Phytomedicine Plus最新文献

{"title":"Evaluation of antioxidant and liver protective activity of ethanolic extract of Vitex peduncularis wall (Lamiaceae) stem bark against carbon tetrachloride (CCl4) induced liver damage using in –vitro, in- vivo and in-silico approaches","authors":"Sheuly Akter ,&nbsp;Bidduth Kumar Sarkar ,&nbsp;Md Mehedi Hasan ,&nbsp;Foyaj Ahmmed ,&nbsp;Papia Nasrin ,&nbsp;Gazi Mohammad Al Shajib ,&nbsp;Shaikh Jamal Uddin ,&nbsp;Fahmida Zaman ,&nbsp;Sukalyan Kumar Kundu ,&nbsp;Jamil Ahmad Shilpi","doi":"10.1016/j.phyplu.2025.100867","DOIUrl":"10.1016/j.phyplu.2025.100867","url":null,"abstract":"<div><div>Various components of <em>Vitex peduncularis</em> Wall are traditionally employed for treating jaundice (bark), urethritis (bark), heavy menstrual bleeding (root), diabetes, and malaria (leaves, bark) in Rangamati, Bangladesh. To validate the therapeutic claim of this plant, current work has conducted various phytochemical and pharmacological investigations to assess the liver protective and antioxidant activities of the ethanol extract from the stem bark of <em>Vitex peduncularis</em>. In carbon tetrachloride (CCl₄) induced hepatic damage test using Sprague-Dawley rats, the extracts at a dose of 250 and 500 mg/kg were administered orally once daily. The markedly increased serum enzyme levels were significantly returned to near-normal levels by the extracts. The level of protection was assessed by quantifying biochemical indicators such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alanine phosphatase (ALP). Silymarin served as a standard reference and demonstrated considerable hepatoprotective efficacy against carbon tetrachloride-induced hepatotoxicity in rats. The findings of this study clearly demonstrate that Vitex peduncularis stem bark possesses significant liver protective effects against carbon tetrachloride-induced liver injury in rats, with statistically significant results (<em>P</em>&lt;0.001). When doing the DPPH scavenging experiment, it was revealed that the extract had an IC₅₀ value of 289.170 µg/ml. When the dried plant material was examined, it was discovered that the phenolic content, flavonoid content and tanin contents were 78.408 mg GAE/g, 89.983 mg QE/g and 84.983 mg GAE/g respectively. The SC₅₀ of the extract was determined to be 185.092 mg/l when it was subjected to the H₂O₂ scavenging assay. Luteolin, Ursolic acid, Friedelinol, and Epifriedelinol are the compounds that have been identified as being responsible for the antioxidant and in vivo liver protective potential of <em>Vitex peduncularis</em> bark extract. This is indicated by the presence of a number of notable phytochemicals and the in-silico docking study that was performed using these compounds. The potential for free radical scavenging capacity that is brought about by the presence of flavonoids in the extracts is one of the possible mechanisms that could be responsible for this therapeutically potential action. It is necessary to conduct additional research in order to investigate the precise mechanism of action and phytoconstituents that are responsible for the pharmacological response.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100867"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Gentisic acid's protective effects on scopolamine-induced Alzheimer’s disease in male mice","authors":"Marjan Gholami ,&nbsp;Shadi Sarahroodi ,&nbsp;Saeid Abbasi-Maleki","doi":"10.1016/j.phyplu.2025.100872","DOIUrl":"10.1016/j.phyplu.2025.100872","url":null,"abstract":"<div><h3>Introduction</h3><div>Alzheimer’s disease (AD) has detrimental effects on behavioral responses and antioxidant status, and the use of gentisic acid (GA) may help alleviate these adverse effects due to its antioxidant properties. We evaluated the impact of GA on behavioral and antioxidant responses in mice.</div></div><div><h3>Methods</h3><div>In this experimental-laboratory study, 36 male NMRI mice were allocated to 6 groups (<em>n</em> = 6), including control groups, scopolamine (SC; 1 mg/kg), rivastigmine (Riv; 2.5 mg/kg), and different doses of GA (112.5, 225, and 450 mg/kg). The therapies were administered orally for 14 continuous days. Behavioral tests, including the passive avoidance test (PAT), the elevated plus maze test (EPM), and the open-field test (OFT), were conducted. Finally, blood and tissue samples were collected to evaluate the changes in antioxidants, and histopathological analysis was performed sequentially.</div></div><div><h3>Results</h3><div>GA could significantly improve memory and cognitive disorders, prevent nerve damage, and maintain the weight of the mice, as well as the normal histological characteristics of the hippocampus (<em>P</em> &lt; 0.05). Additionally, GA increased serum levels of catalase (CAT) and glutathione (GSH) while decreasing nitric oxide (NO) levels. The high dose of GA (450 mg/kg) exhibited the maximum therapeutic effect.