Endocrine and Metabolic Science最新文献

{"title":"Lipid profile, insulin resistance & non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes patients getting treatment in Jaffna","authors":"Sittampalam Rajendra ,&nbsp;Shakthivel Vaishnavi ,&nbsp;Nadarasa Hamsavakini ,&nbsp;Rajendra Nalini ,&nbsp;Mahalingam Aravnithan ,&nbsp;Paramanathan Shathana","doi":"10.1016/j.endmts.2024.100166","DOIUrl":"https://doi.org/10.1016/j.endmts.2024.100166","url":null,"abstract":"<div><h3>Introduction</h3><p>Diabetes mellitus (DM) poses a significant global public health challenge, affecting approximately 10.2 % of adults by 2030. Insulin Resistance (IR) is an impaired or subnormal biologic response to insulin stimulation of target tissues. IR alters the mechanisms involved in lipid metabolism in the adipose tissue and liver leading to dyslipidaemia and accumulation of fat in the liver (NAFLD). Non-alcoholic fatty liver disease (NAFLD) has an estimated global prevalence of 25 %. NAFLD is identified frequently on ultrasonography examination of the abdomen of patients with DM because of associated insulin resistance and obesity.</p></div><div><h3>Methodology</h3><p>This study conducted at TH Jaffna aimed to assess the lipid profile status of type 2 diabetic patients undergoing treatment, and its association with Insulin Resistance and NAFLD.</p></div><div><h3>Result</h3><p>In a cross-sectional analytical study of 112 diabetic patients (average age 58.26 years, 61.6 % female), a significant prevalence of insulin resistance (70.5 %) and NAFLD (77.7 %) was observed, with comorbid dyslipidaemia in 51.7 % of patients. No gender-based difference in lipid profile parameters was found. Total cholesterol, LDL, and TG were mostly within non dyslipidaemic levels, while HDL levels were low. There is a statistically significant association (<em>p</em> &lt; 0.05) between prevalence of NAFLD and HDL. Duration of diabetes had minimal impact on lipid profile parameters.</p></div><div><h3>Conclusion</h3><p>Understanding the complex interplay between lipid profile, insulin resistance, and NAFLD is crucial for better patient outcomes. Our study revealed a significant number of type 2 DM patients exhibited insulin resistance (70.5 %) and NAFLD (77.7 %), with a majority having comorbid dyslipidaemia (51.7 %). Larger clinical study at multicentre level is needed to validate the study's findings.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"15 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000104/pdfft?md5=fb54de17e34e0f21339cfa65a8cee4f0&pid=1-s2.0-S2666396124000104-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139710201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology","authors":"Matthew T.J. Halma ,&nbsp;Paul E. Marik ,&nbsp;Yusuf M. Saleeby","doi":"10.1016/j.endmts.2024.100163","DOIUrl":"https://doi.org/10.1016/j.endmts.2024.100163","url":null,"abstract":"<div><p>Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology and the role of interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, and metformin. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention for SARS-CoV-2 spike protein related diseases; with broad implications for human health. This review presents the therapeutic possibility of using autophagy to treat spike protein related diseases, and details the interventions to deploy this therapeutic modality.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000074/pdfft?md5=1be0126f441e121ffeac0efe3829c356&pid=1-s2.0-S2666396124000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on critical appraisal and pathogenesis of polycystic ovarian syndrome","authors":"Younis Ahmad Hajam ,&nbsp;Hilal Ahmad Rather ,&nbsp;Neelam ,&nbsp;Rajesh Kumar ,&nbsp;Muddasir Basheer ,&nbsp;Mohd Salim Reshi","doi":"10.1016/j.endmts.2024.100162","DOIUrl":"https://doi.org/10.1016/j.endmts.2024.100162","url":null,"abstract":"<div><p>Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder affecting reproductive-aged women, characterized by clinical manifestations such as hyperandrogenism, menstrual irregularities, and polycystic ovaries. Despite its prevalence and impact on women's health, the pathogenesis of PCOS remains incompletely understood. This review provides a comprehensive critical appraisal of existing literature on PCOS pathogenesis, addressing knowledge gaps and highlighting its multifactorial nature. A systematic literature review identified relevant articles published up to the knowledge cutoff date in 2023, focusing on molecular, genetic, hormonal, and environmental factors contributing to PCOS pathogenesis. Electronic databases, including PubMed, MEDLINE, and Embase, were systematically