Brain Hemorrhages最新文献_第3页

The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage 脑出血后脑部免疫细胞和外周免疫细胞之间的串联在血脑屏障损伤和保护中的作用

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2024.02.002

Yihui Wang , Wencao Liu , Jianing Zhang , Panpan Geng , Xinchun Jin

{"title":"The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage","authors":"Yihui Wang , Wencao Liu , Jianing Zhang , Panpan Geng , Xinchun Jin","doi":"10.1016/j.hest.2024.02.002","DOIUrl":"10.1016/j.hest.2024.02.002","url":null,"abstract":"<div><p>Blood-brain barrier (BBB) damage is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of brain edema and the inflammatory response post-ICH. Cerebral immune cells (CICs), including microglia, pericytes, and astrocytes play a crucial role in the damage and protection of the BBB after ICH. Recent evidence suggests that peripheral immune cells (PICs) also play an important role in BBB damage and protection, brain edema, and neurological function impairment. Therefore, regulating interactions between glial cells and immune cells is expected to alleviate ICH-induced BBB damage. In this review, we first introduce the role of CICs, endothelial cells (ECs), oligodendrocytes (OLs), and PICs in BBB damage and protection after ICH, focusing on their polarization and inflammatory response. Next, we specifically discuss the crosstalk between CICs and PICs, such as the brain-spleen axis and brain-gut axis after ICH. Finally, we suggest that glial cells, PICs and, meningeal lymphatic system may be potential targets for alleviating BBB damage after ICH, and discuss some molecular targets and potential strategies for alleviating BBB damage after ICH by modulating CICs, ECs, and PICs.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000159/pdfft?md5=f4f82d9fad453b6947d2ad9a479d5cd2&pid=1-s2.0-S2589238X24000159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139875937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice 小鼠蛛网膜下腔出血后迟发性神经功能缺损的发生率和因素

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2023.12.006

William Wroe , Ari Dienel , Sungha Hong , Kanako Matsumura , Jose Guzman , Kiara Torres , Angelica Bernal , Hussein A. Zeineddine , Peeyush Thankamani Pandit , Spiros L. Blackburn , Devin W. McBride

{"title":"Incidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice","authors":"William Wroe , Ari Dienel , Sungha Hong , Kanako Matsumura , Jose Guzman , Kiara Torres , Angelica Bernal , Hussein A. Zeineddine , Peeyush Thankamani Pandit , Spiros L. Blackburn , Devin W. McBride","doi":"10.1016/j.hest.2023.12.006","DOIUrl":"10.1016/j.hest.2023.12.006","url":null,"abstract":"<div><h3>Objective</h3><p>Delayed cerebral ischemia (DCI) is one of the most feared complications in aneurysmal subarachnoid hemorrhage (SAH). Animal models are crucial to studying the disease mechanisms and potential treatments. DCI in rodents was thought to not exist; herein we examine literature and our experience with DCI in rodents.</p></div><div><h3>Methods</h3><p>Daily behavioral performance was assessed every day from day 1 to up to 7 days post-SAH on mice from 5 different studies that used the endovascular perforation model. Performance was graded using an 8-test sensorimotor neuroscore previously described. The daily neuroscore was then used to identify the incidence and timing of delayed neurological deficits (DND), a clinical surrogate for DCI. A total number of 298 mice (134 males, 164 females) were subjected to SAH. Fifty-one mice had histological staining done to identify infarct volume.</p></div><div><h3>Results</h3><p>The overall incidence of DND was 33.9%; 27.6% in males and 39.0% in females, but this difference was not statistically significant. The overall incidence of delayed death was 21.1%, and there was no significant difference for delayed mortality in females versus male mice. There is a non-statistically significant trend towards increased infarct volume in mice suffering DND.</p></div><div><h3>Conclusions</h3><p>Mice with endovascular puncture induced SAH develop DND at rates comparable to human patients. Future work needs to correlate the DND seen with decreased regional cerebral blood flow, another hallmark of DCI, but in spite of this need, researchers may use the murine models to test therapies for DCI after SAH.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000669/pdfft?md5=3a6d47bede9831f45699e6d118dfe55e&pid=1-s2.0-S2589238X23000669-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inspiration for the treatment of intracerebral hemorrhage from the duality of glial scar: The right time point for reactive astrocytes reprogramming 从神经胶质疤痕的双重性中获得治疗脑出血的灵感：反应性星形胶质细胞重编程的正确时间点

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2024.04.004

Liyang Huang , Jingyi Wang , Shiling Chen , Xiaoxiao Xv , Yuanwei Li , Gaigai Li , Zhouping Tang

