Clinical Practice and Epidemiology in Mental Health最新文献

{"title":"The Effects of Tyrosine Kinase Inhibitors (TKIs) in Monotherapy and with Add-on Treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: A Systematic Review of Randomized-Controlled Trials","authors":"Antonio E. Nardi, Federica Sancassiani, Vanessa Barrui, Goce Kalcev, Veronica Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, Mauro Giovanni Carta","doi":"10.2174/17450179-v17-e211118-2021-ht2-1910-12","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211118-2021-ht2-1910-12","url":null,"abstract":"Background: The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy due to the development of TKIs, even if it requires long-term, often lifelong, treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic; sometimes the data have been obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment. Methods: A systematic review has been conducted by searching the relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020. Results: 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed. Conclusion: All the included RCTs pointed out significant findings regarding the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135368715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Depression: A Survey on Psychopathological, Diagnostic, and Therapeutic Approaches among a Sample of Italian Psychiatrists","authors":"L. Mineo, A. Rodolico, C. Concerto, A. Natale, Manuela Pennisi, M. Tusconi, A. Aguglia, A. Amerio, G. Serafini, M. Amore, E. Aguglia","doi":"10.2174/1745017902117010331","DOIUrl":"https://doi.org/10.2174/1745017902117010331","url":null,"abstract":"\u0000 \u0000 The Diagnostic and Statistical Manual for Mental Disorders (5th edition) introduced the specifier “with Mixed Features” to the diagnosis of Major Depressive Episode to designate the presence of (hypo) manic symptoms as part of the clinical presentation. This change has led to renewed attention on the operational definition, diagnosis, and treatment of Mixed Depression.\u0000 \u0000 \u0000 \u0000 To investigate the diagnostic and therapeutic approaches towards Mixed Depression among a representative sample of Italian psychiatrists.\u0000 \u0000 \u0000 \u0000 Between March and April 2021, 342 psychiatrists working in Italian adult mental health services were invited to participate in an anonymous online survey comprising 32 questions designed to investigate clinical and psychopathological approaches regarding the management of mixed depression in daily psychiatric practice.\u0000 \u0000 \u0000 \u0000 83.74% of participants reported having performed a diagnosis of mixed depression in the last five years, with the majority of respondents affirming that they had not used any diagnostic tool. Only 7,5% of the surveyed psychiatrists considered the DSM-5 criteria to be fully adequate in the description of this clinical entity. The most used pharmacological approach was combined therapy, in particular antipsychotics plus mood stabilizers. For monotherapy, the preferred drugs were Valproate and Quetiapine. Regarding the conceptualization of mood disorders, 199 of the participants chose the Kraepelinian unitary spectrum view; meanwhile, 101 expressed their preference for the binary model.\u0000 \u0000 \u0000 \u0000 Our results suggest a prominent position of mixed depression in the context of mood disorders. Univocal operational criteria and additional research on pharmacological treatment are also needed to ensure the correct recognition and management of mixed depression.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83371278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTSD and Depression in Healthcare Workers in the Italian Epicenter of the COVID-19 Outbreak.","authors":"Claudia Carmassi,&nbsp;Virginia Pedrinelli,&nbsp;Valerio Dell'Oste,&nbsp;Carlo Antonio Bertelloni,&nbsp;Chiara Grossi,&nbsp;Camilla Gesi,&nbsp;Giancarlo Cerveri,&nbsp;Liliana Dell'Osso","doi":"10.2174/1745017902117010242","DOIUrl":"https://doi.org/10.2174/1745017902117010242","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence highlights the susceptibility of Healthcare Workers to develop psychopathological sequelae, including Post-Traumatic Stress Disorder (PTSD) and depression, in the current COronaVIrus Disease-19 (COVID-19) pandemic, but little data have been reported in the acute phase of the pandemic.</p><p><strong>Objective: </strong>To explore Healthcare Workers' mental health reactions in the acute phase of the COVID-19 pandemic in the first European epicenter (Lodi/Codogno, Italy), with particular attention to post-traumatic stress and depressive symptoms and their interplay with other psychological outcomes.