Endocrine and Metabolic Science最新文献

{"title":"Impending thyroid storm in a case of Down syndrome with burr hole surgery: A case report","authors":"Ayyesha Yuanita ,&nbsp;Hermina Novida","doi":"10.1016/j.endmts.2025.100250","DOIUrl":"10.1016/j.endmts.2025.100250","url":null,"abstract":"<div><h3>Introduction</h3><div>An accidental injury requiring surgery in a patient with Down syndrome (DS) and hyperthyroidism is an uncommon case, in which thyroid hormone control plays a crucial role in successful surgery.</div></div><div><h3>Case presentation</h3><div>An Indonesian woman, 33 years old, suffered an accidental brain injury and gradually lost consciousness. She was born with DS and had no prior medical consultation. At the emergency room, she was diagnosed with hyperthyroidism and an acute subdural hematoma. According to the Burch-Wartofsky (BW) score, the examination revealed an impending thyroid storm (40 points). Management of hyperthyroidism aims to avoid the thyroid storm before, during, and after double burr hole drainage, which is treated with glucocorticoid and antithyroid drugs. She was followed up for 6 months after surgery and had considerable improvement.</div></div><div><h3>Conclusion</h3><div>Management of hyperthyroidism have a crucial role in DS patient with burr hole drainage to improve surgical outcomes, control of cardiac output, and minimize thyroid storm.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-carnitine protects against bile acid-induced mitochondrial dysfunction and IGF-1 impairment in hepatocyte cultures","authors":"Wafa'a Alqabandi,&nbsp;Maira Alsaeid,&nbsp;Gursev Dhaunsi","doi":"10.1016/j.endmts.2025.100249","DOIUrl":"10.1016/j.endmts.2025.100249","url":null,"abstract":"<div><h3>Background and aims</h3><div>Excessive amounts of bile acids (ΒΑ) exert hepatotoxic effects. We investigated the effects of glycochenodeoxycholic acid (GCDC) on mitochondrial function and insulin-like growth factor-1 (IGF-1) activity in hepatocytes and also examined if <span>l</span>-carnitine (CRNT) has any protective role.</div></div><div><h3>Methods</h3><div>Primary hepatocyte cultures were treated with 0–100 μM GCDC with or without 5 mM <span>l</span>-carnitine (CRNT). DNA synthesis was measured by bromodeoxyuridine incorporation assay. Enzymic activities of carnitine palmitoyltransferase-1 (CPT-1), cytochrome <em>c</em> oxidase (CcO) and medium chain-acylCoA dehydrogenase (MCAD), were measured in hepatocyte homogenates. Expression of peroxisome proliferator activated receptor gamma coactivator 1-α (PGC-1α) and IGF-1 receptor (IGF-1R) was detected by RT- PCR and Western blot analysis, respectively<em>.</em></div></div><div><h3>Results</h3><div>Treatment with GCDC significantly decreased the enzymatic activity of MCAD, CPT-1 and CcO (<em>P</em> &lt; 0.01), and mitochondrial ATP content. Additionally, GCDC significantly increased malondialdehyde (MDA) levels in mitochondria and downregulated PGC-1α (<em>p</em> &lt; 0.01). Furthermore, the IGF-1-induced DNA synthesis and IGF-1R gene expression were also notably reduced in GCDC-treated hepatocytes. However, co-treatment with 5 mM CRNT markedly abrogated the GCDC-induced impairment of CcO activity and PGC-1α downregulation, while it had no effect on MCAD activity. In addition, CRNT treatment also restored the enzymatic activity of CPT-1 and the gene expression levels of IGF-1 in GCDC-treated hepatocytes (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>GCDC-induced hepatotoxic effects could be triggered by mitochondrial dysfunction and impairment of IGF-1 activity. CRNT has potential beneficial effects against ΒΑ-induced cytotoxicity via enhancing the CPT-1 and CcO enzyme activities, and ATP production in addition to upregulation of PGC-1α and IGF-1R.