Phytomedicine Plus最新文献

{"title":"Therapeutic potential of Asplenium caudatum in Aluminum Chloride-induced Alzheimer’s diseases: An insight of integrative approaches","authors":"Mohd Sajad ,&nbsp;Rafat Ali ,&nbsp;Rajesh Kumar ,&nbsp;Nida Jamil Khan ,&nbsp;Sonu Chand Thakur","doi":"10.1016/j.phyplu.2025.100806","DOIUrl":"10.1016/j.phyplu.2025.100806","url":null,"abstract":"<div><h3>Background</h3><div><em>Asplenium caudatum,</em> or <em>Khagpie</em>, is a plant native to Africa and Southeast Asia that tribal communities have long relied upon for medicinal purposes.</div></div><div><h3>Purpose</h3><div>This study aims to evaluate the antioxidant and anti-Alzheimer’s potential of <em>Asplenium caudatum</em> by <em>in vitro, in vivo</em>, and <em>in silico</em> methods<em>.</em></div></div><div><h3>Methods</h3><div>We have evaluated the <em>in vitro</em> free radical scavenging ability and phenolic content assays of aqueous (ASP-W) and hexane (ASP-H) extracts. Moreover, the inhibitory activities against AChE, BuChE, ROCK II, GSK-3β, LOX-5, TNF-α, COX-2, and Na⁺K⁺ATPase, along with the levels of oxidative stress biomarkers (malondialdehyde, reduced glutathione, nitric oxide, catalase, and superoxide dismutase activity) were also studied. Histopathological alterations in the hippocampus and cerebral cortex of the rat brain were also assessed.</div></div><div><h3>Results</h3><div>It was found that the ASP-W and ASP-H fractions had much stronger radical scavenging activity than the other fractions. Based on <em>in vitro</em> results ASP-H and ASP-W fractions were chosen for <em>in vivo</em> studies in AlCl₃-stimulated cognitive damage. Cognitive function was evaluated using the Morris water maze test. Cognitive impairment caused by AlCl₃ was prevented by the ASP-H and ASP-W fractions in a dose-dependent manner in male Wistar rats. Moreover, the substantial improvement of cholinergic function by reducing oxidative stress, and the suppression of GSK-3β, ROCK II, LOX-5, TNF-α, COX-2, and Na+K+ATPase expression and activity were observed. <em>In silico</em> studies demonstrated the strong affinity of phytochemicals towards AD biomarkers, confirming their function in preventing and regulating AD pathogenesis.</div></div><div><h3>Conclusion</h3><div>Consequently, the findings point to an anti-Alzheimer's ability of the ASP-W and ASP-H fractions.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100806"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salidroside alleviates Aβ1–42-induced ferroptosis in human neuroblastoma cells by AKT/GSK-3β activation via inhibiting VDAC1","authors":"Bensi Zhang ,&nbsp;Xiujun Zhang ,&nbsp;Waleephan Treebuphachatsakul ,&nbsp;Rungusa Pantan ,&nbsp;Natnicha Kampan ,&nbsp;Manussabhorn Phatsara ,&nbsp;Chun Shi ,&nbsp;Suteera Narakornsak","doi":"10.1016/j.phyplu.2025.100802","DOIUrl":"10.1016/j.phyplu.2025.100802","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) is a degenerative neurological disease, and SH-SY5Y cells play an important role in the pathogenesis of AD. Salidroside is the main active ingredient of Rhodiola rosea L.</div></div><div><h3>Purpose</h3><div>The aim of this study was to investigate the effect of salidroside on the induction of ferroptosis in SH-SY5Y cells by Aβ_1–42.</div></div><div><h3>Methods</h3><div>Aβ_1–42-induced SH-SY5Y cells were used to construct an AD cell model, and cell viability was measured by CCK-8. The expression of ferroptosis-related proteins, VDAC1, and AKT/GSK-3β signaling pathway-related proteins was detected by western blotting; the Fe²⁺ content of cells was determined by an iron content assay kit; the level of ROS in cells was detected by immunofluorescence; and apoptosis was detected by flow cytometry.</div></div><div><h3>Results</h3><div>This research showed that salidroside alleviated Aβ_1–42-induced ferroptosis in SH-SY5Y cells at an optimal concentration of 30 mM. The expression of GPX4 and FTH1 increased, and the expression of IREB2 decreased after salidroside treatment. The apoptosis rate decreased, as did the intracellular Fe²⁺ content and the level of ROS. After transfection with si-VDAC1, the trend of change was similar to that after salidroside treatment. Furthermore, treatment with an AKT inhibitor and AKT activator demonstrated the involvement of the AKT/GSK-3β signaling pathway in the induction of ferroptosis in SH-SY5Y cells by Aβ_1–42.</div></div><div><h3>Conclusion</h3><div>The findings suggest that salidroside alleviates cellular ferroptosis by AKT/GSK-3β pathway activation via inhibiting VDAC1.