</p><p><strong>Methods: </strong>74 Healthcare Workers employed at the Azienda Socio Sanitaria Territoriale of Lodi (Lombardy, Italy) were recruited and assessed by means of the <i>Impact of Event Scale- Revised</i>, the <i>Professional Quality of Life Scale-5</i>, the <i>Patient Health Questionnaire-9</i>, the <i>Generalized Anxiety Disorder-7 item</i>, the <i>Resilience Scale</i> and the <i>Work and Social Adjustment Scale</i>. Socio-demographic and clinical variables were compared across three subgroups of the sample (No PTSD, PTSD only, PTSD and depression).</p><p><strong>Results: </strong>A total of 31% of subjects endorsed a diagnosis of PTSD and 28.4% reported PTSD comorbid with major depression. Females were more prone to develop post-traumatic stress and depressive symptoms. Subjects with PTSD and depression groups showed high levels of PTSD, depression, burnout and impairment in functioning. Anxiety symptoms were higher in both PTSD and depression and PTSD groups rather than in the No PTSD group.</p><p><strong>Conclusion: </strong>Our results showed high rates of PTSD and depression among Healthcare Workers and their comorbidity overall being associated with worse outcomes. Current findings suggest that interventions to prevent and treat psychological implications among Healthcare Workers facing infectious outbreaks are needed.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"242-252"},"PeriodicalIF":0.0,"publicationDate":"2021-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of Depressive Symptoms in a Russian General Population Sample: A Web-based Cross-sectional Study.","authors":"Andrey Alexandrovich Kibitov,&nbsp;Alexander Sergeevich Rakitko,&nbsp;Evgeniy Dmitirevich Kasyanov,&nbsp;Grigoriy Viktorovich Rukavishnikov,&nbsp;Kira Alexandrovna Kozlova,&nbsp;Valeriy Vladimirovich Ilinsky,&nbsp;Nikolay Grigor'evich Neznanov,&nbsp;Galina Elevna Mazo,&nbsp;Alexander Olegovich Kibitov","doi":"10.2174/1745017902117010205","DOIUrl":"https://doi.org/10.2174/1745017902117010205","url":null,"abstract":"<p><strong>Background and objective: </strong>Web-based screening of depressive symptoms in general non-clinical population can provide better insights into actual prevalence of depressive symptoms and associated risk factors. To study the current prevalence of depressive symptoms in Russian non-clinical population we conducted screening using an online survey based on Depression subscale of Hospital Anxiety and Depression Scale (HADS-D).</p><p><strong>Methods: </strong>The online survey covered 2610 Russian-speaking respondents and included HADS-D, questions about sex, age and presence of cardiovascular diseases (CVD) diagnoses or symptoms in respondents.</p><p><strong>Results: </strong>The proportion of respondents with depressive symptoms, estimated by online HADS-D, was 14.4% (11.5% - at subclinical level, 2.9% - at clinical level). The overall HADS-D score was higher in women (p=0.003), in young individuals under 30 y.o <i>vs</i>. participants over 42 y.o. (p=0.004) and in individuals with self-reported CVD symptoms (p=0.00002). Linear regression analysis showed that self-reported CVD symptoms increase HADS-D score (p<0.001), but male sex (p=0.002) and older age (p<0.001) decrease it. Logistic regression showed that CVD symptoms increase the risk of depressive symptoms by HADS-D (p=0.033, OR=1.29), but older age (p=0.015, OR=0.87) and male sex (as a trend, p=0.052, OR=0.80) decrease this risk.</p><p><strong>Conclusion: </strong>Online survey based on HADS-D showed new patterns of depressive symptoms prevalence in Russian non-clinical population. Depressive symptoms prevalence did not differ between men and women and was higher among young people. The reported association between depressive symptoms and CVD was confirmed.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"205-211"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex, Digital Devices, Social Media, and Social Isolation: A Study on Sexual Behavioral During COVID -19 Pandemic.","authors":"Isabela A Melca,&nbsp;Antonio E Nardi,&nbsp;Lucio L Gonçalves,&nbsp;Rachel M Ferreira,&nbsp;Mariana S K Lins de Padua,&nbsp;Anna L S King","doi":"10.2174/1745017902117010235","DOIUrl":"https://doi.org/10.2174/1745017902117010235","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus (COVID-19) pandemic has caused social and economic damages. People have adapted to a new reality of physical distance.</p><p><strong>Objective: </strong>The study aimed to assess the use of digital devices and social media, focusing on psychosocial and demographic factors of people´s sexual behavior during the pandemic.</p><p><strong>Methods: </strong>A total of 1,357 Brazilian adults participated in a cross-sectional online survey. They were recruited through social media to obtain information regarding sexual behavior and the use of digital devices and social media.