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between COVID-19 severity and elevated level of serum glucose","authors":"Zahraa Q. Ali ,&nbsp;Nawar S. Mohammed ,&nbsp;Hussam H. Muhammed","doi":"10.1016/j.endmts.2025.100248","DOIUrl":"10.1016/j.endmts.2025.100248","url":null,"abstract":"<div><div>The collision of COVID-19 and type 2 diabetes (T2D) highlights T2D as the second most prevalent comorbidity in COVID-19. This infection exacerbates complications in diabetics. It elevates blood glucose through excessive glucocorticoid and catecholamine release. This hyperglycemia triggers pro-inflammatory monocytes, heightens platelet reactivity, and amplifies cardiovascular deaths in diabetics. This cross-sectional study, conducted at Private Nursing Home Hospital in Baghdad, focused on 143 COVID-19 patients diagnosed via RNA detection in nasopharyngeal secretions using PCR from May to August 2021. The patients, aged 18 to 76, had no prior history of diabetes upon admission. An 86-member control group, free from COVID-19 and diabetes history, aged 20 to 73, was also included. BMI, platelet count, WBC, ESR, RBG, and serum levels of the alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels were measured. The results revealed statistically highly differences in RBG between the two groups (<em>p</em>-value = 0.001), and significant variations in the Mean ± SD values of ALT and AST enzyme levels, as well as in WBC and ESR, when comparing COVID patients to non-COVID patients. In summary, our findings show a positive correlation between admission hyperglycemia and the risk of severe COVID-19, emphasizing the significance of monitoring and managing blood glucose levels. Effective glycemic control could aid in mitigating COVID-19 progression and is integral to comprehensive treatment. These glucose-related changes and COVID-19 impact on the pancreas may contribute to the development of T2D.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and effectiveness of oxandrolone on different clinical conditions: A systematic review","authors":"Izabelle de Mello Gindri ,&nbsp;Gabriel Almeida ,&nbsp;Caio Saraiva ,&nbsp;Gustavo Ferrari ,&nbsp;Darlan Dallacosta ,&nbsp;Carlos Rodrigo de Mello Roesler","doi":"10.1016/j.endmts.2025.100246","DOIUrl":"10.1016/j.endmts.2025.100246","url":null,"abstract":"<div><h3>Background</h3><div>Oxandrolone is a synthetic chemical compound derived from testosterone with a 17-alpha-alkylated structure, showing high potential to enhance the hypermetabolic response and improve clinical outcomes.</div></div><div><h3>Objectives</h3><div>We aimed to synthesize evidence regarding the safety and effectiveness of Oxandrolone for recognized health problems.</div></div><div><h3>Data sources</h3><div>A systematic review was performed across six databases using Medical Subject Headings (MeSH) terms and keywords.</div></div><div><h3>Study eligibility criteria, participants, and interventions</h3><div>We included randomized controlled trials involving children, adolescents, adults, and older adults treated with oral Oxandrolone at doses ranging from 5 to 80 mg.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Two reviewers independently conducted the selection, extraction, and quality assessment processes. A protocol was registered in PROSPERO (CRD42024539483).</div></div><div><h3>Results</h3><div>A total of 24 studies with 1905 participants were included. In children with burns, Oxandrolone increased bone mineral content, preserved lean body mass, and reduced intensive care length of stay. In children with Klinefelter Syndrome, it improved lean body mass and measures of cardiometabolic health. Positive effects on weight and well-being were noted in adults with HIV, and improvements in lean mass and muscle strength were observed in older women. Most reported adverse events were elevated liver enzymes and musculoskeletal complaints.</div></div><div><h3>Limitations</h3><div>Studies showed heterogeneity in populations, interventions, and outcomes assessed.</div></div><div><h3>Conclusions and implications of key findings</h3><div>Oxandrolone administration appears to be associated with improvements in body mass, composition indices, and reduced hospitalization time, with a low incidence of side effects. Further investigations are necessary to confirm clinical benefits for specific diseases.</div></div><div><h3>Systematic review registration</h3><div>PROSPERO CRD42024539483.