Phytomedicine Plus最新文献

{"title":"Bioprocess strategies for maximizing SCOBY growth and evaluating fermentation dynamics on phenolic content and antioxidant activity in Roselle-based Kombucha","authors":"Widiastuti Setyaningsih ,&nbsp;Wa Ode Reza Sindy Warni ,&nbsp;Intan Dewi Larasati ,&nbsp;Rini Yanti ,&nbsp;Tyas Utami","doi":"10.1016/j.phyplu.2025.100791","DOIUrl":"10.1016/j.phyplu.2025.100791","url":null,"abstract":"<div><div>Roselle-based kombucha is a promising functional beverage due to its bioactive compounds, high phenolic content, and anthocyanins, which contribute to color stability, anti-inflammatory effects, and cardioprotective benefits. This study aimed to optimize fermentation parameters—roselle concentration, sucrose levels, and initial symbiotic culture of bacteria and yeast (SCOBY) mass—to enhance microbial activity, phenolic stability, and antioxidant properties.</div><div>High-performance liquid chromatography (HPLC) identified chlorogenic acid (270.62 mg L⁻¹), quercetin-3-glucoside (31.96 mg L⁻¹), and rutin (7.7 mg L⁻¹) as predominant phenolics, with protocatechuic acid increasing over 14 days. Optimized fermentation conditions (5 g roselle, 12% sucrose, 25 g SCOBY) resulted in higher SCOBY growth (41.66 g) and superior bioactive stability compared to traditional tea kombucha. Fermentation significantly influenced key parameters: pH remained stable (2.16 to 2.21) due to buffering organic acids, titratable acidity increased (0.60% to 2.33%), and sucrose concentration decreased (12.0 to 10.2 °Brix). Color analysis (CIELab) revealed dynamic pigment changes, reflecting anthocyanin degradation and transformation. Storage stability tests showed that phenolic compounds remained stable at 4°C, while room-temperature storage increased phenolic content, likely due to continued microbial metabolism. Antioxidant activity assays confirmed robust antioxidant potential, with IC50 values remaining stable in cold storage: DPPH (9.71 to 9.59 mg L⁻¹), ABTS (8.68 to 7.60 mg L⁻¹), and FRAP (10.01 to 9.84 mg L⁻¹). These findings underscore roselle kombucha's potential as a scalable, nutritionally enhanced functional beverage, emphasizing its phenolic stability and antioxidant properties under optimized fermentation and storage conditions. This study provides practical insights for scaling production, improving cost-efficiency, and advancing functional beverage development.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100791"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety behavior in adult Zebrafish modulated by the alkaloid fraction of Cissampelos sympodialis Eichl. roots","authors":"Johnatan Wellisson da Silva Mendes ,&nbsp;Joice Barbosa do Nascimento ,&nbsp;José Jonas Ferreira Viturino ,&nbsp;Lariza Leisla Leandro Nascimento ,&nbsp;Débora Odília Duarte Leite ,&nbsp;Natália Kelly Gomes de Carvalho ,&nbsp;Hélcio Silva dos Santos ,&nbsp;Emmanuel Silva Marinho ,&nbsp;Márcia Machado Marinho ,&nbsp;Jane Eire Silva Alencar de Menezes ,&nbsp;José Galberto Martins da Costa","doi":"10.1016/j.phyplu.2025.100789","DOIUrl":"10.1016/j.phyplu.2025.100789","url":null,"abstract":"<div><div><em>Cissampelos sympodialis</em> (Menispermaceae), a species endemic to Brazil, it is used in folk medicine to treat inflammation and respiratory disorders. These activities are probably associated with the presence of alkaloids in the plant. This study aims to investigate the effect of the alkaloid fraction of <em>C. sympodialis</em> (FARCs) on anxiety behavior in adult zebrafish. Locomotor activity was evaluated using the open field test and acute toxicity was analyzed within 96 h. The light and dark tests were applied for anxiolytic evaluation. Berberine (BRB) quantification was performed in FARCs, through spectrophotometry. GABAergic neuromodulation was evaluated, and molecular docking was performed. FARCs was not toxic to adult zebrafish, all doses indicated a sedative effect, also caused anxiolytic behavior in animals. The anxiety mechanism via GABAergic neurotransmission was confirmed. It was observed that the BRB corresponds to the majority of the composition of the FARCs. Molecular docking showed that BRB can exert neuromodulatory function on GABA receptors with safety and metabolic stability. The study indicated that FARCs exhibit an anxiolytic effect on animals without showing toxicity. Quantitative analysis determined for the first time in the species the presence of BRB. Molecular docking indicated that berberine constitutes a promising active principle in neuromodulation.