Current Research in Microbial Sciences最新文献

{"title":"Microbial contributions to sustainable paddy straw utilization for economic gain and environmental conservation","authors":"Baljeet Singh Saharan ,&nbsp;Deepika Dhanda ,&nbsp;Neelam Kumari Mandal ,&nbsp;Ramesh Kumar ,&nbsp;Deepansh Sharma ,&nbsp;Pardeep Kumar Sadh ,&nbsp;Dilfuza Jabborova ,&nbsp;Joginder Singh Duhan","doi":"10.1016/j.crmicr.2024.100264","DOIUrl":"10.1016/j.crmicr.2024.100264","url":null,"abstract":"<div><p>Paddy straw is a versatile and valuable resource with multifaceted benefits for nutrient cycling, soil health, and climate mitigation. Its role as a rich nutrient source and organic matter significantly enhances soil vitality while improving soil structure and moisture retention. The impact of paddy straw extends beyond traditional agricultural benefits, encompassing the promotion of microbial activity, erosion control, and carbon sequestration, highlighting its crucial role in maintaining ecological balance. Furthermore, the potential of paddy straw in bioenergy is explored, encompassing its conversion into biogas, biofuels, and thermal energy. The inherent characteristics of paddy straw, including its high cellulose, hemicellulose, and lignin content, position it as a viable candidate for bioenergy production through innovative processes like pyrolysis, gasification, anaerobic digestion, and combustion. Recent research has uncovered state-of-the-art techniques and innovative technologies capable of converting paddy straw into valuable products, including sugar, ethanol, paper, and fiber, broadening its potential applications. This paper aims to underscore the possibilities for value creation through paddy straw, emphasizing its potential use in bioenergy, bio-products, and other environmental applications. Therefore, by recognizing and harnessing the value of paddy straw, we can advocate for sustainable farming practices, reduce waste, and pave the way for a resource-efficient circular economy. Incorporating paddy straw utilization into agricultural systems can pave the way for enhanced resource efficiency and a more sustainable circular economy.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100264"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000464/pdfft?md5=85663c8ca88d7bb242da35d1d00533d2&pid=1-s2.0-S2666517424000464-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acridones as promising drug candidates against Oropouche virus","authors":"Marielena Vogel Saivish ,&nbsp;Gabriela de Lima Menezes ,&nbsp;Roosevelt Alves da Silva ,&nbsp;Leticia Ribeiro de Assis ,&nbsp;Igor da Silva Teixeira ,&nbsp;Umberto Laino Fulco ,&nbsp;Clarita Maria Secco Avilla ,&nbsp;Raphael Josef Eberle ,&nbsp;Igor de Andrade Santos ,&nbsp;Karolina Korostov ,&nbsp;Mayara Lucia Webber ,&nbsp;Gislaine Celestino Dutra da Silva ,&nbsp;Maurício Lacerda Nogueira ,&nbsp;Ana Carolina Gomes Jardim ,&nbsp;Luis Octavio Regasin ,&nbsp;Mônika Aparecida Coronado ,&nbsp;Carolina Colombelli Pacca","doi":"10.1016/j.crmicr.2023.100217","DOIUrl":"https://doi.org/10.1016/j.crmicr.2023.100217","url":null,"abstract":"<div><p>Oropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that causes Oropouche fever, a febrile infection similar to dengue fever. It has a high epidemic potential, causing illness in over 500,000 cases diagnosed since the virus was first discovered in 1955. Currently, the prevention of human viral infection depends on vaccination, but availability for many viruses is limited, and they are classified as neglected viruses. At present, there are no vaccines or antiviral treatments available. An alternative approach to limiting the spread of the virus is to selectively disrupt viral replication mechanisms. Here, we demonstrate the inhibitory effect of acridones, which efficiently inhibited viral replication by 99.9 % <em>in vitro</em>. To evaluate possible mechanisms of action, we conducted tests with dsRNA, an intermediate in virus replication, as well as MD simulations, docking, and binding free energy analysis. The results showed a strong interaction between FAC21 and the OROV endonuclease, which possibly limits the interaction of viral RNA with other proteins. Therefore, our results suggest a dual mechanism of antiviral action, possibly caused by ds-RNA intercalation. In summary, our findings demonstrate that a new generation of antiviral drugs could be developed based on the selective optimization of molecules.