Frontiers in Nanotechnology最新文献_第10页

Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release 无机纳米粒子增强的生物材料混合物：工程有效载荷释放

Frontiers in Nanotechnology Pub Date : 2022-10-04 DOI: 10.3389/fnano.2022.999923

Lucía Morillas-Becerill, L. De Cola, J. Zuidema

{"title":"Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release","authors":"Lucía Morillas-Becerill, L. De Cola, J. Zuidema","doi":"10.3389/fnano.2022.999923","DOIUrl":"https://doi.org/10.3389/fnano.2022.999923","url":null,"abstract":"There are many challenges in delivering active pharmaceutical ingredients from biomaterials, including retention of payload activity, accurate temporal release, and precise spatial administration, to name only a few. With our constantly increasing knowledge of biology and physiology, pathologies that require therapeutic interventions are becoming more understood. While the desired temporal and spatial administration of a therapy might be theorized, the ability to deliver an active therapeutic in a precise location during a specific time frame is often challenging. This has led researchers to develop hybrid biomaterials containing inorganic nanoparticles in order to combine the advantages of both inorganics and organics in payload delivery applications. Organic materials have many beneficial properties, including the ability to form networks and matrices to create three-dimensional structures from the nanometer to centimeter scale, biodegradability, the versatility to use both synthetic and natural precursors, and ease of chemical modifications, while inorganic materials offer highly controllable nanoscale features, can entrap and protect therapeutics, and have degradation properties that can be tightly regulated. Here in, we discuss the current state-of-the-art in active pharmaceutical ingredient delivery from biomaterial hybrids, demonstrate the added levels of control that these hybrid biomaterials offer, and give our perspective on future innovations in the field.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45168790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recommendation: Treatment of clinical long COVID encephalopathies with nasal administered mesenchymal stromal cell extracellular vesicles 建议:经鼻给药间充质间质细胞胞外囊泡治疗临床长冠脑病

Frontiers in Nanotechnology Pub Date : 2022-10-04 DOI: 10.3389/fnano.2022.987117

P. Askenase

{"title":"Recommendation: Treatment of clinical long COVID encephalopathies with nasal administered mesenchymal stromal cell extracellular vesicles","authors":"P. Askenase","doi":"10.3389/fnano.2022.987117","DOIUrl":"https://doi.org/10.3389/fnano.2022.987117","url":null,"abstract":"We propose therapy with extracellular vesicles (EVs) for dominant central nervous system aspects of chronic Long COVID Syndromes (LCS). These clinical conditions have a delayed onset of 1–3 months following the cessation of active SARS-CoV-2 virus infections that cause an acute disease called COVID-19. The therapy of LCS will be achieved by direct access to the central nervous system (CNS) by nasal administration of small EVs derived from Mesenchymal Stromal Cells (MSC). When administered nasally, they target CNS microglia and endothelia involved in LCS encephalopathy, as indicated by experimental animal models and human autopsy and spinal fluid studies. Underlying this approach is the discovery that MSC-sEV treatment for healing neuro injury targets, microglia, and macrophages that then likely release secondary trophic EVs that affect the local capillary endothelial cells to restore vascular integrity. It is postulated that the pathways of endothelial and neural pathologies in acute SARS-CoV-2 virus infections may carry over to produce underlying vascular and neurological defects mediating LCS that are susceptible to this proposed nasal therapy with MSC-sEVs.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47309373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Processing helix–coil transition data: Account of chain length and solvent effects 处理螺旋线圈过渡数据:考虑链长和溶剂效应

Frontiers in Nanotechnology Pub Date : 2022-10-04 DOI: 10.3389/fnano.2022.982644

K. Yeritsyan, M. Valant, A. Badasyan

引用次数: 1

Improved two-photon photopolymerisation and optical trapping with aberration-corrected structured light 用像差校正的结构光改进双光子光聚合和光学捕获

