Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology最新文献

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Assignment of genetic linkage maps to diploid Solanum tuberosum pachytene chromosomes by BAC-FISH technology. 利用BAC-FISH技术定位二倍体龙葵粗线染色体的遗传连锁图谱。
IF 2.6
Xiaomin Tang, Jan M de Boer, Herman J van Eck, Christian Bachem, Richard G F Visser, Hans de Jong
{"title":"Assignment of genetic linkage maps to diploid Solanum tuberosum pachytene chromosomes by BAC-FISH technology.","authors":"Xiaomin Tang,&nbsp;Jan M de Boer,&nbsp;Herman J van Eck,&nbsp;Christian Bachem,&nbsp;Richard G F Visser,&nbsp;Hans de Jong","doi":"10.1007/s10577-009-9077-3","DOIUrl":"https://doi.org/10.1007/s10577-009-9077-3","url":null,"abstract":"<p><p>A cytogenetic map has been developed for diploid potato (Solanum tuberosum), in which the arms of the 12 potato bivalents can be identified in pachytene complements using multicolor fluorescence in situ hybridization (FISH) with a set of 60 genetically anchored bacterial artificial chromosome (BAC) clones from the RHPOTKEY BAC library. This diagnostic set of selected BACs (five per chromosome) hybridizes to euchromatic regions and corresponds to well-defined loci in the ultradense genetic map, and with these probes a new detailed and reliable pachytene karyotype could be established. Chromosome size has been estimated both from microscopic length measurements and from 4',6-diamidino-2-phenylindole fluorescence-based DNA content measurements. In both approaches, chromosome 1 is the largest (100-115 Mb) and chromosome 11 the smallest (49-53 Mb). Detailed measurements of mega-base-pair to micrometer ratios have been obtained for chromosome 5, with average values of 1.07 Mb/mum for euchromatin and 3.67 Mb/mum for heterochromatin. In addition, our FISH results helped to solve two discrepancies in the potato genetic map related to chromosomes 8 and 12. Finally, we discuss the significance of the potato cytogenetic map for extended FISH studies in potato and related Solanaceae, which will be especially beneficial for the potato genome-sequencing project.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"899-915"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9077-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40030346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
The position of repetitive DNA sequence in the southern cattle tick genome permits chromosome identification. 南方牛蜱基因组中重复DNA序列的位置允许染色体鉴定。
IF 2.6
Catherine A Hill, Felix D Guerrero, Janice P Van Zee, Nicholas S Geraci, Jason G Walling, Jeffrey J Stuart
{"title":"The position of repetitive DNA sequence in the southern cattle tick genome permits chromosome identification.","authors":"Catherine A Hill,&nbsp;Felix D Guerrero,&nbsp;Janice P Van Zee,&nbsp;Nicholas S Geraci,&nbsp;Jason G Walling,&nbsp;Jeffrey J Stuart","doi":"10.1007/s10577-008-9003-0","DOIUrl":"https://doi.org/10.1007/s10577-008-9003-0","url":null,"abstract":"<p><p>Fluorescent in-situ hybridization (FISH) using meiotic chromosome preparations and highly repetitive DNA from the southern cattle tick, Rhipicephalus microplus, was undertaken to investigate genome organization. Several classes of highly repetitive DNA elements were identified by screening a R. microplus bacterial artificial chromosome (BAC) library. A repeat unit of approximately 149 bp, RMR-1 was localized to the subtelomeric regions of R. microplus autosomes 1-6 and 8-10. A second repeat unit, RMR-2 was localized to the subtelomeric regions of all autosomes and the X chromosome. RMR-2 was composed of three distinct repeat populations, RMR-2a, RMR-2b and RMR-2c of 178, 177 and 216 bp in length, respectively. Localization of an rDNA probe identified a single nucleolar organizing region on one autosome. Using a combination of labeled probes, we developed a preliminary karyotype for R. microplus. We present evidence that R. microplus has holocentric chromosomes and explore the implications of these findings for tick chromosome biology and genomic research.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"77-89"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-008-9003-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. 在终末分化的小鼠红母细胞中,染色质凝聚不涉及特殊的结构蛋白,而是依赖于组蛋白去乙酰化。
Evgenya Y Popova, Sharon Wald Krauss, Sarah A Short, Gloria Lee, Jonathan Villalobos, Joan Etzell, Mark J Koury, Paul A Ney, Joel Anne Chasis, Sergei A Grigoryev
