Brain Hemorrhages最新文献

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Identification of non-invasive biomarkers associated with glioma hemorrhage 与胶质瘤出血相关的非侵入性生物标志物的鉴定
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2025.05.001
Ozal Beylerli , Leili Gulieva , Valentin Pavlov , Huaizhang Shi
{"title":"Identification of non-invasive biomarkers associated with glioma hemorrhage","authors":"Ozal Beylerli ,&nbsp;Leili Gulieva ,&nbsp;Valentin Pavlov ,&nbsp;Huaizhang Shi","doi":"10.1016/j.hest.2025.05.001","DOIUrl":"10.1016/j.hest.2025.05.001","url":null,"abstract":"<div><div>Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively uncommon, can exacerbate disease progression, complicate clinical decision-making, and worsen patient outcomes. Identifying reliable, non-invasive biomarkers that predict or detect hemorrhage risk in glioma is an emerging research priority. This review examines the current landscape of non-invasive biomarkers—including advanced neuroimaging parameters, circulating molecular signatures, and genetic markers—that have shown potential in identifying glioma hemorrhage. We begin by summarizing the mechanisms and risk factors underlying hemorrhagic events in glioma, emphasizing the pathophysiological interplay between tumor angiogenesis, microvascular fragility, and coagulopathies. We then explore the role of modern neuroimaging techniques, such as susceptibility-weighted imaging (SWI), dynamic contrast-enhanced MRI, and radiomic-based analytical models, in uncovering hemodynamic and structural features predictive of hemorrhage. Concurrently, we evaluate key circulating biomarkers—ranging from cell-free DNA to microRNAs and extracellular vesicles—that hold promise for real-time, minimally invasive assessment of vascular integrity. By synthesizing evidence from these domains, we highlight their individual strengths and limitations and propose an integrative strategy that combines imaging and liquid biopsy approaches for enhanced diagnostic accuracy. Collectively, this review aims to provide clinicians and researchers with a comprehensive understanding of the utility and prospects of non-invasive biomarkers in the context of glioma hemorrhage, ultimately guiding more personalized surveillance and therapeutic interventions.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 176-187"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME 多模态超快超声显微镜(MUSM)用于血管紧张素- ii和L-NAME诱导的高血压小鼠模型的脑血管动力学超分辨率成像
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2024.11.001
Bing-Qiao Wang , Yu-Fan Ma , Guo-Qing Zhang , Ke Yan , Yan-Yun Wang , Qin Zhang , Lan Chen , Chen-Hao Zhao , Sen Lin , Qing-Wu Yang
{"title":"Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME","authors":"Bing-Qiao Wang ,&nbsp;Yu-Fan Ma ,&nbsp;Guo-Qing Zhang ,&nbsp;Ke Yan ,&nbsp;Yan-Yun Wang ,&nbsp;Qin Zhang ,&nbsp;Lan Chen ,&nbsp;Chen-Hao Zhao ,&nbsp;Sen Lin ,&nbsp;Qing-Wu Yang","doi":"10.1016/j.hest.2024.11.001","DOIUrl":"10.1016/j.hest.2024.11.001","url":null,"abstract":"<div><div>Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron emission tomography and magnetic resonance imaging, often fall short in dynamically visualizing cerebral microcirculation blood flow in rodent models. This study leveraged the high spatiotemporal resolution of multimodal ultrafast sonography microscopy (MUSM) to assess cerebrovascular hemodynamics in vivo within hypertensive mice induced by Angiotensin II (Ang II) and Nω-nitro-L-arginine methyl ester (L-NAME). Cerebrovascular hemodynamics were quantified using variations in cerebral vascular density, diameter, velocity, tortuosity, cerebral flow pulsatility, and instant flow direction. Our findings revealed a decrease in cerebral vascular density and perfusion index after blood pressure increased, particularly in the cortex and basal ganglia regions. This study not only provides a comprehensive view of cerebral dynamics in hypertension but also introduces MUSM as a novel tool for in vivo cerebrovascular hemodynamic analysis in preclinical animal research.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 154-161"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications 非编码rna在脑出血中的作用、机制和治疗意义
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2024.10.001
Shijie Mao , Shi Tang , Qi Wang , Ling Shen , Ying Bai