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 3","pages":"Article 100802"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ethnomedicinal uses and relevance to phytochemical profile, pharmacological activities, and tissue culture of Tecoma stans (L.) Juss. ex Kunth","authors":"Rowida Omar ,&nbsp;Marwa Elsbaey ,&nbsp;Madiha Hassan ,&nbsp;Mohamed Abd El-Salam","doi":"10.1016/j.phyplu.2025.100800","DOIUrl":"10.1016/j.phyplu.2025.100800","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Ethnopharmacological relevance&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Tecoma stans&lt;/em&gt; (L.) Juss. ex Kunth (Bignoniaceae) is a flowering plant native to the Americas and widely naturalized in tropical and subtropical regions. It has been traditionally used to treat diabetes, arthritis, and urinary disorders, with additional benefits including anti-inflammatory, antimicrobial, and antioxidant properties.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;Our review provides a comprehensive overview on the therapeutic potential of &lt;em&gt;Tecoma stans&lt;/em&gt; focusing on its anti-diabetic properties, traditional ethnomedicinal uses, pharmacological activities, mechanisms of action of its key phytochemicals, and the comparison of these findings with results from plant tissue culture studies. Furthermore, the review explores the applications of &lt;em&gt;Tecoma&lt;/em&gt; in green biotechnology and tissue culture, emphasizing conservation and sustainable production of bioactive compounds.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methodology&lt;/h3&gt;&lt;div&gt;The literature on &lt;em&gt;Tecoma stans&lt;/em&gt; was sourced from Google Scholar, PubMed, and ScienceDirect search engines, covering publications from the first report on the topic in 1954 until April 2024. The review focused on studies highlighting the ethnomedicinal uses, pharmacological activities, phytochemical composition, tissue culture, isolated endophytic fungi and relevant preclinical studies. Particular emphasis was placed on delineating the molecular mechanisms of action of isolated bioactive compounds and systematically evaluating the potential biotechnological applications of the plant, with a focus on sustainable production methodologies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Several studies have demonstrated the efficacy of &lt;em&gt;Tecoma stans&lt;/em&gt; in managing diabetes, with evidence suggesting that its therapeutic effectiveness is comparable to that of established conventional treatments. Key phytochemicals such as tecostanine, tecomine, anthranilic acid, and gallic acid have been linked to hypoglycemic, anti-inflammatory, antioxidant, and antimicrobial activities. Mechanistic insights suggest that these compounds modulate various biological targets involved in glycemic control and inflammation. While these compounds have shown promising activity against several biological targets, further clinical trials are necessary to fully validate these effects. Preclinical studies indicate low toxicity; however, comprehensive toxicity assessments are still needed to confirm safety for clinical use. Additionally, tissue culture approaches and isolated endophytes have been investigated as sustainable methods for the production of these bioactive secondary metabolites.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In summary, the phytochemicals derived from &lt;em&gt;Tecoma stans&lt;/em&gt; exhibit significant therapeutic potential, particularly in the management of diabetes and related conditions, without notable side effects. These findings suggest that &lt;em&gt;Tecoma stans&lt;/em&gt; could be considered a viabl","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100800"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats","authors":"Basiru Olaitan Ajiboye ,&nbsp;Courage Dele Famusiwa ,&nbsp;John Adeolu Falode ,&nbsp;Daniel Okwukwe Akojuru ,&nbsp;Bamikole Tosin Owolabi ,&nbsp;Adedeji A. Adejumo ,&nbsp;Babatunji Emmanuel Oyinloye ,&nbsp;Olawale Razaq Ajuwon ,&nbsp;Oluwatosin Olalekan Ogedengbe ,&nbsp;Oluwafemi Adeleke Ojo","doi":"10.1016/j.phyplu.2025.100808","DOIUrl":"10.1016/j.phyplu.2025.100808","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the protective effects of flavonoid-rich extracts from <em>Hibiscus sabdariffa</em> leaves on testicular cumulative reproductive function biomarkers in streptozotocin (STZ)-induced diabetic rats.</div></div><div><h3>Methods</h3><div>Rats were induced with 40 mg/kg body weight (bwt) STZ intraperitoneally (i.p.), after which they were administered either a low (150 mg/kg bwt) or a high (300 mg/kg bwt) dose of flavonoid-rich extracts from <em>H. sabdariffa</em> leaves. Testicular redox biomarkers, reproductive hormone biomarkers, and relative gene expression levels of PDE-5 and iNOS were assessed. Additionally, histological data, glucose levels, G6PDH activity, and hydroxysteroid dehydrogenase activities (3β-HSD and 17β-HSD) were analyzed.