Current Research in Microbial Sciences最新文献

{"title":"Erratum to ‘Genomic insights of a native bacterial consortium for wheat production sustainability’ [Current Research in Microbial Sciences Volume 6, 2024, 100230]","authors":"Marisol Ayala Zepeda, Valeria Valenzuela Ruiz, Fannie Isela Parra Cota, Cristina Chinchilla-Soto, Eulogio de la Cruz Torres, María Itria Ibba, María Isabel Estrada Alvarado, Sergio de los Santos Villalobos","doi":"10.1016/j.crmicr.2026.100622","DOIUrl":"10.1016/j.crmicr.2026.100622","url":null,"abstract":"","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"11 ","pages":"Article 100622"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling Fusobacterium lifestyles transitions by integrating transcriptomics and growth data","authors":"Michele Giovannini ,&nbsp;Emanuele Bosi ,&nbsp;Walter Vieri ,&nbsp;Luana Presta ,&nbsp;Elisa Viciani ,&nbsp;Ilaria Bernabei ,&nbsp;Giulia Nannini ,&nbsp;Mark D. Stares ,&nbsp;Hilary Browne ,&nbsp;Trevor D. Lawley ,&nbsp;Thomas Sauter ,&nbsp;Elisabeth Letellier ,&nbsp;Jessica Karta ,&nbsp;Amedeo Amedei ,&nbsp;Renato Fani ,&nbsp;Marco Fondi","doi":"10.1016/j.crmicr.2026.100573","DOIUrl":"10.1016/j.crmicr.2026.100573","url":null,"abstract":"<div><div>Bacteria living inside the tumoral micro-environment play a crucial role in the development of cancer and its progression. Enrichment of <em>Fusobacterium nucleatum</em> in colorectal cancer (CRC) tissue has been acknowledged as a major driver of its proliferation and mortality. Representatives of the <em>F. nucleatum</em> species exhibit a remarkable variability, being linked to a growing list of diseases. In this process, cellular metabolism plays a key role, allowing bacterial cells to efficiently cope with an ever-changing environment. To date, however, a mechanistic understanding of its relationship(s) with virulence and/or cancer-associated phenotypes is missing. In this work we characterize the basal physiology of this bacterium by reconstructing an experimentally validated genome-scale metabolic model (GEM) to simulate the major phenotypical features of <em>F. nucleatum</em> in different nutritional conditions. Further, we used gene expression data obtained from <em>in vitro</em> models to contextualize this metabolic reconstruction and simulate relevant phenotypes such as its interaction with human cells. Our analyses revealed that adhesion triggers a metabolic rewiring, with suppression of branched-chain amino acid catabolism and increased uptake of specific nutrients (e.g., methionine and serine), while invasion leads to a partial reactivation of central carbon and nitrogen pathways. Moreover, we identified shifts in short-chain fatty acid production and redox balance that may contribute to bacterial persistence and modulation of the tumor microenvironment.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100573"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in viral disease management","authors":"Fatima Safeer,&nbsp;Thokur Sreepathy Murali","doi":"10.1016/j.crmicr.2025.100527","DOIUrl":"10.1016/j.crmicr.2025.100527","url":null,"abstract":"<div><h3>Introduction/Background</h3><div>Extracellular vesicles (EVs) are non-replicating lipid-bilayered bodies that are naturally released by a cell that aid in various biological functions including cell-to-cell communication. They resemble the cells that they originate from, mimicking their composition and contents. The shared Endosomal Sorting Complex Required for Transport (ESCRT) mechanism between virions and EVs allows EVs to aid in the dispersion and infection of viruses.</div></div><div><h3>Scope/Objectives</h3><div>The aim of this review is to encapsulate important studies that highlight the potential use of EVs in diagnosis and therapeutics against viral diseases. It also discusses their benefits and limitations compared to currently available anti-virals, for their use in the medical sector.</div></div><div><h3>Summary of Key Findings</h3><div>Virus-infected host cells release extracellular vesicles that are markedly different from EVs secreted by a healthy host cell. Increase in certain biomarker levels in EVs prove to be highly beneficial in diagnostics. Depending on the cell source, EVs also exhibit the natural ability to defend against viral diseases. This innate ability to defend against viral infections, can thus be exploited to produce potent anti-viral responses in infected hosts.</div></div><div><h3>Conclusion/Implications</h3><div>By navigating the challenges associated with EVs, they can be utilised to prepare alternatives to anti-viral drugs currently available in the market that show low specificity and high toxicity, thus helping mitigate and manage viral diseases.