{"title":"Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation.","authors":"Evgenya Y Popova, Sharon Wald Krauss, Sarah A Short, Gloria Lee, Jonathan Villalobos, Joan Etzell, Mark J Koury, Paul A Ney, Joel Anne Chasis, Sergei A Grigoryev","doi":"10.1007/s10577-008-9005-y","DOIUrl":"10.1007/s10577-008-9005-y","url":null,"abstract":"<p><p>Terminal erythroid differentiation in vertebrates is characterized by progressive heterochromatin formation and chromatin condensation and, in mammals, culminates in nuclear extrusion. To date, although mechanisms regulating avian erythroid chromatin condensation have been identified, little is known regarding this process during mammalian erythropoiesis. To elucidate the molecular basis for mammalian erythroblast chromatin condensation, we used Friend virus-infected murine spleen erythroblasts that undergo terminal differentiation in vitro. Chromatin isolated from early and late-stage erythroblasts had similar levels of linker and core histones, only a slight difference in nucleosome repeats, and no significant accumulation of known developmentally regulated architectural chromatin proteins. However, histone H3(K9) dimethylation markedly increased while histone H4(K12) acetylation dramatically decreased and became segregated from the histone methylation as chromatin condensed. One histone deacetylase, HDAC5, was significantly upregulated during the terminal stages of Friend virus-infected erythroblast differentiation. Treatment with histone deacetylase inhibitor, trichostatin A, blocked both chromatin condensation and nuclear extrusion. Based on our data, we propose a model for a unique mechanism in which extensive histone deacetylation at pericentromeric heterochromatin mediates heterochromatin condensation in vertebrate erythroblasts that would otherwise be mediated by developmentally-regulated architectural proteins in nucleated blood cells.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"47-64"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667965/pdf/nihms94346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27948603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X chromosomal regulation in flies: when less is more. 果蝇的X染色体调控:少即是多。
IF 2.6
Erinc Hallacli, Asifa Akhtar
{"title":"X chromosomal regulation in flies: when less is more.","authors":"Erinc Hallacli,&nbsp;Asifa Akhtar","doi":"10.1007/s10577-009-9054-x","DOIUrl":"https://doi.org/10.1007/s10577-009-9054-x","url":null,"abstract":"<p><p>In Drosophila, dosage compensation of the single male X chromosome involves upregulation of expression of X linked genes. Dosage compensation complex or the male specific lethal (MSL) complex is intimately involved in this regulation. The MSL complex members decorate the male X chromosome by binding on hundreds of sites along the X chromosome. Recent genome wide analysis has brought new light into X chromosomal regulation. It is becoming increasingly clear that although the X chromosome achieves male specific regulation via the MSL complex members, a number of general factors also impinge on this regulation. Future studies integrating these aspects promise to shed more light into this epigenetic phenomenon.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"603-19"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9054-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40054910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Implication of long-distance regulation of the HOXA cluster in a patient with postaxial polydactyly. 轴后多指畸形患者HOXA簇远距离调控的意义。
IF 2.6
Elisabeth M Lodder, Bert H Eussen, Daniëlla A C M van Hassel, A Jeannette M Hoogeboom, Pino J Poddighe, J Henk Coert, Ben A Oostra, Annelies de Klein, Esther de Graaff
{"title":"Implication of long-distance regulation of the HOXA cluster in a patient with postaxial polydactyly.","authors":"Elisabeth M Lodder,&nbsp;Bert H Eussen,&nbsp;Daniëlla A C M van Hassel,&nbsp;A Jeannette M Hoogeboom,&nbsp;Pino J Poddighe,&nbsp;J Henk Coert,&nbsp;Ben A Oostra,&nbsp;Annelies de Klein,&nbsp;Esther de Graaff","doi":"10.1007/s10577-009-9059-5","DOIUrl":"https://doi.org/10.1007/s10577-009-9059-5","url":null,"abstract":"<p><p>Apparently balanced chromosomal inversions may lead to disruption of developmentally important genes at the breakpoints of the inversion, causing congenital malformations. Characterization of such inversions may therefore lead to new insights in human development. Here, we report on a de novo inversion of chromosome 7 (p15.2q36.3) in a patient with postaxial polysyndactyly. The breakpoints do not disrupt likely candidate genes for the limb phenotype observed in the patient. However, on the p-arm the breakpoint separates the HOXA cluster from a gene desert containing several conserved noncoding elements, suggesting that a disruption of a cis-regulatory circuit of the HOXA cluster could be the underlying cause of the phenotype in this patient.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"737-44"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9059-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40028350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years. 大象X染色体的物理图谱:1.05亿年来基因顺序的保存。