searched using predefined terms. Eligible studies investigated molecular, genetic, hormonal, and environmental factors associated with PCOS pathogenesis. The critical appraisal revealed diverse studies enriching our understanding of PCOS. Molecular and genetic studies highlighted alterations in signaling pathways, hormonal dysregulation, and the role of insulin resistance. Environmental factors, including lifestyle and exposure to endocrine-disrupting chemicals, were implicated. Heterogeneity in study designs and methodologies underscored the need for standardized approaches to enhance comparability. This review synthesizes current evidence on PCOS critical appraisal and pathogenesis, emphasizing its multifaceted nature. Standardization of study designs and methodologies will facilitate future comparisons, enabling the development of targeted therapeutic interventions and personalized management strategies for women affected by PCOS.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000062/pdfft?md5=d10c6c73ae17d54aa8ae32ae7794ef2a&pid=1-s2.0-S2666396124000062-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139748220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness of iGlarLixi in individuals with T2D sub-optimally controlled on oral anti-diabetic drugs with or without basal insulin in daily practice in Saudi Arabia (EMPOWER study)","authors":"Anwar Jammah ,&nbsp;Nagwa Roushdy ,&nbsp;Mohamed Gamil ,&nbsp;Nidal Abu Diab ,&nbsp;Naglaa Abdelmonaem ,&nbsp;Saher Safarini ,&nbsp;Mohamed Gadallah ,&nbsp;Nedal Abu Zaid ,&nbsp;Yahya Shihadeh ,&nbsp;Mohamed Saeed ,&nbsp;Jamaa Sadik ,&nbsp;Yasser Akil","doi":"10.1016/j.endmts.2024.100164","DOIUrl":"10.1016/j.endmts.2024.100164","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of type 2 diabetes mellitus (T2DM) has increased in Saudi Arabia over recent decades, with current estimates showing that 19% of adults have T2DM. There is a need to confirm the clinical outcomes and safety of iGlarLixi in the routine clinical practice setting.</p></div><div><h3>Methods</h3><p>A multicenter retrospective non-comparative study was conducted on 224 people with T2DM on Oral anti-diabetics (OADs) or in combination with basal insulin who initiated treatment with iGlarLixi in Saudi Arabia. Data of at least 180 days (± 30 days) before and after initiating iGlarLixi were retrieved.</p></div><div><h3>Results</h3><p>Mean HbA1c significantly decreased after iGlarLixi start, with a mean reduction of 1.6% at six months. The mean reduction in the FPG was −38.8 (95% CI -46.5 to −31.1, <em>p</em> &lt; 0.001). The weight dropped from 86.17 kg to 83.33 kg after 6 months post-iGlarLixi initiation [mean reduction = −2.86, <em>P</em> &lt; 0.001]. The incidence of reported hypoglycemia, symptomatic documented and/or severe cases, decreased from 0.513 (95% CI 0.33 to 0.76) per person-year at baseline to 0.002 (95% CI 0.001 to 0.011) six months after iGlarLixi.</p></div><div><h3>Conclusion</h3><p>iGlarLixi is effective and well tolerated for improved glycemic control in patients with advanced therapy from OADs or insulin in Saudi Arabia.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"15 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000086/pdfft?md5=173ff472e5e95cc4614cb64f05323614&pid=1-s2.0-S2666396124000086-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital hypopituitarism in familial Turner syndrome cases caused by a highly prevalent PROP1 gene mutation in Tunisia","authors":"Hassen Hadj Kacem ,&nbsp;Mariam Moalla ,&nbsp;Faten Hadj Kacem ,&nbsp;Oumeyma Trimeche ,&nbsp;Wajdi Safi ,&nbsp;Mouna Mnif-Feki ,&nbsp;Mohamed Abid","doi":"10.1016/j.endmts.2024.100160","DOIUrl":"10.1016/j.endmts.2024.100160","url":null,"abstract":"<div><h3>Background</h3><p>Turner syndrome (TS) is a genetic disorder found only in females who are completely or partially missing an X chromosome. It is rarely inherited from parent to offspring and is not reported to be associated with any causal gene. In addition, familial forms are less frequent than sporadic ones. A Tunisian family with four girls affected by TS showed an unusual association with congenital hypopituitarism among three of them.</p></div><div><h3>Objectives</h3><p>Conduct a genetic investigation by exploring the <em>PROP1</em> gene genomic sequence to identify a possible causal variant explaining the simultaneous presence of the TS and the congenital hypopituitarism in the family.</p></div><div><h3>Methods</h3><p>The coding regions of the gene and their flanking introns are Sanger sequenced among four sisters and their mother and compared to the reference sequences.