Endocrine and Metabolic Science最新文献

{"title":"WT1: A single gene associated with multiple and severe phenotypes","authors":"Maria Tereza Martins Ferrari ,&nbsp;Felipe Martins Elias ,&nbsp;Nathalia Lisboa Rosa Almeida Gomes ,&nbsp;Rafael Loch Batista ,&nbsp;José Antonio Diniz Faria Jr ,&nbsp;Mirian Yumie Nishi ,&nbsp;Berenice Bilharinho de Mendonca ,&nbsp;Sorahia Domenice","doi":"10.1016/j.endmts.2023.100143","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100143","url":null,"abstract":"<div><p>The Wilms tumor suppressor gene (WT1) is a transcription factor with a wide array of functions, that affects the differentiation and survival of several cell types in different organs. It plays a special role in renal and gonadal development, organs in which <em>WT1</em> deleterious variants determine well-established conditions, such as Wilms tumor, corticosteroid-resistant nephropathy with progression to loss of renal function, and a spectrum of gonadal development abnormalities (XX and XY gonadal dysgenesis, XX testicular and XX ovotesticular) and testicular tumors. Moreover, <em>WT1</em> variants are also associated with urinary tract malformations, heart and nervous system diseases, diaphragmatic hernias, leukemia, and tumorigenesis. Consequently, an increasingly broad phenotypic spectrum has been associated with <em>WT1</em> deleterious variants in 46,XX, and 46,XY individuals. The genotype-phenotype causal relationship involving <em>WT1</em> pathogenic variants and their heterogeneous clinical manifestations is also discussed.</p><p>This review summarizes current knowledge regarding the clinical implications of WT1 disorders and highlights the importance of diagnosing deleterious variants of <em>WT1</em> for the early identification of individuals at high risk of developing severe phenotypes, for the adequate planning of the therapeutic approach, and for familiar genetic counseling.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49736060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between metabolic phenotypes and diabetes risk: A systematic review and meta-analysis","authors":"Víctor Juan Vera-Ponce ,&nbsp;Joan A. Loayza-Castro ,&nbsp;Fiorella E. Zuzunaga-Montoya ,&nbsp;Jenny Raquel Torres-Malca ,&nbsp;Rosa A. García-Lara ,&nbsp;Cori Raquel Iturregui-Paucar ,&nbsp;Eder Jesús Orihuela Manrique ,&nbsp;Mario J. Valladares-Garrido ,&nbsp;Jhony A. De La Cruz-Vargas","doi":"10.1016/j.endmts.2023.100142","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100142","url":null,"abstract":"<div><h3>Introduction</h3><p>It seems that the risk of developing diabetes cannot be predicted solely based on weight or BMI. Metabolic phenotypes might offer a more precise tool for identifying patients at higher risk of diabetes, thus enabling more effective and targeted preventive interventions.</p></div><div><h3>Objective</h3><p>To determine the association between these metabolic phenotypes and the risk of diabetes.</p></div><div><h3>Materials</h3><p>Systematic Review (SR) with a meta-analysis of cohort studies. The search was carried out in four databases: Pubmed/Medline, SCOPUS, Web of Science, and EMBASE. Metabolic states were classified into six groups: Metabolically Healthy Normal Weight (MHNW), Metabolically Unhealthy Normal Weight (MUNW), Metabolically Healthy Overweight (MHOW), Metabolically Unhealthy Overweight (MUOW), Metabolically Healthy Obesity (MHO), and Metabolically Unhealthy Obesity (MUO). Association measures were presented as odds ratios (OR) and hazard ratios (HR) along with their 95 % confidence intervals (CI95%).</p></div><div><h3>Results</h3><p>A total of six studies were evaluated. For the meta-analysis, only studies using OR as the measure of association were included. Compared with individuals with MHNW, a statistically significant association was found for MUNW (OR: 1.82; CI95% 1.62, 2.04), MHOW (OR: 1.19; CI95% 1.07, 1.32), MUOW (OR: 2.44; CI95% 2.19, 2.72), MHO (OR: 2.14; CI95% 1.52, 3.01), and MUO (OR: 3.94; CI95% 3.28, 4.74).</p></div><div><h3>Conclusions</h3><p>Metabolic phenotypes are significantly associated with the risk of diabetes, regardless of BMI. Further research in this field is required, and should be conducted in other regions of the world where obesity and diabetes rates are rapidly increasing.