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266651742300038X/pdfft?md5=abf89b7a169016aafa40b65605884d97&pid=1-s2.0-S266651742300038X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement in the development of gene/protein-based vaccines against African swine fever virus","authors":"Ning Wang ,&nbsp;Pan Huang ,&nbsp;Jun Zhang ,&nbsp;Minqi Lin ,&nbsp;Xiaoru Lai ,&nbsp;Jianwen Chen ,&nbsp;Chungen Pan","doi":"10.1016/j.crmicr.2024.100232","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100232","url":null,"abstract":"<div><p>African swine fever (ASF) is a highly contagious acute hemorrhagic viral disease, with the mortality rate of up to 100 % in domestic pigs. In recent years, ASF outbreaks have caused huge economic losses in numerous countries and regions, especially in Asia. Therefore, there is a pressing need to develop safe and effective vaccines against infection of the causative pathogen, African swine fever virus (ASFV). ASFV contains a large genome composed of double-stranded DNA with a size of 170–194 kb, which encodes nearly 200 viral proteins. Understanding the function of these complex genes/proteins and their roles in the generation of protective immunity will help in the development of ASFV vaccines. In this article, the gene/protein-based vaccine candidate are summarized, and the structural proteins which have been previously reported to protect animals from the virus challenge were emphatically described.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000142/pdfft?md5=577c2c1d51722e2a55abf9ee21b17e8e&pid=1-s2.0-S2666517424000142-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphing the Green route: Enzymatic hydrolysis in sustainable decomposition","authors":"Rajat Singh ,&nbsp;Rajul Jain ,&nbsp;Priyanka Soni ,&nbsp;Sergio de los Santos-Villalobos ,&nbsp;Sourav Chattaraj ,&nbsp;Deblina Roy ,&nbsp;Debasis Mitra ,&nbsp;Ashish Gaur","doi":"10.1016/j.crmicr.2024.100281","DOIUrl":"10.1016/j.crmicr.2024.100281","url":null,"abstract":"<div><div>This graphical review article explores how sustainable decomposition contributes to environmental sustainability in waste management with a focus on enzymatic hydrolysis. Methods such as composting and anaerobic digestion efficiently break down organic waste and reduce landfill use and greenhouse gas emissions, while producing valuable resources such as compost and biogas. In particular, enzymatic hydrolysis offers advantages over chemical methods because it operates under mild conditions, targets specific substrates precisely, and yields purer products with fewer side reactions. Its renewable and biodegradable nature aligns with sustainability goals, making it suitable for waste decomposition, biorefining, and resource recovery. Enzymatic waste conversion reduces waste and pollution, conserves natural resources, and supports circular economy. Various ongoing studies have aimed to enhance the efficiency and environmental benefits of enzymatic hydrolysis, enabling innovative waste-to-value solutions that address environmental, economic, and social challenges. This article emphasizes the importance of its timely examination of enzymatic hydrolysis as a prominent method for sustainable waste decomposition, stressing its environmental, economic, and societal benefits. It distinguishes itself through its extensive analysis of chemical methods, its emphasis on the circular economy, and its delineation of future research directions and the need for interdisciplinary collaboration to advance this innovative technology.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100281"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revalorization of degraded maguey pulquero substrate for Lycopersicon esculentum germination","authors":"B.S. Velázquez-De Lucio ,&nbsp;E.M. Hernández-Domínguez ,&nbsp;M.P. Falcón-León ,&nbsp;A. Téllez-Jurado ,&nbsp;J Álvarez-Cervantes","doi":"10.1016/j.crmicr.2024.100283","DOIUrl":"10.1016/j.crmicr.2024.100283","url":null,"abstract":"<div><div>The bagasse of <em>Agave salmiana</em> (maguey pulquero) is a residue generated during the exploitation of the plant to obtain pulque, inulin, honey, etc. Due to its chemical composition, it can be used for the cultivation of fungi of the <em>Pleurotus</em> genus and the subsequent use of