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-lipoic acid regulates pro-inflammatory cytokines and hormones in letrozole-induced polycystic ovary syndrome in rats","authors":"Fehintoluwa Joy Femi-Olabisi ,&nbsp;Olawunmi Rashidat Oyerinde ,&nbsp;Opeyemi Olubunmi Faokunla ,&nbsp;Sikemi Adejoke Omar ,&nbsp;Precious Evy Igene ,&nbsp;Olamide Esther Asaluwala ,&nbsp;Bisi Olajumoke Adeoye ,&nbsp;Odunayo Olowolehin Oladoye","doi":"10.1016/j.endmts.2025.100245","DOIUrl":"10.1016/j.endmts.2025.100245","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS) a common endocrine disorder affecting 5–10 % of women in their reproductive age with reproductive and metabolic disorders such as anovulation/oligo-ovulation, hyperinsulinemia, glucose intolerance, obesity and dyslipidemia. Among other heterogeneous symptoms, studies have linked PCOS to low-grade chronic inflammation. Alpha-lipoic acid (ALA), an essential mitochondrial co-factor and safe natural molecule acts as an antioxidant. In this study, letrozole-induced PCOS rat model was used to investigate the effect of ALA on inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and hormones such as testosterone (T), luteinizing hormone (LH) and insulin. Twenty-eight rats were randomly divided into four groups of seven rats each- Group 1,2,3 and 4 (Control, PCOS, PCOS+metformin (MET) + clomiphene citrate (CC), and PCOS+ALA respectively). PCOS was induced by orally administering 1 mg/kg/day of letrozole for 21 days. ALA (1 mg/day) was administered orally to PCOS rats, and the reference drugs (7.14 mg/kg/day of MET co-administered with 2 mg/kg/day CC) were given orally for 14 days. Results revealed acyclicity in the oestrous cycle of PCOS rats characterized by persistent estrus and diestrus phases was completely reversed by ALA compared to the reference drug-treated PCOS group. ALA decreased serum fasting blood sugar, IL-6, TNF-α, total cholesterol (TC), Triglycerides (trigs), low-density lipoprotein-cholesterol (LDL-C), insulin, and LH. Serum high-density lipoprotein-cholesterol (HDL<img>C) was significantly increased (<em>p</em> &lt; 0.05) in the ALA-treated group compared to the control rats. Therefore, the efficacy of ALA as a regulator of pro-inflammatory cytokines and reproductive factors can be exploited in developing treatments for PCOS.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between serum leptin, adiponectin and resistin levels with chronic kidney disease with and without hemodialysis patients","authors":"Maha Elttayef Jasim ,&nbsp;Firas Faris Rija ,&nbsp;Sura Zahim Hussein","doi":"10.1016/j.endmts.2025.100244","DOIUrl":"10.1016/j.endmts.2025.100244","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) is major and urgent public health problem caused by a progressive reduce in renal function during some months or years which cause functional or structural abnormalities of the kidney. In renal failure, many adipokines are important in endothelial dysfunction, like inflammation and oxidative stress. This study aims to evaluate the changes of some adipokines in chronic kidney disease (CKD) with and without hemodialysis (HD) Patients. Blood samples were collected from dialysis Unit in Tikrit Teaching Hospital in Tikrit city which started from January- July 2024 who aged (18 - 68) years old. The study subjects were 90 individuals who consist of 30 healthy individuals, 30 CKD patients with hemodialysis treatment and 30 CKD patients without hemodialysis treatment. The present study showed that leptin, adiponectin and resistin were increased in CKD patients with HD and (adiponectin and resistin) were decreased in CKD patients without HD while leptin was increased in CKD patients without HD when compared with control group. Adipokines changes in hemodialysis patients rather than pre dialysis CKD patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing pre-genetic diagnosis of monogenic diabetes: clinical thresholds for targeted testing","authors":"Pichakacheri Sureshkumar ,&nbsp;Sidharth S. Kumar","doi":"10.1016/j.endmts.2025.100243","DOIUrl":"10.1016/j.endmts.2025.100243","url":null,"abstract":"<div><h3>Background</h3><div>Monogenic Diabetes Mellitus (MDM) represents a minority of Diabetes Mellitus (DM) cases but poses diagnostic complexities owing to its clinical overlap with other forms of DM. Preliminary clinical screening is crucial for diagnosis due to the paucity of genetic testing facilities.