Current Enzyme Inhibition最新文献

Apocynaceae as a Potential Source for Acetylcholinesterase Inhibition inSymptomatic Regulation and Management of Alzheimer's Disease 天南星科植物作为乙酰胆碱酯酶抑制剂在阿尔茨海默病症状调节和治疗中的潜在来源

Current Enzyme Inhibition Pub Date : 2024-07-11 DOI: 10.2174/0115734080296802240528073027

Priyanka Kumari, N. Sarwa, Deepak Meena, Ajaya Easha, Navneet Singh Chaudhary

{"title":"Apocynaceae as a Potential Source for Acetylcholinesterase Inhibition in\u0000Symptomatic Regulation and Management of Alzheimer's Disease","authors":"Priyanka Kumari, N. Sarwa, Deepak Meena, Ajaya Easha, Navneet Singh Chaudhary","doi":"10.2174/0115734080296802240528073027","DOIUrl":"https://doi.org/10.2174/0115734080296802240528073027","url":null,"abstract":"\u0000\u0000Memory loss or dementia is the key symptom of Alzheimer's disease (AD). In AD, significant interference in a progressive manner is observed in memory, behaviour, and cognitive abilities that affect the daily life of a person. At present, more than 50 million people are affected\u0000worldwide with Alzheimer's disease. Urgent attention is needed for the symptomatic regulation and\u0000management of this disease. The significant pharmacotherapy research in the last two decades gave\u0000only four drug compounds galanthamine, donepezil, rivastigmine, and memantine that inhibit the\u0000enzyme acetylcholinesterase (AChE) to elevate the availability of acetylcholine in the brain for\u0000symptomatic relief in AD patients. Plant-based AChE inhibitors from many plant families, mainly\u0000including Rutaceae, Papaveraceae, Apocynaceae, Rubiaceae, Amaryllidaceae, Liliaceae, Lycopodiaceae, Fabaceae, Lamiaceae, etc., have been characterized for the management of AD progression.\u0000AD progression is described by cholinergic, amyloid, Tau protein, oxidative stress, and neuroinflammatory hypothesis. To date, there is no comprehensive review in the literature that combined all\u0000plants of the Apocynaceae family showing anti-AChE activity. Therefore, the current review aims to\u0000present significant literature, especially on plant-derived compounds from the Apocynaceae family\u0000that inhibit AChE. The review compiled all plants showing potent anti-acetylcholinesterase activity.\u0000The anti-AChE activity of more than 30 plants is described, which may be potential targets to find\u0000new drug molecules by attracting the attention of researchers toward the Apocynaceae family. More\u0000than 8 species of genus Tabernaemontana of Apocynaceae have been investigated for indole alkaloids, demonstrating AChE inhibitory activity. The majority of anti-AChE compounds belong to the\u0000class of alkaloids.\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Perforin: A Potential Therapeutic Approach against Human Ailments 抑制穿孔素：人类疾病的潜在治疗方法

Current Enzyme Inhibition Pub Date : 2024-05-14 DOI: 10.2174/0115734080298673240424052128

Aman Rai, Rohit Bhatia

引用次数: 0

Molecular Docking as a Method to Identify Prospective Compounds fromOcimum sanctum with Anti-Candidal Properties 将分子对接作为一种方法，从洋甘菊中发现具有抗念珠菌特性的前瞻性化合物

Current Enzyme Inhibition Pub Date : 2024-04-02 DOI: 10.2174/0115734080289478240319094430

N. Rani, Randhir Singh

{"title":"Molecular Docking as a Method to Identify Prospective Compounds from\u0000Ocimum sanctum with Anti-Candidal Properties","authors":"N. Rani, Randhir Singh","doi":"10.2174/0115734080289478240319094430","DOIUrl":"https://doi.org/10.2174/0115734080289478240319094430","url":null,"abstract":"\u0000\u0000To search for antifungal bioactive molecules from Ocimum sanctum, we\u0000used a molecular docking approach to identify the natural compound responsible for the property\u0000with a specific target. Our goal is to identify the potential antifungal compounds based on computational\u0000screening from reported chemical constituents of Tulsi as potential inhibitors of 14α-\u0000demethylase.\u0000\u0000\u0000\u0000Molecular docking was performed using Molergo Virtual docker software and validated\u0000based on the Root Mean Square Deviation (RMSD) value.\u0000\u0000\u0000\u0000The compounds were docked to the pocket of the enzyme, and the docking results depicted\u0000that only oxygenated compounds were important for an antifungal profile with a good docking\u0000score and interaction with the enzyme molecule.\u0000\u0000\u0000\u0000The results suggest the availability of significant compounds with high potential for\u0000antifungal properties from O. sanctum. This suggests isolating these compounds for further lead\u0000identification to develop new antifungal compounds with specific targets.\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Cyclobut-3-Ene-1,2 Dione Derivatives as Anti-tubercular Agents 设计作为抗结核药物的环丁-3-炔-1,2-二酮衍生物

