Endocrine and Metabolic Science最新文献

{"title":"Acute and prolonged ketosis lower serum IGF-I levels in human subjects","authors":"Mads Svart ,&nbsp;Alisa D. Kjaergaard ,&nbsp;Thien Vinh Luong ,&nbsp;Lars C. Gormsen ,&nbsp;Niels Møller ,&nbsp;Jens Otto L. Jørgensen ,&nbsp;Esben Søndergaard","doi":"10.1016/j.endmts.2024.100207","DOIUrl":"10.1016/j.endmts.2024.100207","url":null,"abstract":"<div><h3>Objective</h3><div>Metabolic health and longevity are influenced by numerous factors including the growth hormone (GH) – insulin-like growth factor I (IGF<img>I) axis and ketone bodies (KB). However, data on the impact of KB exposure on GH and IGF-I levels are few.</div></div><div><h3>Design and patients</h3><div>To investigate the effect of acute and chronic KB exposure on GH and IGF-I levels in human subjects. GH and IGF-I levels were measured in three human studies: i) After a single oral ingestion of KB (36.5 g of Na-D/L-βOHB) vs. placebo in six healthy individuals; ii): after a three-week isocaloric ketogenic diet (KD) compared to a standard diet (SD) in 11 overweight individuals; and iii) in a genetic predisposition study using the specific genetic variants in the SCOT gene (rs7712274 and rs7728482), which is associated with ketonuria.</div></div><div><h3>Results</h3><div>A single oral KB ingestion significantly lowered serum IGF-I with 33 ng/ml (KB ingestion) vs 15 ng/ml (placebo), <em>P</em> = 0.01. Ketogenic diet significantly lowered serum IGF-I levels 111 ng/ml (KD) vs 125 ng/ml (SD), P = 0.01 in combination with a two-fold increase in serum GH 0.9 ng/ml to 1.8 ng/ml (KD) compared to 0.9 ng/ml to 0.4 ng/ml (SD), <em>P</em> = 0.03. Individuals with genetic predisposition to ketonuria had lower levels of IGF-I (β = −0.0068, SE = 0.0029, <em>P</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>KB exposure is associated with reduced serum IGF-I levels in the presence of non-suppressed or elevated GH levels. This observation points to a suppressive effect of KB on hepatic IGF-I production. The association between genetic predisposition to ketonuria and increased body size is unexpected and deserves further investigations.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and temporal trends of anemia in patients with thyroid disease: 1999–2018 NHANES","authors":"Juan Liu,&nbsp;Xin Wang,&nbsp;Liping Huang,&nbsp;Yanqiu Li,&nbsp;Mingliang Chen","doi":"10.1016/j.endmts.2024.100198","DOIUrl":"10.1016/j.endmts.2024.100198","url":null,"abstract":"<div><h3>Background</h3><div>Anemia and thyroid disease, both prevalent health conditions, often co-occur and may be easily overlooked, collectively imposing a significant burden on society. This study specifically investigated the prevalence and temporal trends of anemia among individuals with thyroid disease in the US population, shedding light on a critical intersection in public health.</div></div><div><h3>Methods</h3><div>Utilizing National Health and Nutrition Examination data from 10 survey cycles (1999<strong>–</strong>2018), this study included participants aged 20<strong>–</strong>85 years who self-reported a diagnosis of thyroid disease. Anemia was defined with a cutoff of 12 g/dL for women and 13 g/dL for men. The chi-square test compared prevalence across different categories and survey cycles. Data analysis employed R 4.3.2, with <em>P</em> &lt; 0.05 considered statistically significant.</div></div><div><h3>Results</h3><div>The median hemoglobin level among all individuals with thyroid disease was 13.6 g/dL. The overall prevalence of anemia among the US thyroid disease patients was 12.00 % (95 % CI: 10.96–13.09). A noteworthy upward trend in the prevalence of anemia among thyroid disease patients occurred during 1999<strong>–</strong>2008 (9.58 %, 95 % CI: 8.14<strong>–</strong>11.18) and 2009<strong>–</strong>2018 (13.68 %, 95 % CI: 12.26<strong>–</strong>15.21). Anemia incidence in individuals with thyroid disease was higher in females (9.05 %, 95 % CI: 8.14<strong>–</strong>10.02), the elderly population (7.98 %, 95 % CI: 7.12<strong>–</strong>8.91), individuals living alone (5.96 %, 95 % CI: 5.21<strong>–</strong>6.77), those with high body mass index (5.38 %, 95 % CI: 4.67<strong>–</strong>6.17), and non-Hispanic Whites (5.33 %, 95 % CI: 4.62<strong>–</strong>6.11).