Phytomedicine Plus最新文献

{"title":"Spinach ameliorates dietary oxidized tallow-induced NAFLD by regulating inflammatory cytokines, peroxisome proliferator-activated receptors, and antioxidant systems","authors":"Neelab ,&nbsp;Alam Zeb ,&nbsp;Muhammad Jamil","doi":"10.1016/j.phyplu.2024.100722","DOIUrl":"10.1016/j.phyplu.2024.100722","url":null,"abstract":"<div><h3>Background</h3><div>Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver disorders globally and is a major clinical concern that is increasing in both industrialized and developing countries.</div></div><div><h3>Purpose</h3><div>This study aimed to evaluate the ability of <em>Spinacia oleracea</em> dried powder in protecting rabbits from the toxicity caused by oxidized-tallow.</div></div><div><h3>Methods</h3><div>Oxidized tallow and spinach powder were administered to the rabbits. The phenolic profile of spinach was studied using HPLC-DAD. Investigations were conducted on the liver phospholipid composition, liver-histology analysis, levels of antioxidants, liver-associated inflammatory cytokines, and the serum-lipid profile.</div></div><div><h3>Results</h3><div>The findings revealed that the primary constituents of the extracts were gallic acid, luteolin-3-glucoside, kaempferol-3-glucoside, and chlorogenic acid. Histological and biochemical examination of the liver revealed greater fat storage in the OT-group than in the control or therapy groups. The OT-treated rabbits exhibited increased levels of hepatic inflammatory cytokines, decreased antioxidant status, and elevated lipid profiles. After consuming spinach, the levels of proinflammatory cytokines (IL-1, IL-4, IL-6, and TNF-α), PPARs, and antioxidants (CATs, SODs, TBARS, GSH-Px, and GSHs) returned to normal.</div></div><div><h3>Conclusion</h3><div>Dried spinach powder is an excellent dietary source of liver-protective chemicals that ameliorate NAFLD by reducing proinflammatory cytokines and enhancing antioxidant status.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100722"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy","authors":"Joshi Gaurav Santoshrao ,&nbsp;Smriti Jamwal ,&nbsp;Rakesh Kumar,&nbsp;Ekta Bisht,&nbsp;Bisen Harsh Krishnakumar,&nbsp;Shreya Katoch,&nbsp;R.K. Asrani","doi":"10.1016/j.phyplu.2024.100674","DOIUrl":"10.1016/j.phyplu.2024.100674","url":null,"abstract":"<div><h3>Background</h3><div>Cancer remains a significant health challenge, with increasing incidence and mortality rates attributed to lifestyle factors and environmental pollutants. Despite decades of research, a universal cure for cancer remains elusive. The natural flora, particularly medicinal plants, offers a rich source of bioactive compounds with potential therapeutic benefits. <em>Inula racemosa</em>, a plant used in Ayurveda and Traditional Chinese Medicine, has been recognised for its various medicinal properties.</div></div><div><h3>Purpose</h3><div>This review aims to summarize the recent research and advances concerning the anti-cancer effects of two key phytoconstituents—alantolactone and isoalantolactone—derived from <em>Inula racemosa</em>. The review focuses on understanding their mechanisms of action and potential as alternative cancer therapies.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted using databases such as PubMed, Google Scholar, and Web of Science. Keywords like \"Inula,\" \"anticancer,\" and \"cell lines\" were employed to identify relevant studies. Initially 126 papers were screened in total and the collected data were analysed to assess the anti-cancer properties of alantolactone and isoalantolactone.</div></div><div><h3>Results</h3><div>Studies indicate that alantolactone and isoalantolactone exhibit significant anti-cancer activities through various mechanisms. These include the induction of apoptosis, regulation of the cell cycle, inhibition of angiogenesis, and suppression of metastasis. The compounds have demonstrated efficacy in vitro and in vivo, affecting various cancer cell lines with minimal toxicity to normal cells.</div></div><div><h3>Conclusion</h3><div>Alantolactone and isoalantolactone from <em>Inula racemosa</em> show promising potential as anti-cancer agents. Their diverse mechanisms of action and minimal side effects position them as candidates for further research and development. Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100674"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin-induced mouse model","authors":"Gyamcho Tshering Bhutia ,&nbsp;Asit Kumar De ,&nbsp;Manas Bhowmik ,&nbsp;Pavia Bera ,&nbsp;Tanmoy Bera","doi":"10.1016/j.phyplu.2025.100742","DOIUrl":"10.1016/j.phyplu.2025.100742","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic nephropathy (DN) causes significant morbidity and mortality, leading to substantial psycho-economic costs. New strategies and medications are needed to manage DN more effectively.