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100527"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion","authors":"Shuo Ni ,&nbsp;Weicong Fu ,&nbsp;Lizong Zhang ,&nbsp;Zhonghua Zhang ,&nbsp;Xiaolin Li","doi":"10.1016/j.crmicr.2026.100561","DOIUrl":"10.1016/j.crmicr.2026.100561","url":null,"abstract":"<div><div>The circadian clock coordinates diverse biological processes to maintain physiological function and homeostasis in mammals under the day-night light cycle. Disruption of circadian rhythms impairs immune and metabolic functions and increases susceptibility to various diseases. Here, we demonstrate that long-term rest-phase time-restricted feeding (TRF), which disrupts circadian rhythmicity, induces bone loss and gut microbiota dysbiosis in male mice. Fecal microbiota transplantation (FMT) from circadian-misaligned feeding donors to germ-free recipients increased Th17 cell populations, thereby promoting the fusion of osteomorphs—a recently identified osteoclast precursor—into mature osteoclasts through the RANKL–RANK–OPG signaling pathway. Collectively, our findings identify a gut microbiota–Th17–osteomorph axis as a critical mediator of circadian disruption–induced bone loss, uncovering a previously unrecognized mechanism by which circadian rhythms regulate skeletal homeostasis.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100561"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How are kefir microbial communities and product characteristics maintained in industrial production?","authors":"Ji Qingyang ,&nbsp;Li Qiming ,&nbsp;Gu Ruixia","doi":"10.1016/j.crmicr.2026.100579","DOIUrl":"10.1016/j.crmicr.2026.100579","url":null,"abstract":"<div><div>Kefir, a millennia-old symbiotic fermented dairy product, has emerged as a focal point of research in the global functional foods sector owing to its distinctive organoleptic properties and extensive health-promoting effects. Kefir grains, serving as the natural starter culture for traditional kefir, constitute a complex symbiotic consortium comprising lactic acid bacteria, acetic acid bacteria, and yeasts, whose stratified spatial distribution and metabolic synergistic interactions determine the characteristic flavor profile and probiotic functionality of kefir. Nevertheless, contemporary kefir production faces fundamental challenges stemming from the incompatibility between traditional fermentation methodologies and modern industrial manufacturing processes, resulting in commercial kefir products exhibiting deficiencies in core functional microbial populations, flavor homogenization, and suboptimal functional efficacy claims. This review analyzes the current research landscape concerning kefir grains and kefir microbial communities, while providing a comprehensive overview of the organoleptic characteristics, nutritional composition, and functional properties of kefir. Through a systematic examination of three distinct fermentation production methodologies and principal challenges confronting commercial development, this study proposes synthetic microbial communities and kefir grain-like starter cultures as innovative production strategies for advancing kefir manufacturing.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100579"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MrkA enhances the virulence phenotype of carbapenem-resistant Klebsiella pneumoniae both in vitro and in vivo","authors":"Xiaoyu Zhao ,&nbsp;Qingqing Du ,&nbsp;Yunuo Xiang ,&nbsp;Yujia Wang ,&nbsp;Zishu Lin ,&nbsp;Yuxin Duan ,&nbsp;Qingqing Xu ,&nbsp;Xiaogang Xu ,&nbsp;Min Hao ,&nbsp;Xiaohua Qin","doi":"10.1016/j.crmicr.2026.100584","DOIUrl":"10.1016/j.crmicr.2026.100584","url":null,"abstract":"<div><div>Carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) poses a severe threat to public health, but the factors underlying its virulence are not fully understood. This study identified a novel and critical role for the type 3 fimbrial component MrkA in orchestrating CRKP pathogenesis through mechanisms extending far beyond its canonical function in adhesion. We demonstrated that <em>mrkA</em> deletion in a clinical CRKP strain severely impairs siderophore production, uncovering an unexpected link between fimbrial function and iron uptake. Furthermore, the mutant exhibited a specific defect in its capacity to adhere to both bladder and intestinal epithelial cells, suggesting a previously unrecognized role for <em>mrkA</em> in mediating the tropism to key mucosal sites preceding invasion. Transcriptomic analysis revealed that <em>mrkA</em> is essential for maintaining bacterial carbon homeostasis, as its suppression led to a profound dysregulation of carbohydrate transport systems, including the phosphotransferase system (PTS) and ABC transporters, as well as the global regulator <em>csrA</em>. This metabolic reprogramming was accompanied by a noticeable decrease in the virulence of the strain in a murine model, with tissue damage and pro-inflammatory cytokine response (IL-1β, IL-6) being ameliorated in comparison to a wild-type strain. Our findings redefine <em>mrkA</em> as a central regulator that integrates nutritional competence (iron and carbon uptake) with epithelial adhesion to drive systemic CRKP infection.