Nigerian Journal of Physiological Sciences最新文献_第8页

The hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa may occur through the attenuation of Autonomic nervous system activity. 芙蓉花萼水提物的降压作用可能是通过抑制自主神经系统的活性来实现的。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/nigerjphysiolsci.v36i2.9

F. Mojiminiyi, B. Aliyu, O. Oyeni̇ran, Alex Isu

{"title":"The hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa may occur through the attenuation of Autonomic nervous system activity.","authors":"F. Mojiminiyi, B. Aliyu, O. Oyeni̇ran, Alex Isu","doi":"10.54548/nigerjphysiolsci.v36i2.9","DOIUrl":"https://doi.org/10.54548/nigerjphysiolsci.v36i2.9","url":null,"abstract":"This study tested the hypothesis that the hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa (HS) occurs through autonomic mechanisms that may be associated with a reduction in the double product (DP) of the heart. Experiments were performed in accordance with the Principles of the Declaration of Helsinki. Following ethical approval and informed consent, the Harvard step test (HST) was performed in healthy subjects (n=14) to activate the autonomic nervous system before and after the oral administration of 15mg/kg HS. The blood pressure (BP) and heart rate (HR) responses were measured and DPs and the mean arterial pressure (MAP) were calculated. Results were expressed as mean ±SEM. Paired t-test and one way ANOVA with a posthoc Bonferoni test were used for statistical analyses. P<0.05 was considered significant. HST without HS resulted in a significant rise in MAP, HR and DP (112.6±2.7mmHg, 97.7±2.5/min and 12630.0±642 mmHg.bpm) from the basal values (98.5±2.3mmHg, 76.5±2.0/min and 8730.7±354.9 mmHg.bpm, P<0.001, P<0.01 and P<0.001 respectively). In the presence of HS, HST-induced changes (∆MAP=7.8±1.6mmHg; ∆HR=8.1±1.6/min; ∆DP= 1113.6±103.4 mmHg.bpm) were significantly dampened compared to its absence (∆MAP= 13.3±2.6mmHg; ∆HR=17.0±3.7/min; ∆DP= 3899.3±287.2 mmHg.bpm; P<0.001, P<0.01 and P<0.0001 respectively). The HST-induced increase in BP, HR and DP suggest sympathetic nervous system (SNS) activation and parasympathetic nervous system (PNS) withdrawal associated with an increased cardiac O2 consumption and workload. These were dampened by HS suggesting that its hypotensive effect occurs through the inhibition of SNS activation, PNS withdrawal and an associated reduction in cardiac O2 demand and workload.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"33 1","pages":"203-209"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76497657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Angiotensin receptor blockade on Plasma Osmolality and Neurohumoral Responses to High Environmental Temperature in Rats Fed a High Salt Diet. 血管紧张素受体阻断对高盐饮食大鼠高环境温度下血浆渗透压和神经体液反应的影响。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/nigerjphysiolsci.v36i2.2

