Endocrine and Metabolic Science最新文献

{"title":"Vitamin D regulation of cortisol through the HPA axis: A focused review","authors":"Dinara S. Kulzhanova ,&nbsp;Ainur Amanzholkyzy ,&nbsp;Sholpan Kosmuratova ,&nbsp;Arailym K. Altymova ,&nbsp;Wassim Y. Almawi","doi":"10.1016/j.endmts.2025.100275","DOIUrl":"10.1016/j.endmts.2025.100275","url":null,"abstract":"<div><div>Vitamin D has a significant influence on neuroendocrine regulation by modulating cortisol levels through hypothalamic-pituitary-adrenal (HPA) axis mechanisms. This review explores the biological mechanisms connecting vitamin D to cortisol regulation and its clinical implications beyond bone health. Vitamin D receptors are widely distributed in stress-responsive brain regions, and evidence suggests that vitamin D signaling regulates cortisol through both genomic and non-genomic pathways. Clinical findings are mixed; some studies suggest cortisol levels decrease after vitamin D supplementation in cases of obesity, depression, or inflammation, while others show minimal effects in healthy populations. This relationship varies with age and gender. Variability in study results stems from differences in research design, baseline vitamin D levels, cortisol measurement methods, and genetic polymorphisms that affect metabolism. Despite this, vitamin D acts as a modulator of the stress response, especially benefiting vulnerable groups. Future research should implement standardized protocols that consider circadian rhythms and population differences.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal thrombophilia and intrauterine growth restriction: A review of current evidence and clinical implications","authors":"Rajalakshmi A S ,&nbsp;Anarghya Ananda Murthy ,&nbsp;Sree Lakshmi K","doi":"10.1016/j.endmts.2025.100274","DOIUrl":"10.1016/j.endmts.2025.100274","url":null,"abstract":"<div><div>Intrauterine growth restriction (IUGR) is a significant contributor to perinatal illness and death, arising from a variety of complex and multifactorial causes. Increasing evidence suggests that maternal thrombophilia, particularly deficiencies in natural anticoagulants such as Protein C, Protein S, and Antithrombin III, is a key factor in placental dysfunction and impaired fetal growth. These effects are thought to occur via placental thrombosis, impaired spiral artery remodelling, and reduced placental perfusion, which can compromise fetal growth. This systematic review, covering studies published between 1963 and 2025 and compiles and evaluates existing research on the association between thrombophilic conditions and IUGR. Although several studies have reported an increased prevalence of thrombophilia markers in pregnancies affected by IUGR, the overall evidence is inconclusive. Variability in study design, patient populations, and diagnostic definitions of both thrombophilia and IUGR contributes to conflicting findings and hinders firm conclusions regarding their role in diagnosis or intervention. Additionally, the review explores the role of anticoagulant therapies, including low molecular weight heparin, in enhancing pregnancy outcomes for women with these conditions. However, the evidence is limited by small study sizes, design constraints, and regional biases, underscoring the necessity for larger, multicenter investigations. Current findings highlight the importance of further research into the contribution of thrombophilia in IUGR. While thrombophilia screening may hold potential for risk stratification in selected high-risk populations, current evidence does not support universal screening in routine prenatal care. Larger, multicentred studies are needed before screening strategies can be formally recommended.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100274"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of uric acid, blood pressure anticipating proteinuria worsening in pregnant women of advanced age","authors":"Hang Thi Thu Ho ,&nbsp;Thuan Hoa Nguyen ,&nbsp;Ha Hong Nguyen ,&nbsp;Sam Phan Hai Nguyen ,&nbsp;Kien Trung Nguyen","doi":"10.1016/j.endmts.2025.100273","DOIUrl":"10.1016/j.endmts.2025.100273","url":null,"abstract":"<div><h3>Background</h3><div>Women of advanced maternal age are considered a high-risk obstetric population. Increases in serum uric acid levels, body mass index, and blood pressure have been associated with a higher likelihood of developing proteinuria. However, data on the predictive value of these factors for proteinuria progression specifically in this population remain limited.