Brain Hemorrhages最新文献_第10页

Before blaming SARS-CoV-2 for intra-cerebral aneurysm formation and rupture, alternative mechanisms need to be ruled out 在将脑内动脉瘤形成和破裂归咎于SARS-CoV-2之前，需要排除其他机制

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.09.001

Josef Finsterer

引用次数: 2

Models of cerebral amyloid angiopathy-related intracerebral hemorrhage 脑淀粉样血管病相关脑出血模型

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.05.001

Sebastian Vargas-George , Kunjan R. Dave

{"title":"Models of cerebral amyloid angiopathy-related intracerebral hemorrhage","authors":"Sebastian Vargas-George , Kunjan R. Dave","doi":"10.1016/j.hest.2022.05.001","DOIUrl":"10.1016/j.hest.2022.05.001","url":null,"abstract":"<div><p>Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease with vascular amyloid-β deposits and is commonly observed among the elderly. Often associated with Alzheimer’s disease, CAA is among the leading causes of intracerebral hemorrhage (ICH) and age-related cognitive decline. Several research studies have tried to understand the mechanisms underlying CAA, but further use of in vivo models is needed to fully understand its pathophysiology. In this review, we provide information gathered from key findings dealing with the mechanisms of beta deposition in cerebral arteries, the diagnosis of different CAA types, and advances in treatment for CAA. Since CAA is a risk factor for ICH, we also review previously used in vivo and in vitro models of CAA and their features with respect to CAA-related ICH. Currently available transgenic mouse models of CAA show a limited occurrence of hemorrhage at variable locations, which often do not produce any obvious neurological deficits. Thus, the development of novel models to more closely mimic the clinical condition of CAA-related ICH is warranted.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"3 4","pages":"Pages 189-199"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X22000195/pdfft?md5=624da9a0afd747574ef9f309af4cbac7&pid=1-s2.0-S2589238X22000195-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78342175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eicosanoid ratios are associated with hemorrhage severity and predict development of delayed cerebral ischemia following subarachnoid hemorrhage 类二十烷酸比值与出血严重程度相关，可预测蛛网膜下腔出血后迟发性脑缺血的发展

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.05.004

Dominic A. Siler , Alexa M. Semonche , Ravi Samatham , Jesse J. Liu , Ross P. Martini , Nabil J. Alkayed , Holly E. Hinson , Justin S. Cetas

{"title":"Eicosanoid ratios are associated with hemorrhage severity and predict development of delayed cerebral ischemia following subarachnoid hemorrhage","authors":"Dominic A. Siler , Alexa M. Semonche , Ravi Samatham , Jesse J. Liu , Ross P. Martini , Nabil J. Alkayed , Holly E. Hinson , Justin S. Cetas","doi":"10.1016/j.hest.2022.05.004","DOIUrl":"10.1016/j.hest.2022.05.004","url":null,"abstract":"<div><p>Delayed cerebral ischemia (DCI) is a life-threatening complication of aneurysmal subarachnoid hemorrhage (aSAH). The vasoactive P450 eicosanoids 20-hydroxyeicosatretraenoate (20-HETE) and 14,15-epoxyeicosatrenoate (14,15-EET) are associated with the development of DCI and may play opposing roles in DCI risk. We hypothesized that the ratio of these opposing eicosanoids in cerebrospinal fluid (CSF) is associated with hemorrhage severity and the risk of developing DCI after aSAH. In a preclinical model, rats received intracisternal blood injections to approximate aSAH. Hemorrhage severity, cerebral blood flow (CBF), cortical spreading depolarizations were recorded, and CSF eicosanoid levels were quantified using mass spectrometry. In a parallel clinical study<em>,</em> CSF samples were collected and analyzed prospectively from subjects with aSAH and outcomes were tracked. Preclinically, rats with greater hemorrhage severity had impaired CBF and lower median 14,15-EET/20-HETE ratios compared to those with lesser or no hemorrhage. In aSAH patients, the CSF 14,15-EET/20-HETE ratio was negatively correlated with hemorrhage grade on imaging. Patients who developed DCI had lower median 14,15-EET/20-HETE ratios compared to those without DCI. The CSF 14,15-EET/20-HETE ratio correlates with hemorrhage severity and may reflect a mechanistic underpinning of microvascular dysfunction that contributes to DCI. These results suggest that vasoactive eicosanoids may be a therapeutic target in aSAH.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"3 4","pages":"Pages 135-142"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X22000225/pdfft?md5=e788109266a6318eeac951f6abbeda4b&pid=1-s2.0-S2589238X22000225-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80744886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and radiological study profile of cerebral venous sinus thrombosis at a tertiary care center in Pakistan 巴基斯坦三级保健中心脑静脉窦血栓形成的临床和放射学研究概况