F. Agbaraolorunpo, A. Oloyo, S. Ogunnowo, C. Anigbogu, O. Sofola

{"title":"Effect of Angiotensin receptor blockade on Plasma Osmolality and Neurohumoral Responses to High Environmental Temperature in Rats Fed a High Salt Diet.","authors":"F. Agbaraolorunpo, A. Oloyo, S. Ogunnowo, C. Anigbogu, O. Sofola","doi":"10.54548/nigerjphysiolsci.v36i2.2","DOIUrl":"https://doi.org/10.54548/nigerjphysiolsci.v36i2.2","url":null,"abstract":"Plasma osmolality (pOsmol) and neurohumoral signals play important roles in the pathophysiology of cardiovascular diseases. Our study investigated the effect of high environmental temperature (HET) on neurohumoral responses and pOsmol in rats fed a high salt diet (HSD), with and without angiotensin II receptor blockade (ARB), using telmisartan. Fifty-six male 8-week old Sprague-Dawley rats (95-110g) were randomly assigned into seven groups of 8 rats. These included control rats (I) fed with 0.3% NaCl diet (normal diet, ND); salt-loaded rats (II) fed with 8% NaCl (high salt) diet; ND rats (III) exposed to HET (38.5±0.5oC ) 4 hours daily per week; rats (IV) fed with 8% NaCl diet and exposed to HET daily. Others included rats (V) fed with 8% NaCl diet and treated with telmisartan (30mg/kg); ND rats (VI) exposed to HET and treated with telmisartan; rats (VI) fed with 8% NaCl diet, exposed to HET and treated with telmisartan. Plasma angiotensin II, aldosterone, vasopressin and norepinephrine (NE) concentrations were determined by ELISA technique; pOsmol from plasma K+, Na+ and Urea. HSD combined with HET in rats synergistically increased pOsmol (P<0.001) with an associated non-synergistic rise in fluid intake (P<0.001), fluid balance (P<0.001), plasma angiotensin II (P<0.01) and aldosterone (P<0.05), NE (P<0.001) and vasopressin (P<0.05) concentrations compared to control. Telmisartan did not alter pOsmol in all the treated-rats, but normalized fluid intake levels and plasma vasopressin in the rats exposed to either HSD or HEt alone. Prolonged exposure of rats to hot environment exacerbated the effect of excess dietary salt on pOsmol, with no effect on angiotensin II-mediated neurohumoral responses.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"57 1","pages":"149-157"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75364843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Carpolobia lutea Root Extract Improved Steroidogenic Activity in Male Wistar Rats Exposed to Cadmium. 黄茶根提取物提高镉暴露雄性Wistar大鼠的类固醇生成活性。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.6

Adeniran Oluwadamilare Akinola, Oyeyemi Adekunle Wahab, Yinusa Raji

{"title":"Carpolobia lutea Root Extract Improved Steroidogenic Activity in Male Wistar Rats Exposed to Cadmium.","authors":"Adeniran Oluwadamilare Akinola, Oyeyemi Adekunle Wahab, Yinusa Raji","doi":"10.54548/njps.v36i2.6","DOIUrl":"https://doi.org/10.54548/njps.v36i2.6","url":null,"abstract":"Cadmium (Cd) is known to affect reproductive functions adversely. Carpolobia lutea is a protective herbal derivative due to its antioxidant potential. This study investigates the steroidogenic activities of methanol extract of Carpolobia lutea root on cadmium-induced reproductive toxicity in male Wistar rats. Carpolobia lutea root was obtained in Ijare via Akure. The plant was authenticated at the herbarium of Forestry Research Institute of Nigeria (FRIN), Ibadan, Nigeria, with FHI number 109784. The methanol extract Carpolobia lutea root (MCL) was obtained by Soxhlet extraction. Thirty male Wistar rats (150-170g) were used in this study (n=5) and treated as follows: Control, Cd (2 mg/kg), Cd+MCL (2 mg/kg+100 mg/kg), Cd+MCL (2 mg/kg+200 mg/kg), MCL (100 mg/kg), and MCL (200 mg/kg). The extract was administered orally for eight weeks, and a single dose of 2 mg/kg Cd was given intraperitoneally. Serum Follicle Stimulating Hormone (FSH), Luteinizing hormone (LH), testosterone levels, testicular hydroxysteroid dehydrogenases (HSDs) activities and Steroidogenic Acute Regulatory protein (StAR) expression were evaluated. Data were subjected to descriptive statistics and analysed using ANOVA at p<0.05. Serum FSH, LH, testosterone levels, 3β-HSD, 17β-HSD activities and StAR expression were significantly reduced (p<0.05) in Cd group. The co-administration of Cd with MCL (200mg/kg) significantly increased (p<0.05) serum FSH, LH, testosterone levels, 3β-HSD, 17β-HSD activities and StAR expression when compared with Cd group. Carpolobia lutea root extract improved steroidogenic activity in male Wistar rats exposed to cadmium.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teratogenic Effect of Aqueous Leaf Extract of Aspilia africana on The Dentate Gyrus of Wistar Rat Fetuses. 非洲木条叶水提物对Wistar大鼠胎齿状回的致畸作用。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.13