{"title":"Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications","authors":"Shijie Mao ,&nbsp;Shi Tang ,&nbsp;Qi Wang ,&nbsp;Ling Shen ,&nbsp;Ying Bai","doi":"10.1016/j.hest.2024.10.001","DOIUrl":"10.1016/j.hest.2024.10.001","url":null,"abstract":"<div><div>Intracerebral hemorrhage (ICH), which is a form of stroke triggered by the rupture of blood vessels within the brain tissue, is a leading cause of morbidity and mortality worldwide. Although significant progress has been made in comprehending the pathophysiology, diagnosis, and treatment of ICH, effective therapies remain limited, and specific biomarkers for monitoring disease progression are still lacking. Non-coding RNAs (ncRNAs) have been shown to be promising biomarkers in numerous central nervous system (CNS) diseases. In particular, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are usually studied as potential targets for disease therapy. However, their roles in ICH are not yet fully understood. This review seeks to consolidate current knowledge on the roles of ncRNAs in ICH, explore the underlying mechanisms, and discuss potential therapeutic strategies.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 188-194"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage 峰值血肿周围水肿扩张预测脑出血患者预后不良
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2024.10.005
Sihui Wang , Xiaochen Wang , Xuening Zhao , Lingxu Chen , Shengjun Sun
{"title":"Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage","authors":"Sihui Wang ,&nbsp;Xiaochen Wang ,&nbsp;Xuening Zhao ,&nbsp;Lingxu Chen ,&nbsp;Shengjun Sun","doi":"10.1016/j.hest.2024.10.005","DOIUrl":"10.1016/j.hest.2024.10.005","url":null,"abstract":"<div><h3>Objective</h3><div>Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and holds significant relevance in the assessment of disease outcome. Through a longitudinal cohort study, we examined the association between the expansion of peak PHE and functional outcome.</div></div><div><h3>Methods</h3><div>We retrospectively enrolled supratentorial ICH patients with available computed tomography (CT) scans on admission within 6 h as well as day 1, day 8 ± 2, day 12 ± 2. Peak PHE expansion was defined as the the difference between maximum volume measured in any of the available CT scans and PHE volume on admission. We stratified patients into groups with unfavorable and favorable outcome, utilizing the modified Rankin Scale (mRS) score at the 90-day mark post-onset (with an mRS score >3 signifying an unfavorable outcome)</div></div><div><h3>Results</h3><div>Eventually, a total of 140 patients were enrolled, and 84 patients (60 %) had poor outcome on day 90. Multivariable logistic regression revealed peak PHE expansion (OR 1.098 [95 % CI 1.049–1.150]) was independently associated with poor outcome. The best cutoff value was 12.8 ml with an AUC of 0.842.</div></div><div><h3>Conclusion</h3><div>The peak PHE expansion correlates independently with adverse outcome for ICH patients within three months post-injury. It is anticipated that interventional therapies administered during the edema expansion phase could enhance the prognosis for ICH patients.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 148-153"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage 铜眼畸形的预试验:激活PPARγ可抑制脑出血后铜眼畸形
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2025.02.002
Wenying Zhang , Wanyu Ma , Siying Ren , Likun Wang , Guofeng Wu
{"title":"A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage","authors":"Wenying Zhang ,&nbsp;Wanyu Ma ,&nbsp;Siying Ren ,&nbsp;Likun Wang ,&nbsp;Guofeng Wu","doi":"10.1016/j.hest.2025.02.002","DOIUrl":"10.1016/j.hest.2025.02.002","url":null,"abstract":"<div><div>Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the role of which in ICH is unclear. Upon activation by ligand agonists, peroxisome proliferator-activated receptor-γ (PPARγ), can alleviate brain injury after ICH. To investigate the inhibitory effect of activating PPARγ on cuproptosis following ICH, we established the ICH model in vivo and in vitro and they were treated with the PPARγ agonist or antagonist after models being established successfully. Then, the copper ion concentration was measured by copper colorimetric assay and the expression of cuproptosis-related regulatory factors and copper transporter 1 was detected by western blotting and immunofluorescence staining (except in the cell level). We found that the increase in copper ion concentration following ICH leads to the disruption of copper homeostasis, inducing cuproptosis via copper toxicity. Activating PPARγ regulates the expression of cuproptosis-associated positive or negative regulatory factors and mitigates copper toxicity by inhibiting the influx of copper ions into the cell, thereby inhibiting cuproptosis. This study not only reveals the relationship between ICH and cuproptosis but also may provide new therapeutic strategies for improving the prognosis of patients with ICH.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 166-175"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries 预防性巴比妥酸降压输注治疗老年和非老年重型颅脑损伤患者疗效相似且良好
