Apollo Medicine最新文献_第10页

Assessment of Programmed Cell Death Ligand-1 Expression in Non-small Cell Lung Carcinomas by Immunohistochemistry 程序性细胞死亡配体-1在非小细胞肺癌中表达的免疫组织化学评价

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_133_23

Sandeep Mani, Archana Lakshmanan, Annapurneswari Subramanyan

{"title":"Assessment of Programmed Cell Death Ligand-1 Expression in Non-small Cell Lung Carcinomas by Immunohistochemistry","authors":"Sandeep Mani, Archana Lakshmanan, Annapurneswari Subramanyan","doi":"10.4103/am.am_133_23","DOIUrl":"https://doi.org/10.4103/am.am_133_23","url":null,"abstract":"\u0000 \u0000 \u0000 Non-small cell lung carcinomas (NSCLCs) expressing programmed cell death ligand-1 (PD-L1), a transmembrane protein, are more likely to respond to immunotherapy drugs. All advanced NSCLC samples should be examined with PD-L1 immunohistochemistry (IHC). PD-L1 is now the only approved predictive biomarker of immunotherapy response in NSCLC patients. This study evaluates the expression of PD-L1 in NSCLC by IHC and assesses the morphological and clinical correlation of PD-L1 expression.\u0000 \u0000 \u0000 \u0000 All patients with histologically proven NSCLC with needle core biopsies and resected specimens were analyzed in the department of pathology. The correlation of PD-L1 expression with morphological and clinical parameters was analyzed.\u0000 \u0000 \u0000 \u0000 On evaluating PD-L1 expression in 97 cases of NSCLC, 61.85% (n = 60) had positive PD-L1 staining. Among patients with a positive tumor proportion score, 22 had a history of smoking, 51 were ≥50 years old, 43 were male patients, 24 were in Stage IV, 44 had a history of chemotherapy or radiotherapy, 47 had adenocarcinoma, and 33 had Grade II tumors. The association of PD-L1 expression with various clinicopathological parameters such as gender, smoking status, histological type, histological grade, clinical tumor stage, previous treatment history, site and type of biopsy, necrosis, and peritumoral lymphoid response was not statistically significant.\u0000 \u0000 \u0000 \u0000 Our study indicated that PD-L1 expression was not associated with various clinicopathological variables in NSCLC. More research is needed to look into the probable factors that influence the PD-L1-positive distribution. Since expression of the PD-L1 protein is proven to be of therapeutic and prognostic significance, we recommend that testing for PD-L1 should be done at least in cases of advanced-stage NSCLC.\u0000","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43841903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Takotsubo Cardiomyopathy following Eye Surgery under Local Anesthesia – A Case Report 局部麻醉下眼科手术后Takotsubo心肌病一例报告

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_72_23

C. Hemnath, K. N. Srinivasan, I. Sathyamurthy, Manodaya Neelagandan

{"title":"Takotsubo Cardiomyopathy following Eye Surgery under Local Anesthesia – A Case Report","authors":"C. Hemnath, K. N. Srinivasan, I. Sathyamurthy, Manodaya Neelagandan","doi":"10.4103/am.am_72_23","DOIUrl":"https://doi.org/10.4103/am.am_72_23","url":null,"abstract":"\u0000 \u0000 \u0000 Takotsubo syndrome is extremely rare and usually seen in postmenopausal women. It manifests as acute coronary syndromes (ACS), but coronaries are usually normal and the majority recover completely without residual myocardial damage.\u0000 \u0000 \u0000 \u0000 We are reporting one such case, which followed laser therapy for glaucoma under local anesthesia. She fulfilled all the revised Mayo Clinic criteria for diagnosis. Her preoperative cardiac evaluation and computerized tomography coronary angiograms were normal.\u0000 \u0000 \u0000 \u0000 This report highlights the need for a wide index of suspicion in those presenting as ACS. Surgical procedures however minor they are, even under local anesthesia should not be considered no-risk ones.\u0000 \u0000 \u0000 \u0000 Takotsubo cardiomyopathy is reversible acute cardiomyopathy that can occur even after minor eye surgery under local anesthesia. Patients may need coronary angiogram and serial echocardiogram at follow-up. It can be prevented by avoiding trigger factors, addressing preexisting neuropsychiatric ailments, and institution of prophylactic beta-blocker therapy.\u0000","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49313085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Utero Fetal Ovarian Cyst 子宫内胎儿卵巢囊肿