</p><p><strong>Results: </strong>Digital devices and social media were used by 38.8% of the participants. Among the group that used technological devices, most claimed to have changed their sexual behavior, with 76.9% consuming more sexual content through movies or series.</p><p><strong>Conclusion: </strong>In a smaller group, technological resources appeared as an alternative for safer sex, reducing the risks of COVID-19 transmission.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"235-241"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can an Investigation of a Single Gene be Effective in Differentiating Certain Features of the Bipolar Disorder Profile?","authors":"Martina Piras,&nbsp;Alessandra Scano,&nbsp;Germano Orrù,&nbsp;Antonio Preti,&nbsp;Cinzia Marchese,&nbsp;Goce Kalcev","doi":"10.2174/1745017902117010187","DOIUrl":"https://doi.org/10.2174/1745017902117010187","url":null,"abstract":"<p><p>Bipolar disorder (BD) is amongst the most common heritable mental disorders, but the clarification of its genetic roots has proven to be very challenging. Many single nucleotide polymorphisms (SNPs) have been identified to be associated with BD. SNPs in the CACNA1C gene have emerged as the most significantly associated with the disease. The aim of the present study is to provide a concise description of SNP 1006737 variants identified by Real Time PCR and confirm sequencing analysis with the Sanger method in order to estimate the association with BD. The molecular method was tested on 47 Sardinian subjects of whom 23 were found to not be mutated, 1 was found to be a carrier of the homozygous A allele and 23 were found to be carriers of the heterozygous G allele. Moreover, the positive results of the preliminary application suggest that the development of the screener could be extended to the other 5 genetic variables identified as associated with BD.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and Predictors of Internet Gaming Disorder: An Observational Study from Jordan.","authors":"Reema Karasneh,&nbsp;Sayer Al-Azzam,&nbsp;Karem H Alzoubi,&nbsp;Mohammad B Nusair,&nbsp;Sahar Hawamdeh,&nbsp;Amal T Nusir","doi":"10.2174/1745017902117010217","DOIUrl":"https://doi.org/10.2174/1745017902117010217","url":null,"abstract":"<p><strong>Objective: </strong>Internet Gaming Disorder (IGD) is a rapidly growing public health problem that may have detrimental effects. The purpose of this study is to identify factors associated with IGD status.</p><p><strong>Methods: </strong>In this cross-sectional observational study, a convenient sample of gamers in Jordan was recruited and asked to participate in an online survey based on the nine criteria of the 20-item Internet Gaming Disorder (IGD-20) used to assess gaming disorder. Sociodemographic and psychosocial data were also obtained.</p><p><strong>Results: </strong>A total of 504 gamers participated in this study. The mean age of respondents was 21.6 ± 3.90 years. Using the standard IGD-20 scale, 96 participants (19%) were classified as potential IGD cases, compared to 408 (80.9%) non-disordered gamers. Males were dominant among the population, constituting 348 (69%) of gamers. Males also played significantly more hours per week [17.8 ±16.75] compared to females [13 ± 17.65]. The majority of gamers (411 (81.5%)) were students, although unemployed adults played for the highest total time [23.9 ± 30.84 hours/week]. Device type used for gaming also significantly (p <0.05) affected the time spent playing. Predictors of IGD included educational level (p< 0.05) and playing hours/week (p< 005). Conversely, no significant associations were found between IGD and gender, age, employment, or sleeping hours. IGD is increasingly being diagnosed among both genders and presents a health challenge for internet users.</p><p><strong>Conclusion: </strong>Establishing gamer profiles and recognizing predictors of IGD is therefore vital for guiding clinical classification and diagnosis of the disease.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"217-223"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Gender and Clinician's Subjective Experience during the Interaction with Psychiatric Patients.","authors":"Federico Dazzi,&nbsp;Laura Fonzi,&nbsp;Mauro Pallagrosi,&nbsp;Marina Duro,&nbsp;Massimo Biondi,&nbsp;Angelo Picardi","doi":"10.2174/1745017902117010190","DOIUrl":"https://doi.org/10.2174/1745017902117010190","url":null,"abstract":"<p><strong>Introduction: </strong>The clinician's subjective experience can be a valuable element for diagnosis and treatment. A few factors have been recognized that affect it, such as the patient's personality, the severity of psychopathology, and diagnosis. Other factors, such as patient's and clinician's gender, have not been specifically investigated. The aim of this study is to explore the impact of gender differences on the clinician's subjective experience in a large sample of psychiatric patients.