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100789"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the male fertility potential of medicinal plants from central and West African countries: A systematic review","authors":"Ismahil Adekunle Adeniyi ,&nbsp;Olufunke Onaadepo ,&nbsp;Daniel Owu ,&nbsp;Ishak Abdi Jama ,&nbsp;Augustine Oviosun ,&nbsp;Ekom Monday Etukudo ,&nbsp;Elna Owembabazi ,&nbsp;Emeka Anyanwu ,&nbsp;Patrick Maduabuch Aja ,&nbsp;Josiah Ifie ,&nbsp;Eric Aigbogun ,&nbsp;Wusa Makena ,&nbsp;Oluwatosin Olasheu Omoola ,&nbsp;Comfort Ojochenemi Usman ,&nbsp;Ibe Michael Usman","doi":"10.1016/j.phyplu.2025.100786","DOIUrl":"10.1016/j.phyplu.2025.100786","url":null,"abstract":"<div><h3>Background</h3><div>Male fertility related issue among couples in developing countries has continued to prevail despites the availability of variety of synthetic drug; hence, the need to develop more effective treatment with less side effects. The present study sort to explore medicinal plants with male fertility potential in Central and West (C&amp;W) Africa countries.</div></div><div><h3>Method</h3><div>The present study is a systematic review that included 25 randomized controlled trial studies using experimental animal models for various male fertility related issues treated with medicine plants sourced from within any of the C&amp;W African countries.</div></div><div><h3>Result</h3><div>Most of the included studies were conducted in Nigeria 80 % (20/25). The mechanisms through which C&amp;W African plant extracts enhance fertility include reducing inflammatory biomarkers, modulating oxidative stress biomarkers (SOD, CAT, and GPx), and improving reproductive hormone levels (testosterone, luteinizing hormone, and follicle-stimulating hormone). Treatment with the plant extracts were associated with increased sperm count, motility, and viability, and improved histoarchitecture of the testes. However, only a few of the included studies chemical characterized the plant used for the study; ultraviolet spectrophotometry 4 % (1/25), gas chromatography-mass spectrometry 12 % (3/25), high-performance liquid chromatography 8 % (2/25), nuclear magnetic resonance 4 % (1/25), fourier transform infrared spectroscopy 4 % (1/25)</div></div><div><h3>Conclusion</h3><div>This review highlights the promising fertility-enhancing potential of plant species used in C&amp;W Africa, demonstrating their ability to improve male reproductive health through antioxidative, anti-inflammatory, and hormonal modulation pathways. We recommend proper chemical characterization of the included plants to help improve our understanding of their mechanism of action.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100786"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients","authors":"Awatef Sassi ,&nbsp;Aicha Laouani ,&nbsp;Mohamed Aymen Ben Abdessalem ,&nbsp;Imen Jarray ,&nbsp;Hana Nasrallah ,&nbsp;Farhana Ferdousi ,&nbsp;Manel Nouira ,&nbsp;Ali Mtiraoui ,&nbsp;Abdallah Mahdhaoui ,&nbsp;Hiroko Isoda ,&nbsp;Saad Saguem","doi":"10.1016/j.phyplu.2025.100783","DOIUrl":"10.1016/j.phyplu.2025.100783","url":null,"abstract":"<div><h3>Background</h3><div>Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary. However, clinical studies on its effects on hypertension are lacking.</div></div><div><h3>Objective</h3><div>This study aimed to explore the efficacy, safety, and tolerability of a 45-day administration of rosemary infusion in both healthy participants and individuals with grade 1 hypertension.</div></div><div><h3>Methods</h3><div>A total of 18 healthy subjects and 35 grade 1 hypertensive patients were enrolled and instructed to consume a daily infusion prepared by steeping 2 g of powdered rosemary leaves in 100 ml of boiled water. The study was completed by 15 healthy participants and 30 hypertensive patients. Baseline and post-intervention clinical and biochemical parameters, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), and pulse pressure (PP), were measured using ambulatory blood pressure monitoring (MBP).</div></div><div><h3>Results</h3><div>In the hypertensive group, rosemary infusion consumption over 45 days led to a significant reduction in 24-h SBP (<em>P</em> = 0.005), DBP (<em>P</em> = 0.003), daytime SBP and DBP (<em>P</em> = 0.003 and <em>P</em> = 0.002, respectively), MBP (<em>P</em> = 0.003), and Nocturnal SBP dipping (<em>P</em> = 0.04). In contrast, no significant changes in SBP or DBP were observed among healthy participants. Biochemical safety assessments showed no significant differences between baseline and post-intervention values for both groups. Additionally, no adverse effects were reported, further supporting the safety and efficacy of rosemary infusion.