Endocrine and Metabolic Science最新文献

{"title":"Metabolic association of serum prolactin in polycystic ovary syndrome: A retrospective analysis of 840 patients in Bangladesh","authors":"A.B.M. Kamrul-Hasan ,&nbsp;Fatema Tuz Zahura Aalpona","doi":"10.1016/j.endmts.2023.100153","DOIUrl":"10.1016/j.endmts.2023.100153","url":null,"abstract":"<div><h3>Aims</h3><p>To explore the metabolic influence of prolactin in subjects with polycystic ovary syndrome (PCOS).</p></div><div><h3>Methods</h3><p>This retrospective cross-sectional study analyzed data of women newly diagnosed with PCOS attending the Endocrinology outpatient department of a tertiary hospital in Mymensingh, Bangladesh, during 2017–2022. Clinical, anthropometric, and laboratory data, including results of oral glucose tolerance test, measurements of serum lipids, total testosterone (TT), thyroid-stimulating hormone (TSH), and prolactin, were extracted and analyzed. Cases of high prolactin (≥100 ng/mL) were excluded.</p></div><div><h3>Results</h3><p>840 cases [median age 21.5 (18.0–25.7) years] were considered for final analysis; 17.1 % had hyperprolactinemia. Serum prolactin had significant negative correlations (<em>P</em> &lt; 0.05) with age (r_s = − 0.153), body mass index (r_s = − 0.172), waist circumference (r_s = − 0.193), triglyceride (r_s = − 0.174), and TT (r_s = − 0.133) levels, and the presence of metabolic syndrome (r_s = − 0.073) and positive correlations with TSH (r_s = 0.090). In multiple regression analysis, prolactin was inversely associated with fasting plasma glucose (FPG) and positively associated with TSH after correcting for age and BMI.</p></div><div><h3>Conclusion</h3><p>An inverse association exists between serum prolactin levels and some metabolic risk factors, such as FPG, in women with PCOS.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000304/pdfft?md5=9a6d64464ea86f5d6276809937ba5f75&pid=1-s2.0-S2666396123000304-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135615730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and patterns of dyslipidemia among lipid-lowering drug-naïve patients with type 2 diabetes mellitus – A countrywide study in Bangladesh","authors":"A.B.M. Kamrul-Hasan ,&nbsp;Muhammad Shah Alam ,&nbsp;Nusrat Zarin ,&nbsp;Md Ahamedul Kabir ,&nbsp;Abu Jar Gaffar ,&nbsp;Md Firoj Hossain ,&nbsp;Samir Kumar Talukder ,&nbsp;Ahmed Ifrad Bin Raunak ,&nbsp;Md Masud Un Nabi ,&nbsp;Md Asaduzzaman ,&nbsp;Mohammad Jahid Hasan ,&nbsp;Md. Abdullah Saeed Khan ,&nbsp;Shahjada Selim","doi":"10.1016/j.endmts.2023.100152","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100152","url":null,"abstract":"<div><h3>Background</h3><p>Dyslipidemia is a major risk factor for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). This countrywide study explored the prevalence and patterns of dyslipidemia among patients with T2DM who were not taking lipid-lowering drugs (LLD).</p></div><div><h3>Methods</h3><p>This cross-sectional study included 2241 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. Lipid profiles were measured in fasting blood samples using automatic analyzers. Data were analyzed using Stata 17 (Stata Corp LLC, TX, USA).</p></div><div><h3>Results</h3><p>2241 patients were investigated; their mean age was 46.27 (±11.27, SD) years, and 57.16 % were women. Overall, the prevalence of dyslipidemia was 96.83 %. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and triglyceride (TG) were high in 42.88 %, 63.54 %, and 71.40 % of patients, respectively; high-density lipoprotein cholesterol (HDLC) was low in 77.60 %. Mixed dyslipidemia (including raised TC, LDLC, TG, and low HDLC) was the most prevalent (24.05 %) type. Being woman (adjusted OR: 5.63, 95%CI: 3.07–11.1) and uncontrolled diabetes (HbA1c &lt;7 %) (adjusted OR: 2.64, 95%CI: 1.54–4.52) were independently associated with dyslipidemia. Dyslipidemia was associated with microvascular complications of diabetes.</p></div><div><h3>Conclusion</h3><p>Dyslipidemia is a highly prevalent abnormality among LLD-naïve T2DM patients in Bangladesh. Early detection and prompt management are required to prevent complications arising from dyslipidemia.