引用次数: 0

Cerebral venous impairment and cerebral venous sinus thrombosis 脑静脉损伤和脑静脉窦血栓形成

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2024.03.002

Jiaqi Wang , Anatol Manaenko , Qin Hu , Xiaohua Zhang

{"title":"Cerebral venous impairment and cerebral venous sinus thrombosis","authors":"Jiaqi Wang , Anatol Manaenko , Qin Hu , Xiaohua Zhang","doi":"10.1016/j.hest.2024.03.002","DOIUrl":"10.1016/j.hest.2024.03.002","url":null,"abstract":"<div><p>Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance of cerebral venous drainage has been emphasized in various neurological diseases. Impaired venous outflow may lead to brain edema, blood–brain barrier (BBB) disruption, inflammatory responses and hemorrhagic complications. With the development of imaging technologies, several imaging-based signs for venous assessment are proposed. Therapies targeting cerebral venous drainage have shown beneficial outcomes in cerebral venous sinus thrombosis (CVST) in clinic, however more insight into the cellular and molecular level should be elucidated. Here we review the pathological changes following cerebral venous drainage impairment, summary the advances in image-based evaluation, address the potential molecular mechanisms, and discuss venous drainage-focused therapies. A better understanding of cerebral venous drainage and its underlying mechanism will promote the pharmacological development and clinical management of CVST.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000263/pdfft?md5=490cc945d39f55ce93058e8a775a117f&pid=1-s2.0-S2589238X24000263-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral pupil sparing oculomotor nerve paresis with an anterior communicating artery aneurysm: A case report with literature review 伴有前交通动脉瘤的单侧瞳孔疏松性眼运动神经麻痹：病例报告与文献综述

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2023.08.002

Shuja Ikram, Ahtesham Khizar, Muhammad Waqas Umer

{"title":"Unilateral pupil sparing oculomotor nerve paresis with an anterior communicating artery aneurysm: A case report with literature review","authors":"Shuja Ikram, Ahtesham Khizar, Muhammad Waqas Umer","doi":"10.1016/j.hest.2023.08.002","DOIUrl":"10.1016/j.hest.2023.08.002","url":null,"abstract":"<div><h3>Objective</h3><p>An anterior communicating artery (ACoA) aneurysm causing unilateral pupil sparing oculomotor nerve paresis is highly unusual. This is, to the best of our knowledge, the second case report of its sort. Compression, ischemia, or haemorrhage affecting the anterior visual pathway are common neuro-ophthalmic manifestations of ACoA aneurysm but when there is partial paresis it only affects the superior division of the third cranial nerve's fibres which is an extremely rare occurrence.</p></div><div><h3>Case presentation</h3><p>A 45-year-old man came in as an outpatient with complaints of severe headache and right eyelid drooping for the previous 6 days. He had GCS 15 (E4,V5,M6), and right eyelid partial ptosis with normal reactive pupils. The other cranial nerves and neurological examination came out normal. A non-contrast enhanced computed tomography (CT) scan of the brain revealed a hyperdense area around the ACoA region and SAH. During CT angiography, an ACoA aneurysm was found. The patient was clipped on the 24th post-bleeding day. On the three-week follow-up appointment, the ptosis had improved somewhat.</p></div><div><h3>Conclusions</h3><p>Although unilateral pupil sparing oculomotor nerve paresis has little localising utility, it does help to comprehend acute microvascular spasm, which may have therapeutic implications.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000268/pdfft?md5=eb614f8b2e18e4d9f3ca5f6a6fc67d87&pid=1-s2.0-S2589238X23000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74256630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare central neurocytoma in fourth ventricle: A case report with intratumoral hemorrhage and cerebellar mutism syndrome 第四脑室罕见中枢神经细胞瘤：伴瘤内出血和小脑畸形综合征的病例报告

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2023.11.008

H. Setenay Unal , R. Nur Balcın , Pinar Eser , Mine Ozsen , Ahmet Bekar

{"title":"Rare central neurocytoma in fourth ventricle: A case report with intratumoral hemorrhage and cerebellar mutism syndrome","authors":"H. Setenay Unal , R. Nur Balcın , Pinar Eser , Mine Ozsen , Ahmet Bekar","doi":"10.1016/j.hest.2023.11.008","DOIUrl":"10.1016/j.hest.2023.11.008","url":null,"abstract":"<div><h3>Objective</h3><p>Central neurocytoma (CN) is a rare benign tumor usually found in the lateral and third ventricles. This report highlights an exceptional case of CN in the fourth ventricle, leading to acute hydrocephalus due to bleeding. The patient later developed cerebellar mutism syndrome (CMS), a rare condition following posterior fossa surgery. We retrospectively analyzed data from a patient who experienced sudden loss of consciousness due to hemorrhagic fourth ventricular CN.</p></div><div><h3>Case presentation</h3><p>A 43-year-old male presented with sudden loss of consciousness. Initial computed tomography (CT) scan revealed a large left cerebellar hemorrhagic lesion causing hydrocephalus. An external ventricular drainage catheter was inserted to alleviate hydrocephalus, followed by emergent surgery to address the mass. A second surgery was needed due to rebleeding, achieving complete tumor removal. A ventriculoperitoneal shunt was inserted for permanent hydrocephalus management. Post-surgery, the patient presented with significant neurological symptoms, including muteness, ataxia, and hypotonia, which improved with medical treatment involving fluoxetine and bromocriptine. A one-year follow-up magnetic resonance imaging (MRI) confirmed successful tumor removal with no signs of recurrence.</p></div><div><h3>Conclusion</h3><p>This case emphasizes the unusual occurrence of CN in the fourth ventricle with bleeding and the possibility of CMS in adult patients after posterior fossa surgery.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000591/pdfft?md5=dbdc7f6a2316cb88970b81224b12f900&pid=1-s2.0-S2589238X23000591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139299323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of mechanical thrombectomy for acute ischemic stroke in primary immune thrombocytopenia patient: Case report and literature review 机械性血栓切除术治疗原发性免疫血小板减少症患者急性缺血性中风的疗效：病例报告和文献综述