</div></div><div><h3>Conclusion</h3><div>This preliminary trial allowed the exploration of the effectiveness of rosemary infusion in reducing SBP and DBP in hypertensive patients with grade 1 hypertension over a 45-day period.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100783"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear pyranocoumarins are potential dazzling dancers between nature, chemistry, and clinical application","authors":"Marwa Mohammed Alshaher,&nbsp;Yasser Fakri Mustafa","doi":"10.1016/j.phyplu.2025.100785","DOIUrl":"10.1016/j.phyplu.2025.100785","url":null,"abstract":"<div><div><em>Angelica gigas Nakai, Angelica decursiva</em>, and other healing plants have secondary metabolites called natural linear pyranocoumarins (N-PYCs) that are very uncommon. As anticancer, antidiabetic, antioxidant, antimicrobial, anti-inflammatory, and neuroprotective agents, they have different effects on biological, toxicological, and ecological systems. Despite their potential advantages, research on these N-PYCs is scarce and necessitates additional evaluation of their pharmacological applications. The goal of this study is to find out more about how N-PYCs are biosynthesized, what their structural features are, and how they can be used in medicine to treat cancer, scavenge free radicals, help people with diabetes, treat microbial infections and inflammation, and protect neurons. We conducted a search on N-PYCs using some scientific platforms, such as Google Scholar, PubMed, Web of Science, Scopus, and Google, as well as analyzing 173 papers published between 2000 and 2024. We also looked at how N-PYCs work, how their structure affects their activity, and their therapeutic potential. The findings show that these natural products have the function to treat a wide range of illnesses. For instance, they have been shown to fight cancer by inducing apoptosis, and their antioxidant activity is achieved by lowering the production of reactive oxygen species inside cells. Also, N-PYCs work well against diabetes mellitus by mitigating glucose absorption and lowering oxidative stress. Furthermore, they achieved the anti-inflammatory effect by inhibiting the induction of inflammatory mediators. Lastly, they showed strong antimicrobial activity and interesting MICs, in addition to protecting neurons from damage. This study highlights the crucial importance of N-PYCs in medicinal chemistry and drug development. These natural products have potential for use in medicine because they can easily undergo structural modification and perform a variety of biological functions. However, more research is needed to go from studying them in nature to using them in medicine.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100785"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shikimic acid, a phenolic acid reverses isoproterenol-induced myocardial infarction in rat model","authors":"Mudassir Khattak ,&nbsp;Irfan Amir Khan ,&nbsp;Nabi Shah ,&nbsp;Saud A Abdulsamad ,&nbsp;Abdulghani A Naeem ,&nbsp;Abdul Jabbar Shah","doi":"10.1016/j.phyplu.2025.100788","DOIUrl":"10.1016/j.phyplu.2025.100788","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial infarction (MI), a leading cause of death in ischemic heart disease, may be mitigated by natural phenolic acids due to their antioxidant properties. This study investigates the cardioprotective role of shikimic acid (SA) against isoproterenol (ISO)-induced myocardial infarction in rats.</div></div><div><h3>Methods</h3><div>Rats were divided into six groups; all received ISO (85 mg/kg/day, s.c) on days 6 and 7, except the control (normal saline). Groups III-V received SA (10, 30, and 50 mg/kg/day, i.p) for seven days, while group VI was given atenolol (10 mg/kg/day, i.p). In-vitro studies were performed on isolated rat aortic rings and right atrium.</div></div><div><h3>Results</h3><div>SA pretreatment significantly prevented ISO-induced ECG changes (ST elevation, pathological Q wave), reduced cardiac biomarkers (cTnI, CPK, LDH, AST), improved heart histology, and increased tissue viability. Similarly, SA also showed a significant vasorelaxant effect against phenylephrine-induced precontraction, probably by inhibiting the receptor operated Ca²⁺ channels without having effect on voltage-dependent Ca²⁺ channels. SA showed mild negative chronotropic and ionotropic effects, potentially reducing MI-related cardiac workload.</div></div><div><h3>Conclusion</h3><div>These results indicate that SA preventing MI in rats through improving ECG, cardiac biomarkers and histopathological changes; the effect of SA may be attributed to the decrease in Ca²⁺movement and cardiac workload.