</div></div><div><h3>Results</h3><div><em>H. sabdariffa</em> leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function.</div></div><div><h3>Conclusion</h3><div>These data suggest a potential therapeutic role of <em>H. sabdariffa</em> leaves in mitigating the testicular dysfunction associated with diabetes.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100808"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of ginger (Zingiber officinale roscoe) inclusisve diet on testicular disorder in high cholesterol diet-induced obese rats: Involvement of cholesterol pathway” [Phytomedicine Plus 4 (2024) 100618]","authors":"Seun Funmilola Akomolafe ,&nbsp;Isaac Adeola Oriyomi","doi":"10.1016/j.phyplu.2024.100685","DOIUrl":"10.1016/j.phyplu.2024.100685","url":null,"abstract":"","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100685"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of curcumin in cadmium-induced physiological and reproductive toxicity in male BALB/c mice","authors":"Ranjit Shaw ,&nbsp;Raktim Hati ,&nbsp;Sandhya Sharma,&nbsp;Shikhar Deep,&nbsp;Radha Chaube","doi":"10.1016/j.phyplu.2025.100803","DOIUrl":"10.1016/j.phyplu.2025.100803","url":null,"abstract":"<div><div>Cadmium is one of the main worries these days due to its various harmful health effects, including adverse reproductive health concerns on humans. To overcome the side effects of synthetic drugs, we aimed to evaluate curcumin’s preventive role against cadmium-induced toxicity using an <em>in vivo</em> animal model. Treatment groups included control, cadmium chloride (6 mg/kg b.w.), curcumin (20 mg/kg b.w.), and cadmium chloride + curcumin (6 mg/kg and 20 mg/kg b.w., respectively), and the dosage was continued for 21 days. Our result demonstrated that curcumin ameliorates organs’ weight and sperm morphologies and improves the viability and fertility of sperm. Curcumin treatment led to a significant increase in catalase and SOD levels in the testis, liver, and kidney. Testosterone levels also got elevated; however, levels of Estradiol-17β decreased on treatment with curcumin. Moreover, the treatment restored vital genes such as Cyp19A1 and 3β-HSD, which were downregulated due to cadmium toxicity. Histological alterations due to cadmium toxicity in the testis, epididymis, and liver were restored with curcumin treatment. Results of H/E staining of the testis exhibited that the vacuolization of germinal epithelium due to cadmium toxicity improved due to curcumin treatment. Also, the concentration of the spermatogonia and spermatids appeared normal, and the seminiferous epithelium became well-organized. Histology of the liver showed that hepatocytes recovered in contrast to the cadmium-treated animals, and no infiltration of inflammatory cells was observed. However, future research needs to be envisioned to improve the oral bioavailability of curcumin, as it could act as a prospective candidate for the treatment of cadmium toxicity.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100803"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Potential efficacy of nanocurcumin on levodopa-induced dyskinesia in a rat parkinsonian model” [Phytomedicine Plus Volume 2, Issue 4 (November 2022) 100334]","authors":"Pegah Ashrafi ,&nbsp;Mahsa Hadipour Jahromy","doi":"10.1016/j.phyplu.2025.100790","DOIUrl":"10.1016/j.phyplu.2025.100790","url":null,"abstract":"","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100790"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mistletoe (Viscum album L.) for human papillomavirus: A seven-case series","authors":"Nilo E. Gardin ,&nbsp;Beatriz Gardin-Machado","doi":"10.1016/j.phyplu.2025.100805","DOIUrl":"10.1016/j.phyplu.2025.100805","url":null,"abstract":"<div><h3>Background</h3><div>Human papillomavirus (HPV) is a significant public health concern, as 50 % of the population are at risk of being infected by this virus at least once in their lifetime. Although the host immune system clears most infections, a small percentage of patients do not fully clear genital HPV. They have an increased risk of developing HPV-associated cancers and can transmit HPV. Currently, no conventional treatments are available to eliminate the virus in HPV carriers.