Brain Hemorrhages最新文献

Increased plasma pigment epithelium-derived factor (PEDF) concentrations as a negative predictor of angiographic vasospasm after aneurysmal subarachnoid hemorrhage 血浆色素上皮衍生因子（PEDF）浓度的增加是动脉瘤性蛛网膜下腔出血后血管造影血管痉挛的负面预测因子

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.02.001

{"title":"Increased plasma pigment epithelium-derived factor (PEDF) concentrations as a negative predictor of angiographic vasospasm after aneurysmal subarachnoid hemorrhage","authors":"","doi":"10.1016/j.hest.2024.02.001","DOIUrl":"10.1016/j.hest.2024.02.001","url":null,"abstract":"<div><h3>Objective</h3><p>Cerebral vasospasm remains a major determinant of delayed cerebral ischemia (DCI) and poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). This study was aimed to investigate if a matricellular protein pigment epithelium-derived factor (PEDF) can be a biomarker of angiographic vasospasm (aVSP) after SAH.</p></div><div><h3>Methods</h3><p>In 197 consecutive patients with aneurysmal SAH, plasma PEDF concentrations were serially measured at days 1–12 post-SAH.</p></div><div><h3>Results</h3><p>Plasma PEDF concentrations in SAH patients were elevated compared with patients with unruptured cerebral aneurysms, and especially higher in patients with admission World Federation of Neurological Surgeons (WFNS) grades IV–V. However, higher plasma PEDF concentrations at days 1–3 and 10–12 were associated with no development of aVSP. In an analysis limited to 72 non-sedated patients with preoperative WFNS grades I–III, plasma PEDF concentrations were also significantly higher in patients with neither DCI nor aVSP. Multivariate analysis showed that increased plasma PEDF concentration at days 1–3 was an independent predictor of no development of aVSP.</p></div><div><h3>Conclusion</h3><p>This was the first study to measure plasma PEDF concentrations and to show the relationships with aVSP development in SAH patients. PEDF may act protectively against aVSP, and serve as a negative biomarker and a target for drug discovery for aVSP.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000147/pdfft?md5=886bf25ddd8a2763e2546c402cad65f7&pid=1-s2.0-S2589238X24000147-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum Regarding Previously Published Articles 关于以前发表的文章的更正

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2023.11.009

引用次数: 0

Chronic subdural hematoma: Epidemiological analysis and factors associated with hematoma size – A single center experience 慢性硬膜下血肿：流行病学分析及与血肿大小相关的因素 - 单中心经验

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2023.12.005

{"title":"Chronic subdural hematoma: Epidemiological analysis and factors associated with hematoma size – A single center experience","authors":"","doi":"10.1016/j.hest.2023.12.005","DOIUrl":"10.1016/j.hest.2023.12.005","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to analyze the profile of patients with chronic subdural hematoma (cSDH) and to verify the factors associated with hematoma size.</p></div><div><h3>Methods</h3><p>We conducted a single-center, retrospective and observational case series of consecutive patients who underwent surgical treatment for cSDH at the Hospital de Clínicas de Passo Fundo, between 2018 and 2022. Data were extracted from the patients’ history records and imaging exams available. Patients’ characteristics were grouped and described through their respective prevalence. The relationship between patients’ characteristics and outcome (discharge or death) was analyzed using Fisher's exact test. Hematoma size was described in millimeters using means, and the relationship between hematoma size, patient age and hematoma side was tested using Student's <em>t</em> test.</p></div><div><h3>Results</h3><p>A total of 95 individuals were included in the study. Of these, 66.3 % were male and 7.4 % died. The mean age was 72 years. The most common symptoms and history findings were history of trauma (69.9 %), motor deficit (68.4 %) and cognitive deficit (26.3 %). The average hematoma size was similar on both sides, and showed an increasing trend with aging. The size of cSDH was also greater in those who presented motor deficits.</p></div><div><h3>Conclusion</h3><p>Surgically treated patients with cSDH had high rates of cognitive deficit, motor deficit and history of trauma. In addition, mortality rate was considered low and the size of hematoma was associated with age and motor deficits.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000657/pdfft?md5=cccc46c197d8787732028fc32ff73854&pid=1-s2.0-S2589238X23000657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Delayed hematoma growth in a patient with thrombocytopenia 血小板减少症患者血肿延迟生长

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.01.002

引用次数: 0

The use of bioinformatic analysis to study intracerebral hemorrhage 利用生物信息分析研究脑出血