</div></div><div><h3>Conclusion</h3><div>GA may be useful in the treatment of AD due to its antioxidant effects. Nonetheless, further research is needed to determine the exact anti-Alzheimer's mechanism of this compound. This study was conducted on mice, and the results cannot be generalized to humans.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100872"},"PeriodicalIF":0.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apigenin and its derivatives in breast cancer prevention and therapy: a review on bioavailability and recent developments","authors":"Ghumika Pandita ,&nbsp;Disha Mittal ,&nbsp;Piyush Kashyap ,&nbsp;Wing-Fu Lai ,&nbsp;Naveen Kumar ,&nbsp;Rahul Mehra ,&nbsp;Mohd Adnan ,&nbsp;Syed Amir Ashraf","doi":"10.1016/j.phyplu.2025.100870","DOIUrl":"10.1016/j.phyplu.2025.100870","url":null,"abstract":"<div><div>Breast cancer has emerged as the most prevalent cancer and the leading contributor to cancer-related fatalities among women worldwide. The treatments directed at primary breast tumors have significantly advanced; however, those aimed at elusive micro-metastases have shown comparatively lower effectiveness. In this regard, bioactive compounds specifically flavonoids derived from plants have gained worldwide attention due to their potential in cancer chemoprevention and treatment. Among them, Apigenin (APN), a flavonoid rich in several fruits, vegetables, and herbs, has been studied extensively for its possible role in treating and preventing breast cancer. This review discusses APN and its derivatives anticancer activity, including their molecular mechanisms, therapeutic effects, and latest developments in improving bioavailability. The anti-proliferative, pro-apoptotic, anti-inflammatory, and antimetastatic activity of APN are mediated through signal transduction pathways such as PI3K/Akt, MAPK, and NF-κB. APN found to initiates apoptosis, suppresses cell proliferation, prevents cell cycle progression, and inhibits metastasis and angiogenesis in different breast cancer models, including triple-negative breast cancer (TNBC). Even though preclinical studies of APN are promising but the clinical use of it is limited due to its poor solubility, low bioavailability, fast metabolism, and low absorption. To address these limitations, researchers have created derivatives (such as methylated or glycosylated versions) with enhanced stability and activity, and nanoformulations such as liposomes, lipid nanoparticles, and micelles for improved solubility, degradation resistance, and targeted delivery. As a results, APN and its derivatives are highly promising for breast cancer prevention and treatment. More research on delivery systems and modifications of their structures is critical for improving their clinical effectiveness. Thus, the focus of this review is also on recent mechanisms of action, bioavailability problems, and formulation approaches for eventual clinical applications. The future needs to focus on clinical trials and combination therapy in order to maximize their therapeutic potential.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100870"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective mechanism of salidroside derivative SHPL-49 involves amelioration of brain lipid metabolism disorder to mitigate ferroptosis in a rat model of pMCAO","authors":"Ruyi Wang,&nbsp;Yue Shen,&nbsp;Dong Xie,&nbsp;Zhirui Zheng,&nbsp;Yuying Zhu,&nbsp;Pei Zhang,&nbsp;Jiange Zhang","doi":"10.1016/j.phyplu.2025.100871","DOIUrl":"10.1016/j.phyplu.2025.100871","url":null,"abstract":"<div><div>Ischemic stroke, characterized by high incidence and mortality, severely endangers human health. This study investigated the neuroprotective potential of salidroside derivative SHPL-49 (NB-SHPL-49-A-3, Supplementary Material 1). Male Sprague-Dawley rats with permanent middle cerebral artery occlusion (pMCAO) received oral SHPL-49 at 60 mg/kg and 90 mg/kg for 14 days, with Butylphthalide (NBP) as a positive control. In vivo, neurological function, infarct volume, cognitive ability, and grip strength were evaluated, and lipid metabolism and the ferroptosis-related ACSL4-GPX4 pathway were analyzed. In vitro PC12 cell oxygen-glucose deprivation (OGD) models were established. Results showed that 90 mg/kg SHPL-49 significantly improved neurological and cognitive functions, reduced infarct volume, regulated lipid metabolism, and inhibited ferroptosis via the ACSL4-GPX4 pathway. In conclusion, 90 mg/kg oral SHPL-49 protected against neurodegeneration and reversed lipid metabolism disorder in ischemic stroke rats.