Olaitan Ruth Asuquo, P E Edet, M A Eluwa, O O O Kennedy

{"title":"Teratogenic Effect of Aqueous Leaf Extract of Aspilia africana on The Dentate Gyrus of Wistar Rat Fetuses.","authors":"Olaitan Ruth Asuquo, P E Edet, M A Eluwa, O O O Kennedy","doi":"10.54548/njps.v36i2.13","DOIUrl":"https://doi.org/10.54548/njps.v36i2.13","url":null,"abstract":"Aspilia africana is an herbal plant widespread in Africa used for medicinal purposes and also used by pregnant women for health related issues. This study was aimed at investigating the teratogenic effect of aqueous leaf extract of Aspilia africana on the dentate gyrus of albino wistar rat fetuses. Twenty (20) female adult rats weighing between 190-205g were used for this study. The rats were divided into four groups; control, low dose, medium dose and high dose with each group containing five rats. Pregnancy was induced by caging the female rats with sexually matured males. The presence of vaginal plug and tail structure in the vaginal smear the following morning confirmed coition, and it was regarded as day 0 of pregnancy. The control group was given distilled water. The low dose, medium dose, and the high dose groups received 750mg/kg, 1000mg/kg, and 1250mg/kg body weight of aqueous leaf extract of Aspilia africana through an orogastric tube from day 7-11 of gestation. On the 20th day of gestation, the animals were sacrificed using chloroform-inhalation method. Their fetuses were harvested via uterectomy, the brain was excised and fixed in 10% buffered formalin, and then routine histological processes were carried out. Staining was done using Haematoxylin and Eosin method. Histological observation of the dentate gyri of experimental groups revealed marked distortion, reduction of the polymorphic layer, hyperplasia and hypertrophy of cells in the molecular and granular layer especially in the high dose group whose mothers received 1250mg/kg of the extracts. The result suggests high doses of aqueous leaf extract of Aspilia africana may be teratogenic to the dentate gyrus of Wistar rat fetuses.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"237-240"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanolic extract of Salacia nitida root bark ameliorates lipid peroxidation and hepatosplenomegaly in Plasmodium berghei-malaria infected mice. 硝酸菌根皮乙醇提取物改善伯氏疟原虫感染小鼠的脂质过氧化和肝脾肿大。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.8

Barine Nwiloh, Augustine Amadikwa Uwakwe, Joyce Oronne Akaninwor

{"title":"Ethanolic extract of Salacia nitida root bark ameliorates lipid peroxidation and hepatosplenomegaly in Plasmodium berghei-malaria infected mice.","authors":"Barine Nwiloh, Augustine Amadikwa Uwakwe, Joyce Oronne Akaninwor","doi":"10.54548/njps.v36i2.8","DOIUrl":"https://doi.org/10.54548/njps.v36i2.8","url":null,"abstract":"The root bark of Salacia nitida L.benth (celastraceae) is used as remedy for malaria and typhoid fever in Southern part of Nigeria. This study is designed to evaluate the effect of treatment with ethanolic extract from root bark of S. nitida on lipid peroxidation, hepatomegaly and splenomegaly in Plasmodium berghei-malaria infected mice. Thirty malaria-infected and six uninfected mice were used for the study. 280, 430, and 580 mg kg-1 body weight day-1 of ethanolic extract and 4 mg kg-1 body weight day-1 of artesunate were administered orally to infected mice in groups B, C, D, and E, while 4 ml kg-1 body weight day-1 of physiological saline was given to infected untreated mice in group A and the uninfected untreated mice in group F. Treatments were done for five days. Levels of malondialdehyde were measured as means of assessing lipid peroxidation in the experimental animals. Weights of experimental animals, liver, and spleen, and the length of spleen from experimental animals were also measured. Animal's liver and spleen-body weight ratios were determined. Results from the study showed significant decrease (P < 0.05) in levels of malondialdehyde, and significant increase (P < 0.05) in body weights. Also, significant decreases (P < 0.05) were seen in the weights of liver and spleen, lengths of spleen, and organ-body weight ratios of malaria-infected treated mice. Therefore, this study confirmed that ethanolic extract from root bark of S. nitida is effective in the treatment of malaria, as it is seen in its ability to attenuate lipid peroxidation and hepatosplenomegaly in mice, thus corroborating its traditional use for the treatment of malaria.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa may occur through the attenuation of Autonomic nervous system activity. 木槿水提取液的降压作用可能通过减弱自主神经系统的活性而发生。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.9

