Frontiers in Nanotechnology最新文献_第2页

Direct quantification of hydrophobicity: a case study of environmentally relevant silver nanoparticles 疏水性的直接量化:环境相关银纳米粒子的案例研究

Frontiers in Nanotechnology Pub Date : 2023-10-02 DOI: 10.3389/fnano.2023.1271009

Francesco Roncari, Salimar Cordero, Cloé Desmet, Pascal Colpo, Boris L. T. Lau, Andrea Valsesia

{"title":"Direct quantification of hydrophobicity: a case study of environmentally relevant silver nanoparticles","authors":"Francesco Roncari, Salimar Cordero, Cloé Desmet, Pascal Colpo, Boris L. T. Lau, Andrea Valsesia","doi":"10.3389/fnano.2023.1271009","DOIUrl":"https://doi.org/10.3389/fnano.2023.1271009","url":null,"abstract":"Among the physical and chemical properties of nanomaterials, hydrophobicity is considered to play a key role in their impact on the environment. Changes in hydrophobicity resulting from abiotic and biotic processes can be used to predict the behaviours of nanoparticles (NPs) in the environment (e.g., aggregation, toxicity, and bioaccumulation). Hydrophobicity changes induced by sulfidation and natural organic matter (NOM) corona formation were evaluated by monitoring the binding rate of silver (Ag) NPs on engineered surfaces using dark-field microscopy (DFM). It was found that this DFM-based method was more capable of distinguishing the hydrophobicity of environmentally relevant AgNPs than the dye adsorption method. Under the conditions tested in this study, sulfidation and adsorption of sulfidized NOM/“lipid-free” (LF-)NOM increased the hydrophobicity of AgNPs. Both methods demonstrate the tendency of AgNPs to become more hydrophobic after sulfidation. This study shows that DFM-based methods can effectively measure the hydrophobicity of environmentally relevant NPs and have the potential to be widely used as fate predictors in the future.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135899715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culturing cells for life: innovative approaches in macroscopic and microfluidic cultures, with an emphasis on stem cells 培养生命细胞:宏观和微流体培养的创新方法，重点是干细胞

Frontiers in Nanotechnology Pub Date : 2023-09-29 DOI: 10.3389/fnano.2023.1264498

Simona Badilescu, Subhathirai Subramaniyan Parimalam, Muthukumaran Packirisamy

{"title":"Culturing cells for life: innovative approaches in macroscopic and microfluidic cultures, with an emphasis on stem cells","authors":"Simona Badilescu, Subhathirai Subramaniyan Parimalam, Muthukumaran Packirisamy","doi":"10.3389/fnano.2023.1264498","DOIUrl":"https://doi.org/10.3389/fnano.2023.1264498","url":null,"abstract":"In 2006, Whitesides, writing about microfluidics, said that microfluidics is in early adolescence and it is not yet clear how it will develop. Today, almost 20 years later, microfluidics became a fully developed, highly sophisticated, multidisciplinary field that had entirely honoured its early promise. Its strength stems from the knowledge and know-how, coming from multiple disciplines such as physics of fluids, engineering, and microfabrication in the beginning, followed, more recently, by cell biological research, in full bloom nowadays. In microfluidic devices, the environment of cells such as chemical and mechanical gradients can be reproduced, making biological studies even more compelling. The red thread of this review paper follows the new insights and discoveries in both traditional macro- and microfluidic cell culture brought into the cell biology field, especially in the culture of stem cells, filled with promise in the field of regenerative medicine. Microfluidic devices provide an environment that is much closer to that of in vivo cell culture than the conventional culture platforms, where large amounts of cells are cultured and the environment of individual cells cannot be distinguished. The convenience of live cell imaging, portability, and the integration of sensors to precisely, control various parameters, has expanded cell biologists’ arsenal In addition, microfluidic devices, integrated with different functionalities, that is, the automated cell culture systems, will be discussed as well.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fine periodic nanostructure formation on stainless steel and gallium arsenide with few-cycle 7-fs laser pulses 7-fs激光脉冲在不锈钢和砷化镓表面形成精细周期纳米结构