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_127_23

V. Sharmila, T. Babu, Vandana Kamatham, Prudhvinath Annapureddy Reddy

引用次数: 0

Small Blisters over an Erythematous Background on Right Side of the Neck 颈部右侧红斑背景上的小水泡

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_122_23

Surajit Gorai, Piyali Banerjee, Kinnor Das

引用次数: 0

Recurrent Harlequin Ichthyosis in a Family 一个家族中的复发性哈勒昆鱼病

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_96_23

Meghana Somasundara, Srinivasa Somasundara

{"title":"Recurrent Harlequin Ichthyosis in a Family","authors":"Meghana Somasundara, Srinivasa Somasundara","doi":"10.4103/am.am_96_23","DOIUrl":"https://doi.org/10.4103/am.am_96_23","url":null,"abstract":"\u0000 \u0000 \u0000 Harlequin ichthyosis is a severe form of erythrodermic ichthyosis that manifests in a distinctive and distressing appearance at birth. The newborn baby is covered in thick, plate-like scales with distorted surface features, resulting in limited mobility. Fortunately, this condition is rare, with an estimated incidence of approximately 1 in 300,000 births. It is inherited in an autosomal recessive manner and is caused by a mutation in the adenosine triphosphate binding cassette subfamily A member 12 (ABCA12) gene. This mutation affects lipid transport, and the activity of ABCA12 is crucial to produce long-chain ceramides, which are essential for the development of a normal skin barrier.\u0000 \u0000 \u0000 \u0000 We present a case report of a newborn who presented with thick, firmly adherent dense plaques covering the entire body, accompanied by deep fissures that extended into the dermis. The facial features included severe ectropion, conjunctival chemosis, eclabium, tethered ears, and a rudimentary nose. In addition, there was flexion contracture of the arms, legs, and digits, along with hypoplastic nails.\u0000 \u0000 \u0000 \u0000 The baby experienced respiratory difficulty, poor sucking, and a severe cutaneous infection. Unfortunately, the baby’s condition deteriorated and passed away on the 20th day after delivery.\u0000 \u0000 \u0000 \u0000 Previously considered universally fatal, harlequin ichthyosis now has reported cases of survivors, although it remains a challenging condition. It is crucial to provide parents and family with comprehensive information about the implications of the condition. They should be encouraged to explore all available options and receive psychological support throughout the process. It is essential for the neonatal intensive care unit staff to be trained in providing specialized care for these babies. In addition, parents should be offered the option of antenatal counseling, particularly in cases where there is a previously affected sibling or a history of consanguinity.\u0000","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49021450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Curious Case of Invasive Fungal Sinusitis in a Post-COVID-19 Patient covid -19后患者侵袭性真菌鼻窦炎的一例奇怪病例

