Nigerian Journal of Physiological Sciences最新文献

{"title":"Chemo-Intervention of Paullinia pinnata Methanol Leaf Extract on Ethylene Glycol Monomethyl Ether-Induced Toxicity in Wistar Rats.","authors":"Oluwatoyin Adeyemo-Salami, Damilola Kolade, Lateefah Akande","doi":"10.54548/njps.v40i1.22","DOIUrl":"https://doi.org/10.54548/njps.v40i1.22","url":null,"abstract":"<p><p>Paullinia pinnata (PP) is a medicinal vine used folklorically as a result of this attribute to treat various ailments. Ethylene glycol monomethyl ether (EGME) is a solvent of wide application and has been shown to be toxic. This study is designed to elucidate the potential of P. pinnata methanol leaf extract in preventing the deleterious effect of EGME in the liver and kidney. As a sequel to our previous study, seventy adult male Wistar rats were weight-matched into seven groups (n=10). Groups I and II served as controls and received distilled water and 10% dimethyl sulfoxide, respectively. Group III received EGME (200 mg/kg) only. Groups IV-VII were co-treated with EGME (200 mg/kg) and PP at 25, 50, 75 and 100 mg/kg doses, respectively. The administration was done by oral gavage daily for 14 consecutive days. On day 15, the animals were euthanized by cervical dislocation and the liver and kidneys were excised. Sections of the liver and kidney were fixed in 10% formalin for histology. The remainder liver and kidney were processed and used for liver function and kidney function assays, respectively. EGME significantly (p<0.05 )increased the activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase in the liver, while the concentration of sodium ion was reduced in the kidney. Lesions were observed in the EGME only and EGME + PP (25 mg/kg) groups and not in the other co-administered groups. The methanol leaf extract of Paullinia pinnata prevented the perturbations of EGME at moderate doses in the liver and kidney.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"191-196"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioassay and histopathological effects of water-soluble fractions of crude oil on Coptodon guineensis.","authors":"Beatrice Bello, Olayide Lawal, Gbenga Olumayede, Stanley Agbo","doi":"10.54548/njps.v40i1.18","DOIUrl":"https://doi.org/10.54548/njps.v40i1.18","url":null,"abstract":"<p><p>Acute and subacute effects of crude oil's water-soluble fraction (WSF) and associated histopathological changes in the gills and liver of juvenile Coptodon guineensis were investigated. An acute toxicity test (96 hrs) was performed by a static non-renewal method at various concentrations of 0.25, 1, 5, 15, and 30%. Similarly, test organisms were tested in 2.5% sublethal concentration for 28 days. Water quality parameters, heavy metals, and total polycyclic aromatic hydrocarbons (PAHs) were determined using standard methods. After fish exposure in WSF of crude oil, gills and liver were harvested, stained with hematoxylin/eosin, and later prepared for photomicrography. Results revealed the LC50 as 26.73% (26.73 g/L), while total PAHs and heavy metal (Ni, Cd, and Pb) levels varied significantly (p < 0.05) in Coptodon guineensis over the period of exposure. Histopathological alterations were evident in gills and further revealed the presence of deformed secondary lamellae, with corresponding congestion of the passive central vein and cytoplasmic vacuolation in the liver. Apart from toxicity values to unravel the adverse impacts of the bioavailable water-soluble fraction of crude oil on juvenile Coptodon guineensis, the histopathological assay revealed underlying sub-lethal responses that can serve as early warning signals. Keywords: Bioassay, water-soluble fraction, crude oil, histopathological, Coptodon guineensis.