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100871"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of combined treatment with chlorogenic acid and 5-fluorouracil in colorectal cancer through Wnt/β-catenin pathway modulation","authors":"Ana María Sepúlveda ,&nbsp;Ana María Castañeda-Cifuentes ,&nbsp;Diego Uribe,&nbsp;Gloria A. Santa-González,&nbsp;Johanna Pedroza-Díaz","doi":"10.1016/j.phyplu.2025.100868","DOIUrl":"10.1016/j.phyplu.2025.100868","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) has become a significant public health concern due to its rising incidence and mortality rates. Given the limitations of chemotherapy, exploring novel therapeutic strategies is essential. The Wnt/β-catenin pathway is often deregulated in CRC, contributing to its development and progression. Chlorogenic acid has demonstrated a promising modulatory effect on this pathway.</div></div><div><h3>Purpose</h3><div>In this context, this study evaluated the effect of chlorogenic acid in combination with the chemotherapeutic 5-fluorouracil on cell viability and proliferation, as well as on the modulation of the Wnt/β-catenin pathway.</div></div><div><h3>Study design</h3><div>Combined treatments were performed on CRC cell lines SW480 and HT-29. Both lines exhibit alterations in the <em>APC</em> gene, a key component of the Wnt/β-catenin pathway; however, SW480 displays higher transcriptional activity of the pathway.</div></div><div><h3>Methods</h3><div>Cellular and molecular biology techniques were employed in this study. The MTT assay was used to assess cell viability, while flow cytometry was used to analyze cell cycle progression as a measure of cellular proliferation. qRT-PCR was conducted to quantify the expression of genes involved in the Wnt/β-catenin signaling pathway and its target genes. Western blotting was performed to measure β-catenin protein levels, and fluorescence microscopy was applied to evaluate the fluorescence intensity and cellular localization of β-catenin.</div></div><div><h3>Results</h3><div>The results showed that co-treatment decreased cell viability and altered the cycle in both lines, with SW480 cells showing greater sensitivity. Furthermore, differential modulation of pathway-related gene expression levels was observed, including decreased β-catenin and TCF7L2. Changes in the expression of genes associated with drug resistance and tumor metabolism were also identified, significant decreases of <em>ABCG2</em> in HT-29 and of <em>SLC16A1</em> in SW480.</div></div><div><h3>Conclusion</h3><div>The results suggest that chlorogenic acid enhances the efficacy of conventional therapy by modulating the Wnt/β-catenin pathway, which could potentially impact the carcinogenesis of CRC.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100868"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging","authors":"Boyu Chen ,&nbsp;Jiaxin Liu ,&nbsp;Xu Dai ,&nbsp;Lufan Xu ,&nbsp;Wenying Cui ,&nbsp;Rouan Chen ,&nbsp;Tian Lan ,&nbsp;Yiider Tseng","doi":"10.1016/j.phyplu.2025.100869","DOIUrl":"10.1016/j.phyplu.2025.100869","url":null,"abstract":"<div><h3>Background</h3><div><em>Artemisia argyi</em> (<em>A. argyi</em>), a pivotal herb extensively used in moxibustion therapy, has long been widely recognized in Traditional Chinese Medicine (TCM) for its significant clinical efficacy. Since the therapeutic effects of a drug are inherently linked to its chemical composition, the identification of potential active compounds in <em>A. argyi</em> leaves becomes one of the priorities for continuously advancing moxibustion.</div></div><div><h3>Purpose</h3><div>Hence, this study aims to extract key bioactive compounds contributing to its medicinal properties by performing data mining from literature. Three criteria, commonality, authenticity and aging, are applied to identify the common compounds across different regions; the superior compounds unique to the authentic Qichun <em>A. argyi</em> leaves; and the distinctive compounds emerging during the aging process.</div></div><div><h3>Methods</h3><div>Data-driven approaches, which have been developed through decades of literature mining, are grounded in conventional evaluation principles of commonality, authenticity, and aging. The therapeutic effects of bioactive compounds have been verified using 3 individual rheumatoid arthritis (RA)-associated primary fibroblast-like synovial cells (FLS) with 3 times. The anti-proliferative effects were assessed utilizing the CCK-8 assay and the real-time cell analysis (RTCA) system. In addition, the anti-invasive effects were also evaluated through RTCA, while the anti-inflammatory effects were investigated using enzyme-linked immunosorbent assays (ELISA).</div></div><div><h3>Results</h3><div>Our work highlights the potential key functional compounds of <em>A. argyi</em> leaves, including volatile substances, including 1,8-Cineole, <em>β</em>-Caryophyllene, <em>p</em>-Cymene and Caryophyllene oxide, as well as non-volatile compounds, including Eupatilin, Isochlorogenic acid C, Isochlorogenic acid A, and Vitexin. We further validated the anti-proliferative, anti-invasive and anti-inflammatory effects of these compounds on RA-FLS <em>in vitro</em>, demonstrating their therapeutic potential in RA.