通过下丘脑-卵巢轴抑制荷尔蒙失衡、芳香化酶和细胞炎症，从珊瑚虫中提取的硒纳米颗粒可纠正雌性大鼠的多囊卵巢综合征

Q3 Medicine

Endocrine and Metabolic Science Pub Date : 2024-09-30 DOI:10.1016/j.endmts.2024.100202

T.E. Akintola , J.K. Akintunde , O.E. Eteng , F.C. Thomas , J.T. Adeleke

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引用次数: 0

摘要

多囊卵巢综合征（PCOS）是一种内分泌失调症，主要表现为多囊卵巢、雄激素过多和月经不调。由于纳米药物能够穿过细胞壁，最近已被推荐用于治疗多种疾病。因此，本研究的目的是评估从吴茱萸叶中合成的硒纳米颗粒（CO-SeNPs）对多囊卵巢综合征并发高血压的疗效。方法共分九组，包括对照组、来曲唑组、L-NAME组、来曲唑+L-NAME组、来曲唑+CO-SeNPs组、L-NAME+CO-SeNPs组、来曲唑+L-NAME+CO-SeNPs组、来曲唑+二甲双胍组、仅CO-SeNPs组。来曲唑和L-NAME分别诱导高血压和多囊卵巢综合征21天和14天。结果研究结果表明，来曲唑和L-NAME能降低雌激素和孕激素水平，但能显著提高黄体生成素、促卵泡激素、睾酮、芳香化酶和17β-羟基类固醇脱氢酶的水平。此外，在高血压多囊卵巢综合征大鼠的下丘脑、卵巢和子宫中，肿瘤坏死因子-α和单核细胞趋化蛋白-1大幅升高，但Nrf-2却明显下降。

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Selenium nanoparticles from Corchorus olitorius corrects polycystic ovarian syndrome by inhibition of hormonal imbalance, aromatase and cellular inflammation via hypothalamic-ovarian axis in female rat

Purpose

Women of fertile age are affected by an endocrine disorder called polycystic ovarian syndrome (PCOS) and is typified by polycystic ovaries, hyperandrogenism, and irregular menstruation. Because of their ability to pass through cellular barriers, nanodrugs have recently been recommended as a treatment for a number of disorders. Thus, the purpose of this study was to evaluate the efficacy of synthetized selenium nanoparticles from Corchorus olitorius leaves (CO-SeNPs) against hypertension coexisting with PCOS.

Methods

There were nine groups consisting of Control, Letrozole, L-NAME, Letrozole + L-NAME, Letrozole + CO-SeNPs, L-NAME + CO-SeNPs, Letrozole + L-NAME + CO-SeNPs, Letrozole + metformin, CO-SeNPs only. Letrozole and L-NAME were used to induce hypertension and PCOS for 21 and 14 days, respectively. The estrus cycle was monitored and animals were sacrificed after 35 days.

Result

The findings demonstrated that while letrozole and L-NAME decreased estrogen and progesterone levels, they significantly increased luteinizing hormone, follicle stimulating hormone, testosterone, aromatase, and 17β-hydroxysteroid dehydrogenase levels. Furthermore, in the hypothalamus, ovary, and uterine of rats with hypertensive PCOS, there was a substantial rise in tumor necrosis factor-α and monocyte chemoattractant protein-1, but a significant drop in Nrf-2.