the degraded material \"degraded substrate (DS)\" as a support for the germination of vegetables. The objective of the study was to characterize the bagasse of maguey pulquero biodegraded by <em>Pleurotus djamor</em> as a new perspective in its value chain, and subsequent use for the germination of <em>Lycopersicon esculetum</em> (tomato). The DS was recovered at 60 d from the <em>P. djamor</em> culture, characterized physicochemically and the conformation of the plant tissue was observed by scanning electron microscopy. The DS showed a decrease in protein (4.8–3.3 %) content and fibrous fraction (54–36 %), but dry matter digestibility increased from 47 to 71 %; in addition, changes in mineral composition were observed, mainly in calcium concentration (6 %). Due to its composition, it is possible to revalue DS in the germination of L. <em>esculetum</em> to reduce the use of peat moss (commercial peat). The results show that up to 25 % of maguey DS mixed with 75 % peat moss can be used (25:75), reaching a germination percentage of 85 % and increasing the seedling emergence speed index from 0.96 – 1.25. Concluding that it is possible to implement a circular strategy in which agave bagasse is used for mushroom cultivation and the subsequent recovery of the spent substrate for tomato germination.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100283"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals","authors":"Alejandra Álvarez-Mínguez ,&nbsp;Natalia del Río ,&nbsp;Ana Belén-Blázquez ,&nbsp;Elena Casanova ,&nbsp;José-María Orduña ,&nbsp;Patricia Camarero ,&nbsp;Carolina Hurtado-Marcos ,&nbsp;Carmen del Águila ,&nbsp;María–Jesús Pérez-Pérez ,&nbsp;Miguel A. Martín-Acebes ,&nbsp;Rubén Agudo","doi":"10.1016/j.crmicr.2024.100282","DOIUrl":"10.1016/j.crmicr.2024.100282","url":null,"abstract":"<div><div>West Nile virus (WNV) is a flavivirus responsible for causing febrile illness and severe neurological diseases, with an increasing impact on human health around the world. However, there is still no adequate therapeutic treatment available to struggle WNV infections. Therefore, there is an urgent need to develop new techniques to accelerate the discovery of drugs against this pathogen. The main protein implicated in the replication of WNV is the non-structural protein 5 (NS5). This multifunctional protein contains methyltransferase (MTase) activity involved in the capping formation at the 5′-end of RNA and the methylation of internal viral RNA residues, both functions being essential for viral processes, such as RNA translation and escape from the innate immune response.</div><div>We have developed a straightforward luminescence-based assay to monitor the MTase activity of the WNV NS5 protein with potential for high-throughput screening. We have validated this method as a sensitive and suitable assay for the identification of WNV MTase inhibitors assessing the inhibitory effect of the broad MTase inhibitor sinefungin, a natural nucleoside analog of the universal methyl donor S-adenosyl methionine (SAM). The screening of a small series of purine derivatives identified an adenosine derivative as a dose-dependent inhibitor of the MTase activity. The antiviral efficacy of this compound was further confirmed in WNV infections, displaying a measurable antiviral effect. This result supports the utility of this novel method for the screening of inhibitors against WNV MTase activity, which can be of special relevance to the discovery and development of therapeutics against WNV.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100282"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photosynthetic activity and growth of poblano pepper biofertilized with plant growth promoting rhizobacteria and arbuscular mycorrhizal fungi","authors":"Apolinar González-Mancilla ,&nbsp;Juan José Almaraz-Suárez ,&nbsp;Ronald Ferrera-Cerrato ,&nbsp;María del Pilar Rodríguez-Guzmán ,&nbsp;Oswaldo Rey Taboada-Gaytán","doi":"10.1016/j.crmicr.2024.100269","DOIUrl":"10.1016/j.crmicr.2024.100269","url":null,"abstract":"<div><p>The rhizosphere of plants are natural hosts for beneficial microorganisms such as plant growth-promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF). The objective of this work was to determine the effect of a consortium of AMF and three strains of PGPR on growth, gas exchange and phosphorus content