</div></div><div><h3>Conclusions</h3><div>The prevalence of anemia in the US population with thyroid disease was 12 %, indicating an increase over the past few decades.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term diabetic hyperglycaemia modifies social behaviour in rats","authors":"Justine Renaud ,&nbsp;Alexandre Clouet ,&nbsp;Giulia Costa ,&nbsp;Jimmy Beaulieu ,&nbsp;Domenico Sergi ,&nbsp;Maria-Grazia Martinoli","doi":"10.1016/j.endmts.2024.100197","DOIUrl":"10.1016/j.endmts.2024.100197","url":null,"abstract":"<div><div>Diabetes is a known risk factor for cognitive decline and mood disorders. However, the effects of long-term diabetic hyperglycaemia on the various dimensions of social behaviours, such as play or aggression, remains to be fully elucidated. In this study, we evaluated the social behaviour in a nicotinamide-streptozotocin rat model of long-term diabetic hyperglycaemia, in the absence of glucose-lowering treatments. Five months following induction of hyperglycaemia, we scored affiliative/exploratory or aggressive social interactions between pairs of unacquainted rats in a neutral arena. Our results demonstrate alterations in the behaviour of long-term diabetic rats faced with social novelties. Specifically, diabetic hyperglycaemic rats engaged in hyper-sociable and hyper-aggressive encounters. Interestingly, social interactivity was not associated with the degree of hyperglycaemia in affiliative/exploratory or in aggressive social interactions, in our long-term diabetic rat model. Altogether, our data suggest a lack of social appropriateness in long-term diabetic hyperglycaemic rats which is independent of the degree of hyperglycaemia. These findings support the importance of a tight glycaemic control in the management of diabetes at every stage of the disease and enlighten the importance of impaired glycaemic control as a novel metabolic player impacting the neural networks of social behaviours.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nanoparticles from Corchorus olitorius corrects polycystic ovarian syndrome by inhibition of hormonal imbalance, aromatase and cellular inflammation via hypothalamic-ovarian axis in female rat","authors":"T.E. Akintola ,&nbsp;J.K. Akintunde ,&nbsp;O.E. Eteng ,&nbsp;F.C. Thomas ,&nbsp;J.T. Adeleke","doi":"10.1016/j.endmts.2024.100202","DOIUrl":"10.1016/j.endmts.2024.100202","url":null,"abstract":"<div><h3>Purpose</h3><div>Women of fertile age are affected by an endocrine disorder called polycystic ovarian syndrome (PCOS) and is typified by polycystic ovaries, hyperandrogenism, and irregular menstruation. Because of their ability to pass through cellular barriers, nanodrugs have recently been recommended as a treatment for a number of disorders. Thus, the purpose of this study was to evaluate the efficacy of synthetized selenium nanoparticles from <em>Corchorus olitorius</em> leaves (CO-SeNPs) against hypertension coexisting with PCOS.</div></div><div><h3>Methods</h3><div>There were nine groups consisting of Control, Letrozole, L-NAME, Letrozole + L-NAME, Letrozole + CO-SeNPs, L-NAME + CO-SeNPs, Letrozole + L-NAME + CO-SeNPs, Letrozole + metformin, CO-SeNPs only. Letrozole and L-NAME were used to induce hypertension and PCOS for 21 and 14 days, respectively. The estrus cycle was monitored and animals were sacrificed after 35 days.</div></div><div><h3>Result</h3><div>The findings demonstrated that while letrozole and L-NAME decreased estrogen and progesterone levels, they significantly increased luteinizing hormone, follicle stimulating hormone, testosterone, aromatase, and 17β-hydroxysteroid dehydrogenase levels. Furthermore, in the hypothalamus, ovary, and uterine of rats with hypertensive PCOS, there was a substantial rise in tumor necrosis factor-α and monocyte chemoattractant protein-1, but a significant drop in Nrf-2.</div></div><div><h3>Conclusion</h3><div>By lowering neuroendocrine hormones and steroidogenic enzymes, CO-SeNPs therapy reduced hypertension and PCOS.