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.01.004

Muhammad Hassan , Naveed Ullah Khan , Haris Majid Rajput , Waleed Shahzad , Taimoor Hassan , Hafiza Faiza Mushtaq , Mazhar Badshah

{"title":"Clinical and radiological study profile of cerebral venous sinus thrombosis at a tertiary care center in Pakistan","authors":"Muhammad Hassan , Naveed Ullah Khan , Haris Majid Rajput , Waleed Shahzad , Taimoor Hassan , Hafiza Faiza Mushtaq , Mazhar Badshah","doi":"10.1016/j.hest.2022.01.004","DOIUrl":"10.1016/j.hest.2022.01.004","url":null,"abstract":"<div><h3>Purpose</h3><p>A prospective, observational study was done at the country leading tertiary care hospital to evaluate etiologies, clinical features, diagnosis, and prognosis of cerebral venous sinus thrombosis (CVST) in the Pakistani population.</p></div><div><h3>Methods</h3><p>34 patients with clinical and MRI features suggestive of CVST were evaluated. Modified Rankin Score (mRS) was assessed of all patients at presentation.</p></div><div><h3>Results</h3><p>The mean age of presentation was 30.69 years with female predominance (n = 28). Headache was most common presenting symptoms (97%, n = 33) followed by seizure (59%, n = 20), hemiparesis (56%; n = 19), altered sensorium (47%; n = 16), vomiting (21%; n-7) and cranial nerve involvement (18%; n = 6). 72% of patients (n = 23) had thrombosis of superior sagittal sinus, 53% of patients (n = 17) had thrombosis of the transverse sinus, 25% patients (n = 8) of patients had sigmoid sinus thrombosis, 16 % patients (n = 8) had straight sinus thrombosis. The most common cause for provoked CVST was found to be pregnancy/puerperium in 53% (n = 18 patients), followed by previous CVST/DVT in 12% (n = 4), and then OCP and parainfectious causes which were 3% (n = 1) for each and elevated factor VIII and protein deficiency were found in 7 patients. MRS between 3 and 5 was assessed in most patients on presentation (n = 23).</p></div><div><h3>Conclusion</h3><p>CVST is an under-recognized cause of stroke in the young population, especially in the puerperium period. Clinical presentation is highly variable, and correction with magnetic resonance imaging with venography is the current diagnostic modality of choice. Aggressive management with anticoagulants is safe with excellent clinical outcomes.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"3 4","pages":"Pages 151-154"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X22000110/pdfft?md5=8bc3b4ed3651369287bba4dd02394980&pid=1-s2.0-S2589238X22000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72629187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying subtypes of treatment effects of subthalamic nucleus deep brain stimulation on motor symptoms in patients of late-stage Parkinson’s disease with cluster analysis 聚类分析识别丘脑底核深部脑刺激对晚期帕金森病患者运动症状治疗效果的亚型