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000298/pdfft?md5=d52c2cc4142475baf15a26dda5d92467&pid=1-s2.0-S2666396123000298-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92074083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased insulin resistance with reduced beta cell function in recovered COVID-19 Ghanaians","authors":"Richard Kujo Adatsi ,&nbsp;Ansumana Sandy Bockarie ,&nbsp;Leonard Derkyi-Kwarteng ,&nbsp;Faustina Pappoe ,&nbsp;Paul Nsiah ,&nbsp;Kwabena Dankwa ,&nbsp;Samuel Acquah","doi":"10.1016/j.endmts.2023.100150","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100150","url":null,"abstract":"<div><h3>Aim</h3><p>This study compares levels of insulin resistance and beta-cell function and their relationship with liver enzymes in recovered COVID-19 participants and their uninfected counterparts in a cross-sectional study design in the Tamale metropolis of Ghana.</p></div><div><h3>Methods</h3><p>Biochemical indices for liver function, lipid metabolism, inflammation and oxidative stress were assessed under fasting state in 110 recovered COVID-19 and 116 uninfected participants. The homeostatic model assessment of insulin resistance (HOMA-IR) and the triglyceride-glucose index (TyG) were employed for the assessment of insulin resistance.</p></div><div><h3>Results</h3><p>Recovered COVID-19 participants presented lower (<em>P</em> &lt; 0.05) levels of fasting glucose, insulin, alkaline phosphatase, creatinine and beta-cell function but higher (P &lt; 0.05) levels of alanine/aspartate transferase, total bilirubin, direct bilirubin, total cholesterol, high-density lipoprotein cholesterol and HOMA-IR than their uninfected counterparts. The mean levels of the remaining indices were comparable (<em>P</em> &gt; 0.05) between the study groups. Prevalence of insulin resistance ranged from 61 % (71/116) to 81 % (89/110) for the uninfected and recovered COVID-19 participants respectively. Selected liver enzymes associated with HOMA-IR and TyG.</p></div><div><h3>Conclusion</h3><p>The risk of developing type 2 diabetes mellitus appears higher in recovered COVID-19 participants than their uninfected counterparts despite the high prevalence of insulin resistance in both groups.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000274/pdfft?md5=84b9c42cf9a2df247837126b29addda3&pid=1-s2.0-S2666396123000274-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92074084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of a baseline morning cortisol measurement, in the screening for adrenal insufficiency amongst non-critically ill hospital inpatients","authors":"Rachel Langford,&nbsp;Hye Jin Lee,&nbsp;Barbara Depczynski","doi":"10.1016/j.endmts.2023.100151","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100151","url":null,"abstract":"<div><h3>Background</h3><p>Serum cortisol levels vary according to the daily circadian cycle, with peak levels seen in the morning. There is evidence in ambulatory patients that a morning cortisol level can predict an adequate cortisol response to Synacthen (tetracosactide) stimulation.</p></div><div><h3>Aim</h3><p>The aim of this study is to determine the utility of baseline analysis of the serum cortisol levels in the morning “baseline morning cortisol”, determined using a newer immunoassay, in the screening for adrenal insufficiency amongst non-critically ill hospital inpatients.</p></div><div><h3>Methods</h3><p>This is a retrospective cross-sectional cohort study.</p></div><div><h3>Results</h3><p>64 adult inpatients had undergone a short Synacthen test (SST) (measurement of serum cortisol levels 30 and 60 min after administration of tetracosactide) during the study period. 17 patients returned an abnormal SST result. The measured level of cortisol in the morning correlated to both the 30 min and 60 min stimulated cortisol values (<em>r</em> = 0.612, <em>p</em> &lt; 0.001 and <em>r</em> = 0.639, p &lt; 0.001). After inspecting the receiver operating characteristic curve, a cortisol concentration of 200nmmol/L measured in the morning was selected as a threshold for predicting the SST result. Using this cut off, sensitivity for predicting a normal SST was 100 %, specificity 56 %, positive predictive value 45 % and negative predictive value 100 %.</p></div><div><h3>Conclusion</h3><p>A morning cortisol measurement, determined using a newer immunoassay, is sufficient in most cases to screen for adrenal insufficiency amongst non-critically ill hospital inpatients. Use of clinical judgement in conjunction with single morning cortisol measurement is likely to reduce the need for SST testing amongst inpatients.