</div></div><div><h3>Cases presentation</h3><div>This study describes the clinical evolution of seven consecutive outpatients with HPV treated with <em>Viscum album</em> extract (VAE). In four patients, the persistence of HPV infection was six months or longer (in two of these patients, it had persisted for 22 months); in three patients, the diagnosis was recent. The patients were treated with topical (vaginal) VAE. For those with high-risk HPV or cervical intraepithelial neoplasia, subcutaneous injections of VAE were administered. <em>Calendula officinalis</em> (vaginal ovules) was prescribed for genital inflammation, and <em>Thuja occidentalis</em> ointment for verrucous lesions. Clinical and laboratory parameters were monitored throughout the treatment. All medications were well tolerated, with only mild skin reactions reported at the VAE injection site. Following treatment, six out of seven patients had negative hybrid capture tests for HPV. One of these six patients required a repeat course of treatment, after which the HPV hybrid capture test turned negative. In one patient, treatment failed to eradicate HPV.</div></div><div><h3>Conclusions</h3><div>Although this case series has a small sample size, there is a therapeutic potential to be further investigated regarding VAE for genital HPV. The treatment needs to be validated by future studies, which should be followed by a clinical trial to rigorously assess the efficacy of mistletoe for genital HPV infection.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100805"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and pharmacological profiling of Balanites aegyptiaca linn.: Exploring the therapeutic potential of a traditional medicinal plant","authors":"Vikram Thakkar ,&nbsp;Prashant Kumar Dhakad ,&nbsp;Raghav Mishra ,&nbsp;Ritu M Gilhotra","doi":"10.1016/j.phyplu.2025.100804","DOIUrl":"10.1016/j.phyplu.2025.100804","url":null,"abstract":"<div><div>Numerous tree species that are underutilized can be used as food, fodder, and potentially medicinal substances. <em>Balanites aegyptiaca</em> (L.) Del. (<em>B. aegyptiaca</em>) (family Zygophyllaceae) is an evergreen xerophyte with ample beneficial attribute. It is effective to cure several diseases include malaria, epilepsy, constipation, intestinal worm infection, syphilis, asthma, jaundice, haemorrhoid, stomach aches, asthma, diarrhoea, dysentery, and wound healings. It also has contraceptive antifeedant, anti-carcinogenic, molluscicidal, antimicrobial, anti-inflammatory, anti-helminthic, antioxidant, immune-stimulant, antioxidant, antiviral and antidiabetic activities. <em>Balanites aegyptiaca</em> (L.) Del. (<em>B. aegyptiaca</em>) possesses various active compounds like lipids, carbohydrates, proteins, organic acids, alkaloids, saponins and flavonoids that mainly responsible for its pharmaceutical activities. In conclusion, the diverse pharmacological activities of this plant make it a valuable resource for developing new herbal remedies and pharmaceutical products. This review reveals bioactive compounds, medicinal uses, pharmacological significance, and toxicological effects of various parts of <em>Balanites aegyptiaca.</em></div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100804"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of Matrine in blood and prostate tissue: a microdialysis-HPLC study in a rabbit model","authors":"Yu Liu ,&nbsp;Gefei He ,&nbsp;Jianye Yan ,&nbsp;Meimin Pan ,&nbsp;Binqing Qu","doi":"10.1016/j.phyplu.2025.100801","DOIUrl":"10.1016/j.phyplu.2025.100801","url":null,"abstract":"<div><div>KangFuXiaoYan suppository exhibits therapeutic potential for chronic prostatitis (CP) ,however, its in vivo pharmacokinetic process remains to be elucidated. This study investigated the pharmacokinetics of Matrine, the primary bioactive component of KangFuXiaoYan suppository, using high-performance liquid chromatography (HPLC) with microdialysis in rabbits. The results showed that the C_max of Matrine in jugular vein and prostate tissue were (86.92 ± 2.66) and (45.33 ± 3.65) mg L^-1,the T_max were (30 ± 0.00) and (45 ± 0.00) min, the T_1/2 were (23.55 ± 1.76) and (26.50 ± 5.57) min, the AUC_0-t were (4192.77 ± 67.85) and (2919.78 ± 40.17) mg min L^-1,the MRT_0-t were (48.90 ± 0.13)and (56.25 ± 1 .06) min. Matrine absorption, distribution, and penetration into prostate tissue were quantified. The results demonstrated rapid absorption into blood and prostate tissue, achieving a penetration rate of 73 %, suggesting potential therapeutic effectiveness for chronic prostatitis treatment. These findings provided experimental support for the clinical application of rectally administered KangFuXiaoYan suppository.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100801"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}