Frank Mojiminiyi, Buhari Aliyu, Oluwatosin Oyeniran, Alex Isu

{"title":"The hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa may occur through the attenuation of Autonomic nervous system activity.","authors":"Frank Mojiminiyi, Buhari Aliyu, Oluwatosin Oyeniran, Alex Isu","doi":"10.54548/njps.v36i2.9","DOIUrl":"https://doi.org/10.54548/njps.v36i2.9","url":null,"abstract":"This study tested the hypothesis that the hypotensive effect of the aqueous calyx extract of Hibiscus sabdariffa (HS) occurs through autonomic mechanisms that may be associated with a reduction in the double product (DP) of the heart. Experiments were performed in accordance with the Principles of the Declaration of Helsinki. Following ethical approval and informed consent, the Harvard step test (HST) was performed in healthy subjects (n=14) to activate the autonomic nervous system before and after the oral administration of 15mg/kg HS. The blood pressure (BP) and heart rate (HR) responses were measured and DPs and the mean arterial pressure (MAP) were calculated. Results were expressed as mean ±SEM. Paired t-test and one way ANOVA with a posthoc Bonferoni test were used for statistical analyses. P<0.05 was considered significant. HST without HS resulted in a significant rise in MAP, HR and DP (112.6±2.7mmHg, 97.7±2.5/min and 12630.0±642 mmHg.bpm) from the basal values (98.5±2.3mmHg, 76.5±2.0/min and 8730.7±354.9 mmHg.bpm, P<0.001, P<0.01 and P<0.001 respectively). In the presence of HS, HST-induced changes (∆MAP=7.8±1.6mmHg; ∆HR=8.1±1.6/min; ∆DP= 1113.6±103.4 mmHg.bpm) were significantly dampened compared to its absence (∆MAP= 13.3±2.6mmHg; ∆HR=17.0±3.7/min; ∆DP= 3899.3±287.2 mmHg.bpm; P<0.001, P<0.01 and P<0.0001 respectively). The HST-induced increase in BP, HR and DP suggest sympathetic nervous system (SNS) activation and parasympathetic nervous system (PNS) withdrawal associated with an increased cardiac O2 consumption and workload. These were dampened by HS suggesting that its hypotensive effect occurs through the inhibition of SNS activation, PNS withdrawal and an associated reduction in cardiac O2 demand and workload.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"203-209"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius Plant on Haematology and Some Reproductive Indices of Male Wistar Rats. 紫草甲醇提取物和水提取物对雄性Wistar大鼠血液学和某些生殖指标的影响比较。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.12