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000286/pdfft?md5=9727355ee1be375bdc3b98383e8c3e9e&pid=1-s2.0-S2666396123000286-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91960097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the association between the TCF7L2 rs12255372 (G/T) gene polymorphism and Gestational Diabetes Mellitus (GDM) in the population of Chattogram, Bangladesh","authors":"Yeasmeen Ali ,&nbsp;Sidratul Muntaha ,&nbsp;Mahfuza Akter ,&nbsp;Khondakar Mohammad Ataul Gani ,&nbsp;Sumon Rahman Chowdhury ,&nbsp;Farjana Sharmen","doi":"10.1016/j.endmts.2023.100149","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100149","url":null,"abstract":"<div><h3>Objective</h3><p>Gestational Diabetes Mellitus (GDM) is one of the most common complications of pregnancy and becoming an increasing health problem worldwide. The rate of GDM is increasing in Asian countries including Bangladesh. This study is aimed at investigating the association between the rs12255372 (G/T) polymorphism of the <em>TCF7L2</em> gene with GDM.</p></div><div><h3>Method</h3><p>To carry out the present research, 63 GDM pregnant women and 60 control pregnant women were randomly selected from the city Chattogram, Bangladesh. During the study data was collected between gestational weeks of 24–28. PCR-RFLP was used for genotyping the rs12253372 (G/T) and for genotype analysis Hardy-Weinberg equation (Hardy, 1908) was applied.</p></div><div><h3>Results</h3><p>The fasting and 2-hour plasma glucose level was significantly higher in GDM than the control. Moreover, in the case of family history women with GDM showed higher percentage in first degree relatives (60.31 %) compared to that of control (38.33 %). The frequency of mutant allele T in GDM is 26.2 % which was however not significant. TT genotype was found only in one subject with GDM. However, the percentage of risk allele GT is higher in GDM (49.2 %) compared to that of NGT (35 %).</p></div><div><h3>Conclusions</h3><p>In our pilot study, we did not find an association between rs12255372 (G/T) polymorphism of <em>TCF7L2</em> gene and GDM. Studying in a broader group may help to find a conclusive result.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396123000262/pdfft?md5=7629d7f30f6deed6656b9cc2399a223e&pid=1-s2.0-S2666396123000262-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91960094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep quality and duration with serum lipid profiles in older adults: A population-based study","authors":"Maliheh Khakpash ,&nbsp;Ahmad Khosravi ,&nbsp;Mohammad Hassan Emamian ,&nbsp;Hassan Hashemi ,&nbsp;Akbar Fotouhi ,&nbsp;Mahboobeh Khajeh","doi":"10.1016/j.endmts.2023.100148","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100148","url":null,"abstract":"<div><h3>Aims</h3><p>Sleep duration and quality are increasingly recognized as potential contributors to cardiovascular disease risk, with serum lipids playing a crucial role in this relationship. However, the results regarding this association have been inconsistent across different ethnic groups. This study aims to investigate this association in an Iranian elderly population.</p></div><div><h3>Methods</h3><p>Totally 1392 people 60 to 69 years old were included in this study. Sleep duration and quality were assessed by the Pittsburgh sleep quality index (PSQI). Logistic and linear regression models were employed to determine the association of sleep duration and quality with serum lipid levels; moreover, the effects of other potential confounders were also controlled.</p></div><div><h3>Findings</h3><p>Most of the participants had low sleep quality (70.47 %), which was more notable in males (80.08 %), compared to females (59.15 %), and most of the participants slept 6–7 h per day (42.2 %). No association was observed between sleep quality and serum lipid levels including HDL (OR = 1.12; <em>P</em> = 0.871), LDL (OR = 0.80; <em>P</em> = 0.451), total cholesterol (OR = 0.89; <em>P</em> = 0.702) and triglyceride (OR = 1.13; <em>P</em>: 0.477). As well as, no association between sleep duration and LDL; (β = 0.35; <em>P</em> = 0.094), total cholesterol (β = 0.02; <em>P</em> = 0.918), triglycerides (β = −0.02; <em>P</em> = 0.846), and HDL (β = −0.06; <em>P</em> = 0.534).</p></div><div><h3>Conclusion</h3><p>In the elderly population, poor sleep quality is typical, particularly among males. Sleep quality and duration were not associated with serum lipid profiles, including TG, TC, LDL, and HDL.