Current Enzyme Inhibition Pub Date : 2024-01-25 DOI: 10.2174/0115734080266495231208045622

R. N., K. Bhuvaneshwaran, P. A, N.J. Thulasiraman, M. Bhavani, R. Aysvaryah, S. Arunkumar

{"title":"Design of Cyclobut-3-Ene-1,2 Dione Derivatives as Anti-tubercular Agents","authors":"R. N., K. Bhuvaneshwaran, P. A, N.J. Thulasiraman, M. Bhavani, R. Aysvaryah, S. Arunkumar","doi":"10.2174/0115734080266495231208045622","DOIUrl":"https://doi.org/10.2174/0115734080266495231208045622","url":null,"abstract":"\u0000\u0000Recent studies have shown modified cyclobutene derivatives as potent anti-\u0000tubercular agents, and the discovery of drugs against strains of Mycobacterium tuberculosis is still\u0000a crucial challenge in the modern world.\u0000\u0000\u0000\u0000The objective of the present study is to design and perform molecular docking studies\u0000and in-silico analysis of some novel cyclobut-3-ene-1,2 Dione derivatives with the aim of creating\u0000new, potential Mtb ATP synthase inhibitors.\u0000\u0000\u0000\u0000The structures of 24 compounds of diamino-substituted cyclobut-3-ene-1,2\u0000Dione derivatives against Mtb ATP synthase were drawn using ChemSketch. Further, molecular\u0000docking and in-silico studies for the prediction of drug-likeness and pharmacokinetic parameters\u0000were carried out.\u0000\u0000\u0000\u0000The docking studies of the novel compounds were done, and they had a better docking\u0000score with a good binding affinity towards the protein molecule. The synthesized compounds also\u0000comply with the in-silico prediction of drug-likeness and pharmacokinetic parameters and have\u0000shown good activity against Mtb ATP synthase.\u0000\u0000\u0000\u0000The current study shows that the cyclobut-3-ene-1,2 Dione derivatives can serve as a\u0000better lead molecule against Mtb ATP synthase and can be involved in further drug discovery\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139596552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzyme Inhibition in Managing Cardiovascular Diseases 治疗心血管疾病的酶抑制剂

Current Enzyme Inhibition Pub Date : 2024-01-25 DOI: 10.2174/0115734080275060231228093149

Shivendra Kumar, S. Saha, Arokia Babu, Mohit Agrawal, Kuldeep Singh, Hema Chaudhary, Khushboo Lavania

{"title":"Enzyme Inhibition in Managing Cardiovascular Diseases","authors":"Shivendra Kumar, S. Saha, Arokia Babu, Mohit Agrawal, Kuldeep Singh, Hema Chaudhary, Khushboo Lavania","doi":"10.2174/0115734080275060231228093149","DOIUrl":"https://doi.org/10.2174/0115734080275060231228093149","url":null,"abstract":"\u0000\u0000Enzyme inhibition stands as a crucial strategy in tackling cardiovascular diseases (CVDs),\u0000countering their significant global impact on health. Targeting key enzymes involved in critical disease\u0000pathways has emerged as a pivotal pharmacological approach across various cardiovascular\u0000conditions. In hypertension, ACE inhibitors effectively lower blood pressure by impeding the conversion\u0000of angiotensin I to angiotensin II, promoting vasodilation and reducing cardiac workload.\u0000CAD management often involves statins, which competitively inhibit 3-hydroxy-3-methylglutarylcoenzyme\u0000A reductase, thereby lowering cholesterol levels and curbing plaque formation in coronary\u0000arteries. For heart failure, neprilysin inhibitors combined with ARBs exhibit promise by preserving\u0000beneficial peptides, supporting heart function and regulating fluid balance. Aspirin, an irreversible\u0000COX enzyme inhibitor, reduces platelet aggregation, mitigating thromboxane A2 formation and lowering\u0000the risk of clot-related complications in atherosclerosis. Managing dyslipidemia involves drugs\u0000like ezetimibe, targeting cholesterol absorption in the intestines and reducing LDL cholesterol levels.\u0000However, administering these drugs mandates careful consideration of patient-specific factors, potential\u0000side effects, and contraindications. Integrating lifestyle changes, such as a healthy diet and regular\u0000exercise remains integral to CVD management. The potential of enzyme inhibition in disrupting\u0000disease pathways and addressing key factors in CVD progression is evident. Yet, it necessitates ongoing\u0000research for refining existing therapies and developing novel inhibitors to augment cardiovascular\u0000outcomes and elevate patients' quality of life.\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140496113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite Profiling and In silico Studies to Elucidate the AntiinflammatoryProperties of Pterocarpus Milbreadii 通过代谢物轮廓分析和硅学研究阐明紫檀的抗炎特性

