天南星科植物作为乙酰胆碱酯酶抑制剂在阿尔茨海默病症状调节和治疗中的潜在来源

Q4 Pharmacology, Toxicology and Pharmaceutics
Priyanka Kumari, N. Sarwa, Deepak Meena, Ajaya Easha, Navneet Singh Chaudhary
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引用次数: 0

摘要

记忆力减退或痴呆是阿尔茨海默病(AD)的主要症状。阿兹海默症患者的记忆、行为和认知能力会逐渐受到严重干扰,影响患者的日常生活。目前,全球有 5000 多万人患有阿尔茨海默病。这种疾病的症状调节和管理亟需关注。在过去二十年的重要药物治疗研究中,只有加兰他敏、多奈哌齐、利伐斯的明和美金刚四种药物化合物能够抑制乙酰胆碱酯酶(AChE),从而提高大脑中乙酰胆碱的供应量,缓解阿尔茨海默病患者的症状。许多植物科(主要包括芸香科、木瓜科、芹菜科、茜草科、柽柳科、百合科、茄科、豆科、萝藦科等)的植物性乙酰胆碱酯酶抑制剂已被证实可用于治疗AD进展。AD进展是由胆碱能、淀粉样蛋白、Tau蛋白、氧化应激和神经炎症假说所描述的。迄今为止,还没有文献对所有具有抗 AChE 活性的鸭跖草科植物进行全面综述。因此,本综述旨在介绍重要的文献,特别是关于抑制 AChE 的鸭跖草科植物衍生化合物的文献。本综述汇编了所有具有强效抗乙酰胆碱酯酶活性的植物,描述了 30 多种植物的抗 AChE 活性,这些植物可能成为寻找新药物分子的潜在靶标,从而引起研究人员对鸭跖草科植物的关注。研究人员对鸭脚木科 Tabernaemontana 属的 8 个以上物种进行了吲哚生物碱研究,发现它们具有 AChE 抑制活性。大多数抗 AChE 化合物属于生物碱类。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Apocynaceae as a Potential Source for Acetylcholinesterase Inhibition in Symptomatic Regulation and Management of Alzheimer's Disease
Memory loss or dementia is the key symptom of Alzheimer's disease (AD). In AD, significant interference in a progressive manner is observed in memory, behaviour, and cognitive abilities that affect the daily life of a person. At present, more than 50 million people are affected worldwide with Alzheimer's disease. Urgent attention is needed for the symptomatic regulation and management of this disease. The significant pharmacotherapy research in the last two decades gave only four drug compounds galanthamine, donepezil, rivastigmine, and memantine that inhibit the enzyme acetylcholinesterase (AChE) to elevate the availability of acetylcholine in the brain for symptomatic relief in AD patients. Plant-based AChE inhibitors from many plant families, mainly including Rutaceae, Papaveraceae, Apocynaceae, Rubiaceae, Amaryllidaceae, Liliaceae, Lycopodiaceae, Fabaceae, Lamiaceae, etc., have been characterized for the management of AD progression. AD progression is described by cholinergic, amyloid, Tau protein, oxidative stress, and neuroinflammatory hypothesis. To date, there is no comprehensive review in the literature that combined all plants of the Apocynaceae family showing anti-AChE activity. Therefore, the current review aims to present significant literature, especially on plant-derived compounds from the Apocynaceae family that inhibit AChE. The review compiled all plants showing potent anti-acetylcholinesterase activity. The anti-AChE activity of more than 30 plants is described, which may be potential targets to find new drug molecules by attracting the attention of researchers toward the Apocynaceae family. More than 8 species of genus Tabernaemontana of Apocynaceae have been investigated for indole alkaloids, demonstrating AChE inhibitory activity. The majority of anti-AChE compounds belong to the class of alkaloids.
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来源期刊
Current Enzyme Inhibition
Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
1.30
自引率
0.00%
发文量
30
期刊介绍: Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
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