</div></div><div><h3>Purpose</h3><div>The antidiabetic and antinephritic properties of <em>Pueraria tuberosa</em> and <em>Pterocarpus santalinus</em> have been demonstrated in previous studies. However, poor oral bioavailability has limited their clinical application. A nanostructured lipid carrier (NLC) formulation was created and tested to address this problem. The promising experimental results suggest that this formulation holds potential for further clinical exploration.</div></div><div><h3>Study design</h3><div>The <em>in vivo</em> study evaluated the therapeutic potential of NLCs loaded with hydroalcoholic extracts of <em>P. tuberosa</em> tubers (PTE) and <em>P. santalinus</em> heartwood (PSE) in managing DN over eight weeks in streptozotocin (STZ)-induced diabetic mice.</div></div><div><h3>Methods</h3><div>The protective effects of PTE and PSE were evaluated in mice at a dose of 80 mg/kg body weight. Two weeks after STZ treatment, animals with blood sugar levels above 250 mg/dL were identified as diabetic and showed signs of nephritis. In these diabetic mice, PTE-NLC and PSE-NLC, individually and in their combined form (PTE+PSE)-NLC, were assessed for their hypoglycemic and nephroprotective effects. Animals were sacrificed for histopathological and biochemical analysis after eight weeks of therapy. Nanoparticles were characterized by their morphology, zeta potential, drug loading capacity, particle size, and release profile.</div></div><div><h3>Results</h3><div>In STZ-induced diabetic mice, treatment with (PTE+PSE)-NLC significantly improved pancreas and kidney health. It restored the kidney hypertrophy index, stabilized biochemical parameters, enhanced histopathological outcomes, and increased beta-cell count. Additionally, (PTE+PSE)-NLC led to a 30.53-fold more significant reduction in blood glucose levels than free (PTE+PSE) extracts.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the potential of the NLC formulation of <em>P. tuberosa</em> and <em>P. santalinus</em> extracts in treating diabetic nephropathy. The bioactive compounds in these extracts play a crucial role in their antidiabetic and antinephritic effects, marking significant progress in the field.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100742"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents","authors":"Muhammad Abdullah Bhatti ,&nbsp;Atif Ali Khan Khalil ,&nbsp;Sayed Muhammad Ata Ullah Shah Bukhari ,&nbsp;Faisal Hanif ,&nbsp;Mi-Jeong Ahn ,&nbsp;Sumra Wajid Abbasi ,&nbsp;Nazir Ahmed Lone ,&nbsp;Wen-Jun Li ,&nbsp;Wasim Sajjad","doi":"10.1016/j.phyplu.2024.100698","DOIUrl":"10.1016/j.phyplu.2024.100698","url":null,"abstract":"<div><h3>Background</h3><div>Most nosocomial infections are caused by bacteria that proliferate within quorum sensing mediated biofilms. The disruption of quorum sensing signals in biofilm-forming bacteria is the potential substitution strategy.</div></div><div><h3>Purpose</h3><div>The current study focuses on the evaluation of isolated juglone derivatives from <em>Reynoutria japonica</em> as anti-biofilm agents and enzyme inhibitors against Methicillin Resistant <em>Staphylococcus aureus</em> (MRSA).</div></div><div><h3>Methods</h3><div>The antibacterial and anti-biofilm activity of the juglone derivatives were investigated against laboratory strains MRSA using well and disc diffusion method. In addition, we evaluated the anti-biofilm inhibition potential of the juglone derivatives using a crystal violet-based assay in 96-well micro-titer plate. The suppression of S. aureus β-hemolytic, coagulase and proteolytic activity was evaluated using standard assay protocols. High Performance Liquid Chromatography (HPLC) was performed to analyze the acyl homoserine lactones (AHLs) signals degradation by juglone derivatives. Furthermore, all three ligand molecules were docked into the binding site of the S. aureus coagulase protein.