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_84_23

Ujjwayini Ray, S. Dutta, Nilofar Rana Shams

{"title":"A Curious Case of Invasive Fungal Sinusitis in a Post-COVID-19 Patient","authors":"Ujjwayini Ray, S. Dutta, Nilofar Rana Shams","doi":"10.4103/am.am_84_23","DOIUrl":"https://doi.org/10.4103/am.am_84_23","url":null,"abstract":"\u0000 \u0000 \u0000 Secondary fungal infection following severe acute respiratory syndrome coronavirus 2 is a serious cause of concern as in majority of cases these are associated with devastating consequences. Invasive mucormycosis which was already prevalent in our country came back with a vengeance during the second wave of COVID-19.\u0000 \u0000 \u0000 \u0000 A 34-year-old male who had recovered from mild COVID disease developed invasive rhinosinusitis by two different fungi. The patient was followed up for clinical course, diagnosis, treatment, and outcome.\u0000 \u0000 \u0000 \u0000 This case illustrates a first of a kind of an invasive fungal rhinosinusitis caused by two different fungi: Schizophyllum commune (of phylum Basidiomycota) and Rhizopus arrhizus (of the Mucorales group) in a patient who had recovered from COVID-19. In this case, conventional methods of direct detection and culture only revealed S. commune. Sequencing after DNA extraction from the paraffin blocks was done due to strong clinical suspicion of invasive mucormycosis and R. arrhizus was detected in the tissue sections. Appropriate antifungals for extended duration ensued complete eradication of the infection\u0000 \u0000 \u0000 \u0000 Host risk factors are to be taken into consideration while diagnosing fungal infection. One needs to look beyond the obvious when clinical diagnosis is not consistent with the etiological agent isolated and in this regard molecular tools are a great help in establishing the etiological agent conclusively.\u0000","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44832558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Axillary Lymph Node Dissection by Ultrasonic Dissector Advantageous? 用超声波解剖器解剖腋窝淋巴结有好处吗？

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_83_23

U. Krishnaswamy, Balachandar Kariappa Reddy, Srinivasan Yasvanth Kumar, Kathirazhagan Thulasilingam, Sivaranjani Sivakumar, Vasanth Kumar

引用次数: 0

A Young Female Presenting with Fever and Generalized Lymphadenopathy 一位年轻女性表现为发烧和全身淋巴结病

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_98_23

A. Vasan, R. Choudhary, Gourang Paliwal, Anmol Sharma

引用次数: 0

The Prevalence of Nonvenereal Dermatoses in Male External Genitalia 男性外生殖器非性病性皮肤病的患病率

Apollo Medicine Pub Date : 2023-08-07 DOI: 10.4103/am.am_135_23

S. Raja, K. Premlal

{"title":"The Prevalence of Nonvenereal Dermatoses in Male External Genitalia","authors":"S. Raja, K. Premlal","doi":"10.4103/am.am_135_23","DOIUrl":"https://doi.org/10.4103/am.am_135_23","url":null,"abstract":"\u0000 \u0000 \u0000 Nonvenereal skin diseases are often confused with sexually transmitted diseases. It is responsible not only for the physician’s diagnostic dilemma but also for significant patient concerns. Identifying the cause or aggravating factors can save the patient from distress. Therefore, this study was conducted to determine the clinical pattern and prevalence of nongenital diseases.\u0000 \u0000 \u0000 \u0000 All males attending the dermatology outpatient department in our hospital are included in the study after getting informed consent. Detailed history, including demographic data, chief complaints related to skin, any symptoms in genitalia, drug history, and history of sexual exposures, was recorded.\u0000 \u0000 \u0000 \u0000 The prevalence of nonvenereal genital lesions during the period was 8.2% of patients attending the dermatology department. A total of 21% of nonvenereal genital dermatoses were studied in 82 patients. The most common ones encountered are pearly penile papules and tinea cruris, contributing 19.5% each. Vitiligo is the following most expected condition, involving 13.4% of patients. Among the total 82 patients with nonvenereal genital dermatoses, 65.8% had symptoms in external genitalia, and the rest of the 34.2% of patients did not have any complaints in genitalia.\u0000 \u0000 \u0000 \u0000 Among the 82 patients with nonvenereal dermatoses, 54 (65.85%) had symptoms in external genitalia. The study helped us understand the pattern and clinical characteristics of various nonvenereal genital dermatoses.\u0000","PeriodicalId":34670,"journal":{"name":"Apollo Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48541245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology and Morphometry of Aortic Valve in Humans and Porcines – A Comparative Study 人和猪主动脉瓣的形态学和形态计量学的比较研究

Apollo Medicine Pub Date : 2023-06-09 DOI: 10.4103/am.am_75_23

Supadevi Sundarasamy, S. Vinoth, Anuradha Murugasen, S. Supasakthi

引用次数: 0