</p></div><div><h3>Results</h3><p>Sequences analysis showed the presence of the <em>PROP1</em> gene mutation p.Arg73Cys (rs121917843), the most frequent Maghrebian defect responsible for non-syndromic combined pituitary hormone deficiency. The girls with both TS and congenital hypopituitarism were homozygous. However, the sister who was affected by TS only and their healthy mother were heterozygous.</p></div><div><h3>Conclusion</h3><p>Our findings showed that the uncommon association between TS and congenital hypopituitarism is a random event caused by the high frequency of the <em>PROP1</em> p.Arg73Cys mutation and the high level of consanguinity in the Tunisian population.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000049/pdfft?md5=8a25d43bf7dcec7994ee1f2f86af686c&pid=1-s2.0-S2666396124000049-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with diabetes mellitus among adults: Findings from the Indonesian Family Life Survey-5","authors":"Mohammed Alfaqeeh ,&nbsp;Sofa D. Alfian ,&nbsp;Rizky Abdulah","doi":"10.1016/j.endmts.2024.100161","DOIUrl":"10.1016/j.endmts.2024.100161","url":null,"abstract":"<div><h3>Purpose</h3><p>Diabetes mellitus (DM) is an increasingly prevalent health concern in Indonesia, and national information about its contributing factors remained limited. This study primarily aimed to investigate these factors associated with DM in Indonesia.</p></div><div><h3>Patients and methods</h3><p>This study utilized data from the fifth wave of Indonesian Family Life Survey-5 (IFLS-5) in 2014. The survey included individuals aged ≥15 years and assessed DM based on the obtained glycated hemoglobin values through dried blood spot specimens. Blood pressure data was acquired using omron digital self-inflating sphygmomanometers, with an average of three readings. Mean arterial pressure was used to classify respondents' hypertensive status, while anthropometric measurements were taken according to World Health Organization guidelines to calculate body mass index, providing data on obesity. Specific questions and protocols evaluated lifestyle information encompassed smoking habits, sleep quality, and physical activity, and sociodemographic factors encompassed age, gender, marital status, ethnicity, and employment status, with accordingly categorized responses. Logistic regression analysis assessed the potential associations between these factors with DM, and the results were reported in terms of odds ratios (OR) with a 95 % confidence interval (CI). The analyses were conducted using the SPSS software program.</p></div><div><h3>Results</h3><p>The study included 6740 respondents, of whom 8.4 % had DM. The majority were female (55.2 %), Muslim (89 %), not obese (71.1 %), nonhypertensive (63.3 %), had poor sleep quality (95.9 %), lacked physical activity (77.9 %), and were aged 15–45 years (56 %). Factors that demonstrated higher risks of developing DM are male gender (OR: 1.383, 95 % CI: 1.117–1.712), unemployment (OR: 1.619, 95 % CI: 1.225–2.139), no physical activity (OR: 1.619, 95 % CI: 1.225–2.139), obesity (OR: 3.076, 95 % CI: 2.512–3.766), and hypertension (HTN) (OR: 1.713, 95 % CI: 1.396–2.103). Age between 15 and 44 (OR: 0.348, 95 % CI: 0.295–0.468) has lower likelihood to develop DM.</p></div><div><h3>Conclusion</h3><p>This study has identified associations between HTN, obesity, physical activity, and employment status with DM in Indonesia. Healthcare professionals should integrate more patient-specific factors when designing and implementing tailored interventions to manage DM in Indonesia.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000050/pdfft?md5=ef559e746ae56944123034b4f32cdd1c&pid=1-s2.0-S2666396124000050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments","authors":"V. Unfer ,&nbsp;E. Kandaraki ,&nbsp;L. Pkhaladze ,&nbsp;S. Roseff ,&nbsp;M.H. Vazquez-Levin ,&nbsp;A.S. Laganà ,&nbsp;C. Shiao-Yng ,&nbsp;M.I.M. Yap-Garcia ,&nbsp;N.D.E. Greene ,&nbsp;C.O. Soulage ,&nbsp;A. Bevilacqua ,&nbsp;S. Benvenga ,&nbsp;D. Barbaro ,&nbsp;B. Pintaudi ,&nbsp;A. Wdowiak ,&nbsp;C. Aragona ,&nbsp;Z. Kamenov ,&nbsp;M. Appetecchia ,&nbsp;G. Porcaro ,&nbsp;I. Hernandez Marin ,&nbsp;J. Nestler","doi":"10.1016/j.endmts.2024.100159","DOIUrl":"https://doi.org/10.1016/j.endmts.2024.100159","url":null,"abstract":"<div><p>Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been a matter of contention. Since 1990 scientific societies in the field of human reproduction have tried to define the pivotal criteria for the diagnosis of PCOS. The consensus Rotterdam diagnostic criteria included the presence of hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology (PCOM), and have now been updated to evidence based diagnostic criteria