Current Research in Microbial Sciences最新文献

{"title":"Ibrexafungerp: A narrative overview","authors":"L'Emir Wassim El Ayoubi ,&nbsp;Fatima Allaw ,&nbsp;Elie Moussa ,&nbsp;Souha S. Kanj","doi":"10.1016/j.crmicr.2024.100245","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100245","url":null,"abstract":"<div><p>Ibrexafungerp (IBX) is a new antifungal drug that recently entered the antifungal landscape. It disrupts fungal cell wall synthesis by non-competitive inhibition of the β-(1,3)-D-glucan (BDG) synthase enzyme. It has demonstrated activity against a range of pathogens including <em>Candida</em> and <em>Aspergillus</em> spp., as well as retaining its activity against azole-resistant and echinocandin-resistant strains. It also exhibits anti-biofilm properties. Pharmacokinetic (PK) studies revealed favorable bioavailability, high protein binding, and extensive tissue distribution with a low potential for CYP-mediated drug interactions. It is characterized by the same mechanism of action of echinocandins with limited cross-resistance with other antifungal agents. Resistance to this drug can arise from mutations in the <em>FKS</em> genes, primarily <em>FKS2</em> mutations in <em>Nakaseomyces glabrata</em>. In vivo, IBX was found to be effective in murine models of invasive candidiasis (IC) and invasive pulmonary aspergillosis (IPA). It also showed promising results in preventing and treating <em>Pneumocystis jirovecii</em> infections. Clinical trials showed that IBX was effective and non-inferior to fluconazole in treating vulvovaginal candidiasis (VVC), including complicated cases, as well as in preventing its recurrence. These trials positioned it as a Food and Drug Administration (FDA)-approved option for the treatment and prophylaxis of VVC. Trials showed comparable responses to standard-of-care in IC, with favorable preliminary results in <em>C. auris</em> infections in terms of efficacy and tolerability as well as in refractory cases of IC. Mild adverse reactions have been reported including gastrointestinal symptoms. Overall, IBX represents a significant addition to the antifungal armamentarium, with its unique action, spectrum of activity, and encouraging clinical trial results warranting further investigation.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000270/pdfft?md5=c5569e8a01322f3810b939d41b0f2226&pid=1-s2.0-S2666517424000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An outer membrane vesicle specific lipoprotein promotes Porphyromonas gingivalis aggregation on red blood cells","authors":"Christina M. Rothenberger ,&nbsp;Manda Yu ,&nbsp;Hey-Min Kim ,&nbsp;Yee-Wai Cheung ,&nbsp;Yi-Wei Chang ,&nbsp;Mary Ellen Davey","doi":"10.1016/j.crmicr.2024.100249","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100249","url":null,"abstract":"<div><p><em>Porphyromonas gingivalis</em> uses a variety of mechanisms to actively interact with and promote the hydrolysis of red blood cells (RBCs) to obtain iron in the form of heme. In this study, we investigated the function of lipoprotein PG1881 which was previously shown to be up-regulated during subsurface growth and selectively enriched on outer membrane vesicles (OMVs). Our results show that wildtype strain W83 formed large aggregates encompassing RBCs whereas the PG1881 deletion mutant remained predominately as individual cells. Using a PG1881 antibody, immunofluorescence revealed that the wildtype strain's aggregation to RBCs involves an extracellular matrix enriched with PG1881. Our findings discover that RBCs elicit cell aggregation and matrix formation by <em>P. gingivalis</em> and that this process is promoted by an OMV-specific lipoprotein. We propose this strategy is advantageous for nutrient acquisition as well as dissemination from the oral cavity and survival of this periodontal pathogen.