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100788"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial and antioxidant potential of Streptomyces spp isolated from the rhizosphere of Origanum majorana in Lebanon","authors":"Mona Tfaily,&nbsp;Jamilah Borjac","doi":"10.1016/j.phyplu.2025.100781","DOIUrl":"10.1016/j.phyplu.2025.100781","url":null,"abstract":"<div><h3>Background</h3><div>The increasing threat of multidrug-resistant bacteria highlights the critical requirement for the development of new and effective antibiotics from natural sources. <em>Actinobacteria</em> are main producers of natural products to treat various diseases.</div></div><div><h3>Purpose</h3><div>This study aimed to isolate <em>Actinobacteria</em> from the rhizosphere of <em>Origanum majorana</em>, characterize them, and test the antimicrobial activity of their metabolites.</div></div><div><h3>Methods</h3><div>Rhizospheric soil samples surrounding <em>O. majorana</em> plants were collected from 4 locations in Lebanon. The physicochemical characteristics of the soil were studied. Twenty <em>Actinobacteria</em> were chosen for primary screening against different bacterial pathogens using cross streak method and were identified based on morphological and biochemical characteristics. Two <em>Actinobacteria</em> that we coded as WP and OP were chosen for secondary metabolites’ extraction, followed by antibacterial, antioxidant, and hemolysis assessments. These strains were identified using 16S rRNA sequencing.</div></div><div><h3>Results</h3><div>The lowest minimum inhibitory concentration for WP and OP metabolites were 47 and 94 µg/ml respectively against <em>Staphylococcus aureus</em>. WP showed significant biofilm inhibition reaching 95.47 % against <em>S. aureus</em>. WP exhibited similarity with <em>Streptomyces tuirus</em> while OP was similar to <em>Streptomyces</em> sp. OGA5 (99 % and 98 %, respectively). Their metabolites demonstrated time and dose-dependent activities against the tested bacteria. They did not show any haemolytic activity against human erythrocytes even at high concentrations. WP extract exhibited 91.25 % free radicals scavenging activity at 50 mg/ml.</div></div><div><h3>Conclusion</h3><div>The distribution of <em>Actinobacteria</em> is influenced by the physicochemical parameters of soil. <em>S. tuirus</em> produces potent bioactive compounds with promising antibacterial activity making it a valuable source to produce antimicrobial agents.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100781"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals of Callisia fragrans exhibit significant antimicrobial, pro-wound-healing, and anti-inflammatory properties","authors":"Arik Dahan ,&nbsp;Ludmila Yarmolinsky ,&nbsp;Arie Budovsky ,&nbsp;Boris Khalfin ,&nbsp;Shimon Ben-Shabat","doi":"10.1016/j.phyplu.2025.100780","DOIUrl":"10.1016/j.phyplu.2025.100780","url":null,"abstract":"<div><h3>Background</h3><div><em>Callisia fragrans</em> is a known plant in folk medicine but poorly explored from a scientific perspective.</div></div><div><h3>Purpose</h3><div>The aims of this research were to identify the major phytochemicals of this plant, and to investigate them with regards to antimicrobial, pro-wound healing, and anti-inflammatory properties<em>.</em></div></div><div><h3>Methods</h3><div>Liquid chromatography–electrospray ionization-mass spectrometry (LC-ESI-MS), and high-performance liquid chromatography (HPLC) were used for phytochemical analysis; antimicrobial activity studies included estimation of eradication of the drug-resistant microorganisms and biofilm formation; human dermal fibroblasts were applied for research of pro-wound healing (WH) and anti-inflammatory properties. For bioinformatical assessment, we selected the STITCH database found at <span><span>http://stitch.embl.de/</span><svg><path></path></svg></span>.</div></div><div><h3>Results</h3><div>Seven phytochemical constituents: quinic acid, chlorogenic acid, 4-<em>O</em>-caffeoylquinic acid, 5-<em>O</em>-caffeoylquinic acid, rosmarinic acid, quercetin 3-<em>O</em>-rutinoside and farrerol were successfully identified. The crude extract and quinic acid, chlorogenic acid, 4-<em>O</em>-caffeoylquinic acid, 5-<em>O</em>-caffeoylquinic acid, rosmarinic acid and farrerol were found to exhibit significant antimicrobial effect against antibiotic-resistant <em>Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Serratia marcescens</em> and <em>S. enteritidis</em>. The extract and some phytochemicals of <em>C. fragrans</em> inhibited the growth of biofilm-producing bacterium, while the effect of the extract was greater than that of the positive control streptomycin. The extract, chlorogenic acid and rosmarinic acid significantly enhanced wound healing in the scratch assay (<em>p</em>&lt;0.001). Finally, the extract and identified phytoconstituents exhibited significant anti-inflammatory effects mediated by reduced secretion of IL-6 and IL-8 cytokines in human dermal fibroblasts.