</div></div><div><h3>Results</h3><div>All the three juglone derivatives showed potent antimicrobial activity against clinical strains of MRSA. Among these compounds, 2-ethoxy-6-acetyl-7-methyljuglone displayed potent inhibitory activity with zones of inhibition of 15 ± 0.03 and 17 ± 0.03 against MRSA respectively. In the spectrophotometric assay, we confirmed that juglone derivatives inhibit biofilm formation. All the compounds markedly inhibited the coagulase, <em>β</em>-hemolytic and proteolytic activity of MRSA. The application of compounds as a treatment resulted in a notable decrease in biofilm density and thickness, as demonstrated by HPLC. The untreated MRSA exhibited quorum sensing signals of N-Butanoyl-<span>l</span>-homoserine lactone (C4-HSL) with retention time 3.6 min and of N-hexanoyl-<span>l</span>-Homoserine lactone (C6-HSL) at 5.8 minutes’ vs the treated with MRSA where no peaks were observed. The docking studies and Molecular dynamics (MD) simulation results revealed that all molecules are actively binding in the target site that correlates well with the <em>in-vitro</em> inhibitory properties of compounds against <em>S. aureus</em>.</div></div><div><h3>Conclusion</h3><div>our results demonstrated the potential of juglone derivatives from <em>R. japonica</em> as a promising anti-biofilm agent and as quorum quencher for future therapy to combat multi-drug resistant infections in particular MRSA.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100698"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology","authors":"Haritha Harindranath ,&nbsp;Aishwarya Susil ,&nbsp;Rajeshwari S ,&nbsp;Mahendran Sekar ,&nbsp;B.R. Prashantha Kumar","doi":"10.1016/j.phyplu.2024.100726","DOIUrl":"10.1016/j.phyplu.2024.100726","url":null,"abstract":"<div><h3>Background</h3><div>Rosmarinic acid (RA) is a polyphenol abundantly found in culinary herbs like Rosemary, sage, perilla, and Tulsi, and it has varied therapeutic potential. It is an ester of caffeic acid and 3,4—di hydroxyphenyl lactic acid. It's been used as a food supplement and in traditional medicines since immemorial.</div></div><div><h3>Objectives</h3><div>To review RA's properties, sources, extraction methods, chemical structure, bioavailability, and diverse therapeutic applications such as antioxidant, anti-inflammatory, anticancer, neuroprotective, cardioprotective, and antimicrobial properties.</div></div><div><h3>Methods</h3><div>A systematic data review was carried out focussing on literature from 2004 – 2024 in online databases from Google Scholar, PubMed, ScienceDirect, Web of Science, Researchgate, and Scopus. The articles were searched using “Rosmarinic acid”, “Cancer”, “in silico”, “in vivo”, “in vitro”, “diabetes”, and “therapeutic” as the keywords.</div></div><div><h3>Conclusion</h3><div>This review provides deep insights into the research works carried out on RA's potential as a medicinal source. Advancement from normal traditional usage to modern-day therapeutic practices, RA has come a long way to help mankind with its unique characteristics. From anti-bacterial to anti-cancer remedies RA has proven its healing properties and still provides a scope to explore further.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100726"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants with neuroprotective potential in East African countries: A systematic review","authors":"Ibe Michael Usman ,&nbsp;Ekom Monday Etukudo ,&nbsp;Elna Owembabazi ,&nbsp;Wusa Makena ,&nbsp;Augustine Oviosun ,&nbsp;Makeri Danladi ,&nbsp;Vivian Ojiakor ,&nbsp;Patrick Maduabuchi Aja ,&nbsp;Emeka Anyanwu ,&nbsp;Yanurkis Duranones Rosales ,&nbsp;Mario Edgar Fernandez Diaz ,&nbsp;Josiah Ifie ,&nbsp;Ismahil Adekunle Adeniyi ,&nbsp;Ilemobayo Victor Fasogbon ,&nbsp;Victor Bassey Archibong","doi":"10.1016/j.phyplu.2025.100744","DOIUrl":"10.1016/j.phyplu.2025.100744","url":null,"abstract":"<div><h3>Background</h3><div>The use of plant-derived natural compounds in the management of various human disease conditions has gained lots of attention in recent times; hence, the present study examined medicinal plants with neuroprotective potential in East Africa and their mechanism of action.</div></div><div><h3>Method</h3><div>The present study is a systematic review that included randomized controlled trial studies using experimental animal models for various nervous system related conditions treated with medicine plants sourced from within any of the East African countries.</div></div><div><h3>Result</h3><div>Most of the included studies were conducted in Kenya 6/12 (50 %). Studies from Ethiopia and Uganda accounted for 2/12 (16.7%) and 4/12 (33.3 %) respectively. One-third of the included studies used the leaves of the selected plants. The reviewed studies highlighted neuroprotective activities of the plants, as evidenced by biochemical and behavioral improvements. Key findings included increased levels of glutamine synthetase, Na+/K+ ATPase, calcium ATPase, acetylcholinesterase, catalase, and superoxide dismutase, all of which support enhanced neuronal function and protection against oxidative stress. Conversely, there was a significant decrease in level of malondialdehyde, an important marker of lipid peroxidation, indicating reduced cellular damage from oxidative stress. Behavioral outcomes aligned with these biochemical changes, showing marked improvements in memory and learning, motor activity, seizure threshold, and anxiety-like behavior.