一种来自自然界的重要生物碱

Q3 Pharmacology, Toxicology and Pharmaceutics

Phytomedicine Plus Pub Date : 2025-02-17 DOI:10.1016/j.phyplu.2025.100765

Nitin A. Lunagariya , Purvi Shah

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引用次数: 0

摘要

艾格林是一种天然存在的生物碱，从艾格甜瓜中分离出来，因其多种药理特性而受到广泛关注。本文就其分离、全合成及生物活性等方面的研究进展作一综述。它作为一种治疗各种代谢紊乱的潜在药物，其作用机制是突出的。Aegeline以消旋形式存在。大多数研究都是在从植物中分离出来的egeline上进行的。已经研究过生物活性的合成衍生物或类似物，也没有指定它们的手性。可以做进一步的研究来探索其个体对映体的治疗潜力以及安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Aegeline: A biologically important alkaloid from nature

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Aegeline: A biologically important alkaloid from nature

Aegeline, a naturally occurring alkaloid isolated from Aegle marmelos, has garnered significant attention for its diverse pharmacological properties. This review provides insights into the isolation, total synthesis, and biological activities of aegeline. Its potential as a therapeutic agent for various metabolic disorders, is highlighted with its mechanism of action. Aegeline is naturally available in racemic form. Mostly studies have been done on the isolated aegeline from the plant. Synthetic derivatives or analogues, which have been studied for biological activity, are also not specified for their chirality. Further studies can be done to explore therapeutic potential of its individual enantiomers along with the safety profile.

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