IF 1.3
Brain Hemorrhages Pub Date : 2025-08-01 DOI: 10.1016/j.hest.2024.10.002
Sosho Kajiwara , Yu Hasegawa , Jin Kikuchi , Kiyohiko Sakata , Tetsuya Negoto , Yukihiko Nakamura , Takayuki Kawano , Yusuke Otsu , Yoshikuni Kotaki , Hideo Nakamura , Masaru Hirohata , Motohiro Morioka
{"title":"Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries","authors":"Sosho Kajiwara ,&nbsp;Yu Hasegawa ,&nbsp;Jin Kikuchi ,&nbsp;Kiyohiko Sakata ,&nbsp;Tetsuya Negoto ,&nbsp;Yukihiko Nakamura ,&nbsp;Takayuki Kawano ,&nbsp;Yusuke Otsu ,&nbsp;Yoshikuni Kotaki ,&nbsp;Hideo Nakamura ,&nbsp;Masaru Hirohata ,&nbsp;Motohiro Morioka","doi":"10.1016/j.hest.2024.10.002","DOIUrl":"10.1016/j.hest.2024.10.002","url":null,"abstract":"<div><div><em>Objective</em>: With the aging population, the number of elderly patients with severe traumatic brain injury (sTBI) inevitably increases. The high mortality rate for sTBI in the elderly necessitates effective solutions. While we have previously reported the beneficial effects of a novel barbiturate therapy, a prophylactic step-down infusion of barbiturates (sdB), using thiamylal with normothermia (NOR) in patients with sTBI, its effects on elderly patients remain unclear. This study aimed to compare the efficacy and safety of sdB between elderly and non-elderly patients with sTBI.</div><div><em>Methods</em>: We included 25 sTBI patients treated with sdB+NOR between January 2013 and March 2020. Patients were stratified into elderly (≥75 years, n = 8) and non-elderly (&lt;75 years, n = 17) groups. Patient characteristics were similar between groups except for sex ratio. Outcomes compared included primary endpoints (favorable outcome at discharge and at 6–12 months), secondary endpoints (composite death at discharge and at 6–12 months), side effects, complications, intracranial pressure (ICP), cerebral perfusion pressure (CPP) control, and hospitalization period.</div><div><em>Results</em>: The hospitalization period tended to be longer in elderly patients. There were no significant differences in the incidence of side effects or complications related to sdB between the groups. Both primary (favorable outcome) and secondary (composite death) endpoints were similar at discharge and at 6-12 months for elderly and non-elderly patients. ICP and CPP were well controlled in the elderly patients.</div><div><em>Conclusion</em>: The results suggest that sdB+NOR is as effective and safe for elderly patients with sTBI as it is for non-elderly patients.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 4","pages":"Pages 143-147"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke 发病前长期使用他汀类药物可降低缺血性卒中后出血转化的风险
IF 1.3
Brain Hemorrhages Pub Date : 2025-06-01 DOI: 10.1016/j.hest.2024.12.001
Zhixin Li , Riguge Su , Yu Zhang , Duanlu Hou , Basak Caner , Wei Yan , Xiaobo Yang , Heling Chu , Yuping Tang
{"title":"Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke","authors":"Zhixin Li ,&nbsp;Riguge Su ,&nbsp;Yu Zhang ,&nbsp;Duanlu Hou ,&nbsp;Basak Caner ,&nbsp;Wei Yan ,&nbsp;Xiaobo Yang ,&nbsp;Heling Chu ,&nbsp;Yuping Tang","doi":"10.1016/j.hest.2024.12.001","DOIUrl":"10.1016/j.hest.2024.12.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve clinical prognosis of stroke patients. However, there is not enough evidence that premorbid statin use may affect the risk of hemorrhagic transformation in stroke patients. The aim of our study was to investigate the role of premorbid long-term statin use in HT after acute ischemic stroke.