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.01.003

Yusi Chen, Wei Jiang, Kai Shu

{"title":"Identifying subtypes of treatment effects of subthalamic nucleus deep brain stimulation on motor symptoms in patients of late-stage Parkinson’s disease with cluster analysis","authors":"Yusi Chen, Wei Jiang, Kai Shu","doi":"10.1016/j.hest.2022.01.003","DOIUrl":"10.1016/j.hest.2022.01.003","url":null,"abstract":"<div><p>Parkinson's disease (PD) presents clinical heterogeneity in late-stage patients who show a varied responsivity to subthalamic nucleus deep brain stimulation (STN-DBS) on motor symptoms. To explore the heterogeneity of STN-DBS effect on motor symptoms in late-stage PD patients and to categorize the patients, basic characteristics, preoperative motor symptoms, and motor symptoms one month and one year after the operation of 28 late-stage PD patients were collected and analyzed with agglomerative hierarchicalclustering. Preoperative motor complications, non-motor symptoms, and late-stage related manifestations were also collected and compared among the clusters. The analysis revealed three patient clusters with different motor features: 1) high response; 2) low response, and 3) moderate response with fast progression. Clinical characteristics showed significant differences in disease duration, postoperative UPDRS-III, decrease in UPDRS-III, and index of progression. Patterns of the six major motor symptoms can clearly differentiate the three clusters. Preoperative dyskinesia, memory decline, and visual hallucination were also found to differ in the three clusters. The current study identified three clusters of late-stage PD patients showing distinct responses to STN-DBS on motor symptoms. These clustering patterns may relate with diverse dopaminergic/non-dopaminergic impairments and hopefully help to categorize late-stage PD patients and to select adequate STN-DBS candidates.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"3 4","pages":"Pages 143-150"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X22000109/pdfft?md5=dea8bfb106af92a9690d07b3b523fba3&pid=1-s2.0-S2589238X22000109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75220822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter regarding article, “Vertebral artery dissecting aneurysm rupture under severe COVID-19” 关于“重症COVID-19椎动脉夹层动脉瘤破裂”文章的回复

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.09.002

Takenori Sato, Yoichi Miura, Ryuta Yasuda, Naoki Toma, Hidenori Suzuki

引用次数: 0

Erratum regarding previously published articles 关于以前发表的文章的勘误

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.08.003

引用次数: 0

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.05.005

Ngoc Mai Le, Jun Li

引用次数: 0

Vertebral artery dissecting aneurysm rupture under severe COVID-19 重症COVID-19椎动脉夹层动脉瘤破裂

Brain Hemorrhages Pub Date : 2022-12-01 DOI: 10.1016/j.hest.2022.08.001

Takenori Sato, Yoichi Miura, Ryuta Yasuda, Naoki Toma, Hidenori Suzuki

{"title":"Vertebral artery dissecting aneurysm rupture under severe COVID-19","authors":"Takenori Sato, Yoichi Miura, Ryuta Yasuda, Naoki Toma, Hidenori Suzuki","doi":"10.1016/j.hest.2022.08.001","DOIUrl":"10.1016/j.hest.2022.08.001","url":null,"abstract":"<div><h3>Objective</h3><p>We report a rare case of subarachnoid hemorrhage (SAH) caused by a ruptured vertebral artery (VA) dissecting aneurysm (DA) under severe COVID-19 treatment, and discuss the potential relationships.</p></div><div><h3>Case presentation</h3><p>A 58-year-old woman with COVID-19 fell into severe pneumonia needing mechanical ventilation at 10 days post-onset (day 10). The patient had no risk factors for DA or stroke other than COVID-19 infection. At day 17 when weaning ventilatory management, her systolic blood pressure was transiently elevated, and her consciousness did not recover thereafter. Computed tomography (CT) at day 21 revealed SAH with modified Fisher grade 4, and CT angiography revealed a DA in the right VA just distal to the right posterior inferior cerebellar artery (PICA). The DA was treated emergently with internal trapping by endovascular coiling, while the right PICA was preserved. Postoperative course was uneventful, and 2-time negative SARS-CoV-2 PCR results were obtained at day 45. The patient recovered to 4-month modified Rankin Scale 2.</p></div><div><h3>Conclusions</h3><p>Although it is not clear from the present case alone whether SARS-CoV-2 infection causes SAH by a ruptured VA DA, the accumulation of more cases and further studies are warranted to clarify the relationships between SARS-CoV-2 infection and ruptured intracranial DAs.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"3 4","pages":"Pages 210-213"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9129250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Effect of cerebral microbleeds on hemorrhagic transformation and functional prognosis after intravenous thrombolysis of cerebral infarction 脑微出血对脑梗死静脉溶栓术后出血转化及功能预后的影响

Brain Hemorrhages Pub Date : 2022-09-01 DOI: 10.1016/j.hest.2021.05.004

Jinli Chen , Kamil Duris , Xiaobo Yang

引用次数: 4