117450179394114251013063017","url":null,"abstract":"<p><strong>Purpose: </strong>Mental health issues continue to affect millions despite the availability of evidence-based treatment. The burden of illness and associated characteristics of mild to moderate mental illness (MMMI) among community-dwelling U.S. adults has not been reported in the peer-reviewed literature to date.</p><p><strong>Methods: </strong>Analyses of the cross-sectional 2021 National Survey on Drug Use and Health (NSDUH) conducted across the U.S. allowed for the estimation of the prevalence and correlates of MMMI as well as of the overall and virtual treatment landscape, perceived unmet need, and barriers to care.</p><p><strong>Results: </strong>Nearly 44 million community-dwelling U.S. adults (17.2%), about 1 in 6, are estimated to have past-year MMMI, of whom 41.3% report mental health treatment receipt. Over 62% of those who received mental health treatment did so virtually.</p><p><strong>Discussion: </strong>MMMI commonly affected U.S. adults; a majority are not getting treatment. Several correlates of MMMI and treatment receipt might point to demographic and clinical groups in need to additional services.</p><p><strong>Conclusion: </strong>This study is the first of its kind to report nationally representative estimates and correlates of MMMI among community-dwelling U.S. adults. Despite the widespread use of virtual services when accessing mental health treatment, findings suggest the need for access to low-cost, easily accessible, on-demand mental health services to better serve adults with MMMI.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179394114"},"PeriodicalIF":0.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Chains to Care: Ending <i>Pasung</i> (Physical Restraint) Among Schizophrenia Patients in Indonesia, A Systematic Review.","authors":"Jesslyn Shi, Rama Mahardika Primanov, Rina Amelia, Nanda Andini","doi":"10.2174/0117450179414516251030074059","DOIUrl":"10.2174/0117450179414516251030074059","url":null,"abstract":"<p><strong>Background: </strong><i>Pasung</i>, the physical restraint and confinement of individuals with mental disorders-particularly schizophrenia-continues to occur in Indonesia, despite the national \"Free from <i>Pasung</i>\" campaign and Mental Health Act No. 18/2014. This systematic review aims to synthesize existing evidence on the prevalence, causes, consequences, and policy responses related to <i>pasung</i> among people with schizophrenia in Indonesia.</p><p><strong>Method: </strong>A systematic search was conducted using PubMed, PsycINFO, Cochrane Library, and the Garuda Indonesian research repository. The quality appraisal were analyzed using tools from the Joanna Briggs Institute (JBI) and CASP. The included studies were analyzed using thematic synthesis guided by the Socio-Ecological Model (SEM).</p><p><strong>Results: </strong>Eight studies met the inclusion criteria.</p><p><strong>Discussion: </strong>Findings reveal that <i>pasung</i> is driven by persistent stigma, poverty, limited mental health literacy, cultural beliefs attributing illness to supernatural causes, and the lack of accessible, community-based mental health services. The consequences include muscle atrophy, psychological trauma, loss of dignity, and delayed or denied treatment.</p><p><strong>Conclusion: </strong>The persistence of <i>pasung</i> highlights critical gaps in Indonesia's mental health system, particularly at the community and policy levels. Addressing this issue requires a multi-level approach, including culturally adapted interventions, stronger mental health governance, and community empowerment to support inclusive, rights-based mental health care.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179414516"},"PeriodicalIF":0.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 Cognitive Dysfunction: Analyzing the Role of Age, Lifestyle, and Neurological Impairments: A Multi-Centric Case-Control Study.","authors":"Samar A Amer, Ines F Djelleb, Ehab M Ishteiwy, Mostafa Meshref, Youmna A Amer, Jaffer Shah, Mahmoud Tarek Hefnawy, Noha A Hashim, Carlos Schönfeldt-Lecuona, Mohamed E G Elsayed, Eman F Ali","doi":"10.2174/0117450179395261251006055231","DOIUrl":"10.2174/0117450179395261251006055231","url":null,"abstract":"<p><strong>Introduction: </strong>The effects of COVID-19 extend beyond acute illness, with many survivors experiencing persistent symptoms. This study aimed to determine the frequency and contributing factors of cognitive impairment and other neurological symptoms in COVID-19 survivors four weeks after diagnosis, compared with healthy controls during the pandemic's fourth wave.</p><p><strong>Methods: </strong>A multicenter case-control study was conducted involving 176 COVID-19 survivors, diagnosed four weeks prior, and 92 healthy controls from Algeria, Egypt, and Libya. Data were collected through interviews using a structured, validated questionnaire administered by a trained physician.</p><p><strong>Results: </strong>Post-COVID-19 survivors exhibited significant cognitive deficits, chronic fatigue, and sensory impairments (including loss of appetite, taste, smell, and hearing). Cognitive impairment (Montreal Cognitive Assessment [MoCA] score <26) was observed in 57 participants (32.3%), with those affected being older (44.6 ± 16.9 years, <i>P</i> < 0.001) and consuming more junk food (8.6 ± 3.3 servings, <i>P</i> = 0.04). Cognitive disorders were more frequent among females (83.3%), smokers (57.9%), highly educated individuals (76.5%), and married participants (63.7%).</p><p><strong>Discussion: </strong>The study revealed a substantial burden of cognitive and sensory impairments in post-COVID-19 patients, supporting global observations and emphasizing the need for early screening and lifestyle interventions. The reliance on self-reported data and a case-control design limit causal inference.</p><p><strong>Conclusion: </strong>Post-COVID-19 survivors showed significant cognitive deficits, fatigue, and sensory impairments. Cognitive impairment was present in 32.3%, with higher prevalence in females, smokers, highly educated individuals, and married participants.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"21 ","pages":"e17450179395261"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}