Matthew Olugbenga Oyeyemi, S Modupe, O S Ajani

{"title":"Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius Plant on Haematology and Some Reproductive Indices of Male Wistar Rats.","authors":"Matthew Olugbenga Oyeyemi, S Modupe, O S Ajani","doi":"10.54548/njps.v36i2.12","DOIUrl":"10.54548/njps.v36i2.12","url":null,"abstract":"Corchorus olitorius is a vegetable plant/shrub and the leaves are very nutritious and rich in vitamins, minerals and dietary fibers. The study was carried out to identify the effects two extracts of this plant on the reproductive indices of male Wistar rats Forty-five adult male rats of about 12 weeks old, each weighing about 120g were used for this study, kept in a cage and fed with commercial rat pellets and water was given at ad-libitum. They were randomly divided into groups A, B and C of 15 rats per group. 250mg/kg of the leaf extract was administered orogastrically using once daily for 21 days. Group A and B were treated with methanol and aqueous leaves of Corchorus extract respectively and Group C was given distilled water and served as the control. The weekly sacrifice of five rats per group was done following treatments. In this study, it was observed at the first-week post -treatment that there was significant (p≤0.05) decrease in the PCV and haemoglobin values of group A rats compared to the control group but the values later increased at the second week and third-week post-treatments. There was also a significant decrease in spermatozoa motility in the treated groups A and B compared to the control group C at the first, second- and third-week post treatments. Also, with the results of the serum testosterone level of group A and B compared to group C. The value was higher in group A followed by group B whereas, at the second week and third week, there was no significant difference in the values of the serum testosterone levels compared to the control groups. It is therefore concluded that the methanol and aqueous extract of Corchorus olitorius leaves significantly decreased sperm motility in male albino rats hence could decrease male fertility.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"227-236"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius Plant on Haematology and Some Reproductive Indices of Male Albino Rats (Wistar Strain) 紫草甲醇提取物和水提取物对雄性白化大鼠（Wistar品系）血液学和某些生殖指标的影响

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/nigerjphysiolsci.v36i2.12

M. Oyeyemi

{"title":"Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius Plant on Haematology and Some Reproductive Indices of Male Albino Rats (Wistar Strain)","authors":"M. Oyeyemi","doi":"10.54548/nigerjphysiolsci.v36i2.12","DOIUrl":"https://doi.org/10.54548/nigerjphysiolsci.v36i2.12","url":null,"abstract":"Corchorus olitorius is a vegetable plant/shrub and the leaves are very nutritious and rich in vitamins, minerals and dietary fibers. The study was carried out to identify the effects two extracts of this plant on the reproductive indices of male Wistar rats \u0000Forty-five adult male rats of about 12 weeks old, each weighing about 120g were used for this study, kept in a cage and fed with commercial rat pellets and water was given at ad-libitum. They were randomly divided into groups A, B and C of 15 rats per group. 250mg/kg of the leaf extract was administered orogastrically using once daily for 21 days. Group A and B were treated with methanol and aqueous leaves of Corchorus extract respectively and Group C was given distilled water and served as the control. The weekly sacrifice of five rats per group was done following \u0000treatments. In this study, it was observed at the first-week post -treatment that there was significant (p≤0.05) decrease in the PCV and haemoglobin values of group A rats compared to the control group but the values later increased at the second week and third-week post-treatments. There was also a significant decrease in spermatozoa motility in the treated groups A and B compared to the control group C at the first, second- and third-week post treatments. Also, with the results of the serum testosterone level of group A and B compared to group C. The value was higher in group A followed by group B whereas, at the second week and third week, there was no significant difference in the values of the serum testosterone levels compared to the control groups. \u0000It is therefore concluded that the methanol and aqueous extract of Corchorus olitorius leaves significantly decreased sperm motility in male albino rats hence could decrease male fertility. ","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carpolobia lutea Root Extract Improved Steroidogenic Activity in Male Wistar Rats Exposed to Cadmium. 黄茶根提取物提高镉暴露雄性Wistar大鼠的类固醇生成活性。

