Brain Hemorrhages最新文献

{"title":"Admission triglyceride-glucose index predicts long-term mortality patients with subarachnoid hemorrhage a retrospective analysis of the MIMIC-IV database","authors":"Zhuangbin Liao ,&nbsp;Heng Lin ,&nbsp;Siwei Liu ,&nbsp;Paul R. Krafft","doi":"10.1016/j.hest.2023.10.004","DOIUrl":"10.1016/j.hest.2023.10.004","url":null,"abstract":"<div><p><em>Objective：</em>The triglyceride-glucose (TyG) index is an indicator for insulin resistance (IR). Several studies have validated the impact of the TyG index on cerebrovascular disease. However, the value of the TyG index in patients with subarachnoid hemorrhage (SAH), requiring admission to the intensive care unit (ICU), remains unclear. In this study, we aimed to investigate the relationship between the TyG index and clinical outcomes in SAH patients.</p></div><div><h3>Methods：</h3><p>In this study, we identified patients with severe SAH requiring ICU admission from the Medical Information Marketplace for Intensive Care (MIMIC-IV) database. These patients were then categorized into tertiles based on their TyG index levels. After adjusting for confounders, multivariate Cox proportional hazards analysis and restricted cubic spline analysis were performed to assess the relationship between the TyG index and clinical outcomes in critically ill SAH patients.</p></div><div><h3>Results：</h3><p>The study outcomes included in-hospital mortality and ICU mortality. The rate of in-hospital mortality and ICU mortality were 16.8 % and 13.1 %, respectively. After adjusting for confounders, multivariate Cox proportional hazards analysis showed that an elevated TyG index was significantly associated with all-cause mortality. Specifically, patients with a high TyG index had a significantly higher risk of in-hospital mortality (adjusted hazard ratio: 1.72; 95 % confidence interval: 0.81–3.66; P = 0.16) and ICU mortality (adjusted hazard ratio: 2.60; 95 % confidence interval: 1.04–6.43; P = 0.039). The TyG index was most strongly associated with ICU mortality. Moreover, restricted cubic spline curves demonstrated a progressive increase in the risk of all-cause mortality with an increase in the TyG index.</p></div><div><h3>Conclusion：</h3><p>Overall, our findings suggest that the TyG index may be a useful tool in identifying SAH patients at a higher risk of all-cause mortality in both, the hospital and the ICU setting.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"5 1","pages":"Pages 29-37"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000426/pdfft?md5=8e2cf82630cbea3d5a565b32c5398229&pid=1-s2.0-S2589238X23000426-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased plasma periostin concentration predicts angiographic vasospasm development in non-severe aneurysmal subarachnoid hemorrhage","authors":"Hiroki Oinaka,&nbsp;Fumihiro Kawakita,&nbsp;Hideki Nakajima,&nbsp;Yume Suzuki,&nbsp;Mai Nampei,&nbsp;Takeshi Okada,&nbsp;Ryuta Yasuda,&nbsp;Naoki Toma,&nbsp;Hidenori Suzuki,&nbsp;pSEED Group","doi":"10.1016/j.hest.2023.12.003","DOIUrl":"10.1016/j.hest.2023.12.003","url":null,"abstract":"<div><p>It is unknown whether plasma concentrations of a matricellular protein periostin change in association with the development of angiographic vasospasm after aneurysmal subarachnoid hemorrhage (SAH). In 113 patients with aneurysmal SAH of World Federation of Neurological Surgeons grades 1–3 at admission, plasma periostin concentrations were serially measured at days 1–3, 4–6, 7–9 and 10–12 after SAH onset. Measured periostin levels and clinical variables were compared between patients with and without angiographic vasospasm. Periostin concentrations were significantly higher in patients with angiographic vasospasm at days 4–6 and 7–9. Receiver operating characteristic curve analyses indicated that cutoff plasma periostin values of 54.3 ng/ml at days 4–6 and 58.1 ng/ml at days 7–9 predicted or diagnosed angiographic vasospasm development with a specificity of 66.0 % and a sensitivity of 72.7 %, and a specificity of 75.0 % and a sensitivity of 55.0 %, respectively. Multivariate analyses also revealed that increased plasma periostin concentrations at days 7–9 was independently associated with angiographic vasospasm development. This study showed for the first time that plasma periostin levels were increased in patients with angiographic vasospasm. These findings suggest that plasma periostin can serve as a biomarker and may be a new therapeutic target for angiographic vasospasm after SAH.