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"157-165"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species- and Tissue-Specific Variations in Cholesterol Content among Wild and Domesticated Birds in Nsukka, Nigeria.","authors":"Chinweike N Asogwa, Chinonso Anthony Ezema, Dandy Ahamefula Osibe, Ifebuche Christian Ugwu","doi":"10.54548/njps.v40i1.10","DOIUrl":"https://doi.org/10.54548/njps.v40i1.10","url":null,"abstract":"<p><p>Avian species exhibit variations in adaptive features, including differences in lipid metabolism, which are essential for successful survival and reproduction in unique habitats. However, there is a lack of information on species- and tissue-specific variations in cholesterol metabolism among avian species living in similar habitats. This study aimed to investigate potential variations in tissue cholesterol levels in wild (Corvus albus, Passeriformes; and Coturnix coturnix, Galliformes) and domesticated (Gallus gallus domesticus, Galliformes, both local and exotic breeds) avian species found in Nsukka, Nigeria. These species have diverse diets and behaviours. Tissues from the brain, liver, gizzard, heart, and breast muscle were dissected and used for total lipid extraction and cholesterol quantification. The results showed significant species- and tissue-specific differences in cholesterol levels among the examined birds (One-way ANOVA, p < 0.001). Moreover, the brain and liver had notably higher cholesterol content compared to other tissues (One-way ANOVA, p < 0.001 in most cases). Lastly, multiple comparisons showed that domesticated species generally exhibited higher cholesterol levels than wild species. These findings support the hypothesis of species- and tissue-specific differences in cholesterol metabolism in avian species inhabiting similar environments but differing in diets and behaviors.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methanolic Extract of Kola Nut (Cola acuminata) Decreased Body Weight and Elevated Total Plasma Cholesterol Levels in Adult Male Albino Rats (Rattus norvegicus).","authors":"Chinweike N Asogwa, Dandy Osibe","doi":"10.54548/njps.v40i1.23","DOIUrl":"https://doi.org/10.54548/njps.v40i1.23","url":null,"abstract":"<p><p>Kola and kola-containing beverages are among the most consumed products globally for their stimulatory and energy-boosting potentials. The precise impact of kola nut consumption on various biological indices of consumers remains debatable, necessitated by the fact that the phytochemical compositions of kola nuts are dependent on a range of factors. This study investigated the impacts of a 28-day administration of a methanolic extract of C. acuminata on the body weight and serum cholesterol indices of adult male albino rats (Wistar strain).  The quantitative photochemical compositions and lethal dose (LD50) of the extract were determined using standard bioassay procedures. Rats were randomized into four experimental groups that received various concentrations of the extract: 0, 100, 150, and 200 mg/kg. Results show an LD50 of 3101.37 mg/kg for the extract, whereas flavonoids and tannins were the most abundant phytochemicals. In addition, extract administration caused a dose-dependent reduction in body weight, while significant elevations in total serum cholesterol levels were recorded in rats that received 100 and 150 mg/kg of the extract. These suggest that kola nut consumption may negatively impact on body weight and cholesterol metabolism.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Tadalafil in Doxorubicin-Induced Pulmonary and Hematological Toxicities in Wistar Rats.","authors":"Adejuwon Adewale Adeneye, Favour Mosunmola Olomu, Olufunke Esan Olorundare, Abdulfatai O Ojewale, Ikechukwu Okoye","doi":"10.54548/njps.v40i1.15","DOIUrl":"https://doi.org/10.54548/njps.v40i1.15","url":null,"abstract":"<p><p>Doxorubicin (DOX) therapy is associated with pulmonary toxicity and hematotoxicity as its off-target side-effects. In this study, tadalafil (TAD) was investigated for its chemopreventive potential against DOX-induced pulmonary toxicity and hematotoxicity in 48 male Wistar rats that were divided into 8 groups of 6 rats/group and orally pretreated with 2.5 mg/kg/day, 5.0 mg/kg/day, and 10 mg/kg/day TAD 1 hour before intraperitoneal injection of 2.5 mg/kg DOX on alternate days for 12 days after which the rats were humanely sacrificed. Blood samples for hematological and biochemical endpoints and lung tissue samples for oxidative stress markers, pro-inflammatory cytokines assay and for histopathology were collected. The rats body weights at the start and end of the experiments were measured. Results showed