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic pattern and factors associated with adverse outcomes of diabetic ketoacidosis in medical intensive care units of a tertiary care centre in India","authors":"Shubhadeep Paul ,&nbsp;Sourav Debnath ,&nbsp;Anurag Kumar Singh ,&nbsp;Shivang Mishra ,&nbsp;Sumit Rajotiya ,&nbsp;Mahaveer Singh ,&nbsp;Rahul Parashar ,&nbsp;Pusparghya Pal ,&nbsp;Sachin Kumar","doi":"10.1016/j.endmts.2024.100204","DOIUrl":"10.1016/j.endmts.2024.100204","url":null,"abstract":"<div><h3>Aim</h3><div>Diabetic ketoacidosis (DKA) is a dreadful complication of diabetes mellitus characterized by a biochemical triad of hyperglycemia, ketosis, and metabolic acidosis. The clinic-epidemiologic pattern and outcomes of DKA in the Indian subcontinent are largely unexplored, yet understanding them is crucial for optimizing management strategies.</div></div><div><h3>Methods</h3><div>A total of 138 patients admitted with a DKA diagnosis were reviewed retrospectively over two years. Patient demographics, clinical history, laboratory findings, precipitating factors, and intensive care management were extracted from case files. Clinical outcomes were classified as either discharge or death. Data analysis was performed using SPSSv29.</div></div><div><h3>Results</h3><div>The mean age of the patients was 41.54 (16) years; 77 (55.79 %) were female, 56.52 % had type 1, 23.19 % had type 2, and 20.29 % had pancreatic diabetes. Non-compliance with infection (21.02 %), and pancreatitis (21.01 %) were common DKA triggers. Severity was assessed by pH, anion gap, and bicarbonate levels. The overall mortality rate was 11.59 %. Factors significantly associated with mortality included age &gt;60 years, &gt;3 previous DKA episodes, hypokalaemia, elevated serum creatinine, and altered sensorium.</div></div><div><h3>Conclusion</h3><div>These findings emphasize the importance of demographics and risk factors in assessing DKA mortality risk, aiding early identification and targeted interventions for high-risk patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase of serum vitamin D levels in the COVID-19 pandemic: Report of a Mexican reference clinical laboratory","authors":"García-Alcalá Héctor ,&nbsp;Minutti-Zanella Claudia ,&nbsp;Orta-Flores Verónica ,&nbsp;López-Martínez Briceida","doi":"10.1016/j.endmts.2024.100199","DOIUrl":"10.1016/j.endmts.2024.100199","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic prompted health professionals to look for prevention and treatment options to improve outcomes. Vitamin D3 (VitD) is a sun dependent, immunomodulatory hormone that was widely used approaching COVID-19 because of previous experience with other RTIs. Its use was recommended in clinical practice guidelines and mainstream media, motivating supplement consumption. This increased the demand for serum VitD determinations, as well as the progressive increase of serum VitD levels.</div></div><div><h3>Objective</h3><div>Study the change in mean VitD serum levels in the population of one reference clinical laboratory before and during pandemic years.</div></div><div><h3>Methods</h3><div>We analyzed 65,481 results (78% female, mean age of 53.47 (M = 55, IQR = 25)).</div></div><div><h3>Results</h3><div>The median Vitamin D level was higher in all seasons in the pandemic years compared to previous years: spring 24 ng/dL (IQR 13.7) vs 25.4 ng/dL (IQR 17), summer 23.5 ng/dL (IQR 13.4) vs 24.2 ng/dL (IQR 16.3), autumn 23.7 ng/dL (IQR 14.3) vs 27 ng/dL (IQR 18.7), winter 22.4 ng/dL (IQR 14.9) vs 23.4 ng/dL (IQR 17.8).</div></div><div><h3>Conclusions</h3><div>The increase in serum VitD during the pandemic years is probably due to the recommendations of its use in guidelines of clinical practice. Although up to date the CDC and NIH have deemed there is not enough information in favor or against VitD use, epidemiology studies should be done to observe the impact of widespread VitD use in COVID-19 and other illnesses.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with quality of life and functional capacity in patients with diabetic foot in the Dominican Republic","authors":"Berniza Calderón ,&nbsp;Manuel Soto ,&nbsp;Alba Beltré","doi":"10.1016/j.endmts.2024.100203","DOIUrl":"10.1016/j.endmts.2024.100203","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the quality of life (QoL) and physical functioning of patients with diabetic foot (DF) and their associated factors.