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49721293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors related to diabetic retinopathy in Vietnamese patients with type 2 diabetes mellitus","authors":"Vu Van Nga ,&nbsp;Nguyen Thi Binh Minh ,&nbsp;Dinh Thi My Dung ,&nbsp;Nguyen Thi Lan Anh ,&nbsp;Nguyen Cong Huu ,&nbsp;Bui Thi Van Anh ,&nbsp;Nguyen Xuan Hiep ,&nbsp;Hoang Thi Thu Ha ,&nbsp;Tran Van Khanh ,&nbsp;Vu Thi Thom ,&nbsp;Le Ngoc Thanh","doi":"10.1016/j.endmts.2023.100145","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100145","url":null,"abstract":"<div><p>Along with the rising incidence of diabetes, the prevalence of diabetic retinopathy (DR) is quickly growing across the world. The incidence of DR complications is high, and many people are not detected until they have complications and visual impairment, causing many difficulties for the treatment process. Aims: The goal of this cross-sectional was to investigate the clinical and subclinical features of Vietnamese diabetic retinopathy patients. Methods: DR was diagnosed using International Clinical Diabetic Retinopathy scale. Complete clinical information (Age, sex, weight, height, history of hypertension and diabetes mellitus, smoking, alcohol), subclinical information (Glucose, urea, creatinine, HbA1c, uric acid, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol blood levels, Complete blood count) were collected. Results: The research enrolled 140 type 2 diabetic patients (70 in each group: DR and no DR). DR patients had significantly higher age, RBC, Hb, eGFR, uric acid, and creatinine blood levels than patients without DR. A duration of diabetes mellitus of over 15 years was associated with an 8.319-fold increased risk of DR. In conclusion, age, RBC, Hb, eGFR, uric acid, creatinine blood levels and duration of diabetes mellitus over 15 years are risk factors for DR.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49721059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive assessment of cortisol and cortisol metabolites provides insight into the complex relationship between HPA axis function and BMI","authors":"Mark S. Newman,&nbsp;Jaclyn Smeaton","doi":"10.1016/j.endmts.2023.100147","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100147","url":null,"abstract":"<div><h3>Aims/objectives</h3><p>Although considerable effort, both experimental and theoretical, has been directed towards understanding the relationship between the HPA axis and weight regulation, no true consensus exists in the literature as to the nature of the relationship. The aim of this study was to explore potential correlations between BMI and measures of cortisol and cortisol metabolites using dried urine and saliva sampling in a large sample of individuals with BMIs ranging from underweight to obese.</p></div><div><h3>Materials and methods</h3><p>A cohort of patients with data available from urinary and/or salivary measures of cortisol and cortisol metabolites who met inclusion criteria was extracted from the database of a commercial clinical laboratory. Pearson correlation coefficients were used to determine associations between variables; Student's <em>t</em>-test and one-way ANOVA were used to examine differences between groups, and the Jonckheere-Terpstra trend test was used to assess for trends by BMI category. A multivariable linear regression model was created to determine which variables explained the largest amounts of variance in BMI.</p></div><div><h3>Results</h3><p>A significant correlation was observed between the urinary cortisol metabolites and BMI (<em>P</em> &lt; 0.0001). In addition, cortisol metabolites were associated with changes in BMI over time. No significant correlation was observed between urinary free cortisol and BMI, and correlations observed between BMI and other variables, with the exception of age, were either weak or not statistically significant.</p></div><div><h3>Conclusions</h3><p>The data presented in this study suggest that cortisol metabolism is a key component of weight regulation and that cortisol metabolite concentrations may potentially serve as informative biomarkers to characterize the relationship between the HPA axis and changes in BMI. The implications of this affect both clinical practice and the research and development of both prevention and treatment strategies aimed at either decreasing or increasing BMI.