that DOX toxicity was associated with significant (p<0.0001) weight loss with corresponding significant (p<0.05) reduction in the relative lung weight. DOX intoxication was also associated with leukopenia, thrombocytopenia, lymphocytopenia, myelocytosis, and neutrophilia suggesting bone marrow suppression, while it induced significant (p<0.0001) decreases in the serum bicarbonate and pH levels, as well as an increase in iCa2+ levels. DOX intoxication was also associated with profound (p<0.0001) increases in the lung tissue oxidative stress markers. However, oral TAD pretreatment did not significantly (p>0.05) improve DOX-associated weight loss but reversed the decrease in relative lung weight. TAD pretreatments also profoundly (p<0.001, p<0.0001) reversed both the DOX-induced hematological and biochemical alterations. Overall, TAD may have potential protective effects on DOX-induced pulmonary and hematological dysfunctions, highlighting the chemopreventive potential of TAD which was probably mediated via antioxidant and/or free radical scavenging and anti-inflammatory mechanisms.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"127-136"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactose Intolerance in Sub-Saharan Africa.","authors":"Hauwa Bako, John I Anetor, Salisu Babura Mu'azu, Ahmad Mohammad Bello, Anas Babangida, Zainab Ibrahim Nadabo","doi":"10.54548/njps.v40i1.1","DOIUrl":"https://doi.org/10.54548/njps.v40i1.1","url":null,"abstract":"<p><p>Lactose is a disaccharide mainly found in dairy and dairy-containing products which yields D-galactose and D-glucose on hydrolysis. Lactose intolerance (LI) is characterized by abdominal pain, bloating, flatulence, nausea and/or diarrhoea following ingestion of dairy or lactose-containing meals. LI affects about 75% of the world's population though the condition is poorly recognized despite being of great public health significance in sub-saharan Africa (ssA). The aim of the review is to highlight the epidemiology, types, pathophysiology, genetics, diagnosis, management and prevention of LI. Literature search was performed using Pubmed, Crossref and Google Scholar databases for the terms \"lactose,\" \"lactose consumption,\" \"lactose intolerance,\" and \"sub-saharan Africa.\" The high prevalence of LI in most countries of ssA is a major cause for concern with malnutrition as an independent entity serving as a key contributor, especially among children. Differential diagnosis for LI poses a huge challenge due to disparity in presentation of symptoms among individuals and unavailability of testing in most routine laboratories in ssA. Though wide variation in prevalence of LI exists between countries and regions within ssA, recognizing regional patterns of LI is important to guide prevention, diagnosis and management of the condition. There is also a need for increased laboratory vigilance and preparedness to tackle the silent epidemic, especially in ssA.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Factors Influencing Cohabitation among Osun State University Students, Nigeria: Implications for Family Demography and Sociological Practices.","authors":"Monica Ewomazino Akokuwebe","doi":"10.54548/njps.v40i1.8","DOIUrl":"https://doi.org/10.54548/njps.v40i1.8","url":null,"abstract":"<p><p>Cohabitation represents a significant shift in family structures as they undergo demographic and economic transitions. This practice is a common phenomenon among Nigerian university undergraduates. Therefore, this study examined the demographic factors that determine cohabitation practices among undergraduates in Osun State, Nigeria. Guided by the individualization theory, the research design adopted was a survey, and questionnaire and in-depth interview instruments were used to collect the data. A sample of 400 respondents was included in the quantitative analysis, while 18 participants were included in the qualitative aspects of the analysis. Descriptive (frequency and percentages) and bivariate (chi-square test and correlation) were used to analyze the quantitative data, while the qualitative data were content analyzed. The findings revealed that a majority of the respondents have high (45.3%) knowledge