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000312/pdfft?md5=9c4453b76cfe73e58ed15aa05c51381d&pid=1-s2.0-S2666517424000312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141324863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial diversity along the geothermal gradients: insights from the high-altitude Himalayan hot spring habitats of Sikkim","authors":"Santosh Kumar ,&nbsp;Sayak Das ,&nbsp;Namrata Jiya ,&nbsp;Avinash Sharma ,&nbsp;Chirantan Saha ,&nbsp;Prayatna Sharma ,&nbsp;Sonia Tamang ,&nbsp;Nagendra Thakur","doi":"10.1016/j.crmicr.2024.100310","DOIUrl":"10.1016/j.crmicr.2024.100310","url":null,"abstract":"<div><div>Geothermal habitats present a unique opportunity to study microbial adaptation to varying temperature conditions. In such environments, distinct temperature gradients foster diverse microbial communities, each adapted to its optimal niche. However, the complex dynamics of bacterial populations in across these gradients high-altitude hot springs remain largely unexplored. We hypothesize that temperature is a primary driver of microbial diversity, and bacterial richness peaks at intermediate temperatures. To investigate this, we analysed bacterial diversity using 16S rRNA amplicon sequencing across three temperature regions: hot region of 56–65 °C (hot spring), warm region of 35–37 °C (path carrying hot spring water to the river), and cold region of 4–7 °C (river basin). Our findings showed that Bacillota was the most abundant phylum (45.51 %), followed by Pseudomonadota (32.81 %) and Actinomycetota (7.2 %). Bacillota and Chloroflexota flourished in the hot and warm regions, while Pseudomonadota thrived in cooler areas. Core microbiome analysis indicated that species richness was highest in the warm region, declining in both cold and hot regions. Interestingly, an anomaly was observed with <em>Staphylococcus</em>, which was more abundant in cases where ponds were used for bathing and recreation. In contrast, <em>Clostridium</em> was mostly found in cold regions, likely due to its viability in soil and ability to remain dormant as a spore-forming bacterium. The warm region showed the highest bacterial diversity, while richness decreased in both cold and hot regions. This highlights the temperature-dependent nature of microbial communities, with optimal diversity in moderate thermal conditions. The study offers new insights into microbial dynamics in high-altitude geothermal systems.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100310"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subinhibitory concentrations of meropenem stimulate membrane vesicle production and modulate immune response in Bacteroides fragilis infection","authors":"Saniya Kozhakhmetova ,&nbsp;Ayazhan Bekbayeva ,&nbsp;Elena Zholdybayeva ,&nbsp;Tatyana Krivoruchko ,&nbsp;Natalya Dashevskaya ,&nbsp;Zhanel Mukhanbetzhanova ,&nbsp;Elizaveta Vinogradova ,&nbsp;Almagul Kushugulova ,&nbsp;Samat Kozhakhmetov","doi":"10.1016/j.crmicr.2024.100294","DOIUrl":"10.1016/j.crmicr.2024.100294","url":null,"abstract":"<div><div>This study explores an adaptation mechanism of <em>Bacteroides fragilis</em> to subinhibitory concentrations of meropenem, characterized by an alteration in the production of membrane vesicles (MVs) and modulation of the host inflammatory response. Using a rat model of infection, we demonstrated a significant increase in the size of MVs accompanied by a nonsignificant increase in their number in the meropenem-treated group compared to the infected control. Both infected groups showed significantly altered hematological parameters and shifts in monocyte on day 8 (average increase of 21.5 %). At the same time, significant changes in neutrophils (decrease by 26 %) and eosinophils (increase by 3 %) were observed only in the infected group but not in the infected meropenem-treated group. On day 16, increased macrophage activation, neovascularization, and fibrosis were observed in the tissues of the antibiotic-treated group. Immunological profile analysis revealed a slight increase in the levels of pro-inflammatory cytokines (IL-5, IL-6, IFN-γ and G-CSF) on day 8 of the experiment, followed by a sharp decrease on day 16 in both infected groups compared to the negative control. At the same time, network analysis of correlations between these immunological factors showed complex changes in response to subinhibitory concentrations of meropenem. The bacterial load did not differ between the infected groups on days 8 and 16, but only in the meropenem-free group a significant decrease in the number of bacteria was observed on day 16 in all samples. These findings suggest that subinhibitory antibiotic concentrations can influence the pathophysiological progression of <em>B. fragilis</em> infection, modulating both the bacterial response and the host immune reaction, potentially leading to a more complex and chronic disease course.