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49721296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An effect of statin on serum uric acid in patients with dyslipidemia at a tertiary care hospital","authors":"Anjan Palikhey ,&nbsp;Anil Lodh ,&nbsp;Jharana Shrestha ,&nbsp;Manoj Karki ,&nbsp;Amit Kumar Shrivastava","doi":"10.1016/j.endmts.2023.100146","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100146","url":null,"abstract":"<div><h3>Background</h3><p>Hyperuricemia in dyslipidemic patients has been addressed as a potential risk factor for cardiovascular disease, because of its association with atherosclerosis and elevated oxidative stress. Hence, the main objective of the present study was to evaluate the effect of statins on blood uric acid level in patients being treated for dyslipidemia at a tertiary care hospital.</p></div><div><h3>Methods</h3><p>The study comprised 120 patients with dyslipidemia who were treated at UCMS-TH's outpatient medicine department over a six-month period from December 2022 to May 2023. Participants who met the inclusion criteria for this interventional longitudinal study had their serum uric acid and lipid parameters measured at the start of the study and again after 6 weeks of statin therapy. Using a dependent <em>t</em>-test, we compared the effects of statin on uric acid reduction in the serum.</p></div><div><h3>Results</h3><p>Statin significantly reduced serum uric acid levels from 6.36 ± 1.02 mg/dL baseline to 5.12 ± 0.43 mg/dL (<em>P</em> &lt; 0.001) after 6 weeks of treatment. The lipid markers LDL-C, TG, TC, and VLDL were all lowered, whereas the HDL level was raised (<em>P</em> &lt; 0.05) after 6 weeks of statin medication.</p></div><div><h3>Conclusion</h3><p>Because of the association between elevated serum uric acid levels and an increased risk of cardiovascular disease, statins like atorvastatin may be prescribed to dyslipidemic individuals at high risk for cardiovascular mortality due to hyperuricemia.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"13 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49736256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration and effectiveness of glucose-lowering regimens in the real world management of diabetes: Data from the Australian EXTEND45 Linked Cohort Study","authors":"Tamara K. Young ,&nbsp;Carinna Hockham ,&nbsp;Louisa Sukkar ,&nbsp;Amy Kang ,&nbsp;Min Jun ,&nbsp;Celine Foote ,&nbsp;Jannah Baker ,&nbsp;Kris Rogers ,&nbsp;Sophia Zoungas ,&nbsp;Alan Cass ,&nbsp;David Sullivan ,&nbsp;Meg J. Jardine ,&nbsp;on behalf of the EXTEND45 Steering Commitee","doi":"10.1016/j.endmts.2023.100135","DOIUrl":"10.1016/j.endmts.2023.100135","url":null,"abstract":"<div><h3>Background</h3><p>Diabetes is a common condition that often requires increasing intensity of glucose lowering regimens. We describe the population trends in the intensity of regimens, and associations of achieved HbA1c and treatment persistence.</p></div><div><h3>Methods</h3><p>We performed an episode-based analysis of the EXTEND-45 dataset, assessing trends in glucose lowering therapy and the associated outcomes of HbA1c and treatment persistence. Trends from 2009 to 2014 were assessed for each intensity level of a glucose lowering therapy regimen, according to the year prescribed. Episodes were defined as the length of time that an individual adhered to a regimen through ongoing prescription, and this was used as to define persistence. Mean HbA1c were calculated for each episode. Persistence and HbA1c were compared across the different regimens of treatment intensity.</p></div><div><h3>Results</h3><p>The intensity of glucose lowering therapy remained stable over time with around one third of episodes utilising a single glucose lowering agent. Mean HbA1c was higher for insulin-based treatment (mean 7.9 % SD = 1.3 %), and lowest for episodes of no glucose lowering treatment (mean 6.3 % (SD = 0.8 %). Around half of participants achieved glycemic targets of 7 %. While there was considerable variation in persistence, the median persistence was around 3 months (94 days, IQR 51–201 days).</p></div><div><h3>Conclusions</h3><p>Therapeutic intensity for diabetes has remained stable over 9 years. Whilst there was considerable variability in persistence with glucose lowering regimens, the mean duration of all regimens was less than a year. Requirement for higher intensity treatment with insulin was related to poorer glycemic control.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"12 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41483386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}