A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Nusrat Zarin , Md Ahamedul Kabir , Abu Jar Gaffar , Md Firoj Hossain , Samir Kumar Talukder , Ahmed Ifrad Bin Raunak , Md Masud Un Nabi , Md Asaduzzaman , Mohammad Jahid Hasan , Md. Abdullah Saeed Khan , Shahjada Selim
{"title":"降脂drug-naïve 2型糖尿病患者血脂异常的患病率和模式-孟加拉国的一项全国性研究","authors":"A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Nusrat Zarin , Md Ahamedul Kabir , Abu Jar Gaffar , Md Firoj Hossain , Samir Kumar Talukder , Ahmed Ifrad Bin Raunak , Md Masud Un Nabi , Md Asaduzzaman , Mohammad Jahid Hasan , Md. Abdullah Saeed Khan , Shahjada Selim","doi":"10.1016/j.endmts.2023.100152","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Dyslipidemia is a major risk factor for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). This countrywide study explored the prevalence and patterns of dyslipidemia among patients with T2DM who were not taking lipid-lowering drugs (LLD).</p></div><div><h3>Methods</h3><p>This cross-sectional study included 2241 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. Lipid profiles were measured in fasting blood samples using automatic analyzers. Data were analyzed using Stata 17 (Stata Corp LLC, TX, USA).</p></div><div><h3>Results</h3><p>2241 patients were investigated; their mean age was 46.27 (±11.27, SD) years, and 57.16 % were women. Overall, the prevalence of dyslipidemia was 96.83 %. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) were high in 42.88 %, 63.54 %, and 71.40 % of patients, respectively; high-density lipoprotein cholesterol (HDLC) was low in 77.60 %. Mixed dyslipidemia (including raised TC, LDLC, TG, and low HDLC) was the most prevalent (24.05 %) type. Being woman (adjusted OR: 5.63, 95%CI: 3.07–11.1) and uncontrolled diabetes (HbA1c <7 %) (adjusted OR: 2.64, 95%CI: 1.54–4.52) were independently associated with dyslipidemia. Dyslipidemia was associated with microvascular complications of diabetes.</p></div><div><h3>Conclusion</h3><p>Dyslipidemia is a highly prevalent abnormality among LLD-naïve T2DM patients in Bangladesh. Early detection and prompt management are required to prevent complications arising from dyslipidemia.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000298/pdfft?md5=d52c2cc4142475baf15a26dda5d92467&pid=1-s2.0-S2666396123000298-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Prevalence and patterns of dyslipidemia among lipid-lowering drug-naïve patients with type 2 diabetes mellitus – A countrywide study in Bangladesh\",\"authors\":\"A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Nusrat Zarin , Md Ahamedul Kabir , Abu Jar Gaffar , Md Firoj Hossain , Samir Kumar Talukder , Ahmed Ifrad Bin Raunak , Md Masud Un Nabi , Md Asaduzzaman , Mohammad Jahid Hasan , Md. Abdullah Saeed Khan , Shahjada Selim\",\"doi\":\"10.1016/j.endmts.2023.100152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Dyslipidemia is a major risk factor for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). This countrywide study explored the prevalence and patterns of dyslipidemia among patients with T2DM who were not taking lipid-lowering drugs (LLD).</p></div><div><h3>Methods</h3><p>This cross-sectional study included 2241 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. Lipid profiles were measured in fasting blood samples using automatic analyzers. Data were analyzed using Stata 17 (Stata Corp LLC, TX, USA).</p></div><div><h3>Results</h3><p>2241 patients were investigated; their mean age was 46.27 (±11.27, SD) years, and 57.16 % were women. Overall, the prevalence of dyslipidemia was 96.83 %. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) were high in 42.88 %, 63.54 %, and 71.40 % of patients, respectively; high-density lipoprotein cholesterol (HDLC) was low in 77.60 %. Mixed dyslipidemia (including raised TC, LDLC, TG, and low HDLC) was the most prevalent (24.05 %) type. Being woman (adjusted OR: 5.63, 95%CI: 3.07–11.1) and uncontrolled diabetes (HbA1c <7 %) (adjusted OR: 2.64, 95%CI: 1.54–4.52) were independently associated with dyslipidemia. Dyslipidemia was associated with microvascular complications of diabetes.</p></div><div><h3>Conclusion</h3><p>Dyslipidemia is a highly prevalent abnormality among LLD-naïve T2DM patients in Bangladesh. Early detection and prompt management are required to prevent complications arising from dyslipidemia.</p></div>\",\"PeriodicalId\":34427,\"journal\":{\"name\":\"Endocrine and Metabolic Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666396123000298/pdfft?md5=d52c2cc4142475baf15a26dda5d92467&pid=1-s2.0-S2666396123000298-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine and Metabolic Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666396123000298\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine and Metabolic Science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666396123000298","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Prevalence and patterns of dyslipidemia among lipid-lowering drug-naïve patients with type 2 diabetes mellitus – A countrywide study in Bangladesh
Background
Dyslipidemia is a major risk factor for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). This countrywide study explored the prevalence and patterns of dyslipidemia among patients with T2DM who were not taking lipid-lowering drugs (LLD).
Methods
This cross-sectional study included 2241 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. Lipid profiles were measured in fasting blood samples using automatic analyzers. Data were analyzed using Stata 17 (Stata Corp LLC, TX, USA).
Results
2241 patients were investigated; their mean age was 46.27 (±11.27, SD) years, and 57.16 % were women. Overall, the prevalence of dyslipidemia was 96.83 %. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) were high in 42.88 %, 63.54 %, and 71.40 % of patients, respectively; high-density lipoprotein cholesterol (HDLC) was low in 77.60 %. Mixed dyslipidemia (including raised TC, LDLC, TG, and low HDLC) was the most prevalent (24.05 %) type. Being woman (adjusted OR: 5.63, 95%CI: 3.07–11.1) and uncontrolled diabetes (HbA1c <7 %) (adjusted OR: 2.64, 95%CI: 1.54–4.52) were independently associated with dyslipidemia. Dyslipidemia was associated with microvascular complications of diabetes.
Conclusion
Dyslipidemia is a highly prevalent abnormality among LLD-naïve T2DM patients in Bangladesh. Early detection and prompt management are required to prevent complications arising from dyslipidemia.
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