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/nigerjphysiolsci.v36i2.6

A. Akinola, O. A. Wahab, Y. Raji

{"title":"Carpolobia lutea Root Extract Improved Steroidogenic Activity in Male Wistar Rats Exposed to Cadmium.","authors":"A. Akinola, O. A. Wahab, Y. Raji","doi":"10.54548/nigerjphysiolsci.v36i2.6","DOIUrl":"https://doi.org/10.54548/nigerjphysiolsci.v36i2.6","url":null,"abstract":"Cadmium (Cd) is known to affect reproductive functions adversely. Carpolobia lutea is a protective herbal derivative due to its antioxidant potential. This study investigates the steroidogenic activities of methanol extract of Carpolobia lutea root on cadmium-induced reproductive toxicity in male Wistar rats. Carpolobia lutea root was obtained in Ijare via Akure. The plant was authenticated at the herbarium of Forestry Research Institute of Nigeria (FRIN), Ibadan, Nigeria, with FHI number 109784. The methanol extract Carpolobia lutea root (MCL) was obtained by Soxhlet extraction. Thirty male Wistar rats (150-170g) were used in this study (n=5) and treated as follows: Control, Cd (2 mg/kg), Cd+MCL (2 mg/kg+100 mg/kg), Cd+MCL (2 mg/kg+200 mg/kg), MCL (100 mg/kg), and MCL (200 mg/kg). The extract was administered orally for eight weeks, and a single dose of 2 mg/kg Cd was given intraperitoneally. Serum Follicle Stimulating Hormone (FSH), Luteinizing hormone (LH), testosterone levels, testicular hydroxysteroid dehydrogenases (HSDs) activities and Steroidogenic Acute Regulatory protein (StAR) expression were evaluated. Data were subjected to descriptive statistics and analysed using ANOVA at p<0.05. Serum FSH, LH, testosterone levels, 3β-HSD, 17β-HSD activities and StAR expression were significantly reduced (p<0.05) in Cd group. The co-administration of Cd with MCL (200mg/kg) significantly increased (p<0.05) serum FSH, LH, testosterone levels, 3β-HSD, 17β-HSD activities and StAR expression when compared with Cd group. Carpolobia lutea root extract improved steroidogenic activity in male Wistar rats exposed to cadmium.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"342 1","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75373466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glycated Haemogloin, Fasting Plasma Glucose, Plasminogen Activator Inhibitor Type-1, and Soluble Thrombomodulin Levels in Patients with Type 2 Diabetes Mellitus. 2型糖尿病患者糖化血红蛋白、空腹血糖、1型纤溶酶原激活物抑制剂和可溶性血栓调节蛋白水平

Nigerian Journal of Physiological Sciences Pub Date : 2021-12-31 DOI: 10.54548/njps.v36i2.3

Euphoria Akwiwu, Margaret Edem, Josephine Akpotuzor, Enosakhare Asemota, Idongesit Isong

{"title":"Glycated Haemogloin, Fasting Plasma Glucose, Plasminogen Activator Inhibitor Type-1, and Soluble Thrombomodulin Levels in Patients with Type 2 Diabetes Mellitus.","authors":"Euphoria Akwiwu, Margaret Edem, Josephine Akpotuzor, Enosakhare Asemota, Idongesit Isong","doi":"10.54548/njps.v36i2.3","DOIUrl":"https://doi.org/10.54548/njps.v36i2.3","url":null,"abstract":"Diabetes mellitus has become increasingly prevalent over the years. The chronic hyperglycaemia of diabetes is associated with long-term damage, dysfunctions, and failure of different organs suggesting that the most effective tool to prevent complications is the effective control of hyperglycaemia itself. The study is set to determine the effect of glycemic control on plasminogen activator inhibitor type 1 (PAI-1), soluble thrombomodulin (STM) alongside fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) among type 2 diabetic subjects. One hundred diabetic subjects accessing care at the University of Calabar Teaching Hospital Calabar and 100 non -diabetics that served as controls were enrolled. Blood samples from participants were analyzed for FPG, HbA1c, PAI-1 and STM by standard methods. The result shows 74% of the diabetic to be females. Half of the diabetics were managed on only oral anti-diabetic drugs while the remaining half were either on insulin injection or a combination of oral and insulin injection. Poor glycemic control was observed in 56% of the studied subjects. The mean age of 54.69 ± 9.94 years for the diabetics was comparable to the age-matched controls (p=.097). Diabetics showed significantly higher FPG, HbA1c, PAI-1and STM (P=0.001) compared to control values. Correlations between STM, PAI 1 and glycated hemoglobin (figures 2 p=0.001, p =0.001) and STM, PAI-1 and FPG revealed significantly robust association (p=0.001, p=0.001). The study concludes that there is poor glycemic control among the treated diabetic subjects with PAI-1 and STM showing a very strong positive correlation with HbA1c than FPG.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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