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.05.002

{"title":"The use of bioinformatic analysis to study intracerebral hemorrhage","authors":"","doi":"10.1016/j.hest.2024.05.002","DOIUrl":"10.1016/j.hest.2024.05.002","url":null,"abstract":"<div><p>The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological disorder. By leveraging the power of bioinformatics, the scientific community is poised to make significant strides in combating this devastating condition, ultimately improving patient outcomes and quality of life. This study provides a comprehensive overview of the application of bioinformatics tools and techniques in elucidating the genetic, molecular, and environmental underpinnings of ICH. Through a detailed examination of genomic sequencing, transcriptomics, proteomics, and machine learning, we explore how these bioinformatics approaches have contributed to identifying genetic variants, understanding molecular pathways, and discovering biomarkers related to ICH. Challenges such as data complexity, integration of multi-omics data, and the translation of bioinformatics findings into clinical practice are discussed, alongside ethical considerations surrounding data privacy and patient consent. This study underscores the critical role of bioinformatics in advancing our understanding of ICH, offering insights into its pathophysiology, and paving the way for personalized medicine and targeted therapeutic interventions.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000433/pdfft?md5=6150f307dd64af01d6fe7fdc9b9ac9c7&pid=1-s2.0-S2589238X24000433-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anterior cranial fossa dural arteriovenous fistula presenting with left basal ganglia hemorrhage: A case report 前颅窝硬脑膜动静脉瘘伴有左侧基底节出血：病例报告

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2023.11.005

引用次数: 0

Association between glucose-to-lymphocyte ratio and short-term mortality in critically ill subarachnoid hemorrhage patients: A retrospective cohort study 重症蛛网膜下腔出血患者葡萄糖与淋巴细胞比率与短期死亡率之间的关系：回顾性队列研究

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.01.001

{"title":"Association between glucose-to-lymphocyte ratio and short-term mortality in critically ill subarachnoid hemorrhage patients: A retrospective cohort study","authors":"","doi":"10.1016/j.hest.2024.01.001","DOIUrl":"10.1016/j.hest.2024.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to evaluate the association between admission glucose-to-lymphocyte ratio (GLR) and 28-day all-cause mortality in critically ill patients with non-traumatic SAH.</p></div><div><h3>Methods</h3><p>Data were extracted from the Medical Information Mart for Intensive Care IV database. The primary outcome was 28-day all-cause mortality. Cox regression analysis, Kaplan-Meier curves, restricted cubic spline curves, subgroup analysis and sensitivity analysis were used to assess the relationship between GLR and patient outcome.</p></div><div><h3>Results</h3><p>A total of 530 patients were included in this study. The Kaplan-Meier curves demonstrated that SAH patients in the high-GLR group (GLR ≧7.4) had a lower 28-day survival rate. A linear relationship was found between GLR and 28-day mortality. Multivariable Cox regression revealed that admission GLR was independently associated with 28-day mortality in critically ill SAH patients (hazard ratio [<em>HR</em>] = 1.03, 95 % confidence interval [<em>CI</em>] = 1.01–1.06, P = 0.011). SAH patients in the high-GLR group had a higher risk of 28-day mortality, compared with those in the low-GLR group (<em>HR</em> = 1.62, 95 % <em>CI</em> = 1.10–2.37, <em>P</em> = 0.015). Subgroup and sensitivity analyses supported the robustness of our results.</p></div><div><h3>Conclusion</h3><p>High GLR levels at admission were associated with increased 28-day all-cause mortality in critically ill SAH patients.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000019/pdfft?md5=43c49935cb2f4f008c3810e1fc480f13&pid=1-s2.0-S2589238X24000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139456443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The function of astrocytes in cerebral infarction and potential therapeutic approaches 星形胶质细胞在脑梗塞中的功能及潜在治疗方法

IF 1.3

Brain Hemorrhages Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.03.003

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Immune system perspective in intracerebral hemorrhage Research: A focus on monocytes and Macrophages 脑出血研究中的免疫系统视角：聚焦单核细胞和巨噬细胞

IF 1.3

Brain Hemorrhages Pub Date : 2024-07-01 DOI: 10.1016/j.hest.2024.07.004

Hang Hang, Lei Huang, Yuan-hong Mao, Guofeng Wu

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Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage 降压输注巴比妥酸盐可改善蛛网膜下腔出血再出血新模型大鼠的神经功能

IF 1.3

Brain Hemorrhages Pub Date : 2024-07-01 DOI: 10.1016/j.hest.2024.07.001

Sosho Kajiwara, Yu Hasegawa, Kana Fujimori, Motohiro Morioka

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