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49721358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between metabolic phenotypes and diabetes risk: A systematic review and meta-analysis","authors":"V. Vera-Ponce, Joan A. Loayza-Castro, Fiorella E. Zuzunaga-Montoya, J. R. Torres-Malca, Rosa A. García-Lara, Cori Raquel Iturregui Paucar, Eder Jesús Orihuela Manrique, Mario J. Valladares-Garrido, J. A. De La Cruz-Vargas","doi":"10.1016/j.endmts.2023.100142","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100142","url":null,"abstract":"","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54451644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of new obesity markers with symptoms of depression: Analysis of a 4-year Peruvian national survey","authors":"Víctor Juan Vera-Ponce ,&nbsp;Gianella Zulema Zeñas-Trujillo ,&nbsp;Joan A. Loayza-Castro ,&nbsp;Jamee Guerra Valencia ,&nbsp;Fiorella E. Zuzunaga-Montoya ,&nbsp;Mario J. Valladares-Garrido ,&nbsp;Cori Raquel Iturregui Paucar ,&nbsp;Jhony A. De La Cruz-Vargas","doi":"10.1016/j.endmts.2023.100141","DOIUrl":"10.1016/j.endmts.2023.100141","url":null,"abstract":"<div><h3>Introduction</h3><p>Although body mass index (BMI) and waist circumference (WC) are the most commonly used obesity markers in clinical practice regarding depression, some studies suggest that other obesity markers such as waist-to-height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), and conicity index (CI) may be more accurate in identifying patients with depression.</p></div><div><h3>Objective</h3><p>To determine the relationship between different markers of obesity and the presence of symptoms of depression.</p></div><div><h3>Methods</h3><p>Analytical cross-sectional study. A secondary analysis was conducted on the Demographic and Family Health Survey (ENDES) from 2018 to 2021. The main variable of the present study was the depression score. Numerical variables were presented as mean and confidence interval at 95 % (CI 95 %). A generalized linear model of the Gaussian family and Identity link function was performed to evaluate the strength of association between the variables of interest.</p></div><div><h3>Results</h3><p>The average depression score in the study population was 2.61 (95 % CI 2.56–2.65). In the multivariable analysis, the depression score increased for each unit that increased the BMI by 0.011 points (β = 0.011; 95 % CI 0.002–0.020), the WHtR by 0.207 points (β = 0.207; 95 % CI 0.145–0.267), the ABSI by 0.158 points (β = 0.158; IC95% 0.047–0.269), the BRI by 0.096 points (β = 0.096; IC95% 0.069–0.122), and the CI by 0.010 points (β = 0.010; IC95% 0.004–0.016). There was no statistically significant association for WC.</p></div><div><h3>Conclusions</h3><p>The WHtR may be a better marker of obesity for identifying patients with depressive symptoms compared to other markers.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42675683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching to a hybrid minimed 780G closed handle system: Real-life experience in Central Latin America","authors":"Guillermo Edinson Guzmán Gómez, Karen Milena Feriz Bonelo, Víctor Manuel Blanco Pico, María Angélica Guerra, Oriana Arias-Valderrama, Valentina Marin Betancourth, Andrés Octavio García Trujillo","doi":"10.1016/j.endmts.2023.100139","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100139","url":null,"abstract":"","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49247248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood social cohesion and obesity in the United States","authors":"Dana M. Alhasan ,&nbsp;Symielle A. Gaston ,&nbsp;Lauren R. Gullett ,&nbsp;W. Braxton Jackson II ,&nbsp;Fatima Cody Stanford ,&nbsp;Chandra L. Jackson","doi":"10.1016/j.endmts.2023.100129","DOIUrl":"10.1016/j.endmts.2023.100129","url":null,"abstract":"<div><p>Low neighborhood social cohesion (nSC) has been associated with obesity. Still, few studies have assessed the nSC-obesity relationship among a large, nationally representative, and racially/ethnically diverse sample of the United States population. To address this literature gap, we examined cross-sectional associations among 154,480 adult participants of the National Health Interview Survey (NHIS) from 2013 to 2018. We also determined if associations varied by race/ethnicity, sex/gender, age, annual household income, and food security status. Based on a 4-item scale from the Project on Human Development in Chicago Neighborhoods Community Survey, we categorized nSC as low, medium, and high. Based on body mass index (BMI) recommendations, we categorized obesity as ≥30 kg/m². We used Poisson regression with robust variance to directly estimate prevalence ratios (PRs) and 95 % confidence intervals (CIs) while adjusting for sociodemographic characteristics, such as annual household income, educational attainment, and marital status, along with other confounders. Study