in poblano pepper plants. An experiment was established in a completely randomized design with factorial arrangement, with two factors: AMF [<em>Funneliformis geosporum</em> and <em>Claroideoglomus</em> sp. (AM) and without AM (WM)] and PGPR [<em>Rhizobium nepotum</em> (B1), <em>Serratia plymuthica</em> (B2), <em>Pseudomonas tolaasii</em> (B3) and without PGPR (WB)]; generating eight treatments: T1) AM+B1, T2) AM+B2, T3) AM+B3, T4) AM+WB, T5) WM+B1, T6) WM+B2, T7) WM+B3 and T8) WM+WB. Plant height, number of leaves, leaf area, number of flowers, dry biomass, phosphorus content and AMF colonization were measured; internal CO₂ concentration (Ci), transpiration rate (E), stomatal conductance (gS) and photosynthesis rate (Pn) were determined in leaves. Co-inoculation with AM+B3 promoted greater height (35%), number of leaves (66%), leaf area (62%), dry biomass (140%), phosphorus content (195%) and mycorrhizal colonization (26%); AM+B2 improved Ci (5%), E (8%), gS (5%) and Pn (9%) in poblano pepper leaves, compared to the control treatment (WM+WB). Biofertilization with AMF and PGPR improved gas exchange and growth of poblano pepper.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100269"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000518/pdfft?md5=50039a96de11bdfd7ff4eaf3349a30f9&pid=1-s2.0-S2666517424000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutting edge tools in the field of soil microbiology","authors":"Diksha Garg ,&nbsp;Niketan Patel ,&nbsp;Anamika Rawat ,&nbsp;Alexandre Soares Rosado","doi":"10.1016/j.crmicr.2024.100226","DOIUrl":"https://doi.org/10.1016/j.crmicr.2024.100226","url":null,"abstract":"<div><p>The study of the whole of the genetic material contained within the microbial populations found in a certain environment is made possible by metagenomics. This technique enables a thorough knowledge of the variety, function, and interactions of microbial communities that are notoriously difficult to research. Due to the limitations of conventional techniques such as culturing and PCR-based methodologies, soil microbiology is a particularly challenging field. Metagenomics has emerged as an effective technique for overcoming these obstacles and shedding light on the dynamic nature of the microbial communities in soil. This review focuses on the principle of metagenomics techniques, their potential applications and limitations in soil microbial diversity analysis. The effectiveness of target-based metagenomics in determining the function of individual genes and microorganisms in soil ecosystems is also highlighted. Targeted metagenomics, including high-throughput sequencing and stable-isotope probing, is essential for studying microbial taxa and genes in complex ecosystems. Shotgun metagenomics may reveal the diversity of soil bacteria, composition, and function impacted by land use and soil management. Sanger, Next Generation Sequencing, Illumina, and Ion Torrent sequencing revolutionise soil microbiome research. Oxford Nanopore Technology (ONT) and Pacific Biosciences (PacBio)'s third and fourth generation sequencing systems revolutionise long-read technology. GeoChip, clone libraries, metagenomics, and metabarcoding help comprehend soil microbial communities. The article indicates that metagenomics may improve environmental management and agriculture despite existing limitations.Metagenomics has revolutionised soil microbiology research by revealing the complete diversity, function, and interactions of microorganisms in soil. Metagenomics is anticipated to continue defining the future of soil microbiology research despite some limitations, such as the difficulty of locating the appropriate sequencing method for specific genes.