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100584"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-serine metabolism enhances Escherichia coli fitness in the gut and could contribute to Enterobacteriaceae expansion in Crohn's disease patients","authors":"Maria Ines Moreira de Gouveia ,&nbsp;Amelie Blanchot ,&nbsp;Annie Garrivier ,&nbsp;Julien Daniel ,&nbsp;Anvi Laetitia Nguyen ,&nbsp;Aurélie Messager ,&nbsp;Annick Bernalier-Donadille ,&nbsp;Gregory Jubelin","doi":"10.1016/j.crmicr.2026.100585","DOIUrl":"10.1016/j.crmicr.2026.100585","url":null,"abstract":"<div><div>Gut dysbiosis associated with several intestinal and extra-intestinal diseases is frequently characterized by an expansion of <em>Enterobacteriaceae</em>, which typically represent only a few percent of the total gut microbiota in healthy individuals. This expansion can be partially explained by the selection of strains that are metabolically adapted to the altered gut environment. In this study, we performed a phenotypic screening to identify substrates that are differentially catabolized by commensal <em>Escherichia coli</em> strains isolated from healthy individuals (HI) or from patients with Crohn’s disease (CD) or rheumatoid arthritis (RA), two inflammatory diseases associated with gut dysbiosis. While RA strains were metabolically similar to HI strains, CD strains displayed a metabolic pattern with greater dissimilarities. Among the substrates identified, we notably observed opposite metabolic capacities of HI and CD strains to utilize D‑serine and sucrose, a phenotype arising from genetic rearrangements within the argW locus of the <em>E. coli</em> chromosome. The D‑serine–positive phenotype of CD strains was shown to depend on the presence of the dsdCXA genes and to confer a nutritional advantage both <em>in vitro</em> and <em>in vivo</em>. Overall, our findings provide new insights into the metabolic traits that could drive the expansion of <em>Enterobacteriaceae</em> under dysbiotic conditions and highlight D‑serine utilization as a key determinant of <em>E. coli</em> fitness in the gut.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100585"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic-driven microbiome remodeling is associated with coordinated immune and metabolic responses, improving growth and disease resistance in farmed tongue sole (Cynoglossus semilaevis)","authors":"Yuanri Hu ,&nbsp;Xu Yan ,&nbsp;Fengtao Gao ,&nbsp;Dan Xu ,&nbsp;Yingming Yang ,&nbsp;Jiayu Cheng ,&nbsp;Songlin Chen ,&nbsp;Zhongkai Cui","doi":"10.1016/j.crmicr.2026.100600","DOIUrl":"10.1016/j.crmicr.2026.100600","url":null,"abstract":"<div><div>In flatfish aquaculture, labour-intensive tank cleaning represents a major operational challenge, limiting sustainability due to its high labour requirements and associated costs. We tested a new semi-closed recirculating aquaculture system (RAS) protocol for <em>Cynoglossus semilaevis</em> (tongue sole), replacing manual cleaning with post-feeding water exchange (80% drained) and probiotic application. Compared with control groups, the probiotic-water exchange protocol significantly improved growth (+0.18%/day) and survival (+7.9%), while shifting the gut microbiota from a <em>Vibrio</em>-dominated configuration to a <em>Photobacterium</em>-dominated one. Metagenomics revealed that <em>Photobacterium damselae</em> became the predominant taxon (86%) in the probiotic group, accompanied by the enrichment of quorum sensing pathways, CAZymes (CEs, AAs), and nutrient metabolism functions. Histological examination showed improvements in the intestinal muscular layer and villi structure. Multi-tissue transcriptomics identified systemic changes in immune and metabolic pathways, including activation of intestinal immune networks (IgA production, NF-κB signaling) and antimicrobial peptide genes. Liver, gill, and skin transcriptomes revealed enhanced DNA repair, cytokine signaling, and barrier pathways. JAK–STAT pathway was also activated, linking microbial metabolite sensing to growth promotion (<em>stat5b, igf2bp3</em>). The probiotic-integrated protocol modifies the gut microbiome by shifting microbial composition through changes in competitive interactions and microbial signaling pathways. It also improves the intestinal wall, overall immunity, and nutrient absorption. These findings provide insights into the microbiome-host interaction under probiotic treatment and suggest that this strategy may offer potential benefits under farm conditions, but further studies are needed to validate its safety and ecological implications.