participants' mean age ± standard error was 47.1 ± 0.1 years; most (69.2 %) self-identified as Non-Hispanic (NH)-White; and 51.0 % were women. NH-Black and Hispanic/Latinx adults comprised more of the population in neighborhoods with low nSC (14.0 % NH-Black, 19.1 % Hispanic/Latinx, and 61.8 % NH-White) versus high nSC (7.7 % NH-Black, 10.4 % Hispanic/Latinx and 77.0 % NH-White). Low vs. high nSC was associated with a 15 % higher prevalence of obesity (PR = 1.15 [95 % CI: 1.12–1.18]), and the magnitude of the association was more substantial among NH-White adults (PR = 1.21 [95 % CI: 1.17–1.25]) compared to associations among Hispanic/Latinx (PR = 1.04 [95 % CI: 0.97–1.11]) and NH-Black (PR = 1.01 [95 % CI: 0.95–1.07]) adults. Low vs. high nSC was associated with a 20 % higher prevalence of obesity in women (PR = 1.20 [95 % CI: 1.16–1.24]) compared to a 10 % higher prevalence in men (PR = 1.10 [95 % CI: 1.06–1.14]). Low vs. high nSC was associated with a 19 % higher prevalence of obesity among adults ≥50 years old (PR = 1.19 [95 % CI: 1.15–1.23]) compared to a 7 % higher prevalence of obesity among adults &lt;50 years old (PR = 1.07 [95 % CI: 1.03–1.11]). Efforts to address nSC may improve health and address health disparities.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"11 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9806917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethylene glycol and plantain peel fraction ripened with calcium carbide inhibit reproductive mediators in male rats","authors":"J.K. Akintunde ,&nbsp;S.A. Lateef ,&nbsp;C.J. Amadi ,&nbsp;O.S. Okoh","doi":"10.1016/j.endmts.2023.100130","DOIUrl":"10.1016/j.endmts.2023.100130","url":null,"abstract":"<div><p>The application of artificial fruit ripeners has become a great burden to the public health clinicians. This study assessed the toxicity effect of ethylene glycol (EOGH) and plantain peel fraction ripened with calcium carbide (CaC₂) on male reproductive functions. Forty male rats were divided into five groups (<em>n</em> = 8). Group 1 received distilled water only; group 2 received 200 mg/m³ ethylene glycol; group 3 received 1000 mg/kg of CaC₂; group 4 received 200 mg/kg plantain peel extract (PPE) and group 5 received 200 mg/kg plantain-peel extract ripened with CaC₂ (PPECC). The exposure via oral route lasted for 14 days. Sub-acute exposure of male rats to ethylene glycol, CaC₂ and PPECC elicited spermatogenic lesions through significant (<em>p</em> &lt; 0.05) depletion of testosterone level, daily sperm production, sperm motility, live sperm and sperm count with elevated sperm deformity and testicular 5¹-nucleotidase activity upon exposure to ethylene-glycol, CaC₂ and PPECC in relation to PPE. Also, exposure to ethylene glycol, CaC₂ and PPECC remarkably increased testicular MDA content and serum AST, ALT and ALP activities which predisposes to spermatogenic abnormalities. Altogether, application of PPECC is suggested as one of the risk factors of liver failure associated with reproductive disruption in rat model.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"11 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49228459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of aldosterone and endothelin-1 with incident diabetes among African Americans: The Jackson Heart Study","authors":"Joshua J. Joseph ,&nbsp;Bjorn Kluwe ,&nbsp;Songzhu Zhao ,&nbsp;David Kline ,&nbsp;Divya Nedungadi ,&nbsp;Guy Brock ,&nbsp;Willa A. Hsueh ,&nbsp;Sherita H. Golden","doi":"10.1016/j.endmts.2023.100128","DOIUrl":"10.1016/j.endmts.2023.100128","url":null,"abstract":"<div><h3>Introduction</h3><p>African Americans (AAs) have the highest prevalence of hypertension among United States racial/ethnic groups. Regulators of blood pressure, such as aldosterone and endothelin-1, impact glucose regulation. The relationship between these factors and incident diabetes is not well elucidated among AAs.</p></div><div><h3>Methods</h3><p>Among 3914 AA participants without prevalent diabetes in the Jackson Heart Study, linear regression models were used to examine cross-sectional associations of exposures (aldosterone, endothelin-1, and a combined aldosterone-endothelin-1 score [2–8]) with glycemic measures (fasting plasma glucose [FPG], HbA1c, homeostatic model assessments of beta cell function [HOMA-β] and insulin resistance [HOMA-IR]). Longitudinal associations of exposures with incident diabetes were examined using Cox proportional hazard models. Models were adjusted for age, sex, education, occupation, systolic blood pressure, smoking, physical activity, dietary intake, alcohol use and adiponectin.