</div></div><div><h3>Conclusion</h3><div>The included studies collectively suggest a strong neuroprotective activity, with the biochemical enhancements contributing to better neurological health and functional recovery. Hence, the reported plants could be explored as options in complementary and alternative medicine following a thorough examination of their active ingredient and mechanism of action.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100744"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes","authors":"Aishat Omobolanle Olatunji ,&nbsp;Root Oluwapelumi Alegbe ,&nbsp;Suleiman Folorunsho Ambali ,&nbsp;Muftau Shittu ,&nbsp;Ganiu Jimoh Akorede ,&nbsp;Abdulfatai Aremu ,&nbsp;Afisu Basiru ,&nbsp;Jamila Abdulhamid Atata ,&nbsp;Kolawole Yusuf Suleiman ,&nbsp;Charles Amoto Shuaibu","doi":"10.1016/j.phyplu.2024.100699","DOIUrl":"10.1016/j.phyplu.2024.100699","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. Flavonoid compounds possess notable qualities in mitigating diabetes and its complications.</div></div><div><h3>Aim</h3><div><em>Hibiscus sabdariffa</em> linn and daflon-500® were assessed for their effects on body weight, blood glucose/indices, and oxidative changes in type-2 diabetes rats over 28 days.</div></div><div><h3>Methods</h3><div>35 male rats were randomly divided into seven groups (<em>n</em> = 5). Diabetes mellitus was induced in groups 2–7 via a single intraperitoneal injection of streptozotocin (STZ; 55mg/kg). Group 1(DW) received distilled water (2mL/kg) only. Group 2 (STZ; untreated), group 3 {MET; metformin (Glucophage)}, group 4 {HS; <em>Hibiscus sabdariffa</em> (400mg/kg)}, group 5 {DAF; daflon-500® (1000mg/kg)}, group 6 {DAF+HS; daflon-500® (1000mg/kg) and <em>Hibiscus sabdariffa</em> (400mg/kg)}, group 7 {DAF+MET+HS; daflon-500® (1000mg/kg), metformin (Glucophage), and <em>Hibiscus sabdariffa</em> (400mg/kg)}. Body weight and blood glucose were assessed fortnightly. Blood and hepatic/pancreatic tissues were collected for hematological and antioxidant testing.</div></div><div><h3>Results</h3><div>Groups 2–7 revealed a significant (<em>P</em> &lt; 0.05) decrease in body weight on day 14 compared to the increased growth rate observed on day 28 (Group 7).</div><div>Blood glucose levels significantly increased on days 1 and 14 in groups 2–7 but declined on day 28 in groups 4–7. Significantly higher packed cell volume, hemoglobin levels, red blood cell counts, lymphocytes, and mean corpuscular hemoglobin were observed in groups 5–7. Platelet counts were higher in Groups 2 and 5. Untreated group 2 exhibited considerably reduced catalase activity, glutathione, and malondialdehyde concentrations compared to the treated groups.</div></div><div><h3>Conclusion</h3><div><em>Hibiscus sabdariffa</em> linn and Daflon-500® expressed substantial hypoglycemic, antioxidant, and hemato-protective effects.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100699"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review","authors":"José Luis Estela-Zape ,&nbsp;Mayra Liliana Pizarro-Loaiza ,&nbsp;Gabriel Arteaga ,&nbsp;Santiago Castaño ,&nbsp;Leonardo Fierro","doi":"10.1016/j.phyplu.2024.100724","DOIUrl":"10.1016/j.phyplu.2024.100724","url":null,"abstract":"<div><h3>Background</h3><div>Voltage-gated sodium channels (Nav) are critical for generating action potentials in neuronal and muscle tissues. Dysfunction of these channels is associated with neurological disorders such as epilepsy, neuropathic pain, and myopathies. Although plant-derived compounds have shown promise in modulating Nav channels, the molecular mechanisms remain insufficiently understood. This systematic review aims to identify plant metabolites that affect Nav channel activity, with the potential for developing more selective and safer treatments.</div></div><div><h3>Methods</h3><div>The review followed PRISMA 2020 guidelines. A search was conducted in three databases (PubMed, Scopus, Web of Science) using keywords related to sodium channels and medicinal plants. Studies were selected based on predefined eligibility criteria and evaluated through a standard critical appraisal process by two reviewers.</div></div><div><h3>Results</h3><div>Six studies were included, examining the effects of plant metabolites on Nav channels. Isoquinoline alkaloids from <em>Corydalis yanhusuo, hangeshashinto</em>, osthol, and cannabidiol inhibited Na+ currents in cell models, primarily affecting Nav1.7 and Nav1.5. These compounds exhibited analgesic, antiarrhythmic, and neuroprotective properties, suggesting their therapeutic potential for disorders linked to Nav channel dysfunction.