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"5 1","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000633/pdfft?md5=cb9492bcbbc1a49fcf6d9102fc8d57ce&pid=1-s2.0-S2589238X23000633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of endovascular treatment alone or with intravenous alteplase in acute ischemic stroke Patients: A retrospective cohort study","authors":"Mahmoud Galal Ahmed ,&nbsp;Nour Shaheen ,&nbsp;Ahmed Shaheen ,&nbsp;Mostafa Meshref ,&nbsp;Abdulqadir J. Nashwan ,&nbsp;Nourelhuda Ahmed Nassar ,&nbsp;Khaled Sobh","doi":"10.1016/j.hest.2023.09.003","DOIUrl":"10.1016/j.hest.2023.09.003","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study is to compare the clinical outcomes, safety, and workflow of patients who underwent endovascular treatment (EVT) alone or in combination with intravenous thrombolysis (IVT), against a control group who only received EVT.</p></div><div><h3>Methods</h3><p>A retrospective analysis from May 2018 to September 2021 was conducted on 50 patients exhibiting acute ischemic stroke symptoms. 35 patients received EVT alone, while 15 received EVT and IVT. The data collected included demographic information, comorbid diseases, symptom onset time, duration from admission to puncture, and clinical outcomes via the National Institutes of Health Stroke Scale score and modified Rankin scale score at admission and 90 days post-procedure.</p></div><div><h3>Results</h3><p>No significant differences were observed in the 90-day modified Rankin scale scores between the EVT + IVT and EVT alone groups (p &gt; 0.05). NIHSS scores were also similar between the groups (p &gt; 0.05). The EVT + IVT group demonstrated higher intracranial hemorrhage and symptomatic intracranial hemorrhage rates than the EVT alone group, but the difference became insignificant after adjusting for age and sex (p &lt; 0.01). Mortality outcomes showed no significant difference (p &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>The combined EVT and IVT treatment's safety outcomes are not inferior, aligning with existing literature.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"5 1","pages":"Pages 21-28"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000384/pdfft?md5=c5607302725aab7c4d4a11bba7aa2d3c&pid=1-s2.0-S2589238X23000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135484332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free-hand bedside catheter evacuation without 3D reconstruction for extensive revascularization-associated hemorrhage after ischemic stroke","authors":"Wang Chen ,&nbsp;Lei Yang ,&nbsp;Feng He ,&nbsp;Xianjun Wang ,&nbsp;Zhenchuan Liu ,&nbsp;Wenli Hu","doi":"10.1016/j.hest.2023.04.001","DOIUrl":"10.1016/j.hest.2023.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the feasibility of free-hand bedside catheterization using axial computed tomography (CT) in patients with brain hemorrhage after ischemic revascularization.</p></div><div><h3>Methods</h3><p>Patients who received revascularization therapy and underwent bedside catheterization were consecutively screened from December 2020 to July 2022. Revascularization included intravenous thrombolysis with or without mechanical thrombectomy, balloon angioplasty, and stenting. The catheter trajectory was designed according to the axial CT along the long axis of the hematoma body and projected onto the scalp at the calculated distance and angle. Urokinase was used locally to drain the hematoma.</p></div><div><h3>Results</h3><p>In 12 patients (mean age 66 ± 8 years), an 86% reduction in hematoma volume was found after catheter drainage, from 48.6 ± 20.4 ml to 6.7 ± 5.7 ml (P＜0.001). In accordance with the reduction of the hematoma volume, the Glasgow Coma Scale improved from 7 (6.5–8) to 10 (7–10.5) (P = 0.031). Four patients (33.3%) achieved good outcomes (modified Rankin Scale 0–3) at the 180-day follow-up. All-cause mortality was 25%. One patient experienced active hemorrhage. No bacterial brain infections were observed.</p></div><div><h3>Conclusions</h3><p>Free-hand bedside catheterization according to axial CT localization is feasible for treating extensive revascularization-related hematoma after ischemic stroke.