</p></div><div><h3>Results</h3><p>Aldosterone and the combined aldosterone-endothelin score were positively associated with FPG, HOMA-IR, and HOMA-β (all p &lt; 0.05). Endothelin-1 was negatively associated with FPG but positively associated with HOMA-β (both p &lt; 0.05). Only the aldosterone-endothelin score was positively associated with HbA1c (p &lt; 0.01). A 1-SD higher serum aldosterone and endothelin-1 was associated with a 22 % and 14 % higher risk of incident diabetes, respectively, while a 1-point higher aldosterone-endothelin score was associated with a 13 % higher risk of incident diabetes after adjustment for diabetes risk factors (all p &lt; 0.01).</p></div><div><h3>Conclusions</h3><p>Aldosterone and endothelin-1, factors integral in blood pressure regulation, may play a significant role in the development of diabetes among AAs.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"11 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/87/nihms-1911035.PMC10358435.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of calcitonin on quality of life in hypothyroid patients – A pilot study","authors":"Wedad Rahman ,&nbsp;Simona Stefan ,&nbsp;Amiya Ahmed ,&nbsp;Muhammad Siddiqi ,&nbsp;Rana Malek ,&nbsp;Elizabeth M. Lamos ,&nbsp;Kashif M. Munir","doi":"10.1016/j.endmts.2023.100125","DOIUrl":"10.1016/j.endmts.2023.100125","url":null,"abstract":"<div><h3>Introduction</h3><p>Hypothyroidism is a very common endocrine disorder routinely treated with levothyroxine replacement therapy. Despite treatment to biochemical euthyroidism, some individuals continue to have hypothyroidism-related symptoms. Many individuals with hypothyroidism also have low levels of calcitonin. Our aim was to evaluate the effects of calcitonin treatment on quality of life in hypothyroid individuals treated with levothyroxine.</p></div><div><h3>Methods</h3><p>Adult, hypothyroid individuals were treated with nasal calcitonin spray, 200 international units daily for 6 weeks. Participants completed a modified City of Hope Quality of Life questionnaire prior to initiating calcitonin and after completing 6 weeks of therapy. Perception of quality-of-life benefit with calcitonin was also assessed.</p></div><div><h3>Results</h3><p>Improvements in quality-of-life scores with calcitonin treatment from 184.77 to 148.44 (<em>p</em> = 0.342) were not statistically significant. Also, only one individual perceived any benefit with calcitonin therapy.</p></div><div><h3>Conclusion</h3><p>Treatment with nasal calcitonin spray in individuals with hypothyroidism on levothyroxine replacement therapy did not result in quality-of-life benefit.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43175291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related thyroid hormone resistance: A friend or foe","authors":"Arshag D. Mooradian","doi":"10.1016/j.endmts.2023.100132","DOIUrl":"10.1016/j.endmts.2023.100132","url":null,"abstract":"<div><p>Clinical experience shows that older people with hyperthyroidism display fewer signs or symptoms compared to younger people with hyperthyroidism. Moreover, older people with normal thyroid function tests display several clinical features of hypothyroidism. These observations suggest that there may be an age-related resistance to the actions of thyroid hormones (TH). Indeed, laboratory experiments have consistently documented an age –related blunting of response to exogenously administered TH. This resistance to TH action has been attributed to reduced cellular transport of TH, possibly reduced nuclear receptors of TH and reduced cytosolic deiodinase activity. In light of these observations, along with epidemiologic studies, the diagnosis and treatment of thyroid disease in older people differ from the current treatment guidelines of younger people with thyroid disease. It is noteworthy that the age-related resistance to TH is distinct from the congenital TH resistance syndromes where plasma TH levels are increased. This distinction is explained by the age-related changes in pituitary responsiveness to the feedback inhibition by TH and reduced thyroid gland response to thyrotropin. The current evidence suggests that the age-related resistance to TH is an adaptive process to prolong life span. At the present time, it is not known if younger people can also experience premature resistance to TH and may have symptoms of hypothyroidism in the face of normal plasma TH concentrations.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"11 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42349863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}