Nigerian Journal of Physiological Sciences最新文献_第5页

Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity. 科拉韦隆和辅酶Q10对鱼藤酮神经毒性中复合物I活性、谷氨酸清除、3,4-二羟基苯乙胺代谢和氧化还原应激的比较影响

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.2

A C Akinmoladun, Ibrahim Saliu, Olaoluwa Abilogun, Omotola Helen Ajibola, Zainab Abiola Amoo, Olubukola Benedicta Ojo, Ebenezer O Farombi, Mary Tolulope Olaleye

{"title":"Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity.","authors":"A C Akinmoladun, Ibrahim Saliu, Olaoluwa Abilogun, Omotola Helen Ajibola, Zainab Abiola Amoo, Olubukola Benedicta Ojo, Ebenezer O Farombi, Mary Tolulope Olaleye","doi":"10.54548/njps.v37i2.2","DOIUrl":"10.54548/njps.v37i2.2","url":null,"abstract":"3,4-dihydroxyphenethylamine (dopamine) depletion, inhibition of complex I activity, oxidative stress, and glutamate excitotoxicity are cardinal biochemical features of neurotoxicity induced by systemic unilateral infusion of rotenone. Kolaviron (KV), a biflavonoid from Garcinia kola seeds, has been proven to have pharmacological effects against neurotoxicity. Coenzyme Q10 plays an essential role in mitochondrial oxidative phosphorylation and as an antioxidant. This study examined the comparative influence of kolaviron and coenzyme Q10 on complex I activity, dopamine metabolism, glutamate clearance, and redox stress in rotenone-induced neurotoxicity in the cortex, hippocampus, and striatum of the brain of rats. Adult Male Wistar rats were pretreated with 200 mg/kg KV or 100 mg/kg coenzyme Q10 for 7 days followed by administration of a progressive six doses of 1.5 mg/kg rotenone within the next 48 h after which the animals were euthanized and the brain excised. On the cortical, hippocampal, and striatal regions of the brain, complex I activity, dopamine metabolism, oxidative stress markers, as well as glutamate metabolism were carried out and analyzed. In all brain regions examined, KV and coenzyme Q10 pretreatment modulated complex I activity, ameliorated redox imbalance, and enhanced dopamine metabolism via increasing the activity of tyrosine hydroxylase and decreasing monoamine oxidase activity. KV facilitated glutamate clearance through augmentation of glutamate dehydrogenase and glutamine synthetase activities. The activity of KV was comparable to that of the mitochondrial membrane antioxidant compound, coenzyme Q10, this indicates that KV is a promising therapeutic agent in the treatment of Parkinson's disease and its activity compares well with coenzyme Q10.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"1 1","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41851446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness and Attitudes of Secondary School Students about Physiology Discipline in Southwest Region, Nigeria. 尼日利亚西南地区中学生对生理学科的认识和态度

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.13

Oluwaseun Samuel Faborode, Issa Olakunle Yusuf, Damilare Hakeem Adeyemi, Olaolu Joseph Odewole, Joy Adebowale Ajisafe, Ayobami Dare, Olugbemi Temitope Olaniyan, Samuel Adetunji Onasanwo

{"title":"Awareness and Attitudes of Secondary School Students about Physiology Discipline in Southwest Region, Nigeria.","authors":"Oluwaseun Samuel Faborode, Issa Olakunle Yusuf, Damilare Hakeem Adeyemi, Olaolu Joseph Odewole, Joy Adebowale Ajisafe, Ayobami Dare, Olugbemi Temitope Olaniyan, Samuel Adetunji Onasanwo","doi":"10.54548/njps.v37i2.13","DOIUrl":"10.54548/njps.v37i2.13","url":null,"abstract":"Physiology remains one of the core disciplines on which all biological and medical sciences were founded. In Nigeria, it is known that most students study Physiology at the undergraduate level by chance and not by choice and end up performing poorly, which could be mainly due to low awareness and knowledge of the discipline, its opportunities, and prospects. Therefore, this study investigated the awareness, attitude, and knowledge about physiology among senior secondary school students in Southwest Nigeria. A cross-sectional of 544 students in science-based senior secondary schools in south-west Nigeria were sampled. Our results showed a high level of awareness, with television being the dominant medium of information. However, knowledge of Physiology was low, while most of the students also showed interest in knowing more about it. Although gender does not seem to influence the level of knowledge, females had a better attitude towards learning about physiology. Similarly, residence did not affect attitude, howbeit associated with the level of knowledge. In conclusion, the high awareness and low knowledge observed in this study would give insights to educate students at the early stages of education about the opportunity and prospects of Physiology and other science-related disciplines.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"255-260"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45578480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haematoprotective and Hepatoprotective Effects of Methanolic Leaf Extract of Parquetina nigrescens on Arsenic trioxide-induced Toxicity in Male Wistar Rats. 三氧化二砷对大鼠血液学和生化的影响。