Current Enzyme Inhibition Pub Date : 2024-01-12 DOI: 10.2174/0115734080277468231129075038

P. Aba, Ismaila Onuche Odugbo

{"title":"Metabolite Profiling and In silico Studies to Elucidate the Antiinflammatory\u0000Properties of Pterocarpus Milbreadii","authors":"P. Aba, Ismaila Onuche Odugbo","doi":"10.2174/0115734080277468231129075038","DOIUrl":"https://doi.org/10.2174/0115734080277468231129075038","url":null,"abstract":"\u0000\u0000Pterocarpus milbreadii (PM), called Rosewood in English, is a leafy vegetable\u0000used in preparing soup and has also proven medicinal.\u0000\u0000\u0000\u0000This study aimed to evaluate the most abundant compound in the ethylacetate fraction of\u0000PM using Gas Chromatography-mass Spectrometry (GC-MS) and docking it against cyclooxygenase\u0000isoenzymes.\u0000\u0000\u0000\u0000The PM leaves were extracted with ethyl acetate using the cold maceration method. The\u0000extract was subjected to GC-MS assay. The spectra obtained were matched with NIST 17. AutoDock\u0000Vina was used to perform the molecular docking of the most abundant compound of PM and cyclooxygenase.\u0000Celecoxib was used as the standard ligand.\u0000\u0000\u0000\u0000The results of the study revealed that the ethyl acetate leaf extract of PM contained different\u0000phytochemicals, with hexadecenoic acid being the most abundant, with an intensity count of 9.5 x108\u0000CPS. Docking of hexadecenoic acid and Celecoxib with COX-2 yielded binding energies of -6.7 and\u0000-7.7 kcal/mol, respectively, while with COX-1, the binding energies of -6.3 and -9.8 kcal/mol were\u0000respectively recorded. Hexadecenoic acid interacted with both COX-1 and COX-2 largely via Van\u0000der waals and pi-Alkyl bonds. Celecoxib made conventional hydrogen, carbon-hydrogen, halogen,\u0000pi-sigma, pi-alkyl interactions with the cyclooxygenase isoenzymes.\u0000\u0000\u0000\u0000It was concluded that hexadecenoic acid was the predominant phytochemical in the\u0000ethylacetate leaf extract of PM. The hexadecanoic acid ligand produced a better inhibitory effect on\u0000COX-2 compared to COX-1.\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A QSAR and Pharmacophore Survey on Tyrosine Kinase Inhibitors with Effect on Epidermal Growth Factor Receptor 对表皮生长因子受体有效的酪氨酸激酶抑制剂的 QSAR 和药理调查

Current Enzyme Inhibition Pub Date : 2023-12-20 DOI: 10.2174/0115734080272807231127050546

Atefeh Hajiagha Bozorgi, Fatemeh Samadi

引用次数: 0

Pharmacological Strategies for Enzyme Inhibition in Disease Therapeutics:A Comprehensive Review 疾病治疗中的酶抑制药理策略：全面回顾

Current Enzyme Inhibition Pub Date : 2023-12-19 DOI: 10.2174/0115734080273835231127045336

Garima Verma, Bharat Bhushan, Geetanjali Singh, Kuldeep Singh, Shivendra Kumar, Akash Garg, Pankaj Rajput

{"title":"Pharmacological Strategies for Enzyme Inhibition in Disease Therapeutics:\u0000A Comprehensive Review","authors":"Garima Verma, Bharat Bhushan, Geetanjali Singh, Kuldeep Singh, Shivendra Kumar, Akash Garg, Pankaj Rajput","doi":"10.2174/0115734080273835231127045336","DOIUrl":"https://doi.org/10.2174/0115734080273835231127045336","url":null,"abstract":"\u0000\u0000Enzyme inhibition is a crucial pharmacological approach for treating various diseases as it\u0000targets enzymes involved in disease pathogenesis. This review explores the fundamental concepts of\u0000enzyme inhibition, including reversible and irreversible mechanisms, and the various types of enzymes,\u0000such as proteases, kinases, and polymerases, and their contributions to different disease states.\u0000The review discusses the design and production of enzyme inhibitors using methods like structurebased\u0000drug design, high-throughput screening, and rational drug design. The review also discusses\u0000the challenges and successes encountered in discovering and optimizing potent and selective enzyme\u0000inhibitors. Examples of enzyme inhibition's therapeutic benefits include protease inhibitors in\u0000HIV/AIDS therapy, kinase inhibitors in cancer treatment, and acetylcholinesterase inhibitors in Alzheimer's\u0000disease management. The review also examines possible side effects and limits of enzyme\u0000inhibition, focusing on ways to reduce off-target effects and make drugs more specific. At the end of\u0000the review, new trends and future possibilities in enzyme inhibition for treating diseases are talked\u0000about. These include personalized medicine, combination therapies, and new ways to get drugs into the\u0000body. By shedding light on the latest developments, challenges, and future directions, the review aims to\u0000contribute to the advancement of this vital field and revolutionize disease treatment modalities.\u0000","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Enzyme Inhibition: A Pharmacological Review 酶抑制剂的最新进展：药理学综述