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100294"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic insights of a native bacterial consortium for wheat production sustainability","authors":"Marisol Ayala Zepeda ,&nbsp;Valeria Valenzuela Ruiz ,&nbsp;Fannie Isela Parra Cota ,&nbsp;Cristina Chinchilla-Soto ,&nbsp;Eulogio de la Cruz Torres ,&nbsp;María Itria Ibba ,&nbsp;María Isabel Estrada Alvarado ,&nbsp;Sergio de los Santos Villalobos","doi":"10.1016/j.crmicr.2024.100230","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100230","url":null,"abstract":"<div><p>The use of plant growth-promoting bacteria as bioinoculants is a powerful tool to increase crop yield and quality and to improve nitrogen use efficiency (NUE) from fertilizers in plants. This study aimed to bioprospecting a native bacterial consortium (<em>Bacillus cabrialesii</em> subsp. <em>cabrialesii</em> TE3^T, <em>Priestia megaterium</em> TRQ8, and <em>Bacillus paralicheniformis</em> TRQ65), through bioinformatic analysis, and to quantify the impact of its inoculation on NUE (measured through ¹⁵N-isotopic techniques), grain yield, and grain quality of durum wheat variety CIRNO C2008 grown under three doses of urea (0, 120, and 240 kg N ha⁻¹) during two consecutive agricultural cycles in the Yaqui Valley, Mexico. The inoculation of the bacterial consortium (BC) to the wheat crop, at a total N concentration of 123–225 kg N ha⁻¹ increased crop productivity and maintained grain quality, resulting in a yield increase of 1.1 ton ha⁻¹ (6.0 vs. 7.1 ton ha⁻¹, 0 kg N ha⁻¹ added, 123 kg N ha⁻¹ in the soil) and of 2.0 ton ha⁻¹ (5.9 vs. 7.9 ton ha⁻¹, 120 kg N ha⁻¹ added, 104 kg N ha⁻¹ in the soil) compared to the uninoculated controls at the same doses of N. The genomic bioinformatic analysis of the studied strains showed a great number of biofertilization-related genes regarding N and Fe acquisition, P assimilation, CO₂ fixation, Fe, P, and K solubilization, with important roles in agroecosystems, as well as genes related to the production of siderophores and stress response. A positive effect of the BC on NUE at the studied initial N content (123 and 104 kg N ha⁻¹) was not observed. Nevertheless, increases of 14 % and 12.5 % on NUE (whole plant) were observed when 120 kg N ha⁻¹ was applied compared to when wheat was fully fertilized (240 kg N ha⁻¹). This work represents a link between bioinformatic approaches of a native bacterial inoculant and the quantification of its impact on durum wheat.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000129/pdfft?md5=87da0a38e8bd2da9662034dda18ad225&pid=1-s2.0-S2666517424000129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140096320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A concise review on waste biomass valorization through thermochemical conversion","authors":"Naveen Chandra Joshi ,&nbsp;Somya Sinha ,&nbsp;Pooja Bhatnagar ,&nbsp;Yogesh Nath ,&nbsp;Bhavya Negi ,&nbsp;Vinod Kumar ,&nbsp;Prateek Gururani","doi":"10.1016/j.crmicr.2024.100237","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100237","url":null,"abstract":"<div><p>Due to an increase in industrialization and urbanization, massive amounts of solid waste biomass are speedily accumulating in our environment, which poses several adverse effects on habitat and human health thus becoming a matter of discussion in the environmental community. With reference to the circular economy, continuous efforts have been put forward for setting up an organised management approach in combination with an efficient treatment technique for increasing the profitable utilization of solid waste. This review aims to provide a systematic discussion on the recent thermochemical technologies employed for converting waste biomass generated from different sources into valuable products like biochar, bio-oil, heat, energy and syngas. The article further focuses on a few important aspects of thermochemical conversion of waste biomass to useful products like technical factors affecting thermochemical processes, applications of by-products of thermochemical conversion, and biological pretreatment of waste biomass. The review assists interesting recent and scientific trends for boosting up the systematic management and valorization of solid waste through low-cost, efficient, environment-friendly and sustainable technologies.