</p></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"6 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666517424000087/pdfft?md5=2ce9d5e7893eae4a50ce2b1e5b444897&pid=1-s2.0-S2666517424000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profiling of fungal metabolites via the OSMAC approach: Novel identification of Brianthein W from an endophytic fungus, Hypomontagnella monticulosa Zg15SU","authors":"Anisa Lutfia ,&nbsp;Erman Munir ,&nbsp;Yurnaliza Yurnaliza ,&nbsp;Mohammad Basyuni ,&nbsp;Hirosuke Oku","doi":"10.1016/j.crmicr.2024.100288","DOIUrl":"10.1016/j.crmicr.2024.100288","url":null,"abstract":"<div><div>In the previous report, we reported that <em>Hypomontagnella monticulosa</em> originating from the rhizome of <em>Zingiber griffithii</em> was known to produce a marine-derived natural product. An OSMAC-based approach was designed by modifying the nutritional composition of the growth medium to investigate any possible new metabolites produced by the strain. The culture filtrate and biomass were conditioned through the use of three basal media, namely, Czapek-dox, potato dextrose, and Wickerham broth medium. GC–MS and multivariate analysis was performed to distinguish the chemicals and determine their composition in the tested extracts. Antimicrobial activity was tested against selected human pathogenic microbes using the disk-diffusion method. The MeOH extract of both culture filtrate and biomass from different fermentation media revealed that the majority of identified compounds (<em>n</em> = 40) were found in Wickerham medium (<em>n</em> = 23), which is later termed as MeOH-Wi. The chemical composition of MeOH-Wi was fatty acids (21.74 %), followed by terpenoids (17.38 %), cyclosiloxane (13.04 %), aldehydes (13.04 %), alkenes (8.7 %), hydrocarbons (8.7 %), esters (8.7 %), alkaloids (4.35 %), and an unclassified compound, the 9,9-Dimethyl-3,7-diazabicyclo[3.3.1]nonane. The numerous chemical compounds in MeOH-Wi corresponded with its antimicrobial activities against <em>Micrococcus luteus</em> NBRC 13,867 (±11 mm), <em>Candida maltosa</em> NBRC 1977 (±9 mm), and <em>Escherichia coli</em> JM 109 (±5 mm) which were higher than the other tested extracts. Further purification using HPLC RP-C₁₈ using NP-SiO₂/<em>n</em>-Hex–EtOAc (10:2) to yield compound <strong>(1)</strong>. Compound <strong>(1)</strong> was determined as an analog of briarian W—a diterpene mostly found in marine sponge, <em>Briareum</em> spp.—as a pure compound in the MeOH extract of <em>H. monticulosa</em> based on the 1D and 2D NMR analysis. The anticancer activity (IC₅₀) of compound <strong>(1)</strong> was 0.077, 0.080, and 0.102 µg/mL against the growth of HCT-116, NBT-T2, and Panc-1, respectively. As far as we are aware, this is the first report on finding a briarian diterpene that originates from an endophytic fungus, especially by <em>H. monticulosa.</em></div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100288"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiseptics: An expeditious third force in the prevention and management of coronavirus diseases","authors":"Kizito I. Okeke ,&nbsp;Chukwuemeka Samson Ahamefule ,&nbsp;Obianuju O. Nnabuife ,&nbsp;Ibuchukwu N. Orabueze ,&nbsp;Christian U. Iroegbu ,&nbsp;Kingsley A. Egbe ,&nbsp;Anthony C. Ike","doi":"10.1016/j.crmicr.2024.100293","DOIUrl":"10.1016/j.crmicr.2024.100293","url":null,"abstract":"<div><div>Notably, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19) have all had significant negative impact on global health and economy. COVID-19 alone, has resulted to millions of deaths with new cases and mortality still being reported in its various waves. The development and use of vaccines have not stopped the transmission of SARS coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, even among vaccinated individuals. The use of vaccines and curative drugs should be supplemented with adoption of simple hygiene preventive measures in the fight against the spread of the virus, especially for healthcare workers. Several virucidal topical antiseptics, such as povidone-iodine (PVP-I), citrox, cyclodextrins among others, have been demonstrated to be efficacious in the inactivation of SARS-CoV-2 and other coronaviruses in both <em>in vitro</em> and <em>in vivo</em> studies. The strategic application of these virucidal formulations could provide the additional impetus needed to effectively control the spread of the virus. We have here presented a simple dimension towards curtailing the dissemination of COVID-19, and other coronaviruses, through the application of effective oral, nasal and eye antiseptics among patients and medical personnel. We have further discussed the mechanism of action of some of these commonly available virucidal solutions while also highlighting some essential controversies in their use.</div></div>","PeriodicalId":34305,"journal":{"name":"Current Research in Microbial Sciences","volume":"7 ","pages":"Article 100293"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}