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.11

Oore-Oluwapo Daramola, Wahab Adekunle Oyeyemi Oyeyemi, Adeniran Oluwadamilare Akinola Akinola, Yinusa Raji Raji

{"title":"Haematoprotective and Hepatoprotective Effects of Methanolic Leaf Extract of Parquetina nigrescens on Arsenic trioxide-induced Toxicity in Male Wistar Rats.","authors":"Oore-Oluwapo Daramola, Wahab Adekunle Oyeyemi Oyeyemi, Adeniran Oluwadamilare Akinola Akinola, Yinusa Raji Raji","doi":"10.54548/njps.v37i2.11","DOIUrl":"10.54548/njps.v37i2.11","url":null,"abstract":"This study was designed to investigate the phytochemical composition and protective effects of methanol extract of Parquetina nigrescens leaf (MEPL) in male Wistar rats. Phytochemical screening, in vitro antioxidant assay, gas chromatography-mass spectrometry (GC-MS) and LD50 were determined. Forty male Wistar rats were grouped into eight and orally treated for 54 days as follows: Group 1 (10% tween 80), Group 2 (3 mg/kg As2O3) Groups 3, 4 and 5 (250, 500 and 1000 mg/kg MEPL) and groups 6, 7 and 8, (250 mg/kg+As2O3, 500 mg/kg+As2O3 and 1000 mg/kg+As2O3). The animals were sacrificed on day 55 under anaesthesia. Blood was collected by cardiac puncture for heamatological studies. Liver concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), aspartate aminotransferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) activities were determined spectrophotometrically. Liver histology was also assessed. Flavonoids, tannin, alkaloids, saponin, and anthraquinone were present in MEPL, also, MEPL scavenged 2,2 diphenyl-1-picrylhydrazyl hydrate (DPPH) and Azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS+). The IC50 of MEPL required to chelate metal was also low. The GC-MS revealed the presence of 24 essential oil. The LD50 was > 5000 mg/kg. Packed cell volume and red blood cell count were significantly reduced in 1000 mg/kg MEPL group, white blood cell count and SOD activity reduced (P<0.05) in 3 mg/kg As2O3 when compared with control but increased in groups co-treated with As2O3 and 250, 500 or 1000 mg/kg + As2O3. MDA concentration, AST, ALT and ALP activities increased significantly in 3 mg/kg As2O3 group but decreased (P<0.05) in groups co-treated with As2O3 and 250, 500 or 1000 mg/kg. The methanol extract of Parquetina nigrescens leaf in male Wistar rats has antioxidant, hepatoprotective and white blood cell protective effects.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"235-246"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45902886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Chemopreventive Effects of Azadirachta indica on Lead Acetate-induced Hepatotoxicity in Male Wistar Rats. Azadirachta indica 对雄性 Wistar 大鼠因醋酸铅引起的肝毒性的抗氧化和化学预防作用

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31

Ebunoluwa Asenuga, T O Ajibade, Abiola Adejumobi, Bukola Alaba, Williams Nabofa, Ademola Oyagbemi, Temidayo Omobowale, Joseph Badejo, Olajide Akinboye