</div></div><div><h3>Aim</h3><div>We aimed to identify clinical thresholds that could enhance the likelihood of obtaining positive genetic test results while excluding young-onset T2DM in suspected cases of MDM.</div></div><div><h3>Methodology</h3><div>We analyzed the demographic, anthropometric, and biochemical details of genetically confirmed MDM participants (<em>n</em> = 10) from our center and compared them with those of clinically suspected patients who tested negative for MDM (<em>n</em> = 67), excluding two neonatal DM (NDM) cases. Using Receiver Operating Characteristic curves, we determined the thresholds for various parameters, prioritizing a sensitivity of ≥75 %.</div></div><div><h3>Results</h3><div>The upper cut-off values obtained for identifying individuals with a potential for genetic positivity were age of onset of DM 25.5 years, BMI 23.5 kg/m², visceral fat 7 %, waist circumference (irrespective of gender) 86 cm, random C-peptide 1.41 ng/mL, AST 31 units/dL, ALT 41 units/dL, triglyceride 150 mg/dL, and for HDL, the lower cut-off point was 48.5 mg/dL.</div></div><div><h3>Conclusion</h3><div>These defined thresholds offer a potential to enhance the efficient use of genetic testing by ensuring more targeted utilization, thus optimizing resource allocation and improving diagnostic accuracy in the assessment of MDM.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of MKRN3, DLK1, KISS1, KISS1R, and PROKR2 genes sequences in related girls with central precocious puberty for a personalized management","authors":"Ayah Alhusseni ,&nbsp;Mariam Moalla ,&nbsp;Mona Mahfood ,&nbsp;Faten Hadj Kacem ,&nbsp;Wafa Belabed ,&nbsp;Wajdi Safi ,&nbsp;Mohamed Abid ,&nbsp;Mouna Mnif-Feki ,&nbsp;Hassen Hadj Kacem","doi":"10.1016/j.endmts.2025.100242","DOIUrl":"10.1016/j.endmts.2025.100242","url":null,"abstract":"<div><h3>Purpose</h3><div>Central precocious puberty (CPP) occurs when the hypothalamus prematurely releases gonadotropin-releasing hormone (GnRH), triggering early sexual maturation and the onset of puberty. Mutations in five genes, including <em>KISS1</em>, <em>KISS1R</em>, <em>DLK1</em>, <em>MKRN3</em>, and <em>PROKR2</em>, have been reported in both sporadic and familial CPP cases. Routine screening of these genes is essential for distinguishing between CPP and early physiological puberty. This study aims to evaluate the role of genetic diagnosis in offering personalized management for familial cases of CPP.</div></div><div><h3>Methods</h3><div>Clinical, biochemical, and imaging assessments were conducted on two related girls. The coding regions and flanking intronic sequences of the five genes were sequenced using Sanger sequencing and screened for potential mutations.</div></div><div><h3>Results</h3><div>We identified a heterozygous <em>MKRN3</em> c.482insC (rs763195944) loss-of-function mutation in a girl diagnosed with CPP at 6.1 years (Tanner stage: P2A2B3). She was treated with a GnRH analogue for five years, and her pubertal development has been well managed (Tanner stage: P3A3B3, at 11 years). No pathogenic variants were found in the <em>KISS1</em>, <em>KISS1R</em>, <em>DLK1</em>, or <em>PROKR2</em> genes. Consequently, we recommended clinical follow-up only for her unmutated maternal cousin, who was diagnosed with premature thelarche (Tanner stage: P3A3B3, at 8.8 years).</div></div><div><h3>Conclusions</h3><div>Routine genetic screening of CPP-related genes can assist clinicians in making accurate treatment decisions for patients exhibiting a growth spurt, rapid onset of puberty, and a family history of CPP. This approach enables more targeted and personalized management of the condition.