</div></div><div><h3>Objectives</h3><div>To determine the optimal cutoff values of serum uric acid, body mass index, systolic blood pressure, and diastolic blood pressure in predicting the progression of proteinuria in pregnant women of advanced maternal age.</div></div><div><h3>Materials and methods</h3><div>This was a cross-sectional descriptive study with longitudinal follow-up conducted among pregnant women who attended the Obstetrics Department of Vinh Long General Hospital from November 2022 to October 2023. Advanced maternal age was defined as maternal age of 35 years or older. Proteinuria was considered elevated when the 24-h urinary protein level reached ≥300 mg after the 20th week of gestation.</div></div><div><h3>Results</h3><div>A total of 100 pregnant women were enrolled, with a mean age of 38.6 ± 4.7 years. The proportions of active smoking and alcohol consumption were 18.0 % and 20.0 %, respectively. Overweight and obesity (OR = 6.06; 95 % CI: 1.97–18.59), smoking (OR = 3.89; 95 % CI: 1.30–11.59), and alcohol use (OR = 3.14; 95 % CI: 1.08–9.11) were significantly associated with the development of proteinuria. A pre-pregnancy body mass index (BMI) cut-off of 22.5 kg/m² showed the highest predictive value for proteinuria progression, with an area under the ROC curve (AUC) of 0.89 (95 % CI: 0.81–0.98), sensitivity of 86.2 %, and specificity of 92.3 %. Serum uric acid (AUC = 0.88), systolic blood pressure (AUC = 0.81), and diastolic blood pressure (AUC = 0.80) also demonstrated strong predictive performance.</div></div><div><h3>Conclusion</h3><div>Overweight/obesity, smoking, and alcohol consumption were identified as risk factors for increased proteinuria. In addition, pre-pregnancy BMI, serum uric acid levels, systolic blood pressure, and diastolic blood pressure all demonstrated strong predictive value for proteinuria progression in pregnant women of advanced maternal age.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study","authors":"Milad Shahdkar ,&nbsp;Mahdi Orang Goorabzarmakhi ,&nbsp;Mahdi Shafizadeh ,&nbsp;Farahnaz Joukar ,&nbsp;Saman Maroufizadeh ,&nbsp;Niloofar Faraji ,&nbsp;Tahereh Zeinali ,&nbsp;Fariborz Mansour-Ghanaei","doi":"10.1016/j.endmts.2025.100272","DOIUrl":"10.1016/j.endmts.2025.100272","url":null,"abstract":"<div><h3>Background</h3><div>Dyslipidemia is associated with several health complications that put a heavy burden on the healthcare system and society due to its adverse outcomes. Abnormal lipid profile is known to cause complications in hepatic systems. The aim of this study was to examine the associations of elevated liver enzymes with dyslipidemia and its components in the Prospective Epidemiological Research Studies (PERSIAN) Guilan Cohort study (PGCS) population.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted on data from 10,520 participants in PGCS, Guilan province, Iran. The demographic data and clinical characteristics of the participants were recorded. Lipid profile of the participants, including total cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL); and liver enzymes levels including alanine and aspartate aminotransferase (ALT, AST), γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) were measured. Statistical analyses were performed using SPSS version 16 based on a significant level &lt; 0.05.</div></div><div><h3>Results</h3><div>Of 10,520 participants, 53.6 % (<em>n</em> = 5633) were female, and 36.6 % were aged 45–54. The mean BMI of the participants was 28.14 kg/m². The prevalence of alcohol consumption, fatty liver disease, hepatitis, lipid-lowering medication use, and hepatotoxic drug use were 13.3 %, 0.6 %, 0.3 %, 15.1 %, and 16.5 %, respectively. Abnormal levels of Chol, TG, LDL, HDL, ALT, AST, GGT, and ALP were reported in 40.3 %, 43.1 %, 29.0 %,41.5 %, 19.4 %, 4.6 %, 11.6 %, and 5.1 % individuals, respectively. Dyslipidemia significantly increased the likelihood of elevated ALT, AST, and GGT (<em>P</em> &lt; 0.05), but showed no statistically significant association with elevated ALP (<em>P</em> &gt; 0.05). High Chol, TG, and LDL were strongly associated with elevated liver enzymes, particularly ALT and GGT, while low HDL was less impactful.</div></div><div><h3>Conclusion</h3><div>These results underscore the significant impact of lipid abnormalities on liver function tests, especially for ALT and GGT.