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000191/pdfft?md5=dc9de733212561ec1f8aaa3281f44ba8&pid=1-s2.0-S2666517424000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi","authors":"Kamila Kulig,&nbsp;Maria Rapala-Kozik,&nbsp;Justyna Karkowska-Kuleta","doi":"10.1016/j.crmicr.2024.100255","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100255","url":null,"abstract":"<div><p><em>Candida</em> fungi exploit various virulence strategies to invade the human host, while host cells employ diverse mechanisms to maintain homeostasis and respond to infection. Extracellular vesicles (EVs) are integral components of the multifaceted landscape of host-pathogen interactions, with their abundant production by all contributors involved in these complex and dynamic relations. Herein, we present the current state of knowledge regarding the host response by releasing EVs in reaction to <em>Candida</em>, as well as the influence of fungal EVs on the functionality of the confronted host cells. Fungal vesicles contribute to enhanced adhesion of pathogens to human cells as evidenced for <em>C. auris</em>, and may modulate the production of several cytokines, including IL-6, IL-8, IL-10, IL-12p40, TGF-β and TNF-α, thereby exerting pro-infective and pro-inflammatory effects, as described for <em>C. albicans</em> and other <em>Candida</em> species. Whereas the biosynthesis of EVs by host cells can dynamically modulate the proliferation and viability of fungal cells and affect the candidacidal functionality of other effector cells. The reciprocal influence of EVs from host cells and <em>Candida</em> pathogens is a key focus, explaining their significant role in cell signaling and interkingdom communication.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100255"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000373/pdfft?md5=d9cb8c5dc141ffcc023e09eb7274ba8d&pid=1-s2.0-S2666517424000373-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing novel Aspergillus species for bio-flocculation: A cost-effective approach to harvest Scenedesmus microalgae for biofuel production","authors":"Gyanendra Tripathi ,&nbsp;Vinay Kumar Pandey ,&nbsp;Suhail Ahmad ,&nbsp;Irum ,&nbsp;Nortoji A. Khujamshukurov ,&nbsp;Alvina Farooqui ,&nbsp;Vishal Mishra","doi":"10.1016/j.crmicr.2024.100272","DOIUrl":"10.1016/j.crmicr.2024.100272","url":null,"abstract":"<div><p>The present study aimed to isolate a bioflocculating fungal strain from wastewater collected from a local bike garage. The isolate showed maximum similarity to <em>Aspergillus</em> species<em>.</em> The fungus was identified as <em>Aspergillus flavus</em> species <em>F_GTAF1 IU</em> (accession no OP703382). The isolated fungus was evaluated in terms of biomass recovery efficiency in <em>Scenedesmus</em> Sp. GTAF01. The extent of algal fungal co-pelletization was evaluated as a function of the algae-to-fungi ratio, volume of fungal culture in broth, agitation rate, and pH. results showed that at fungal culture volume of 60<span><math><mi>░</mi></math></span>%v/v, fungal culture volume of 1:3<span><math><mi>░</mi></math></span>%w/w, 100 rpm, and pH 3, 93.6<span><math><mi>░</mi></math></span>% biomass was obtained during the initial 5 h. At wavenumbers 1384 and 1024 cm^-1 a significant alteration in the transmission percentage was observed in co-pellet compared to algae and fungal cells. This shows the significant role of C-H–H and C-N stretches in co-pellet formation. This study provides deep insight into effective microalgal harvesting along with the simultaneous extraction of lipids that can be used for the sustainable production of biodiesel.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100272"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000543/pdfft?md5=b532aa94acec862a01da09a9be65b062&pid=1-s2.0-S2666517424000543-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid composting of groundnut residues through novel microbial consortium: Evaluating maturity, stability, and microbial activity","authors":"Deblina Roy ,&nbsp;Sunil Kumar Gunri ,&nbsp;Champak Kumar Kundu ,&nbsp;Prasanta Kumar Bandyopadhyay","doi":"10.1016/j.crmicr.2024.100277","DOIUrl":"10.1016/j.crmicr.2024.100277","url":null,"abstract":"<div><div>A laboratory pot experiment (Experiment 1) was conducted to determine the optimal ratio of groundnut haulm and shell as composting substrates. The aim was to identify the most effective combination for rapid decomposition under <em>in vivo</em> conditions. The experiment was carried out in 2022, from May to July, using a completely randomized design (CRD) with 6 treatments that were replicated 4 times. The treatment combinations in the pot