in the 2018 and 2023 International Guideline diagnostic criteria endorsed by 39 societies internationally. Within the Rotterdam Criteria, at least two out of three of the above-mentioned features are required to be present to diagnose PCOS, resulting in four phenotypes being identified: phenotype A, characterized by the presence of all the features, phenotype B, exhibiting hyperandrogenism and oligo-anovulation, phenotype C, presenting as hyperandrogenism and PCOM and finally the phenotype D that is characterized by oligo-anovulation and PCOM, lacking the hyperandrogenic component. However, it is the hypothesis of the EGOI group that the Rotterdam phenotypes A, B, and C have a different underlying causality to phenotype D. Recent studies have highlighted the strong correlation between insulin resistance and hyperandrogenism, and the pivotal role of these factors in driving ovarian alterations, such as oligo-anovulation and follicular functional cyst formation. This new understanding of PCOS pathogenesis has led the authors to hypothesis that phenotypes A, B, and C are endocrine-metabolic syndromes with a metabolic clinical onset. Conversely, the absence of hyperandrogenism and metabolic disturbances in phenotype D suggests a different origin of this condition, and point towards novel pathophysiological mechanisms; however, these are still not fully understood. Further questions have been raised regarding the suitability of the “phenotypes” described by the Rotterdam Criteria by the publication by recent GWAS studies, which demonstrated that these phenotypes should be considered clinical subtypes as they are not reflected in the genetic picture. Hence, by capturing the heterogeneity of this complex disorder, current diagnostic criteria may benefit from a reassessment and the evaluation of additional parameters such as insulin resistance and endometrial thickness, with the purpose of not only improving their diagnostic accuracy but also of assigning an appropriate and personalized treatment. In this framework, the present overview aims to analyze the diagnostic criteria currently recognized by the scientific community and assess the suitability of their application in clinical practice in light of the newly emerging evidence.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000037/pdfft?md5=8f686b8e2d5979305dab87f51efb1064&pid=1-s2.0-S2666396124000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139493387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction and diabetes in South Africa: A review","authors":"Brendon Pearce ,&nbsp;Keenau Pearce","doi":"10.1016/j.endmts.2024.100157","DOIUrl":"https://doi.org/10.1016/j.endmts.2024.100157","url":null,"abstract":"<div><p>Type 2 diabetes mellitus (T2DM) is a growing public health concern globally, and more so in developing countries like South Africa where it is characterized by an alarmingly high prevalence. Emerging evidence suggests that mitochondrial dysfunction plays a significant role in the pathophysiology of the disease in this region. This review explores the intricate relationship between mitochondrial dysfunction and T2DM in the context of South Africa by providing an in-depth analysis of the specific mitochondrial factors influencing T2DM. Furthermore, it explores South Africa's unique demographic and epidemiological landscape characterizing its increased susceptibility to T2DM. Understanding the interplay between mitochondrial dysfunction and T2DM is of paramount importance in developing tailored prevention and treatment strategies. A need for further research to elucidate the intricate mechanisms behind this relationship, ultimately aiming to mitigate the diabetes burden in South Africa and beyond is highlighted.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000013/pdfft?md5=f6b314f13003f75842090ec648bcbf00&pid=1-s2.0-S2666396124000013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139433444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1","authors":"Jenifer Centeno Gavica ,&nbsp;Mishelle Centeno Gavica ,&nbsp;Ricardo Franco-Sadud","doi":"10.1016/j.endmts.2024.100158","DOIUrl":"10.1016/j.endmts.2024.100158","url":null,"abstract":"<div><h3>Background/objective</h3><p>To understand the potential effects that severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2) has on the endocrine system.