Frontiers in Nanotechnology Pub Date : 2022-10-04 DOI: 10.3389/fnano.2022.998656

D. Armstrong, A. Stilgoe, T. Nieminen, H. Rubinsztein-Dunlop

{"title":"Improved two-photon photopolymerisation and optical trapping with aberration-corrected structured light","authors":"D. Armstrong, A. Stilgoe, T. Nieminen, H. Rubinsztein-Dunlop","doi":"10.3389/fnano.2022.998656","DOIUrl":"https://doi.org/10.3389/fnano.2022.998656","url":null,"abstract":"We demonstrate the effectiveness of phase only aberration corrections of structured light and their application to versatile optical trapping setups. We calculate phase corrections before (ex-situ) and after (in-situ) a high numerical aperture microscope objective using a spatial light modulator (SLM), and investigate how these corrections can be used to improve the efficiency and resolution of micro-structures fabricated through two-photon-photopolymerisation (2PP). We apply a phase retrieval algorithm to correct for distortions in a femtosecond laser that enables the fabrication of 3D structures using as many as 50 simultaneous foci. The inclusion of aberration correction in the fabrication process shows improved confinement of optically trapped particles and more efficient polymerisation while minimising intensity variations at individual foci, which potentially damage the structure during fabrication. We find that phase corrections allow for consistent voxel sizes, increased sharpness, and an expanded effective printing range when using an SLM, while also allowing for closer proximity of individual trap foci, minimising interference effects that hinder fabrication resolution.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44484003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Applications of graphene-based composites in the anode of lithium-ion batteries 石墨烯基复合材料在锂离子电池负极中的应用

Frontiers in Nanotechnology Pub Date : 2022-09-05 DOI: 10.3389/fnano.2022.952200

Zhiming Liu, Yu Tian, Peng Wang, Guoxin Zhang

{"title":"Applications of graphene-based composites in the anode of lithium-ion batteries","authors":"Zhiming Liu, Yu Tian, Peng Wang, Guoxin Zhang","doi":"10.3389/fnano.2022.952200","DOIUrl":"https://doi.org/10.3389/fnano.2022.952200","url":null,"abstract":"Limited by the disadvantages of low theoretical capacity, sluggish lithium ion deintercalation kinetics as well as inferior energy density, traditional graphite anode material has failed to meet the ever-increasing specific energy demand for lithium-ion battery technologies. Therefore, constructing high-efficiency and stable anodes is of great significance for the practical application of lithium-ion batteries. In response, graphene-based composite anodes have recently achieved much-enhanced electrochemical performance due to their unique two-dimensional cellular lattice structure, excellent electrical conductivity, high specific surface area and superior physicochemical stability. In this review, we start with the geometric and electronic properties of graphene, and then summarize the recent progresses of graphene preparation in terms of both methods and characteristics. Subsequently, we focus on the applications of various graphene based lithium-ion battery anodes and their inherent structure-activity relationships. Finally, the challenges and advisory guidelines for graphene composites are discussed. This review aims to provide a fresh perspective on structure optimization and performance modulation of graphene-based composites as lithium-ion battery anodes.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47122378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SARS-CoV-2 and extracellular vesicles: An intricate interplay in pathogenesis, diagnosis and treatment SARS-CoV-2与细胞外囊泡:在发病、诊断和治疗中的复杂相互作用

Frontiers in Nanotechnology Pub Date : 2022-08-31 DOI: 10.3389/fnano.2022.987034

C. Sbarigia, D. Vardanyan, L. Buccini, S. Tacconi, L. Dini

{"title":"SARS-CoV-2 and extracellular vesicles: An intricate interplay in pathogenesis, diagnosis and treatment","authors":"C. Sbarigia, D. Vardanyan, L. Buccini, S. Tacconi, L. Dini","doi":"10.3389/fnano.2022.987034","DOIUrl":"https://doi.org/10.3389/fnano.2022.987034","url":null,"abstract":"Extracellular vesicles (EVs) are widely recognized as intercellular communication mediators. Among the different biological processes, EVs play a role in viral infections, supporting virus entrance and spread into host cells and immune response evasion. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became an urgent public health issue with significant morbidity and mortality worldwide, being responsible for the current COVID-19 pandemic. Since EVs are implicated in SARS-CoV-2 infection in a morphological and functional level, they have gained growing interest for a better understanding of SARS-CoV-2 pathogenesis and represent possible diagnostic tools to track the disease progression. Furthermore, thanks to their biocompatibility and efficient immune activation, the use of EVs may also represent a promising strategy for the development of new therapeutic strategies against COVID-19. In this review, we explore the role of EVs in viral infections with a focus on SARS-CoV-2 biology and pathogenesis, considering recent morphometric studies. The common biogenesis aspects and structural similarities between EVs and SARS-CoV-2 will be examined, offering a panoramic of their multifaceted interplay and presenting EVs as a machinery supporting the viral cycle. On the other hand, EVs may be exploited as early diagnostic biomarkers and efficient carriers for drug delivery and vaccination, and ongoing studies will be reviewed to highlight EVs as potential alternative therapeutic strategies against SARS-CoV-2 infection.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42162723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review 纳米材料在胶质母细胞瘤多形性诊断中的进展:综述