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We retrospectively analyzed ischemic stroke patients in Huashan Hospital from 1 January 2012 to 31 December 2022 based on hospital electronic case records. Since thrombolysis or thrombectomy might interfere with the effect of statin use we excluded patients who received thrombolysis or thrombectomy treatment. A matched case-control study was conducted for reducing the impact of various confounding factors. The independent roles of statin use and serum lipids in HT was evaluated by binary logistic regression analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 254 ischemic stroke patients met the inclusion criteria and have been matched at 1:1 ratio, according age (± 5 years), admission NIHSS (± 3 scores), prior antiplatelets and anticoagulation therapy and previous stroke history. The patients without HT were regarded as control group. The percentage of HT was significantly lower in patients with premorbid long-term statin use (22.1 % vs. 41.7 %, p = 0.001). The incidence rate of diabetes mellitus and symptomatic deterioration (NIHSS increase ≥ 4) was higher in patients with HT. There were 18 patients having intracerebral hemorrhage before any reperfusion treatment. They had lower level of LDL-C (1.76 (1.73, 2.26) vs 2.72 (2.28, 3.09), p &lt; 0.001) and were prone to previously take statins (55.6 % vs 16.5 %,p &lt; 0.001). However, ECASS classification and all the outcome scores did not present any statistical difference in our study. In logistic regression analysis DM (OR = 2.001, 95 %CI 1.124–3.563, &lt;em&gt;p&lt;/em&gt; = 0.018), increased levels of LDC-C (OR = 0.334, 95 %CI 0.172–0.649), &lt;em&gt;p&lt;/em&gt; = 0.001) and HDL-C (OR = 13.303, 95 %CI 2.050–86.328, p = 0.001) were independent risk factors in occurrence of HT in patients with ischemic stroke, while premorbid statin use (OR = 0.269, 95 %CI 0.117–0.615, p = 0.002) could still be regarded as a protective factor in preventing intracranial hemorrhage after cerebral infarction. Additionally, lower level of LDL-C was also an independent risk factor in spontaneous HT after cerebral infarction (OR = 45.45, 95 %CI 5.62–333.33, p &lt; 0.001), regardless of statin use.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Premorbid long-term statin use plays a protective role in the HT after cerebral infarction. However, low serum LDL-C and high HDL-C might be independent risk factors in the occurrence of HT irrespective of statin use. The previous statin uses and serum li","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 3","pages":"Pages 95-102"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential 藁本内酯促进脑损伤治疗和神经保护:机制和治疗潜力
IF 1.3
Brain Hemorrhages Pub Date : 2025-06-01 DOI: 10.1016/j.hest.2025.01.003
Qiaoqiao Xu, Wei Mei
{"title":"Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential","authors":"Qiaoqiao Xu,&nbsp;Wei Mei","doi":"10.1016/j.hest.2025.01.003","DOIUrl":"10.1016/j.hest.2025.01.003","url":null,"abstract":"<div><div>Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the complex pathophysiology, high prevalence, and limited therapeutic options, brain injury poses significant healthcare challenges. Current treatment for brain injury involves a combination of medical interventions, surgery, and rehabilitation therapies. Ligustilide, a bioactive component purified from traditional Chinese medicinal herb, has been studied as a promising candidate for neuroprotection. In this review, we summarize current research to understand the mechanisms underlying ligustilide neuroprotective activities and assess its therapeutic potential in treating brain injuries.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 3","pages":"Pages 121-127"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review 初次血管造影未发现的基底动脉穿孔动脉瘤破裂与未破裂的大脑前动脉囊状动脉瘤同时存在:病例报告和文献综述
IF 1.3
Brain Hemorrhages Pub Date : 2025-06-01 DOI: 10.1016/j.hest.2024.07.008
Hideki Nakajima , Yu Sato , Tetsushi Yago , Kazuhiko Tsuda , Hidenori Suzuki
{"title":"Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review","authors":"Hideki Nakajima ,&nbsp;Yu Sato ,&nbsp;Tetsushi Yago ,&nbsp;Kazuhiko Tsuda ,&nbsp;Hidenori Suzuki","doi":"10.1016/j.hest.2024.07.008","DOIUrl":"10.1016/j.hest.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>Ruptured basilar artery perforator aneurysm (BAPA) is a rare cause of subarachnoid hemorrhage (SAH) and is difficult to diagnose.