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status of thyroid disorders among patients with type 2 diabetes mellitus in Guilan province, Iran","authors":"Maryam Yaseri ,&nbsp;Haniyeh Sadat Fayazi ,&nbsp;Fatemeh Mahdi ,&nbsp;Faezeh Motevali ,&nbsp;Seyedeh Sahereh Mortazavi Khatibani","doi":"10.1016/j.endmts.2025.100267","DOIUrl":"10.1016/j.endmts.2025.100267","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the prevalence of thyroid disorders and their associated risk factors in patients with type 2 diabetes mellitus.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted among 223 patients with type 2 diabetes mellitus (T2DM). Patients were categorized into two groups based on the presence or absence of thyroid disorders. Demographic, clinical, and laboratory data were collected, and risk factors associated with thyroid disorders were evaluated by comparing diabetic patients with and without thyroid dysfunction. Statistical analysis was performed using SPSS version 22, with the level of significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean age of patients was 54.24 ± 9.73 years, and 72.6 % (<em>n</em> = 162) were female. The prevalence of thyroid disorders among patients with T2DM was 61.9 %, with hypothyroidism being the most common (45.7 %). Cardiovascular disease was the most frequent diabetes-related complication (43.9 %), while nephropathy had the lowest prevalence (40.8 %). Neuropathy, nephropathy, and cardiovascular disease were significantly more frequent in patients with thyroid disorders compared to those without (<em>P</em> &lt; 0.05). A family history of thyroid disease was present in 40.4 % of patients, and 17.0 % were positive for anti-thyroid peroxidase antibodies. Thyroid disorders were more prevalent in females (67.9 %) compared to males (45.9 %) (<em>P</em> = 0.003). Female gender and a positive family history were significant risk factors for developing thyroid disorders (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that female gender and a positive family history of thyroid disease are significant predictors of thyroid dysfunction in patients with T2DM. These findings underscore the need for routine screening for thyroid disorders in this patient population.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100267"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral vascular disease and its associated factors among diabetic patients on follow-up at Ras Desta Damtew Memorial Hospital, Addis Ababa, Ethiopia","authors":"Zerihun Chala Deme ,&nbsp;Getchew Fekadu Feda ,&nbsp;Dereje Tsegaye ,&nbsp;Agumasie Semahegn","doi":"10.1016/j.endmts.2025.100271","DOIUrl":"10.1016/j.endmts.2025.100271","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the prevalence of peripheral vascular disorders and associated factors among diabetic patients on follow-up at Ras Desta Damtew Memorial Hospital, Ethiopia.</div></div><div><h3>Methods</h3><div>An institutional-based cross-sectional study was conducted among 275 randomly selected Diabetes Mellitus patients attending follow-up at Ras Desta Damtew Memorial Hospital, Addis Ababa, Ethiopia, from July to August 2024. Data were collected using structured questionnaires, ankle-brachial index, and Edinburgh Claudication Questionnaire, IPAQ-SF. Data were entered into Epi-data version 4.6 and exported to SPSS version 25 for analysis. Bi-variable and multivariable binary logistic regression analyses were conducted to determine associations between dependent and independent variables. Adjusted odds ratios with 95 % confidence intervals were reported, and statistical significance was considered at <em>p</em> ≤ 0.05.</div></div><div><h3>Results</h3><div>The study found that 12 % (95 % CI: 8.15 %–15.85 %) of diabetic patients developed peripheral vascular disorders. Significant associations were found with smoking (AOR: 5.59; 3.42–8.63), alcohol use (AOR: 4.09; 2.56–7.74), hypertension (AOR: 3.55; 1.69–6.25), and physical inactivity (AOR: 3.80; 1.56–9.47).</div></div><div><h3>Conclusions</h3><div>Over one in ten diabetic patients developed peripheral vascular disease. Key associated factors include smoking, alcohol use, hypertension, and physical inactivity. Interventions targeting these risk factors are necessary to reduce related complications in diabetic patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of periostin in postmenopausal thyroid patients: A prospective case-control study","authors":"Ashok Kumar Gupta ,&nbsp;Saba Faruqui ,&nbsp;Ambika Nand Jha","doi":"10.1016/j.endmts.2025.100270","DOIUrl":"10.1016/j.endmts.2025.100270","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between periostin in postmenopausal hypothyroid women.