experiment were as follows: T₁: haulm + shell (1:1), T₂: haulm + shell (2:1), T₃: haulm + shell (3:1), T₄: T₁ + C_n, T₅: T₂ + C_n, and T₆: T₃ + C_n. Here, C_n refers to the cellulose-degrading efficient microbial consortium containing bacterial strains <em>Priestia megaterium</em> DBJ6, <em>Micrococcus yunnanensis</em> DMB9, and fungal strains <em>Aspergillus foetidus</em> DAJ2, <em>Trichoderma atrobrunnium</em> DTJ4, and <em>Phanerochaete chrysosporium</em> CBS129.27. Based on the results (results of chemical and biological properties) of the pot experiment, treatment T₆ was considered the best treatment (the C/N ratio was 14.36 ± 0.444 after three months of decomposition) for further study under <em>in vivo</em> conditions. The <em>in vivo</em> experiment (Experiment 2) was conducted at the Jaguli Instructional Farm of Bidhan Chandra Krishi Viswavidyalaya, West Bengal, India, during the months of August to October in both 2022 and 2023 with two treatments: the normal composting treatment (NC) and the rapid composting treatment (RC). The findings of Experiment 2 showed that organic substrates degraded more quickly (within 90 days) during rapid composting, as evidenced by a decrease in the C/N ratio to below 15 (14.32 and 13.97 on day 90 in 2022 and 2023, respectively). Whereas, normal composting required more than 90 days to achieve a C/N ratio below 20 (23.80 and 23.15 on day 90 in 2022 and 2023, respectively). The RC treatment also showed a higher microbial population and enzyme activity compared to the NC treatment. Therefore, according to the results of this experiment, it can be concluded that the inoculation of the microbial consortium was more beneficial for accelerating the composting process under the same composting circumstances and substrate ratio.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100277"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous production of biofuel from agricultural wastes and bioremediation of the waste substrates: A review","authors":"Chukwuemeka Samson Ahamefule ,&nbsp;Chidimma Osilo ,&nbsp;Blessing C. Ahamefule ,&nbsp;Stella N. Madueke ,&nbsp;Anene N. Moneke","doi":"10.1016/j.crmicr.2024.100305","DOIUrl":"10.1016/j.crmicr.2024.100305","url":null,"abstract":"<div><div>Pollution from fossil fuel usage coupled with its unsustainability is currently instigating a global drive for affordable and eco-friendly alternatives. A feasible replacement seems to be microbial biofuels. However, the production cost is still high, partly due to the cost of substrates and media. Microalgae, yeasts, moulds and bacteria can grow on cheap and easily available agricultural waste substrates to produce bioethanol, biogas, biobutanol, acetone and/or lipids for biodiesel. Oleaginous microbes, such as several species of <em>Chlorella, Schizochytrium, Rhodotorula, Rhodosporidium, Yarrowia, Aspergillus, Rhodococcus,</em> etc., have been applied in the production of high and choice lipids for biodiesel. High bioethanol, butanol and acetone yields have also been achieved with several agricultural waste substrates either through separate hydrolysis and fermentation or simultaneous saccharification and fermentation. The isolation or transformation of some microbial strains has shown the possibility of using only one microorganism to produce bioethanol from lignocellulose biomass in consolidated bioethanol production. High biogas/biomethane yield has also been recorded from different agricultural wastes, especially in co-digestion systems. Pre-treatment, detoxification, application of microbial co-cultures, co-substrate mixing ratios, organic loading rate, hydraulic retention time among others have been reported to affect the quantity and quality of different biofuels produced from agricultural wastes. Interestingly, these agricultural waste substrates were greatly degraded during fermentation and/or digestion to achieve high level of bioremediation. Therefore, this study presents a holistic review of various agricultural wastes adopted as biofuel substrates, the conditions to attain optimum biofuel productions and cases of simultaneous bioremediation of substrates obtained during biofuel production. The valorization of the biofuel by-products into other essential products to achieve a zero-waste and circular bioeconomy is also properly presented.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100305"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}