IF 2.6
Claudia Leticia Rodríguez Delgado, Paul D Waters, Clément Gilbert, Terence J Robinson, Jennifer A Marshall Graves
{"title":"Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years.","authors":"Claudia Leticia Rodríguez Delgado,&nbsp;Paul D Waters,&nbsp;Clément Gilbert,&nbsp;Terence J Robinson,&nbsp;Jennifer A Marshall Graves","doi":"10.1007/s10577-009-9079-1","DOIUrl":"https://doi.org/10.1007/s10577-009-9079-1","url":null,"abstract":"<p><p>All therian mammals (eutherians and marsupials) have an XX female/XY male sex chromosome system or some variant of it. The X and Y evolved from a homologous pair of autosomes over the 166 million years since therian mammals diverged from monotremes. Comparing the sex chromosomes of eutherians and marsupials defined an ancient X conserved region that is shared between species of these mammalian clades. However, the eutherian X (and the Y) was augmented by a recent addition (XAR) that is autosomal in marsupials. XAR is part of the X in primates, rodents, and artiodactyls (which belong to the eutherian clade Boreoeutheria), but it is uncertain whether XAR is part of the X chromosome in more distantly related eutherian mammals. Here we report on the gene content and order on the X of the elephant (Loxodonta africana)-a representative of Afrotheria, a basal endemic clade of African mammals-and compare these findings to those of other documented eutherian species. A total of 17 genes were mapped to the elephant X chromosome. Our results support the hypothesis that the eutherian X and Y chromosomes were augmented by the addition of autosomal material prior to eutherian radiation. Not only does the elephant X bear the same suite of genes as other eutherian X chromosomes, but gene order appears to have been maintained across 105 million years of evolution, perhaps reflecting strong constraints posed by the eutherian X inactivation system.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"917-26"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9079-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40043620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
Lessons from comparative analysis of X-chromosome inactivation in mammals. 哺乳动物x染色体失活比较分析的启示。
IF 2.6
Ikuhiro Okamoto, Edith Heard
{"title":"Lessons from comparative analysis of X-chromosome inactivation in mammals.","authors":"Ikuhiro Okamoto,&nbsp;Edith Heard","doi":"10.1007/s10577-009-9057-7","DOIUrl":"https://doi.org/10.1007/s10577-009-9057-7","url":null,"abstract":"<p><p>In most mammals, X-chromosome inactivation is used as the strategy to achieve dosage compensation between XX females and XY males. This process is developmentally regulated, resulting in the differential treatment of the two X chromosomes in the same nucleus and mitotic heritability of the silent state. A lack of dosage compensation in an XX embryo is believed to result in early lethality, at least in eutherians. Given its fundamental importance, X-chromosome inactivation would be predicted to be a highly conserved process in mammals. However, recent studies have revealed major mechanistic differences in X inactivation between eutherians and marsupials, suggesting that the evolution of the X chromosome as well as developmental differences between mammals have led to diverse evolutionary strategies for dosage compensation.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"659-69"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9057-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
Molecular marker suggests rapid changes of sex-determining mechanisms in Australian dragon lizards. 分子标记提示澳大利亚龙蜥蜴性别决定机制的快速变化。
IF 2.6
Tariq Ezaz, Alexander E Quinn, Stephen D Sarre, Denis O'Meally, Arthur Georges, Jennifer A Marshall Graves
{"title":"Molecular marker suggests rapid changes of sex-determining mechanisms in Australian dragon lizards.","authors":"Tariq Ezaz,&nbsp;Alexander E Quinn,&nbsp;Stephen D Sarre,&nbsp;Denis O'Meally,&nbsp;Arthur Georges,&nbsp;Jennifer A Marshall Graves","doi":"10.1007/s10577-008-9019-5","DOIUrl":"https://doi.org/10.1007/s10577-008-9019-5","url":null,"abstract":"<p><p>Distribution of sex-determining mechanisms across Australian agamids shows no clear phylogenetic segregation, suggesting multiple transitions between temperature-dependent (TSD) and genotypic sex determination (GSD). These taxa thus present an excellent opportunity for studying the evolution of sex chromosomes, and evolutionary transitions between TSD and GSD. Here we report the hybridization of a 3 kb genomic sequence (PvZW3) that marks the Z and W microchromosomes of the Australian central bearded dragon (Pogona vitticeps) to chromosomes of 12 species of Australian agamids from eight genera using fluorescence in-situ hybridization (FISH). The probe hybridized