Current Enzyme Inhibition Pub Date : 2023-11-27 DOI: 10.2174/0115734080271639231030093152

Kuldeep Singh, Bharat Bhushan, Nidhi Mittal, Abhishek kushwaha, Chandan Kumar Raikwar, Arun Kumar Sharma, D. Chanchal, Shivendra Kumar, Mohit Agrawal

{"title":"Recent Advances in Enzyme Inhibition: A Pharmacological Review","authors":"Kuldeep Singh, Bharat Bhushan, Nidhi Mittal, Abhishek kushwaha, Chandan Kumar Raikwar, Arun Kumar Sharma, D. Chanchal, Shivendra Kumar, Mohit Agrawal","doi":"10.2174/0115734080271639231030093152","DOIUrl":"https://doi.org/10.2174/0115734080271639231030093152","url":null,"abstract":"Enzyme inhibition is a crucial mechanism for regulating biological processes and developing therapeutic interventions. This pharmacological review summarizes recent advances in enzyme inhibition, focusing on key developments and their implications for drug discovery and therapeutic strategies. It explains basic ideas, including the different kinds of inhibitors and how they work, and looks at recent advances in small-molecule inhibitor design, fragment-based drug discovery, and virtual screening techniques. The review also highlights the advances in targeting specific enzyme families, explaining the structural basis of enzyme-inhibitor interactions, optimizing inhibitor potency, selectivity, and pharmacokinetic properties, and new trends in enzyme inhibition. The clinical implications of recent advances in enzyme inhibition include the development of novel therapeutic agents for diseases like cancer, infectious diseases, and neurological disorders. The review addresses challenges and future directions in the field, such as optimizing drug safety, resistance mechanisms, and personalized medicine approaches. Overall, the insights provided in this review may inspire further research and collaborations to accelerate the translation of enzyme inhibitors into effective clinical treatments.","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Potential of Orientin with Antiepileptic Drugs against Pentylenetetrazole-induced Kindling Model and Evaluation of Behavioral Assessment in Mice 荭草苷与抗癫痫药物对戊烯四唑诱导的激灵模型的神经保护潜力及小鼠行为评估

Current Enzyme Inhibition Pub Date : 2023-11-08 DOI: 10.2174/0115734080276565231024054936

Aman Shrivastava, J. K. Gupta, Kamal Shah

{"title":"Neuroprotective Potential of Orientin with Antiepileptic Drugs against Pentylenetetrazole-induced Kindling Model and Evaluation of Behavioral Assessment in Mice","authors":"Aman Shrivastava, J. K. Gupta, Kamal Shah","doi":"10.2174/0115734080276565231024054936","DOIUrl":"https://doi.org/10.2174/0115734080276565231024054936","url":null,"abstract":"The neuroprotective effect of bioflavonoids has been demonstrated in epileptic disorder. The objective of this study was to investigate the anticonvulsant and adjuvant effects of the bioflavonoid and explore behavioural responses of orientin (Ore) on kindled mice induced by pentylenetetrazole [PTZ]. Albino Swiss mice weighing 20-30 g were divided into nine groups [n=6]. Prior to the PTZ dose, alternatively, ore [10 mg/kg, i.p.] was given for 7 days, dissolved in 6% w/v carboxymethylcellulose [CMC] salt. On the 7th day, saline was solubilized with Lamotrigine [Lmt], Phenobarbital [Pb], and Gabapentin [Gbp] and administered as separate intraperitoneal [i.p.] injections 30 minutes prior to the PTZ dose. For the development of kindling seizures in mice, PTZ [30 mg/kg, i.p.] was delivered to all the mice for 12 days, alternatively until the animals appeared to develop full motor muscle jerking seizures. Mice who survived from complete motor seizures were selected for further experimentation. Data showed that anticonvulsive activity was exhibited by the control. Ore [10 mg/kg] with PB [40 mg/kg, i.p.] was administered on the 12th day and showed an increase in transfer delays [ITL and RTL]. Anti-seizure efficacy of drugs was investigated at the effective dose of ore at 10 mg/kg + PB 40mg/kg in group 7 and was found to have promising therapeutic outcomes and potency in therapeutic strategies and associated concerns.","PeriodicalId":35405,"journal":{"name":"Current Enzyme Inhibition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139282441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0