</div></div><div><h3>Case presentation</h3><div>A 60-year-old male was rushed to our hospital due to severe headache. Computed tomography (CT) showed diffuse SAH, and 3-dimensional CT angiography (CTA) showed a saccular aneurysm in the left anterior cerebral artery (ACA), which was treated with clipping. However, intraoperative findings showed little SAH around the aneurysm and neither a rupture point nor a white thrombus on the aneurysm. Postoperative CT showed a marked decrease in SAH in the prepontine cistern, and digital subtraction angiography (DSA) showed disappearance of the ACA aneurysm and no other lesions. SAH in the prepontine cistern re-increased on CT on the 6th postoperative day, when CTA failed to show the cause. On the 12th postoperative day, CT showed further increased SAH in the prepontine cistern, and DSA revealed a BAPA. Stent-assisted coil embolization was planned at the chronic phase, but the patient went into cardiac arrest the next day, presumably due to a third re-rupture of the BAPA.</div></div><div><h3>Conclusion</h3><div>The coexistence of a ruptured BAPA and an unruptured saccular aneurysm is extremely challenging in terms of both diagnosis and treatment strategy.</div></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 3","pages":"Pages 138-141"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage 间质血管部分细胞疗法:脑出血的一种有前景的治疗方法
IF 1.3
Brain Hemorrhages Pub Date : 2025-06-01 DOI: 10.1016/j.hest.2025.01.002
Ilgiz Gareev , Ozal Beylerli , Albert Sufianov , Valentin Pavlov , Huaizhang Shi
{"title":"Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage","authors":"Ilgiz Gareev ,&nbsp;Ozal Beylerli ,&nbsp;Albert Sufianov ,&nbsp;Valentin Pavlov ,&nbsp;Huaizhang Shi","doi":"10.1016/j.hest.2025.01.002","DOIUrl":"10.1016/j.hest.2025.01.002","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality rate and significant long-term disabilities among survivors, underscoring the urgent need for innovative therapeutic strategies that go beyond managing symptoms to actively promote brain repair and functional recovery. Current treatment options are largely limited to supportive care, including surgical interventions to alleviate intracranial pressure and management of underlying risk factors such as hypertension. These approaches, however, fail to address the extensive neurological damage caused by ICH. Emerging evidence highlights the potential of stromal vascular fraction (SVF) cell therapy as a novel regenerative treatment for ICH. SVF, derived from adipose tissue through enzymatic digestion, is a heterogeneous mixture of cells, including mesenchymal stem cells (MSCs), endothelial cells, pericytes, immune cells, and progenitor cells. This cellular composition contributes synergistically to the repair and regeneration of damaged tissues. The mechanisms of action of SVF encompass inflammation modulation, neuroprotection, angiogenesis, and immunomodulation. MSCs within SVF release anti-inflammatory cytokines such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), reducing secondary injury caused by excessive inflammation. Endothelial cells and pericytes promote the formation of new blood vessels, restoring oxygen and nutrient supply to ischemic regions. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) further support neuronal survival and repair of neural circuits. Preclinical studies in animal models have consistently demonstrated the efficacy of SVF therapy, including reductions in brain edema, oxidative stress, and inflammatory cytokines, alongside improvements in angiogenesis, neuronal survival, and functional recovery. Early-phase clinical trials and case studies provide preliminary evidence of safety, feasibility, and potential therapeutic benefits in human patients with acute and chronic ICH. However, significant challenges remain, including the variability in SVF composition, optimal delivery methods, timing of intervention, and long-term safety considerations. This review comprehensively examines the biological properties of SVF, the mechanisms underlying its therapeutic effects, and the preclinical and clinical evidence supporting its use in ICH. Additionally, it explores future directions, including the development of standardized protocols, optimization of delivery techniques, integration with combination therapies, and the potential for personalized medicine approaches. As ongoing research and clinical trials refine these strategies, SVF therapy holds transformative potential to revolutionize ICH treatment by addressing its complex pathophysiology and i","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":"6 3","pages":"Pages 110-120"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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