</div></div><div><h3>Methodology</h3><div>A prospective case-control study was conducted at Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) Hospital, Agamkuan, Patna, India. The study includes 38 postmenopausal hypothyroid women as case and 38 healthy women as control. Demographic details and anthropometric measurements were included. Biochemical parameters like triiodothyronine (T3), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), calcitonin, calcium, phosphorous, creatinine and albumin were determined. Serum periostin level was measured in case as well as in control subjects. Statistical Package for the Social Sciences (SPSS) version 22 was used to perform statistical analysis.</div></div><div><h3>Results</h3><div>Significant differences were noted in hip circumference (HC), waist hip ratio (WHR), white blood cells (WBC), T3, TSH, creatinine, calcium, phosphorous, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, and periostin levels between hypothyroid and euthyroid patients. Euthyroid patients had lower TSH and higher T3 levels, while periostin was higher in hypothyroid subjects. Correlation analysis showed periostin shows positive correlation with height and WBC, and negative correlation with T3, T4, and creatinine. Whereas, TSH shows positive correlation with creatinine in hypothyroid cases and shows negative correlation with weight and body mass index (BMI).</div></div><div><h3>Conclusion</h3><div>Hypothyroid patients observed with higher serum periostin levels in comparison to euthyroid individuals. Further research on periostin in large population is required in hypothyroid cases along with bone mineral density (BMD) to be explored as a possible biomarker.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100270"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of the TG/HDL index for metabolic syndrome and its components: A cross-sectional study in the PERSIAN Guilan Cohort Population","authors":"Amirali Ebrahimi ,&nbsp;Farahnaz Joukar ,&nbsp;Kourosh Mojtahedi ,&nbsp;Saman Maroufizadeh ,&nbsp;Soheil Hassanipour ,&nbsp;Mohammad Reza Naghipour ,&nbsp;Mehrnaz Asgharnezhad ,&nbsp;Fariborz Mansour-Ghanaei","doi":"10.1016/j.endmts.2025.100269","DOIUrl":"10.1016/j.endmts.2025.100269","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is a global health concern linked to cardiovascular disease and type 2 diabetes. The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has emerged as a promising biomarker for MetS due to its strong correlation with insulin resistance and atherogenic dyslipidemia. However, its utility in Middle Eastern populations, particularly in Iran, remains underexplored.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate the association between the TG/HDL-C ratio and MetS in the Guilan Cohort Study (GCS), a population-based survey in northern Iran, and to identify sex-specific cutoff values for MetS prediction.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis included 10,520 adults aged 35–70 from the GCS. Data were collected through structured questionnaires, anthropometric measurements, and biochemical studies. MetS was defined using NCEP ATP-III criteria. Receiver operating characteristic (ROC) curves were used to assess the predictive performance of the TG/HDL-C ratio, and logistic regression models were employed to examine its association with MetS, adjusting for confounders such as age, gender, BMI, and lifestyle factors.</div></div><div><h3>Result</h3><div>The overall prevalence of MetS was 41.8 %, with significant gender disparities (56.3 % in women vs. 25.0 % in men). Central obesity (58.0 %) and dyslipidemia were highly prevalent, particularly among women. The TG/HDL-C ratio demonstrated strong predictive power for MetS, with AUC values of 0.828 for men and 0.832 for women. Sex-specific optimal cutoffs were identified at 3.42 (men) and 2.80 (women), with high sensitivity (83.6 % and 72.2 %) and specificity (69.0 % and 80.9 %). Logistic regression revealed a significant association between the TG/HDL-C ratio and MetS risk, with adjusted odds ratios of 1.49 (men) and 3.02 (women) per unit increase.