to a single microchromosome pair in 11 of these species, but to the tip of the long arm of chromosome pair 2 in the twelfth (Physignathus lesueurii), indicating a micro-macro chromosome rearrangement. Three TSD species shared the marked microchromosome, implying that it is a conserved autosome in related species that determine sex by temperature. C-banding identified the marked microchromosome as the heterochromatic W chromosome in two of the three GSD species. However, in Ctenophorus fordi, the probe hybridized to a different microchromosome from that shown by C-banding to be the heterochromatic W, suggesting an independent origin for the ZW chromosome pair in that species. Given the haphazard distribution of GSD and TSD in this group and the existence of at least two sets of sex microchromosomes in GSD species, we conclude that sex-determining mechanisms in this family have evolved independently, multiple times in a short evolutionary period.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"91-8"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-008-9019-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27948646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 78
Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus. 家鼠亚属5种、3亚种和5个罗伯逊小种的LINE-1序列数量变异。
IF 2.6
Paola Rebuzzini, Riccardo Castiglia, Solomon G Nergadze, George Mitsainas, Pavel Munclinger, Maurizio Zuccotti, Ernesto Capanna, Carlo Alberto Redi, Silvia Garagna
{"title":"Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus.","authors":"Paola Rebuzzini,&nbsp;Riccardo Castiglia,&nbsp;Solomon G Nergadze,&nbsp;George Mitsainas,&nbsp;Pavel Munclinger,&nbsp;Maurizio Zuccotti,&nbsp;Ernesto Capanna,&nbsp;Carlo Alberto Redi,&nbsp;Silvia Garagna","doi":"10.1007/s10577-008-9004-z","DOIUrl":"https://doi.org/10.1007/s10577-008-9004-z","url":null,"abstract":"<p><p>The quantitative variation of a conserved region of the LINE-1 ORF2 sequence was determined in eight species and subspecies of the subgenus Mus (M. m. domesticus, M. m. musculus, M. m. castaneus, M. spicilegus, M. spretus, M. cervicolor, M. cookii, M. caroli) and five Robertsonian races of M. m. domesticus. No differences in LINE-1 ORF2 content were found between all acrocentric or Robertsonian chromosome races, whereas the quantitative variation of the LINE-1 ORF2 sequences detected among the eight taxa partly matches with the clades into which the subgenus is divided. An accumulation of LINE-1 ORF2 elements likely occurred during the evolution of the subgenus. Within the Asiatic clade, M. cervicolor, cookii, and caroli show a low quantity of LINE-1 sequences, also detected within the Palearctic clade in M. m. castaneus and M. spretus, representing perhaps the ancestral condition within the subgenus. On the other hand, M. m. domesticus, M. m. musculus and M. spicilegus showed a high content of LINE-1 ORF2 sequences. Comparison between the chromosomal hybridization pattern of M. m. domesticus, which possesses the highest content, and M. spicilegus did not show any difference in the LINE-1 ORF2 distribution, suggesting that the quantitative variation of this sequence family did not involve chromosome restructuring or a preferential chromosome accumulation, during the evolution of M. m. domesticus.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"65-76"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-008-9004-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27957948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Monosomy for the X chromosome. X染色体的单体。
IF 2.6
Carolyn A Bondy, Clara Cheng
{"title":"Monosomy for the X chromosome.","authors":"Carolyn A Bondy,&nbsp;Clara Cheng","doi":"10.1007/s10577-009-9052-z","DOIUrl":"https://doi.org/10.1007/s10577-009-9052-z","url":null,"abstract":"<p><p>Dosage compensation serves to equalize X chromosome gene expression in mammalian males and females and involves extensive silencing of the 2nd X chromosome in females. If dosage compensation mechanisms completely suppressed the 2nd X chromosome, then actual physical loss of this \"eXtra\" chromosome should have few consequences. However, X monosomy has major effects upon normal development, fertility and longevity in humans and some other species. This article reviews observations and arguments attempting to explain the phenotypic effects of X monosomy in humans and other mammals in terms of X chromosome gene dosage.</p>","PeriodicalId":347802,"journal":{"name":"Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology","volume":" ","pages":"649-58"},"PeriodicalIF":2.6,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10577-009-9052-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40055418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
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