</div></div><div><h3>Conclusions</h3><div>This research revealed convincing and promising indications of significant therapeutic potential of <em>C. fragrans</em> extract and its active phytochemicals.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100780"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosomes: A promising nanocarrier system for enhanced bioavailability and therapeutic efficacy of herbal products","authors":"Marjan Talebi ,&nbsp;Kimia Shahbazi ,&nbsp;Mohammad Sedigh Dakkali ,&nbsp;Marziyeh Akbari ,&nbsp;Rouzbeh Almasi Ghale ,&nbsp;Seyedali Hashemi ,&nbsp;Mahdyeh Sashourpour ,&nbsp;Faraz Mojab ,&nbsp;Saeed Aminzadeh","doi":"10.1016/j.phyplu.2025.100779","DOIUrl":"10.1016/j.phyplu.2025.100779","url":null,"abstract":"<div><h3>Background</h3><div>Herbal products have revealed a variety of therapeutic potential in numerous health conditions. However, limitations regarding their solubility, absorption, bioavailability, and stability have hindered clinical translations. Among various strategies to combat these challenges, using phytosomes as a nanocarrier system has presented a promising approach to enhance the bioavailability and effectiveness of phytoconstituents.</div></div><div><h3>Purpose</h3><div>This study comprehensively reviews the development, preparation, and advantages of phytosomes as a novel nanodelivery system, focusing on overcoming the pharmacokinetic limitations of phytoconstituents.</div></div><div><h3>Methods</h3><div>A scientific literature search was conducted using databases including PubMed, Web of Science, Scopus, and Google Scholar. Keywords such as “phytosome,” “herbasome,” “herbal drug delivery,” and “phospholipid complex” were employed to identify appropriate scientific articles.</div></div><div><h3>Results</h3><div>Phytosomal delivery systems have demonstrated significant improvements in bioavailability, therapeutic outcomes, stability, and targeted distribution of herbal products. Compared to other delivery systems like liposomes, phytosomes exhibit superior pharmacokinetic profiles and distribution efficiency. They show promise in enhancing bioavailability and enabling diverse routes of administration, including oral, topical, and intranasal. They also have numerous therapeutic applications in inflammatory diseases, neurological disorders, cancers, metabolic syndrome, and liver diseases.</div></div><div><h3>Conclusion</h3><div>Phytosomal delivery systems effectively address the pharmacokinetic challenges of herbal products, offering improved bioavailability, stability, and therapeutic outcomes.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100779"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antiepileptic properties of herbal mix of different combinations by PTZ-induced mouse model","authors":"P.S. Venkatesan ,&nbsp;S. Sundaresan ,&nbsp;M. Eswarya ,&nbsp;M. Madhavaselvi ,&nbsp;R. Renuka","doi":"10.1016/j.phyplu.2025.100773","DOIUrl":"10.1016/j.phyplu.2025.100773","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is a neurological disorder characterized by convulsive seizures. Between 50 and 70 million people worldwide are impacted, and safer medications with superior anticonvulsant qualities and greater accessibility are still needed. Antiepileptic drug (AED) side effects continue to be a significant concern despite advances in pharmacotherapy, as they can lower quality of life and adherence. Herbal medicines are becoming more and more popular as complementary and alternative therapies as a result.</div></div><div><h3>Methods</h3><div>Using a mouse seizure model caused by PTZ (Pentylenetetrazole) of dose 120 mg/kg.b.wt, this study examines the anticonvulsant efficacy of a traditional medicinal plant called <em>Withania somnifera, Matricaria recutita and Evolvulus alsinoides</em> which are commonly called as Ashwagandha, Chamomile and Morning glory respectively. The herb was mixed with 1.5 % Carboxymethyl cellulose (CMC) and given to mice with various dosage levels and in combination.</div></div><div><h3>Results</h3><div>The study demonstrates that <em>Evolvulus alsinoides, Withania somnifera</em>, and <em>Matricaria recutita</em>, possesses significant anticonvulsant properties in a PTZ-induced seizure model in mice. Combination of all three showed highest latency of 168.25 ± 30.4s and seizure period of 3.82 ± 7.65 s</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100773"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}