</p><p><strong>Methods: </strong>The study involved 61 psychiatrists and 960 patients attending several inpatient and outpatient psychiatric settings. The clinicians completed the Assessment of Clinician's Subjective Experience (ACSE) questionnaire after observing each patient for the first time.</p><p><strong>Results: </strong>In multivariate analysis, higher scores on the Difficulty in Attunement (p < 0.001), Engagement (p<0.05), and Impotence (p<0.01) scales were significantly associated with female clinician gender, whereas higher scores on the Tension and Disconfirmation scales were significantly associated with male clinician gender. The scores on all ACSE dimensions were also associated with the severity of psychopathology.</p><p><strong>Conclusion: </strong>The findings suggest that clinician's gender might affect a clinician's emotional response toward patients. Specific attention to this issue might be useful in clinical situations, not only in terms of promoting gender-balanced teams but also in terms of enhancing self-observation in clinicians evaluating patients for the first time.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"190-197"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Clinical Correlates in Adults with Social Phobia: A Scoping Review.","authors":"Hui Miin Lau,&nbsp;Kai Samuel Sim,&nbsp;Qian Hui Chew,&nbsp;Kang Sim","doi":"10.2174/1745017902117010224","DOIUrl":"https://doi.org/10.2174/1745017902117010224","url":null,"abstract":"<p><strong>Objective: </strong>In light of the substantial clinical and societal burden of social phobia (SP) and impact on the sense of well-being of affected individuals, we sought to summarise extant data related to quality of life and relevant correlates in adults with SP to distill clinical profiles for earlier identification and appropriate management.</p><p><strong>Methods: </strong>A scoping review was carried out on studies examining quality of life in adults with SP and clinical correlates within different settings. PubMed/Medline and Web of Science databases were searched for relevant articles beginning from database inception until May 2021.</p><p><strong>Results: </strong>A total of 25 papers were included. Most of the studies (92%) were cross sectional in nature (80%), conducted in the West (92%), and within clinic or community settings (88%). Patients with comorbid psychiatric conditions, and undergraduate students reported higher rates of SP compared with community population. Significant correlates of SP included demographic (such as females, younger age, living alone, fewer years of education, unemployment) and clinical factors (such as family history of anxiety disorders, suicidal ideas, avoidant personality features). SP was widely associated with decreased QoL involving several domains and especially related to complexity, greater number of feared or trigger situations, and comorbid medical and psychiatric conditions.</p><p><strong>Conclusion: </strong>SP is not uncommon within clinical, and undergraduate populations, and has a significantly negative impact on quality of life. Awareness of its associated clinical profiles allows better identification and overall management of this condition including improvement in QoL.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"17 ","pages":"224-234"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia Underwent Hematopoietic Stem Cell Transplantation","authors":"O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa","doi":"10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","url":null,"abstract":"\u0000 \u0000 β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy, based on blood transfusions and iron chelation, and nowadays this approach is capable to assure a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). The aim of this paper was to evaluate with a systematic review and meta-analysis the role of HRQoL in transplanted β-TM patients.\u0000 \u0000 \u0000 \u0000 PubMed database, Web of Science and Scopus were systematically searched for studies published between January 1st, 2000 to September, 2020; the following terms were entered in the database queries: β-thalassemia, HRQoL and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement.\u0000 \u0000 \u0000 \u0000 We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with a conventional therapy in Physical an Emotional Function dimension, with a medium effect size (d=0.65, (95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75% and d=0.59, (95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0% respectively).\u0000 \u0000 \u0000 \u0000 HRQoL is generally good in β-TM transplanted patients and may give a significant contribute the difficult choice whether transplant or not a β-TM patient treated with conventional therapy.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}