{"title":"Antioxidant and Chemopreventive Effects of Azadirachta indica on Lead Acetate-induced Hepatotoxicity in Male Wistar Rats.","authors":"Ebunoluwa Asenuga, T O Ajibade, Abiola Adejumobi, Bukola Alaba, Williams Nabofa, Ademola Oyagbemi, Temidayo Omobowale, Joseph Badejo, Olajide Akinboye","doi":"","DOIUrl":"","url":null,"abstract":"Toxic metals such as lead (Pb) cause severe liver damage in humans and animals, with oxidative stress prominently implicated in the pathogenesis of lead acetate‑induced liver injury. Azadirachta indica is hepatoprotective due to its antioxidative effect. This study investigated the antioxidative role of A. indica (AI) and its chemopreventive effect on lead acetate (LA)-induced hepatocellular dysfunction with seventy adult male rats classified into group A- Control (distilled water), group B 0.1% LA only, group C and D- 0.1% LA + 100 mg/kg and 0.1% LA + 200 mg/kg AI respectively, group E- 0.2% LA, group F and G- 0.2% LA + 100 mg/kg and 0.2% LA + 200 mg/kg AI. Oxidative stress markers (MDA and H2O2), antioxidant parameters (GSH, SOD, CAT, GPx, GST), inflammatory markers (MPO and NO), alanine aminotransferase (ALT) and histopathological studies of the liver were evaluated. The results showed that LA administration caused a decrease in GSH, GPx, and GST while AI co-administration increased the activities of the antioxidants. Moreover, LA administration increased MPO, NO, MDA, and H2O2 levels whereas AI significantly reduced (P<0.05) these parameters. Histopathological examination revealed necrosis and mild infiltration by inflammatory cells in LA administered rats, whereas these lesions were absent in AI administered rats. In conclusion, A. indica demonstrates a protective role in lead acetate-induced hepatotoxicity, mainly via oxidative stress inhibition.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"37 2","pages":"219-224"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway. 初椰油补充饮食对苯甲酸钠诱导的乙酰胆碱酯酶功能障碍和认知障碍的神经保护作用:Nrf2/NfKb信号通路的作用

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.10

Abraham Asuku

{"title":"Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway.","authors":"Abraham Asuku","doi":"10.54548/njps.v37i2.10","DOIUrl":"10.54548/njps.v37i2.10","url":null,"abstract":"The effect of virgin coconut oil (VCO) supplemented diet on sodium benzoate (SB) - induced neurotoxicity in male Wistar rats was investigated. Twenty (20) male Wistar rats weighing 160-180g were divided into four (4) groups: Control which received 1ml of normal saline, SB-treated; received 200 mg/kg b.w, SB + Low Dose VCO-treated (SB + 5% VCO mixed with 95g of rat chow), and SB + High Dose VCO-treated (SB+ 15% VCO mixed with 85g of rat chow). The brain was processed for NRF-2, NF-kB, and acetylcholine esterase (AchE) gene expression levels. Also, the blood sample was processed for assessment of superoxide dismutase (SOD), catalase (CAT), and IL1B levels. One-way ANOVA and Tukey post hoc tests were used to analyze data. SB-treated rats with no intervention showed anxiety-like behavior and impaired memory as depicted by a significant (p<0.0001) increase in anxiety index, increase in brain NF-KB, increase in serum IL1B and increase in AchE gene expression level, reduction in the recognition ratio, decreased spontaneous alternation performance, decreased CAT and SOD levels and decreased NRF-2 expression level when compared to other groups (especially control and SB + 5% VCO). VCO supplemented diet (both 5% and 15%) significantly (p<0.0001) increased the CAT and SOD levels, increased the NRF-2 gene expression level, and significantly (p <0.0001) decreased the IL1-B level. Moreover, 5% VCO significantly (p<0.0001) decreased the anxiety index, decreased AchE and NFkB gene expression levels, increased spontaneous alternation performance, and increased recognition ratio compared to 15% VCO. VCO shows a neuroprotective effect in attenuating cognitive impairment and anxiety-like behavior in SB-induced model by modulating oxidative stress and inflammatory pathways, and also enhancing cholinergic neurotransmission. Keywords: Virgin coconut oil; sodium benzoate; acetylcholinesterase; catalase; superoxide dismutase; oxidative stress.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42854066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antihyperlipidemic property of Murraya koenigii ethanolic leaf extract on lipid profile of rats fed with cholesterol-enriched diets. 葛乙醇叶提取物对高胆固醇饮食大鼠血脂的影响