</p></div><div><h3>Case report</h3><p>A 56-year-old female presented with complaints of increased appetite, generalized weakness, facial and neck swelling and a non-pruritic rash across her chest, abdomen and back. Onset of symptoms coincided with a Sars-Cov-2 infection three months prior to current admission. The physical exam revealed cushingoid features. Laboratory results confirmed Cushing's disease. Imaging studies revealed an 11 mm right-sided pituitary adenoma and mild thickening of the adrenals bilaterally. Additionally, a 9.4 × 7.9 cm mass was identified in the caudate lobe of the liver concerning for neoplastic origin. Liver biopsy confirmed a well differentiated neuroendocrine tumor. Endoscopy revealed chronic gastritis with hemorrhage and multiple oozing duodenal ulcers, along with an elevated gastrin level. Subsequently, the patient received a diagnosis of multiple endocrine neoplasia type 1 (MEN-1), attributed to the presence of endocrine tumors involving the anterior pituitary and gastroenteropancreatic tract.</p></div><div><h3>Discussion</h3><p>MEN-1 is a condition predisposing individual with two or more endocrine gland tumors primarily pituitary, parathyroid and gastroenteropancreatric tract. The clinical presentation varies and is often associated with hormone overproduction and tumor location. Coronavirus disease 2019 (COVID-19) is caused by Sars-Cov-2. Studies have shown to link Sars-Cov-2 with endocrinopathy.</p></div><div><h3>Conclusion</h3><p>The impact of SARS-CoV-2 extends beyond the respiratory system, highlighting the need for further research into its direct influence on the endocrine system.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666396124000025/pdfft?md5=777adfde6827688834b30221ed86f2c7&pid=1-s2.0-S2666396124000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary intake and nutrition knowledge with diabetes self-management behavior among Bangladeshi type 2 diabetes mellitus adults: A multi-center cross-sectional study","authors":"Shakil Ahmed ,&nbsp;Md Sajjadul Haque Ripon ,&nbsp;Mohammad Farhan Islam ,&nbsp;Ahmad Ullah ,&nbsp;Safayet Sultan ,&nbsp;Mohammad Sajid ,&nbsp;Tanjina Rahman","doi":"10.1016/j.endmts.2023.100156","DOIUrl":"https://doi.org/10.1016/j.endmts.2023.100156","url":null,"abstract":"<div><p>Diabetes self-management behavior is important for patients to lessen disease-related complications, obtain optimum glycemic control and achieve a better quality of life. The study aimed to determine the relationship between dietary intake, nutrition knowledge, and self-management behaviors in Bangladeshi patients with type 2 diabetes mellitus (T2DM), with a focus on achieving optimal glycemic control, improving their quality of life. A cross-sectional study was conducted among T2DM patients from seven districts throughout Bangladesh. Data were collected using a validated semi-structured questionnaire for evaluating diabetes-related self-management behavior and existing nutrition knowledge. Dietary intakes were obtained using 24 h 3-days diet recall. Logistic regression analysis, Pearson's correlation and independent <em>t</em>-test were used to observe correlation and association among variables. A total of 411 patients with T2DM participated in the study, 59.4 % of patients achieved good dietary control, while 14.4 % were physically active, 49.4 % adhered well to medication, 44.0 % practiced effective self-monitoring, and 27.0 % possessed good diabetic nutrition knowledge. In fully adjusted multivariate logistic regression analysis, patients with a better glycemic control showed 14 times more control in their dietary intake [AOR: 14.21; 95 % CI: 5.62–35.94], and performing a good physical exercise 5 times more than the patients with high blood glucose level [AOR: 5.671; 95 % CI: 1.55–20.686]. Adherence toward medication prescription was also significantly higher among these patients. Glucose level was significantly higher among patients who had moderate [AOR: 3.367; 95 % CI: 1.29–8.73] and poor [AOR: 9.87; 95 % CI: 3.19–30.57] diabetes related nutritional knowledge. Patients with poor glycemic control consumed significantly more carbohydrates (251 ± 62 g vs 213 ± 47 g) and less dietary fiber (16.7 ± 4.5 g vs 20.5 ± 6.1 g) compared to the patients with optimum glycemic control. Our study findings suggest that, an improved level of nutrition knowledge may be beneficial to ensure optimum dietary intake, thus aid in an effective diabetes self-management behavior among Bangladeshi T2DM patients. Efforts should be made to help patient achieve optimum glycemic control, thus reduce their health-related complications and contribute to overall well-being.</p></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"14 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266639612300033X/pdfft?md5=70638f3c34adac3ab07566ed6fece223&pid=1-s2.0-S266639612300033X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139050120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}