Frontiers in Nanotechnology Pub Date : 2022-08-31 DOI: 10.3389/fnano.2022.836802

L. A. Gusmão, F. S. Matsuo, H. F. Barbosa, A. Tedesco

引用次数: 2

Towards computational polar-topotronics: Multiscale neural-network quantum molecular dynamics simulations of polar vortex states in SrTiO3/PbTiO3 nanowires 迈向计算极性拓扑电子学:SrTiO3/PbTiO3纳米线中极性涡旋态的多尺度神经网络量子分子动力学模拟

Frontiers in Nanotechnology Pub Date : 2022-08-30 DOI: 10.3389/fnano.2022.884149

Thomas M Linker, S. Fukushima, R. Kalia, A. Krishnamoorthy, A. Nakano, K. Nomura, K. Shimamura, F. Shimojo, P. Vashishta

{"title":"Towards computational polar-topotronics: Multiscale neural-network quantum molecular dynamics simulations of polar vortex states in SrTiO3/PbTiO3 nanowires","authors":"Thomas M Linker, S. Fukushima, R. Kalia, A. Krishnamoorthy, A. Nakano, K. Nomura, K. Shimamura, F. Shimojo, P. Vashishta","doi":"10.3389/fnano.2022.884149","DOIUrl":"https://doi.org/10.3389/fnano.2022.884149","url":null,"abstract":"Recent discoveries of polar topological structures (e.g., skyrmions and merons) in ferroelectric/paraelectric heterostructures have opened a new field of polar topotronics. However, how complex interplay of photoexcitation, electric field and mechanical strain controls these topological structures remains elusive. To address this challenge, we have developed a computational approach at the nexus of machine learning and first-principles simulations. Our multiscale neural-network quantum molecular dynamics molecular mechanics approach achieves orders-of-magnitude faster computation, while maintaining quantum-mechanical accuracy for atoms within the region of interest. This approach has enabled us to investigate the dynamics of vortex states formed in PbTiO3 nanowires embedded in SrTiO3. We find topological switching of these vortex states to topologically trivial, uniformly polarized states using electric field and trivial domain-wall states using shear strain. These results, along with our earlier results on optical control of polar topology, suggest an exciting new avenue toward opto-electro-mechanical control of ultrafast, ultralow-power polar topotronic devices.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46101064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

12012 fundamental mechanisms behind nanotechnology applications in oil and gas: Emerging nano-EOR processes 12012纳米技术在石油和天然气中应用的基本机制：新兴的纳米EOR工艺

Frontiers in Nanotechnology Pub Date : 2022-08-26 DOI: 10.3389/fnano.2022.887715

Ningyu Wang, Yuzhou Zhao, M. Prodanović, M. Balhoff, C. Huh

引用次数: 1

Physical modeling of HZO-based ferroelectric field-effect transistors with a WO x channel 具有wox通道的hzo型铁电场效应晶体管的物理建模

Frontiers in Nanotechnology Pub Date : 2022-08-25 DOI: 10.3389/fnano.2022.900592

X. Wen, M. Halter, L. Bégon-Lours, M. Luisier

{"title":"Physical modeling of HZO-based ferroelectric field-effect transistors with a WO x channel","authors":"X. Wen, M. Halter, L. Bégon-Lours, M. Luisier","doi":"10.3389/fnano.2022.900592","DOIUrl":"https://doi.org/10.3389/fnano.2022.900592","url":null,"abstract":"The quasistatic and transient transfer characteristics of Hf0.57Zr0.43O2 (HZO)-based ferroelectric field-effect transistors (FeFETs) with a WO x channel are investigated using a 2-D time-dependent Ginzburg-Landau model as implemented in a state-of-the-art technology computer aided design tool. Starting from an existing FeFET configuration, the influence of different design parameters and geometries is analyzed before providing guidelines for next-generation devices with an increased “high (R H ) to low (R L )” resistance ratio, i.e., R H /R L . The suitability of FeFETs as solid-state synapses in memristive crossbar arrays depends on this parameter. Simulations predict that a 13 times larger R H /R L ratio can be achieved in a double-gate FeFET, as compared to a back-gated one with the same channel geometry and ferroelectric layer. The observed improvement can be attributed to the enhanced electrostatic control over the semiconducting channel thanks to the addition of a second gate. A similar effect is obtained by thinning either the HZO dielectric or the WO x channel. These findings could pave the way for FeFETs with enhanced synaptic-like properties that play a key role in future neuromorphic computing applications.","PeriodicalId":34432,"journal":{"name":"Frontiers in Nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41584164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1