Frontiers in Nanotechnology Pub Date : 2023-09-19 DOI: 10.3389/fnano.2023.1249648

Akihiro Ishihara, Godai Miyaji

引用次数: 0

The viewpoint of nanolipid vesicles (liposomes, exosomes, and microvesicles) as biosensors in medical health advances 纳米脂质囊泡(脂质体、外泌体和微囊泡)作为生物传感器在医学健康中的应用进展

Frontiers in Nanotechnology Pub Date : 2023-09-15 DOI: 10.3389/fnano.2023.1230407

Elham Ghazizadeh, Zahra Nasery

引用次数: 0

Detection and quantification of antiviral drug tenofovir using silver nanoparticles and surface enhanced Raman spectroscopy (SERS) with spatially resolved hotspot selection 利用纳米银粒子和具有空间分辨热点选择的表面增强拉曼光谱(SERS)检测和定量抗病毒药物替诺福韦

Frontiers in Nanotechnology Pub Date : 2023-09-12 DOI: 10.3389/fnano.2023.1270474

Marguerite R. Butler, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper

{"title":"Detection and quantification of antiviral drug tenofovir using silver nanoparticles and surface enhanced Raman spectroscopy (SERS) with spatially resolved hotspot selection","authors":"Marguerite R. Butler, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper","doi":"10.3389/fnano.2023.1270474","DOIUrl":"https://doi.org/10.3389/fnano.2023.1270474","url":null,"abstract":"This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS). Novel spatially resolved instrumentation for spectral acquisition and subsequent statistical analysis for hot spot selection was developed for convenient quantification of TFV in an aqueous matrix. Methods of statistical analysis include the use of partial least squares (PLS) regression vector analysis and spectral ranking by quality indices computed using CHAOS theory. Hydroxylamine-reduced Ag colloidal nanoparticles evaporated to dryness on an aluminum well-plate were used as the SERS substrate. To our knowledge, quantification of TFV down to 25 ng/mL by SERS, comprising clinically relevant concentrations, has not been previously reported. Furthermore, in this work we propose a novel method of quantification of aqueous TFV standards by SERS using statistical treatment of data by PLS and CHAOS theory. Based on these data, we propose future studies to develop a method of TFV detection and quantification in biological samples, beneficial to clinicians for rapid assessment of drug adherence during the treatment and prevention of viral diseases.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135884343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles 聚羟基烷酸酯和抗菌/抗病毒金纳米粒子的双重生产

Frontiers in Nanotechnology Pub Date : 2023-09-07 DOI: 10.3389/fnano.2023.1243056

Alexandra Paxinou, Elena Marcello, Vittoria Vecchiato, Lara Erman, Edward Wright, Brendon Noble, Adele McCormick, Pooja Basnett

引用次数: 0

Combining metal nanoparticles and nanobodies to boost the biomedical imaging in neurodegenerative diseases 结合金属纳米粒子和纳米体促进神经退行性疾病的生物医学成像

Frontiers in Nanotechnology Pub Date : 2023-09-04 DOI: 10.3389/fnano.2023.1236810

A. Sanna, A. Quarta, N. Pieroni, B. Parodi, F. Palermo, I. Bukreeva, M. Fratini, L. Massimi, D. Simeone, X. Le Guével, A. Bravin, E. Quintiero, I. Viola, G. Gigli, N. Kerlero de Rosbo, L. Sancey, A. Cedola