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.8

Azubuike Raphael Nwaji

{"title":"Antihyperlipidemic property of Murraya koenigii ethanolic leaf extract on lipid profile of rats fed with cholesterol-enriched diets.","authors":"Azubuike Raphael Nwaji","doi":"10.54548/njps.v37i2.8","DOIUrl":"10.54548/njps.v37i2.8","url":null,"abstract":"This study was designed to investigate the effect of orally administered ethanolic leaf extract of Murraya koenigii on lipid profile of rats fed with cholesterol-enriched diets for 14 days. The study was carried out on 20 male wistar rats divided into 4 groups (n=5). All animals were given ad libitum access to drinking water. Group A was the control group and received normal rat chow, group B received cholesterol-enriched diet (CED); while group C and D received cholesterol-enriched diet and were treated with 200mg and 400mg/kg body weight of ethanolic extract of Murraya koenigii leaf respectively. Blood samples were collected by cardiac puncture on the last day of the experiment for biochemical analysis. Lipid profile was determined by Colorimetric method. Data were expressed as mean ± SEM. Differences in means were compared using ANOVA and Students T-test, P-values ≤ 0.05 were taken as statistically significant. Results showed a significant increase (p ≤ 0.05) in Total cholesterol (TC) level (117.4 ± 4.6) and low density lipoprotein cholesterol (LDL-c) level (50.1 ± 4.7) of group B rats when compared to other groups. The MK (400 mg/kg) treated rats, showed a significant reduction in TC and LDL-c levels, and a significant increase in HDL-c level when compared to CED group. However, there were no significant changes in all the lipid parameters of the treated groups when compared to the control. This study shows that cholesterol-enriched diet causes dyslipidemia and Murraya koenigii exhibited significant hypolipidemic effect on serum TC and LDL-c and increases HDL-c. Hence, Murraya koenigii exhibit antihyperlipidemic properties. Keywords: Murraya Koenigii, hyperlipidemia, Lipid profile, Cholesterol-enriched diet.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"215-218"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49545840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consumption of Aqueous Leaf Extract of Jatropha tanjorensis Improves Fertility Potential and Gestational Outcome in Virgin Female Wistar Rats. 食用麻疯树水叶提取物可提高处女雌性 Wistar 大鼠的生育能力和妊娠结果。

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31

Imoh Ukoh, Bisong Sunday, Atim Antai, Samuel Arikpo, Henrietta Nsa, Izuka David

{"title":"Consumption of Aqueous Leaf Extract of Jatropha tanjorensis Improves Fertility Potential and Gestational Outcome in Virgin Female Wistar Rats.","authors":"Imoh Ukoh, Bisong Sunday, Atim Antai, Samuel Arikpo, Henrietta Nsa, Izuka David","doi":"","DOIUrl":"","url":null,"abstract":"In spite of the overwhelming patronage of the plant Jatropha tanjorensis (J.T) popularly called \"Hospital Too Far\" by pregnant and women of reproductive age for its supposed reproductive benefits, the scientific evidence are hardly known. This study thus sought to examine the effect of consumption of aqueous leaf of J.T extract on female fertility potential and gestational outcome using forty (40) virgin female Wistar rats weighing 120-150g. The extract LD50 was >5000 mg/kg. The female rats were divided into unmated and mated groups (n=10 rats per subgroups). Group A (unmated group) consisted of control which received 0.2mL of normal saline (vehicle) and J.T-treated which received 500mg/kg (orally) once daily for 28 days. For Group B (mated group), the treated dams received 500 mg/kg (orally) once daily prior to mating (2 weeks), during mating (1 week) and throughout gestation, while the control received 0.5ml of physiological saline orally during the same period. All animals had free access to food and water. For the unmated group, after 28 days of treatment samples were collected for hormonal assay. J.T increased follicle stimulating hormone (FSH) and estrogen. For subgroup B, the extract was assessed for it reproductive and gestational performance, as well as pregnancy outcome. Nine (9) J.T-treated rats against seven (7) of control got pregnant. J.T increased mean weight gain, food and water intake. The Birth weight, body length and tail length of pups whose mothers were treated with the aqueous leaf extract of J.T increased significantly. Intake of J.T was effective in boosting female reproductive health, pregnancy health and outcome.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"37 2","pages":"247-253"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cement Dust Exposure Alters Secretory Functions, Biochemical Profile and Morphology of Gastrointestinal Tissues in Rats Exposed to Cement Dust. 水泥粉尘对大鼠胃肠道组织分泌功能、生化特征及形态学的影响

Nigerian Journal of Physiological Sciences Pub Date : 2022-12-31 DOI: 10.54548/njps.v37i2.4

Mathew Wasiu Owonikoko, Adeola Temitope Salami, Olugbenga Adeola Odukanmi, Benjamin O Emikpe, Samuel Babafemi Olaleye