of cohabitation practice, and pre-marital cohabitation (56.5%) is one of the major dimensions of cohabitation reported by the respondents. Determining factors adduced for engaging in cohabitation were the urge to be a 'baby mama' (77.5%) and economic benefits (74.5%); while 73.0% of them have a regular pattern of practicing cohabitation. About 42.0% of them have good perception, and less than 55% have a negative attitude towards cohabitation. A significant age difference in knowledge of cohabitation (χ2 = 96.96, ρ<0.01) and knowledge of cohabitation was positively correlated with attitude (r = 0.611, p<0.01) and perception (r = 0.528, p<0.01) among the respondents. Similarly, perception of cohabitation was positively correlated with attitude towards cohabitation (r = 0.187, p < 0.01). The implication of this finding is that high knowledge will lead to high perception and positive attitude towards disengaging from cohabitation practices. Adolescents and youths should be enlightened about the negative consequences of cohabitation relationships that may jeopardize their future endeavours.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"63-78"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Testosterone Predicts Cognitive Function in Women with Epilepsy of Child-Bearing Age.","authors":"Luqman Ogunjimi, Akindolani Precious Ayomikun, Anderson Ezeonye, Oreoluwa Nifemi Olanrewaju, Fehintola Fatai, Ibrahim Damilola Adesanya, Oluwatosin Odusoga, Opeoluwa Ebenezer Adubi, Moses Omotayo Adedire, Ayotunde Ale, Ayodele Beauty I Ayadi, Zainab Temitope Atanda, Ayotomiwa Fagbemi, Aminat Adepeju Demola-Obasan, Joshua Adegoke, Bamidele Osalusi","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Hormonal disruptions due to seizures and antiseizure medications (ASMs) might be responsible for the cognitive dysfunction in people with epilepsy. This study investigated the association between reproductive hormones and Cognitive Impairment (CI) in women with epilepsy (WWE).  A cross-sectional study was conducted on 150 WWE aged 18-45 years. Epilepsy diagnosis was clinical and supported by electroencephalography (EEG). Cognitive function was evaluated using the Community Screening Instrument for Dementia (CSID). Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone, estradiol, prolactin, and testosterone were measured during the follicular and luteal menstrual phases. Analyses included Age group, which examined CI distribution across different age ranges, Mann-Whitney U tests for group comparisons, logistic regression for predictors, and receiver operating characteristic (ROC) curve analysis for diagnostic accuracy (p < 0.05). Of the participants, 28% had CI. The CI group exhibited higher follicular-phase LH (p = 0.002) and testosterone (p < 0.001), as well as luteal-phase LH (p = 0.039) and LH/FSH ratio (p = 0.046), but lower luteal-phase progesterone (p = 0.039), estradiol (p = 0.042), and prolactin (p = 0.023) compared to the non-CI group. Logistic regression identified testosterone as the sole significant predictor (p = 0.004; odds ratio = 0.555; 95% confidence interval, 0.373-0.825), indicating a 44.5% reduction in CI odds per unit increase. ROC analysis demonstrated moderate predictive accuracy for testosterone (area under the curve = 0.708; p < 0.001). Elevated follicular-phase LH and testosterone, luteal-phase LH alongside LH/ FSH, are associated with CI in WWE, with testosterone emerging as a key predictor. These findings indicate that hormonal factors play a role in cognitive impairment among individuals with epilepsy and suggest that focusing on hormone-based therapies might augment ASMs to improve treatment outcomes. Keywords: Cognitive impairment, women with epilepsy, luteinizing hormone, testosterone, Mann-Whitney U test, logistic regression.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the Clinical Phenotype and Reproductive Hormones of Polycystic Ovarian Syndrome in Nigerian Population.","authors":"Daniel Adewuni, Bolanle Iranloye, Abidoye Gbadegesin, Olubunmi Magbagbeola, Oluyemi Akinloye","doi":"10.54548/njps.v40i1.5","DOIUrl":"https://doi.org/10.54548/njps.v40i1.5","url":null,"abstract":"<p><p>This study described the peculiarity of the clinical phenotypes and the pattern of reproductive hormones among women with PCOS in Nigerian populace.  