</div></div><div><h3>Conclusion</h3><div>This approach, established by three criteria, commonality, authenticity and aging, has identify bioactive compounds in <em>A. argyi</em> that may play a therapeutic role by altering the pathologic phenotype of cells. This study provides insights towards pharmacological research of <em>A. argyi</em> and elucidates unknown therapeutic mechanisms against RA.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100869"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of evidence on efficacy and safety of indian traditional medicine (AYUSH) for COVID-19: Protocol for a country-specific qualitative review and evidence map synthesis","authors":"Azeem Ahmad ,&nbsp;Manohar S. Gundeti ,&nbsp;Meena R ,&nbsp;Eugene Wilson ,&nbsp;Malik Itrat ,&nbsp;Ghazala Javed ,&nbsp;Mohd Aleemuddin Quamri ,&nbsp;Deepti Singh Chalia ,&nbsp;Pooja Yadav ,&nbsp;Athul T P ,&nbsp;Karthik K P ,&nbsp;Anjana C S ,&nbsp;Mythri H S ,&nbsp;Aparna Dileep ,&nbsp;Shifa Shetty P ,&nbsp;Galib R","doi":"10.1016/j.phyplu.2025.100866","DOIUrl":"10.1016/j.phyplu.2025.100866","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic caught the world off guard despite the advanced medical systems and public health strategies. Throughout the pandemic, researchers have actively investigated the role of traditional medicines in the treatment of COVID-19. In India, where there is a rich heritage of traditional therapeutic practices encompassed under AYUSH, each system has assessed the efficacy of its remedies during this challenging time.</div></div><div><h3>Objective</h3><div>The aim of our study protocol is to develop a comprehensive framework for conducting a qualitative review of available studies, synthesizing an evidence map regarding the efficacy and safety of AYUSH interventions in managing COVID-19.</div></div><div><h3>Study design</h3><div>A systematic review without meta-analysis study design was undertaken for this study.</div></div><div><h3>Methods</h3><div>This protocol has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols (PRISMA-P) guidelines. A thorough search will be conducted across selected databases based on a well-defined search strategy. A predetermined set of inclusion criteria will guide the selection of studies for quality appraisal, and data extraction will be performed manually. The quality of the included studies will be evaluated using specific assessment tools developed by the National Institutes of Health (NIH).</div></div><div><h3>Results</h3><div>The protocol deveopment and the initial search process for the identification of potential studies were completed in January 2024. From February to May, two independent reviewers screened the titles and abstracts. The pilot data extraction was finalized in the first week of June 2024. Any issues encountered during the data extraction process were resolved, and the formal screening and data extraction were completed in June. Presently, the review team has started the quality assessment of the included studies.</div></div><div><h3>Conclusion</h3><div>The findings of the study will not only inform practitioners and researchers but also significantly contribute to a broader understanding of integrative health strategies, potentially shaping future approaches to public health crisis.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100866"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Herbal Marker Ranking System (Herb MaRS) affords chemical markers for the standardization of medicinal plants used for male vitality herbal products","authors":"Isaac Kingsley Amponsah ,&nbsp;Flavia Yeboah Owusu ,&nbsp;Joseph Adusei Sarkodie ,&nbsp;Desmond Nkrumah ,&nbsp;Emmanuel Quaye Kontoh ,&nbsp;Anita Nana Abla Oscar Akotey ,&nbsp;Kennedy Ameyaw Baah","doi":"10.1016/j.phyplu.2025.100864","DOIUrl":"10.1016/j.phyplu.2025.100864","url":null,"abstract":"<div><div>The concept of chemical markers in herbal products was introduced to address the lack of standardisation, which is a major obstacle to their wider acceptance and use. However, the selection of these markers has often been based on empirical observations rather than a systematic scientific approach. This study aimed to apply the Herbal Marker Ranking System (Herb MaRS) to identify the most suitable chemical markers for constituent plants of male vitality herbal products in Ghana, for quality control purposes. A cross-sectional survey of products from pharmacies and herbal shops was conducted. A desktop survey was performed on medicinal plants on the product labels, analysing their isolated compounds, bioactivity, toxicity, commercial availability, analytical methods, and concentration of compounds in the plant materials. Herb MaRS scoring assigned 0 or 2 points for sexual enhancing activity; 1 point for symptom management; 1–3 points for concentration of compound in the plant; and 1 point each for the commercial availability of reference standards and analytical methods. Compounds with toxic effects were assigned 8 points. Those that scored 8 were deemed the most suitable markers, while those scoring 4 were regarded as adequately suitable. The selected markers include macamides (<em>Lepidium meyenii</em>), reserpine (<em>Rauvolfia vomitoria</em>), ginsenosides Rb1 (<em>Panax ginseng</em>), ginsenosides Rg1 (<em>Panax ginseng</em>), quercetin, kaempferol, bilobalide, ginkgolides (<em>Ginkgo biloba</em>), asiaticoside, madecassoside, catechin (<em>Centella asiatica</em>), 6-shogaol and 6-gingerol (<em>Zingiber officinale</em>), representing suitable compounds for standardising products incorporating these plant materials. Herb MaRS is an effective tool for selecting chemical markers to ensure quality control of herbal products.