{"title":"Cement Dust Exposure Alters Secretory Functions, Biochemical Profile and Morphology of Gastrointestinal Tissues in Rats Exposed to Cement Dust.","authors":"Mathew Wasiu Owonikoko, Adeola Temitope Salami, Olugbenga Adeola Odukanmi, Benjamin O Emikpe, Samuel Babafemi Olaleye","doi":"10.54548/njps.v37i2.4","DOIUrl":"10.54548/njps.v37i2.4","url":null,"abstract":"Asides direct gastrointestinal exposure, inhalation route is another major xenobiotic exposure pathway to the gastrointestinal tract via mucociliary escalator. This triphasic study assesses cement dust inhalatory exposure effect on the possible alterations of the gastrointestinal tissues and secretion. 72 male, sixteen (16) weeks old Wistar rats were randomized into 3 different phases of 24 animals. Each phase comprised of 3 group of 8 animals. Group 1 (control) were sham-operated with clean ambient air, group 2 (14-days exposed) were exposed to cement dust for 14days, and group 3 (28-day exposed) were exposed to cement dust for 28 days. Biochemical indices including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), sulfhydryl group, carbonyl group, Na+-K+ATPase pump activity, Nitric oxide (NO) were investigated spectrophotometrically in gastric and hepatic tissues while histopathology was studied using standard procedure. There was significant increase in the level of MDA, NO and carbonyl- an observation that contrasts with the level of CAT, SOD and sulfhydryl; no significant difference in Na+-K+-ATPase pump was observed in the exposed groups compared with control. Histopathological alterations in salivary gland and gastric tissues includes edema, inflammatory cell infiltration and vascular congestion. There was significant alteration in basal salivary, gastric and biliary secretions; increased stimulated salivary and gastric secretion via cholinergic stimulation. Conclusively, histopathological and spectrophotometric analyses reflect that inhalatory experimental exposure to cement dust significantly alter gastrointestinal secretions and predisposes the gastrointestinal tract to an array of deleterious effects via protein oxidation and antioxidant depletion and tissue peroxidation.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"185-194"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44615357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does HAART dysregulate angiogenesis in HIV infected preeclampsia? HAART是否会失调HIV感染子痫前期的血管生成?

Nigerian Journal of Physiological Sciences Pub Date : 2022-06-30 DOI: 10.54548/njps.v36i2.4

Sayuri Padayachee, Nalini Govender, Thajasvarie Naicker

引用次数: 1

Skull Shape Variations in the Eidolon helvum (African Fruit Bat) Based on Geographical Location. 基于地理位置的非洲果蝠颅骨形状变化。

Nigerian Journal of Physiological Sciences Pub Date : 2022-06-30 DOI: 10.54548/njps.v37i1.13

Olumayowa Igado, Jemima Joannis

{"title":"Skull Shape Variations in the Eidolon helvum (African Fruit Bat) Based on Geographical Location.","authors":"Olumayowa Igado, Jemima Joannis","doi":"10.54548/njps.v37i1.13","DOIUrl":"https://doi.org/10.54548/njps.v37i1.13","url":null,"abstract":"The shape and size of a skull provides insight into the age, breed and gender of the animal. Skull shape variations have been reported in different animals, with some theories linking these variations to evolution and/or migration. This study assessed the variations observed in the skull shape, size and gross morphometrics of two groups of the Eidolon helvum obtained from two geographical regions in Nigeria (south and north). All skulls were rostro-caudally elongated, having a dolichocephalic appearance. The skulls from the north had a distinct dome shape, with a more prominent zygomatic process, absence of a 'diastema' and an extra upper molar, while the southern skulls showed a more dorsally flattened skull and a less prominent zygomatic process. The shape of the sagittal crest was different in the two groups, while there was the presence of an accessory infraorbital foramen in some of the southern skulls. The southern skulls lacked the palatine foramen. The lacrimal foramen was observed to be more caudally placed in the southern skulls. Values for most linear measurements were higher in the northern skulls, although statistically significant difference was not present in all. The value for the neurocranial volume was considerably higher in the northern skulls (4.41 ± 0.28 mls) relative to the southern skulls (2.0 ± 0.27 mls). Statistically significant differences were not observed between males and females (within regions). Data obtained from this study may find application in evolution and migration studies, wildlife medicine and surgery and comparative and forensic anatomy.","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":" ","pages":"101-111"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40600510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0