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 189-194"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000128/pdfft?md5=961a33994d595a9adcbc93e1b61af05f&pid=1-s2.0-S2589238X23000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88073303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attribute fatal, multiple cavitary lesions with air-fluid levels and hemorraghe to SARS-CoV-2 or ECMO only after ruling out differentials","authors":"Josef Finsterer ,&nbsp;Fulvio A Scorza ,&nbsp;Antonio-Carlos de Almeida","doi":"10.1016/j.hest.2022.09.003","DOIUrl":"10.1016/j.hest.2022.09.003","url":null,"abstract":"","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 226-227"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40391704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before attributing diastolic dysfunction to basal ganglia bleeding differential etiologies need to be ruled out","authors":"Josef Finsterer","doi":"10.1016/j.hest.2022.10.010","DOIUrl":"10.1016/j.hest.2022.10.010","url":null,"abstract":"","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 224-225"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X22000791/pdfft?md5=cc79596411a1d36dda05ca06be3ed980&pid=1-s2.0-S2589238X22000791-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81272101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of spontaneous acute subdural hematoma in Plasmodium falciparum malaria: A systematic review","authors":"Mehul Modi ,&nbsp;Prakash Mahantshetti ,&nbsp;Purvi Gandhi","doi":"10.1016/j.hest.2023.02.006","DOIUrl":"10.1016/j.hest.2023.02.006","url":null,"abstract":"<div><p>Malaria is one of the most common and lethal endemic disease in tropical countries. Severe malaria can be manifested as impaired consciousness, respiratory distress, convulsions, jaundice, pulmonary oedema and even death. Involvement of CNS and spontaneous abnormal bleeding from body organs is common; however spontaneous bleeding in brain is extremely rare. We report a rare case of spontaneous acute subdural hematoma (SDH) in <em>P. falcifarum</em> malaria. A systematic review of cases reported in literature is done with its Neurosurgical implications.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 201-203"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000104/pdfft?md5=b34385e178d0deea420a0715ab8e8b60&pid=1-s2.0-S2589238X23000104-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72820964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CSA cerebral hemorrhage Minimal Invasive treatment Society was successfully established","authors":"Shengjie Li ,&nbsp;Ping Zhang ,&nbsp;Chao Pan ,&nbsp;Gang Chen","doi":"10.1016/j.hest.2023.09.002","DOIUrl":"10.1016/j.hest.2023.09.002","url":null,"abstract":"<div><p>The CSA Cerebral Hemorrhage Minimal Invasive Treatment Society was successfully established in Wuhan, Hubei, China. During the inauguration, the first committee of the CSA Cerebral Hemorrhage Minimal Invasive Treatment Society was established.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 237-239"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000372/pdfft?md5=ceb50be2fa2177f454df52fc0072976a&pid=1-s2.0-S2589238X23000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Call for papers: Special issue on new insights in diagnosis and treatment of hemorrhagic stroke","authors":"Iris Tang ,&nbsp;Serge Marbacher","doi":"10.1016/j.hest.2023.11.001","DOIUrl":"10.1016/j.hest.2023.11.001","url":null,"abstract":"","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Page 223"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000451/pdfft?md5=3c3381839e1a279df208cd59ffadcf7f&pid=1-s2.0-S2589238X23000451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the treatment of chronic intracranial large artery occlusion: Time for large, randomized trials?","authors":"Zhicheng Zhang ,&nbsp;Chao Pan ,&nbsp;Devin McBride ,&nbsp;Zhuojin Wu ,&nbsp;Ge Zhang ,&nbsp;Danyang Chen ,&nbsp;John H. Zhang ,&nbsp;Zhouping Tang","doi":"10.1016/j.hest.2022.10.009","DOIUrl":"10.1016/j.hest.2022.10.009","url":null,"abstract":"<div><p>Chronic cerebral artery occlusion is an important cause of ischemic stroke, resulting in up to 45% of all ischemic strokes. Therefore, treatment of chronic cerebral artery occlusion is critical to improve outcomes in effected patients. In the past, treatment of chronic cerebral artery occlusion focused on drugs and surgical bypass, but effectiveness and potential benefits are not well-supported. In recent years, endovascular recanalization therapy has become more prominent as a treatment for chronic cerebral artery occlusion, due to advances in endovascular procedures, experience and equipment, as well as more advanced imaging methods. Small clinical studies have shown that interventional therapy for chronic cerebral artery occlusions may be safe and effective, yet, there is still a lack of uniform guidelines. This review discusses the current support for recanalization of chronic intracranial large vessel occlusion.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"4 4","pages":"Pages 204-209"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X2200078X/pdfft?md5=7187fa016525bc7ec4995aec609223b2&pid=1-s2.0-S2589238X2200078X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84801702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}