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of central compartment lymph node metastasis posterior to the right recurrent laryngeal nerve in differentiated thyroid carcinoma: A single-center prospective study in Vietnam","authors":"Phan Hoang Hiep ,&nbsp;Tran Ngoc Luong ,&nbsp;Doan Quoc Hung ,&nbsp;Tran Doan Ket ,&nbsp;Pham Quyet Thang ,&nbsp;Do Van Ky ,&nbsp;Nguyen Giang Son ,&nbsp;Truong Quang Huy ,&nbsp;Ngo Van Thanh ,&nbsp;Do Trung Anh ,&nbsp;Doan Vu Tu Quyen","doi":"10.1016/j.endmts.2025.100240","DOIUrl":"10.1016/j.endmts.2025.100240","url":null,"abstract":"<div><div>The study aims to examine the incidence of central compartment lymph node metastasis on the right side posterior to the recurrent laryngeal nerve in cases of papillary thyroid cancer, as well as the risk factors that may increase this incidence. A total thyroidectomy was conducted on 230 patients diagnosed with differentiated thyroid cancer, accompanied by right central compartment lymph node dissection at Viet Nam National hospital of endocrinology in 2024. The central lymph nodes were categorized into two groups: pre-nerve lymph nodes and post-nerve lymph nodes. The clinical and paraclinical characteristics of the primary tumor and metastatic cervical lymph nodes were documented. The result showed that 52 cases (22.6 %) presenting metastatic lymph nodes. Age &gt;55 years, female gender, tumor size exceeding 1 cm, concurrent thyroiditis, and metastasis to pre-nerve central lymph nodes and ipsilateral lateral neck lymph nodes were significantly correlated with elevated rates of metastasis to lymph nodes located posterior to the recurrent laryngeal nerve (p &lt; 0.05). Tumor location, multifocality, and extrathyroidal invasion did not significantly influence the metastasis rate to post-nerve lymph nodes (p &gt; 0.05). Multivariate regression analysis revealed four independent prognostic factors for post-nerve lymph node metastasis: tumor size exceeding 1 cm, concurrent chronic thyroiditis, metastasis to pre-nerve lymph nodes, and metastasis to ipsilateral lateral neck lymph nodes. In conclusion, patient with above characteristics, precise dissection is recommended to prevent the oversight of metastatic lymph nodes.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis","authors":"Nanny Natalia Mulyani Soetedjo ,&nbsp;Louis Fabio Jonathan Jusni ,&nbsp;Eric Ricardo Yonatan ,&nbsp;Steven Alvianto ,&nbsp;Nicolas Daniel Widjanarko ,&nbsp;Hikmat Permana","doi":"10.1016/j.endmts.2025.100234","DOIUrl":"10.1016/j.endmts.2025.100234","url":null,"abstract":"<div><h3>Introduction</h3><div>Graves orbitopathy (GO) is an autoimmune disorder affecting the tissues around the eyes, seen in 25–50 % of individuals with Graves disease (GD). Thyroid receptor antibodies (TRAb) target the TSH receptor, which can provoke an inflammatory response and promote fat cell formation by activating these receptors. Given this mechanism, statins that are commonly used for managing hyperlipidemia could be a potential treatment for GO. This review explores the connection between Graves orbitopathy and lipid profiles.</div></div><div><h3>Method</h3><div>This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were sourced from databases such as MEDLINE, ScienceDirect, EBSCO, ProQuest, Cochrane, and Google Scholar. The inclusion criteria covered both published and unpublished studies examining the relationship between GO and lipid profiles. Meta-analysis was conducted using Review Manager 5.4, and the risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS).</div></div><div><h3>Result</h3><div>This review included a total of four cross-sectional studies. All studies found a significant association between LDL cholesterol levels and Graves orbitopathy. However, the relationships with triglycerides (TG), HDL levels, and total cholesterol (TC) were not consistently statistically significant. The meta-analysis revealed significant differences in TC, LDL cholesterol, and TG levels across all groups (SMD = 0.48, CI = 0.17–0.80, <em>p</em> = 0.002, I² = 67 %; SMD = 0.42, CI = 0.18–0.67, <em>p</em> = 0.0008, I² = 47 %; SMD = 0.24, CI = 0.07–0.41, <em>p</em> = 0.005, I² = 0 %, respectively), while HDL levels did not show significant differences among the groups (SMD = 0.16, CI = −0.02-0.34, <em>p</em> = 0.08, I² = 10 %).</div></div><div><h3>Conclusion</h3><div>Significant differences in serum lipid profiles, including TC, LDL, and TG except HDL, were found between patients with GO and those without. Further research is needed to confirm these findings.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"18 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}