</div></div><div><h3>Methods</h3><div>120 participants with DF were recruited in 5 diabetic foot clinics in Dominican Republic. QoL and physical function were measured with the SF-36 and FAAM questionnaires respectively. Multiple linear regression models were used to determine the factors associated with each of the SF-36 and FAAM dimensions.</div></div><div><h3>Results</h3><div>The median scores for the SF-36's dimensions were: physical functioning 30 (Interquartile range [IQR]: 40), role limitations due to physical health 0 (IQR: 25), role limitations due to emotional problems 100 (IQR: 100), vitality 55 (IQR: 30), mental health 55 (IQR: 24), social functioning 50 (IQR: 50), bodily pain 45 (IQR: 47.5), general health 50 (IQR: 30). Median scores for the FAAM's activities of daily living and sports dimensions were 39.3 (IQR: 25.7) and 28.6 (IQR: 28.6) respectively. After multiple linear regression analysis, factors associated with lower SF-36 scores were advanced Wagner grade, smoking, unemployment, female sex, time to treatment, comorbidities and microvascular complications. Factors associated to lower FAAM scores were Wagner grade and living alone.</div></div><div><h3>Conclusion</h3><div>Patients with DF have poor QoL and physical function, with Wagner grade being the main associated factor. Attention should be given to prevention and opportune treatment. Studies that evaluate the impact of preventive and chronic disease management programs for DF are needed.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoalbuminemia on admission in diabetic patients correlates with severity of illness in COVID-19: A retrospective clinical study and literature review","authors":"Mayumi Shoji ,&nbsp;Naoya Teramoto ,&nbsp;Takahiro Ishikawa ,&nbsp;Aiko Hayashi ,&nbsp;Ai Matsumoto ,&nbsp;Hidetoshi Ochiai ,&nbsp;Ayano Yamaguchi ,&nbsp;Yukari Maeda ,&nbsp;Atsushi Takasaki ,&nbsp;Chihiro Hiraga ,&nbsp;Shintaro Ide ,&nbsp;Kana Ide ,&nbsp;Masashi Yamamoto ,&nbsp;Yoshiro Maezawa ,&nbsp;Ayako Shigeta ,&nbsp;Seiichiro Sakao ,&nbsp;Takuji Suzuki ,&nbsp;Misuzu Yahaba ,&nbsp;Toshihumi Taniguchi ,&nbsp;Hidetoshi Igari ,&nbsp;Masaya Koshizaka","doi":"10.1016/j.endmts.2024.100196","DOIUrl":"10.1016/j.endmts.2024.100196","url":null,"abstract":"<div><h3>Introduction</h3><p>To elucidate factors associated with severe disease in patients with coronavirus disease 2019 (COVID-19) pneumonia complicated with diabetes mellitus.</p></div><div><h3>Methods</h3><p>Among patients with COVID-19 pneumonia hospitalized from January to September 2021, 100 patients with diabetes were included in the study. Patients in the intensive care unit admission or in-hospital death category were defined as the severe group (26 patients), and the other patients as the moderate group (74 patients). Comparisons were made between the two groups. Medical histories were extracted from the medical records, and statistical analysis was performed.</p></div><div><h3>Results</h3><p>Patients were 62.1 ± 13.0 years of age, 70 % male, 48 % aged 65 years and more, and HbA1c was 7.72 ± 1.51 %. The severe group had significantly higher blood glucose level, CRP, WBC, and LDH on admission. Serum albumin level was significantly lower in the severe group and was significantly negatively correlated with number of days on oxygen administration (<em>r</em> = 0.447) and maximal oxygen concentration (<em>r</em> = 0.561). Multiple logistic regression analysis with severity of illness as the objective variable showed that high CRP and low albumin levels on admission, and older age were independently associated.</p></div><div><h3>Conclusions</h3><p>Low albumin levels on admission may be an indicator of severe disease in patients with diabetes.