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100600"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial community characterization in semi-hydroponic systems of Starbor kale (Brassica oleracea L.) grown under normal gravity and simulated microgravity","authors":"Labode Hospice Stevenson Naitchede ,&nbsp;Onyinye C. Ihearahu ,&nbsp;Kishan Saha ,&nbsp;David O. Igwe ,&nbsp;Jie Yan ,&nbsp;Anne A. Osano ,&nbsp;Supriyo Ray ,&nbsp;George Ude","doi":"10.1016/j.crmicr.2026.100592","DOIUrl":"10.1016/j.crmicr.2026.100592","url":null,"abstract":"<div><div>Kale is a member of the <em>Brassicaceae</em> family and contains a range of beneficial compounds. Given the global context of climate change, various vegetable production systems using advanced technologies, such as hydroponics, are being explored to alleviate food insecurity. Herein, we characterized the comprehensive microbial community associated with Starbor kale cultivation systems under normal gravity and simulated microgravity in coco coir, representing an innovative approach compared to previous studies. The kale seedlings were planted in growth vessels set into custom 2D clinostats and placed in a CONVIRON growth chamber for 43 days. The microbial DNA from coco-coir and root samples of grown kale was extracted and subjected to shotgun metagenomic sequencing. Comparisons between components revealed a higher abundance of bacteria in the soilless, while the kale roots were dominated by <em>Eukaryota</em> and a<em>rchaea</em>. The phyla <em>Pseudomonadota</em> and <em>Actinomycetota</em> were highly prevalent across all samples, with relatively high abundance in the coco coir samples from horizontal clinostats (HCR) under simulated gravity and from rotating vertical clinostats (VCR). The HCR group was associated with the highest number of biomarkers (28). Both CAZymes, glycoside hydrolases and carbohydrate esterases, exhibited higher relative abundances in the coco coir samples under normal gravity, whereas carbohydrate-binding modules were more abundant in HCR and VCR. The root samples showed much higher abundances of polysaccharide lyases (ranging from 0.00088 to 0.00097) and carbohydrate esterases (ranging from 0.030 to 0.033). The top four prevalent antibiotic resistance genes were <em>adeF, vanY, vanT</em>, and <em>qacG</em>. The findings of this investigation are crucial for the cultivation of kale and leafy green agriculture in hydroponic systems.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100592"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutations in the superoxide-responsive regulator SoxR confer fluoroquinolone resistance in Stenotrophomonas maltophilia","authors":"Poonyaporn Kanawong ,&nbsp;Parinya Tipanyo ,&nbsp;Suleepon Poomchuchit ,&nbsp;Skorn Mongkolsuk ,&nbsp;Paiboon Vattanaviboon ,&nbsp;Nisanart Charoenlap","doi":"10.1016/j.crmicr.2026.100609","DOIUrl":"10.1016/j.crmicr.2026.100609","url":null,"abstract":"<div><div><em>Stenotrophomonas maltophilia</em> is a multidrug-resistant Gram-negative opportunistic pathogen. Its antimicrobial resistance arises from intrinsic traits and acquired mechanisms. Overexpression of drug efflux transporters is one of the key mechanisms mediating high-level antibiotic resistance. These transporters are regulated by transcriptional factors, including SoxR, a superoxide-responsive regulator containing an iron-sulfur [2Fe-2S] cluster. SoxR controls the multidrug efflux pumps MfsA and SmeVWX, as well as superoxide dismutase SodA1. To examine how <em>soxR</em> mutations affect antimicrobial resistance, random mutagenesis was performed, and mutated genes were ectopically expressed in a Δ<em>soxR</em> mutant. Transformants were selected for ciprofloxacin resistance, a substrate for both MfsA and SmeVWX. Sequencing of 21 resistant colonies revealed five distinct mutation patterns (A–E), each containing multiple mutations. The Δ<em>soxR</em> mutant expressing these <em>soxR</em> variants showed increased resistance to multiple antibiotics targeted by the efflux pumps, correlating with elevated MfsA and SmeVWX expression. This indicates constitutive SoxR activation. To assess the role of the [2Fe-2S] cluster, cysteine-to-serine substitutions at three of the four cluster-binding residues abolished SoxR’s ability. Computational structure prediction and molecular dynamics simulations supported these findings, revealing that mutations enhanced solvent exposure of the [2Fe-2S] cluster. This suggests that the mutations shift SoxR into a conformation more prone to activation. Furthermore, a single amino acid substitution at residue R49 was sufficient to activate SoxR and confer resistance. Together, our findings demonstrate that <em>S. maltophilia</em> can enhance antimicrobial resistance through <em>soxR</em> mutations, particularly under antibiotic pressure. This highlights the role of SoxR in the antimicrobial resistance of <em>S. maltophilia</em>.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"10 ","pages":"Article 100609"},"PeriodicalIF":5.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147995695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}