A total of 90 consented volunteers consisting of 45 PCOS and 45 controls were recruited. The diagnosis of PCOS was established using the International PCOS guidelines 2018. Demographic, anthropometric, and clinicopathological data were obtained from each participant. Hormonal assay was done using the electrochemiluminescence (ECL) technology (Roche Diagnostics, Switzerland). Statistical analysis was done using the Statistical Package for the Social Sciences (SPSS) version 25.  Polycystic ovaries (PCO) are the most popular feature of PCOS, observed in more than 90% of PCOS subjects followed by oligomenorrhea (68 %), while hirsutism and acne were found in about 50% of the cases. The study shows 62 % of PCOS subjects had phenotype D, 52 % Phenotype C, 40 % Phenotype B, while 38 % had Phenotype A. Increased levels of Anti-Mullerian hormone (AMH), Testosterone, Prolactin, Luteinizing hormone (LH) and LH: FSH were observed in PCOS with median (95% Confidence interval) of 4.98(3.4-7.1), 32.5(19.75-53.0), 401.6(230.9-623.0), 9.23(5.4-16.6) and 2.03(1.48-3.58), respectively compared to control [1.43(0.8-2.4), 19.0(12.3-29.5), 252.2(196.3-337.0), 6.36(4.0-12.6) and 1.47(0.7-2.4), respectively] (p<0.05). The serum levels of follicle-stimulating hormone (FSH), estradiol, and sex hormone binding globulin (SHBG) were lower in PCOS with values of 5.21(3.6-5.9), 70.45(50.5-145.9) and 44.84(27.3-75.7), respectively compared to controls [6.0(4.4-7.9), 104.0(64.6-216.6) and 74.05(54.0-96.8), respectively] (P<0.05). FSH, LH:FSH, AMH, testosterone, estradiol, SHBG, and prolactin show significant odd ratio with risk analysis in PCOS (p<0.05). There existed a negative correlation between the hormones (Estradiol and AMH) and the PCOS phenotypes (estimated Spearman's rho were -.310 and -.348, respectively) (p<0.05). Phenotype D and C characterized by ovulatory dysfunction, polycystic ovary morphology and hyperandrogenism are the two predominant phenotypes of PCOS in our study population. This is accompanied by marked changes in hormonal pattern among PCOS subjects, particularly steroids and follicular hormones. Modulating this phenotype-hormonal interplay may support or improve PCOS management in the study population.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopic assessment of cannabis sativa leaf extract on the histoarchitecture of the cerebellum in male wistar rats using transmission electron microscope.","authors":"Ukoha Ukoha, Paul Demshimeno, Okeke Somadina, Ugochukwu Aguwa, Chijioke Okeke","doi":"10.54548/njps.v40i1.20","DOIUrl":"https://doi.org/10.54548/njps.v40i1.20","url":null,"abstract":"<p><p>Cannabis remains the most abused illicit substance in the world. The growing inclination towards decriminalization in several countries creates the need to clearly determine how consumption affects organs of the body, especially the brain. The aim of this research is to determine the effect of cannabis sativa on the histoarchitecture of the cerebellum and motor coordination in Wistar rats. Twenty-five male rats were divided into 5 groups (I-V): Group I received food and water, Group II received 10mg/kg and Group III received 20mg/kg of cannabis sativa aqueous leaf extract for 28 days. Groups IV & V received 10mg/kg and 20mg/kg of cannabis sativa for 28 days and were allowed for another 28 days recovery period. At the end animals were weighed and sacrificed by cervical dislocation. Result from Transmission Electron Microscope (TEM) sections of rat cerebellum in group I shows normal neurons and cellular architecture. Some degrees of cytoarchitectural and neuronal distortions were observed in animals exposed to cannabis. The extent of these distortion however were significantly reduced following a 28 day recovery period for both doses of cannabis administered. It can be deduced therefore that cannabis sativa exposure had significant adverse ultrastructural effects on the cerebellum of adult male Wistar rats.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"40 1","pages":"171-177"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}