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000402/pdfft?md5=91f8e0ec8f217e0cb615ede64a568426&pid=1-s2.0-S2666396124000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the increase in intestinal permeability and microbiota change in the development of Hashimoto's thyroiditis - Systematic review","authors":"Desislav G. Tomov ,&nbsp;Boryana A. Levterova ,&nbsp;Valentina N. Mihailova ,&nbsp;Dimitar M. Troev ,&nbsp;Maria Z. Miteva ,&nbsp;Yordanka I. Uzunova ,&nbsp;Maria M. Orbetzova","doi":"10.1016/j.endmts.2024.100195","DOIUrl":"10.1016/j.endmts.2024.100195","url":null,"abstract":"<div><p>The etiology of Hashimoto's thyroiditis is still unclear. Genetic predisposition and the effects of various environmental factors are discussed. The present article is a systematic review of publications on the occurrence and development of this disease in the presence of impaired functions of the gastrointestinal tract and changes in the microbiota. Increased intestinal permeability, as well as changes in the microbiota, can disrupt the normal functioning of the immune system and can lead to the development of an autoimmune disease. Normalization of the diversity of the microbiota before an autoimmune process occurs can be achieved both with the use of pro-biotic strains and with appropriate dietary changes.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000396/pdfft?md5=60a6896ce017ecd2d4659c8f466d1786&pid=1-s2.0-S2666396124000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression in type 2 diabetes mellitus: Prevalence, characteristics, associated factors, and treatment outcomes","authors":"Hoa Van Tran ,&nbsp;Hiep Ngo Buu Tran ,&nbsp;Toan Hoang Ngo ,&nbsp;Kien Trung Nguyen","doi":"10.1016/j.endmts.2024.100194","DOIUrl":"10.1016/j.endmts.2024.100194","url":null,"abstract":"<div><h3>Background</h3><p>Previous studies have demonstrated that sertraline has a positive impact on improving depression; however, data on the prevalence and treatment outcomes of sertraline among patients with comorbid Type 2 diabetes mellitus and depression remain limited.</p></div><div><h3>Objectives</h3><p>Determine the prevalence and associated factors of depression, and evaluate the treatment outcomes of sertraline intervention at two dosage levels (50 mg per day and 100 mg per day) in patients with comorbid depression and type 2 diabetes mellitus in Vietnam.</p></div><div><h3>Materials and methods</h3><p>The study included type 2 diabetes mellitus patients receiving outpatient treatment at Bac Lieu General Hospital from March 2023 to March 2024. Following the assessment of depression prevalence and associated factors, a randomized, single-blind clinical trial was conducted. Patients were randomly assigned to two groups: odd-numbered patients received treatment with 50 mg/day sertraline dosage, while even-numbered patients received treatment with 100 mg/day sertraline dosage. The criteria for success included improvement in symptoms and severity of depression after 6 months of treatment.</p></div><div><h3>Results</h3><p>A total of 225 type 2 diabetes mellitus patients with a mean age of 63.8 ± 10.7 years were included, among whom 72 were diagnosed with depression, accounting for a prevalence rate of 32 %. Among these patients, 51 were female (70.8 %) and 21 were male (29.2 %). Female gender, overweight, obesity, diabetes duration over 36 months, and a history of cardiovascular disease were found to be associated with depression. However, in the multivariate model, only overweight, obesity, HbA1c ≥ 6.5 %, and a history of cardiovascular disease were identified as independent factors contributing to depression in type 2 diabetes mellitus patients, with odds ratios of 4.12 (95 % CI: 1.78–9.56; <em>p</em> = 0.001), 0.37 (95 % CI: 0.15–0.95; <em>p</em> = 0.038) and 25.90 (95 % CI: 9.05–74.12; <em>p</em> &lt; 0.001), respectively. Following 6 months of treatment, in the 50 mg/day dosage group, the proportion of patients with moderate to severe depression decreased from 77.8 % to 33.3 % (<em>p</em> &lt; 0.001). Similarly, in the 100 mg/day dosage group, the proportion of patients with moderate to severe depression decreased from 94.4 % to 52.8 % (<em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Depression accounts for approximately one-third of type 2 diabetes mellitus cases. Overweight, obesity, HbA1c levels, and cardiovascular disease are independent factors associated with depression. Intervention with sertraline for depression treatment at both 50 mg/day and 100 mg/day dosages demonstrates significant improvements in depression severity after 6 months of treatment.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"16 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000384/pdfft?md5=b18e5467e35be59ff9afb9718b927eb6&pid=1-s2.0-S2666396124000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}