疾病治疗中的酶抑制药理策略：全面回顾

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2023-12-19 DOI:10.2174/0115734080273835231127045336

Garima Verma, Bharat Bhushan, Geetanjali Singh, Kuldeep Singh, Shivendra Kumar, Akash Garg, Pankaj Rajput

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引用次数: 0

摘要

酶抑制是治疗各种疾病的重要药理学方法，因为它针对的是参与疾病发病机制的酶。本综述探讨了酶抑制的基本概念，包括可逆和不可逆机制，以及蛋白酶、激酶和聚合酶等各种类型的酶及其对不同疾病状态的贡献。综述讨论了利用基于结构的药物设计、高通量筛选和合理药物设计等方法设计和生产酶抑制剂的问题。综述还讨论了在发现和优化强效选择性酶抑制剂方面遇到的挑战和取得的成功。酶抑制剂的治疗优势包括用于艾滋病毒/艾滋病治疗的蛋白酶抑制剂、用于癌症治疗的激酶抑制剂以及用于阿尔茨海默病治疗的乙酰胆碱酯酶抑制剂。综述还探讨了酶抑制剂可能产生的副作用和局限性，重点是如何减少脱靶效应并使药物更具特异性。综述最后谈到了酶抑制剂治疗疾病的新趋势和未来可能性。其中包括个性化医疗、联合疗法以及让药物进入人体的新方法。通过阐明最新进展、挑战和未来方向，这篇综述旨在推动这一重要领域的发展，彻底改变疾病治疗模式。

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Pharmacological Strategies for Enzyme Inhibition in Disease Therapeutics: A Comprehensive Review

Enzyme inhibition is a crucial pharmacological approach for treating various diseases as it targets enzymes involved in disease pathogenesis. This review explores the fundamental concepts of enzyme inhibition, including reversible and irreversible mechanisms, and the various types of enzymes, such as proteases, kinases, and polymerases, and their contributions to different disease states. The review discusses the design and production of enzyme inhibitors using methods like structurebased drug design, high-throughput screening, and rational drug design. The review also discusses the challenges and successes encountered in discovering and optimizing potent and selective enzyme inhibitors. Examples of enzyme inhibition's therapeutic benefits include protease inhibitors in HIV/AIDS therapy, kinase inhibitors in cancer treatment, and acetylcholinesterase inhibitors in Alzheimer's disease management. The review also examines possible side effects and limits of enzyme inhibition, focusing on ways to reduce off-target effects and make drugs more specific. At the end of the review, new trends and future possibilities in enzyme inhibition for treating diseases are talked about. These include personalized medicine, combination therapies, and new ways to get drugs into the body. By shedding light on the latest developments, challenges, and future directions, the review aims to contribute to the advancement of this vital field and revolutionize disease treatment modalities.

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.