Elarya Morcos , John H. Zhang , Antoine Sakr , Desislava Doycheva
{"title":"Link between heart failure and stroke: a comprehensive review","authors":"Elarya Morcos , John H. Zhang , Antoine Sakr , Desislava Doycheva","doi":"10.1016/j.hest.2025.07.005","DOIUrl":null,"url":null,"abstract":"<div><div>Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.<span><span><sup>1</sup></span></span> While the link between heart failure and ischemic stroke is well understood, the relationship between heart failure and hemorrhagic stroke is less clear but gaining increased recognition.<span><span><sup>2</sup></span></span> This review explores the complex mechanisms that may link heart failure to both ischemic and hemorrhagic strokes. Key factors include unstable blood flow, neurohormonal activation, cerebral small vessel disease, and the use of anticoagulation therapy, which, while intended to reduce stroke risk, can inadvertently increase the risk of hemorrhagic stroke.<span><span><sup>3</sup></span></span></div><div>Both ischemic and hemorrhagic strokes share overlapping risk factors with heart failure, such as hypertension and impaired blood flow, but the nuanced ways in which heart failure contributes to hemorrhagic stroke risk are still under investigation.<span><span><sup>3</sup></span></span> The review also highlights the importance of clinical outcomes and strategies for managing these risks in heart failure patients, particularly as our understanding of the associations between heart failure and stroke deepens.<span><span><sup>2</sup></span></span> By recognizing these connections, healthcare providers can improve care and implement targeted therapeutic approaches to reduce stroke risk in patients with heart failure.<span><span><sup>4</sup></span></span></div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 5","pages":"Pages 237-246"},"PeriodicalIF":1.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Hemorrhages","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589238X25000567","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well understood, the relationship between heart failure and hemorrhagic stroke is less clear but gaining increased recognition.2 This review explores the complex mechanisms that may link heart failure to both ischemic and hemorrhagic strokes. Key factors include unstable blood flow, neurohormonal activation, cerebral small vessel disease, and the use of anticoagulation therapy, which, while intended to reduce stroke risk, can inadvertently increase the risk of hemorrhagic stroke.3
Both ischemic and hemorrhagic strokes share overlapping risk factors with heart failure, such as hypertension and impaired blood flow, but the nuanced ways in which heart failure contributes to hemorrhagic stroke risk are still under investigation.3 The review also highlights the importance of clinical outcomes and strategies for managing these risks in heart failure patients, particularly as our understanding of the associations between heart failure and stroke deepens.2 By recognizing these connections, healthcare providers can improve care and implement targeted therapeutic approaches to reduce stroke risk in patients with heart failure.4
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