{"title":"Combining metal nanoparticles and nanobodies to boost the biomedical imaging in neurodegenerative diseases","authors":"A. Sanna, A. Quarta, N. Pieroni, B. Parodi, F. Palermo, I. Bukreeva, M. Fratini, L. Massimi, D. Simeone, X. Le Guével, A. Bravin, E. Quintiero, I. Viola, G. Gigli, N. Kerlero de Rosbo, L. Sancey, A. Cedola","doi":"10.3389/fnano.2023.1236810","DOIUrl":"https://doi.org/10.3389/fnano.2023.1236810","url":null,"abstract":"Introduction: In the study of neurodegenerative diseases, the possibility to follow the fate of specific cells or molecules within the whole body would be a milestone to better understand the complex evolution of disease mechanisms and to monitor the effects of therapies. The techniques available today do not allow the visualization of disease-relevant cells within the whole tridimensional biological context at high spatial resolution.Methods: Here we show the results from the first validation steps of a novel approach: by combining the conjugate nanobodies anti-glial fibrillary acidic protein (GFAP) and metal-nanoparticles (i.e. 2 nm gold NP) with X-ray phase contrast tomography (XPCT) we would be able to obtain a tridimensional visualization and identification of cells of interest together with the surrounding tissue and the vascular and neuronal networks.Results: By exploiting the X-ray attenuation properties of metal nanoparticles and the specific targeting capabilities of nanobodies, we could give XPCT the specificity it presently lacks, making it no longer a pure morphological but a molecular and targeted imaging technique. In our case, we synthesized and characterized Gold-NP/GFAP nanobody to target the astrocytes of mouse brain.Discussion: The results of the first tests presented in this paper have provided us with information on the feasibility of the approach, encouraging us to carry out further experiments in order to achieve the ultimate goal of setting up this new imaging technique.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47689320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A short appraisal of nanodiamonds in drug delivery and targeting: recent advancements 纳米金刚石在给药和靶向方面的研究进展

Frontiers in Nanotechnology Pub Date : 2023-08-30 DOI: 10.3389/fnano.2023.1259648

Dilpreet Singh, Supriya Ray

{"title":"A short appraisal of nanodiamonds in drug delivery and targeting: recent advancements","authors":"Dilpreet Singh, Supriya Ray","doi":"10.3389/fnano.2023.1259648","DOIUrl":"https://doi.org/10.3389/fnano.2023.1259648","url":null,"abstract":"Nanodiamonds have emerged as a powerful tool in the field of drug delivery, offering exciting recent advancements and promising future prospects. Recent research has focused on enhancing drug loading efficiency, targeted delivery, and precision medicine using nanodiamonds. Strategies such as surface functionalization, polymer coatings, and encapsulation techniques have been optimized to improve drug loading, stability, and controlled release. Nanodiamonds have shown potential in targeted drug delivery through the incorporation of targeting ligands, enabling site-specific drug delivery and improved therapeutic outcomes. Additionally, nanodiamonds allow for combination therapy by carrying multiple drugs simultaneously, opening avenues for synergistic treatments. Stimuli-responsive nanodiamonds have been developed for precise and controlled drug release. Overcoming biological barriers, such as the blood-brain barrier, has been investigated by modifying nanodiamonds’ surfaces. Recent studies have highlighted innovative strategies for loading a variety of therapeutic cargoes onto nanodiamond platforms, including small molecules, proteins, nucleic acids, and even gene-editing tools. Future prospects include the integration of nanodiamonds with emerging technologies and addressing biocompatibility and safety concerns. Despite the need for further research and clinical studies, the recent advancements and future prospects of nanodiamonds in drug delivery suggest their potential to revolutionize the field and enhance patient care.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46286525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identity crisis of nanostructures inside the human body: a perspective on inflammation 人体内纳米结构的身份危机:对炎症的看法

Frontiers in Nanotechnology Pub Date : 2023-08-22 DOI: 10.3389/fnano.2023.1256952

Sarmistha Saha, L. Saso

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Editorial: New generation nano-biomaterials and their potential application in drug delivery and bio-sensing 社论：新一代纳米生物材料及其在药物递送和生物传感中的潜在应用

Frontiers in Nanotechnology Pub Date : 2023-08-15 DOI: 10.3389/fnano.2023.1260792

Bijayananda Panigrahi, Suresh K. Verma, Sourav Das, Abhishek Kumar

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