</div></div><div><h3>Conclusion</h3><div>The TG/HDL-C ratio is a robust and cost-effective biomarker for predicting MetS, particularly in resource-limited settings. The study highlights significant gender disparities in MetS prevalence and risk factors, underscoring the need for gender-tailored interventions. These findings support the integration of the TG/HDL-C ratio into routine clinical practice for early detection and management of MetS. Future research should focus on longitudinal studies and multiethnic validation to further establish the ratio's applicability across diverse populations.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor","authors":"Jeovanna Lowe ,&nbsp;Arden B. Piepho ,&nbsp;Chetan K. Gomatam ,&nbsp;Peyton Debell ,&nbsp;Megan N. Ballinger ,&nbsp;Jill A. Rafael-Fortney","doi":"10.1016/j.endmts.2025.100266","DOIUrl":"10.1016/j.endmts.2025.100266","url":null,"abstract":"<div><div>Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical studies in mouse models have demonstrated efficacy on multiple steps of skeletal muscle pathology. MRA treatment of the <em>mdx</em> mouse model reduces pro-inflammatory gene expression from skeletal muscle myeloid immune cells and represses muscle cytokine signaling and fibrosis. Myofiber-specific knockout of MR in <em>mdx</em> mice improves muscle force and reduces fibrosis, but inflammation in this model had not been investigated. In this study we investigated muscle inflammation at the cellular level using flow cytometry and at the protein signaling level using an unbiased cytokine assay. Numbers and proportions of myeloid cells were the same in <em>mdx</em> mice and those lacking myofiber MR, similar to the absence of cell type differences previously observed with either MRA treatment or myeloid MR knockout. MRA treatment, but not myofiber MR deletion alone, led to reductions in numerous cytokines and chemokines also previously observed in <em>mdx</em> mice. These data suggest that the beneficial reduction of inflammatory signaling from MRAs is largely independent of myofiber MR and occurs through another mechanism.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of visceral fat rating, measured using bioelectrical impedance analysis, for screening metabolic syndrome in patients diagnosed with obesity in Vietnam","authors":"Chi Khanh Hoang ,&nbsp;Thang Viet Tran ,&nbsp;Hieu Ngoc Thi Tran ,&nbsp;Bao Hoang Le ,&nbsp;Tat Thang Dinh Ngo ,&nbsp;Mai Ngoc Thi Tran ,&nbsp;Luong Dai Ly ,&nbsp;Diem Ngoc Thi Nguyen ,&nbsp;Duy Le Nguyen ,&nbsp;Nam Quang Tran","doi":"10.1016/j.endmts.2025.100264","DOIUrl":"10.1016/j.endmts.2025.100264","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is associated with increased risk for cardiovascular morbidity and mortality, particularly among patients with obesity. This study aimed to establish diagnostic visceral fat rating (VFR) cut-off values using non-invasive bioelectrical impedance analysis (BIA) to screen for MetS in patients with obesity in Vietnam.</div></div><div><h3>Methods</h3><div>This multicenter, cross-sectional study recruited patients with obesity (body mass index ≥25 kg/m²) ≥18 years of age from outpatient clinics at the University Medical Center Ho Chi Minh City and My Duc General Hospital (Ho Chi Minh, Vietnam) between July 2023 and January 2024. MetS was diagnosed based on joint consensus criteria from the International Diabetes Federation, American Heart Association, and the National Heart, Lung, and Blood Institute.</div></div><div><h3>Results</h3><div>In total, 502 patients with obesity (86 % diagnosed with MetS), were included. VFR was significantly higher in obese patients with MetS (<em>p</em> &lt; 0.001). The optimal VFR cut-off for predicting MetS in patients with obesity was 10, with an area under the curve (AUC) of 0.7 (95 % confidence interval [CI] 0.61–0.80) for males and 0.74 (95 % CI 0.64–0.84) for females. Stratified analysis according to sex and obesity class revealed that VFR demonstrated the highest predictive utility for MetS in females (AUC 0.83) and males (AUC 0.76) with class I obesity.</div></div><div><h3>Conclusions</h3><div>VFR was a useful screening tool for MetS, particularly among females with class I obesity. Assessing VFR using BIA may facilitate early detection and prompt intervention to reduce risk for the development of cardiometabolic diseases before further invasive diagnostic procedures are considered.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"19 ","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}