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100864"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacopa monnieri, a wonder plant in the backyard: Emphasizing the role of the microbiome in increasing its potential","authors":"Himani Barthwal ,&nbsp;Charu Sharma ,&nbsp;Vijay Kumar ,&nbsp;Vishal Rajput ,&nbsp;Bindu Naik ,&nbsp;Shivesh Sharma ,&nbsp;Sushila Devi ,&nbsp;Vivek Kumar","doi":"10.1016/j.phyplu.2025.100865","DOIUrl":"10.1016/j.phyplu.2025.100865","url":null,"abstract":"<div><div>Recently, the utilization of natural or herbal products has increased worldwide. Various naturally isolated plant products have been assessed as therapeutics for the treatment of a variety of diseases. Microbes are related to medicinal plants and have enormous potential in the context of promoting plant growth traits and producing active ingredients of therapeutic importance. <em>Bacopa monnieri,</em> also called ‘Brahmi’ and water hyssop, has been utilized extensively in the ayurvedic system of medicine for a long time. Phytochemical investigations of <em>B. monnieri</em> extracts have revealed the occurrence of several active compounds, such as bacosides, alkaloids and triterpenoids. All these active chemical ingredients act as the best memory enhancer and are also used for various illnesses. The microbially mediated production of novel secondary metabolites with key biological activities could be an alternative method to obtain bioactive ingredients. This review highlights the interactions between microbes and the medicinal plant <em>B. monnieri</em>, illuminating the creation of biologically active compounds with medicinal importance within the plant.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100865"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids and related compounds targeting pathomechanisms of Parkinson’s Disease – from bench to bedside: A focused review of current perspectives, clinical trial outcomes, and future directions","authors":"Monika Figura ,&nbsp;Amos A. Fatokun","doi":"10.1016/j.phyplu.2025.100861","DOIUrl":"10.1016/j.phyplu.2025.100861","url":null,"abstract":"<div><h3>Background</h3><div>The pathomechanisms of Parkinson's Disease (PD) remain incompletely understood. Key mechanisms include oxidative stress, neuroinflammation, and mitochondrial dysfunction. Disease-modifying strategies are still being investigated. Flavonoids are suggested to be able to influence the neurodegenerative process, but clinical evidence is limited.</div></div><div><h3>Purpose</h3><div>This review explored current, key pre-clinical but mainly clinical evidence for the potential of flavonoids and related compounds in treating PD.</div></div><div><h3>Study design and Methods</h3><div>Retrospective analysis of ClinicalTrials.gov registry was performed with terms “Parkinson disease” and “parkinsonism”. For trials marked as “completed”, the results were searched in both the “ClinicalTrials” Database and PubMed. PubMed was also searched to identify original papers and meta-analyses of the effects of flavonoid intake in PD patients.</div></div><div><h3>Results</h3><div>2810 interventional studies were identified in the ClinicalTrials registry (<span><span>www.ClinicalTrials.gov</span><svg><path></path></svg></span>). A total of 18 trials were registered, with only 5 of them published as a full text article. Data from preclinical studies showed the promising effects of flavonoids in PD models. Animal studies data and data on flavonoids’ beneficial effects in population-based studies further confirmed their potential in reducing the risk of PD. However, a single, most efficacious flavonoid has yet to be identified.</div></div><div><h3>Conclusion</h3><div>Current evidence, including from epidemiological studies, suggests that diets rich in flavonoids can improve the course of PD. However, clinical trials data to date, which are quite limited, indicate no routine supplementation with flavonoids has proven useful so far in the specific context of eliciting neuroprotection as a primary outcome. More robust preclinical studies followed by more clinical trials are needed to generate sufficient and reliable data.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 4","pages":"Article 100861"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}