</div></div><div><h3>Conclusions</h3><div>Plant-derived metabolites that modulate Nav channels present significant therapeutic potential for treating neurological disorders, offering more targeted treatments with fewer side effects. However, further research is needed to clarify the underlying molecular mechanisms and validate these compounds through preclinical and clinical trials.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100724"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of bioactive components and phytopharmaceutical potentials of Hygrophila auriculata–A herbaceous medicinal plant","authors":"Megha Malpotra ,&nbsp;Meenakshi Garg ,&nbsp;Neha Singh ,&nbsp;Susmita Dey Sadhu ,&nbsp;Rajni Chopra ,&nbsp;Bhupesh Sharma","doi":"10.1016/j.phyplu.2025.100737","DOIUrl":"10.1016/j.phyplu.2025.100737","url":null,"abstract":"<div><div>The current review intends to summarize the bioactive components, nutritional profile, phytopharmaceutical properties, mechanism of action, and functional food aspects of <em>Hygrophila auriculata</em>. It was traditionally used to prepare ancient Indian ayurvedic medicines for treating chronic disorders. Indeed, the plant is a copious source of bioactive compounds like quercetin, ellagic acid, gallic acid, betulin, lupeol, and stigmasterol. The plant is also abundant in sodium, potassium, iron, fiber, vitamin C, and β-carotene. The bioactive compounds are linked to phytopharmaceutical properties like antioxidant, cardioprotective, anti-diabetic, diuretic, hepatoprotective, androgenic, haematinic, anti-cancer, anti-inflammatory, etc. However, more research is still needed to connect existing literature with contemporary pharmacology. The plant holds a promising future in functional food development and bio-packaging. Future research should also focus on isolating bioactive compounds from numerous parts of the plant and analyzing the mechanisms of action of such compounds.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100737"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges","authors":"George Awuku Asare ,&nbsp;Perpetua Dagadu ,&nbsp;Samuel Adjei ,&nbsp;Bernice Asiedu ,&nbsp;Samkeliso Takaidza ,&nbsp;Vivash Naidoo ,&nbsp;Brodrick Amoah ,&nbsp;Ifeoma Celestina Orabueze ,&nbsp;Kwasi Bugyei","doi":"10.1016/j.phyplu.2025.100739","DOIUrl":"10.1016/j.phyplu.2025.100739","url":null,"abstract":"<div><h3>Background</h3><div>Benign Prostatic Hyperplasia (BPH) is a common condition among aging men. This condition often leads to a reduced quality of life due to its debilitating symptoms. Although conventional allopathic treatments are widely used for managing BPH, they are frequently associated with adverse side effects, prompting a global shift toward natural and alternative therapies. This study aims to investigate the therapeutic effects of <em>Rauwolfia vomitoria</em> Aqueous Root Extract (RVARE) as a potential natural oral treatment for BPH.</div></div><div><h3>Methodology</h3><div>Six groups of male Sprague-Dawley rats were established [<em>N</em> = 7/group]. Group 1 comprised of normal rats whilst group 2 to group 6 comprised of BPH induced rats. Group 1: Control group- received normal chow diet. Group 2: Model group- [no treatment]. Group 3: received 10 mg/kg. b. wt. RVARE. Group 4: received 25 mg/kg. b.wt. RVARE. Group 5: received 50 mg/kg. b.wt, RVARE. Group 6: served as a positive control [Finasteride]. The study was carried out for 28 days. Upon termination, blood was sampled for general biochemical, haematological and PSA determination. Systemic organs and the prostate were harvested for histological analyses.</div></div><div><h3>Result</h3><div>Histopathological analysis of the liver of RVARE treated groups demonstrated alterations. Additionally, a reduction in relative prostate weight compared to the model group was observed, though not statistically significant (<em>p</em> &gt; 0.05). However, a significant reduction in prostate specific antigen (PSA) levels was seen in the RVARE-treated groups (Model vs Gp 3, <em>p</em> = 0.001; Model vs Gp 4, <em>p</em> = 0.000; Model vs Gp 5, <em>p</em> = 0.001).</div></div><div><h3>Conclusion</h3><div>RVARE appears to be effective in reducing prostate size and PSA levels. However, its hepatotoxic effect needs further investigation.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 1","pages":"Article 100739"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}