Brain Hemorrhages Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2023.10.002

Hideki Nakajima , Takuro Tsuchiya , Shigetoshi Shimizu , Hidenori Suzuki

{"title":"Efficacy of mechanical thrombectomy for acute ischemic stroke in primary immune thrombocytopenia patient: Case report and literature review","authors":"Hideki Nakajima , Takuro Tsuchiya , Shigetoshi Shimizu , Hidenori Suzuki","doi":"10.1016/j.hest.2023.10.002","DOIUrl":"10.1016/j.hest.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>Primary immune thrombocytopenia (ITP) paradoxically carries a high risk of developing thrombosis. However, the efficacy of mechanical thrombectomy (MT) for acute ischemic stroke (AIS) in ITP patients remains unclear due to its rarity.</p></div><div><h3>Case presentation</h3><p>A 47-year-old female treated for chronic ITP for 2 years was admitted to the hematology department with severe thrombocytopenia. The patient was started on glucocorticoid therapy, and her platelet count rose soon. On sixth day of hospitalization, she suddenly presented with loss of consciousness, conjugate eye deviation to the left, and left hemiplegia. Magnetic resonance imaging and angiography showed an acute ischemic lesion with the left M1 occlusion. Emergent MT was performed and resulted in successful recanalization. Postoperatively, she recovered consciousness and was able to follow instructions. However, on the third day after MT, the patient suffered hemorrhagic infarction and brain herniation, and decompression craniectomy was performed. Her consciousness slowly recovered, and cranioplasty was performed after brain swelling improved. The patient was transferred to a rehabilitation hospital with modified Rankin Scale (mRS) 4 on 84th day of hospitalization, and eventually improved to mRS 3 with motor aphasia and right hemiparesis.</p></div><div><h3>Conclusion</h3><p>MT may be effective for AIS in ITP patients with appropriate case selection.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000402/pdfft?md5=a58e45aec021030c47540a55da4683ae&pid=1-s2.0-S2589238X23000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135762535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: A case series 使用克拉生坦治疗动脉瘤性蛛网膜下腔出血患者的体液平衡管理：病例系列

Brain Hemorrhages Pub Date : 2024-04-01 DOI: 10.1016/j.hest.2023.10.003

Yosuke Akamatsu , Kohei Chida , Kenya Miyoshi , Daigo Kojima , Jun-Ichi Nomura , Kengo Setta , Takayuki Chiba , Takahiro Koji , Shunrou Fujiwara , Hiroshi Kashimura , Yoshitaka Kubo , Kuniaki Ogasawara

{"title":"Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: A case series","authors":"Yosuke Akamatsu , Kohei Chida , Kenya Miyoshi , Daigo Kojima , Jun-Ichi Nomura , Kengo Setta , Takayuki Chiba , Takahiro Koji , Shunrou Fujiwara , Hiroshi Kashimura , Yoshitaka Kubo , Kuniaki Ogasawara","doi":"10.1016/j.hest.2023.10.003","DOIUrl":"10.1016/j.hest.2023.10.003","url":null,"abstract":"<div><h3>Objective</h3><p>Pulmonary edema is a common complication in patients receiving clazonsentan. Here, we report our experience in managing fluid balance with loop diuretics in patients with aneurysmal subarachnoid hemorrhage (aSAH) treated with clazosentan.</p></div><div><h3>Methods</h3><p>Patients with aSAH who received prophylactic agents for vasospasm after aneurysm obliteration between June 2021 and April 2023 were enrolled. Fluid balance parameters and asymptomatic and symptomatic vasospasm and pulmonary edema incidence were compared in three periods: 1st period (fasudil therapy), 2nd period (clazosentan therapy alone), and 3rd period (clazosentan with loop diuretic therapy).</p></div><div><h3>Results</h3><p>Fluid intake and urine volume during the 2nd and 3rd periods were considerably lesser than those during the 1st period. Asymptomatic vasospasm incidence was considerably lesser in the 3rd period than that in the 1st and 2nd periods. However, the incidences of symptomatic vasospasm and rescue endovascular treatment were comparable among the three groups. Although the clinical outcomes at the last follow-up were comparable among the three groups, pulmonary edema incidence was markedly higher during the 2nd period than that in the 1st and 3rd periods.</p></div><div><h3>Conclusion</h3><p>Thus, proper management of fluid balance with clazosentan and diuretics would help in effective clazosentan therapy for vasospasm prophylaxis.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X23000414/pdfft?md5=d0c4658f8715f5141a48e41c4af0ee67&pid=1-s2.0-S2589238X23000414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135762608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage 氯唑生坦附加治疗对动脉瘤性蛛网膜下腔出血后迟发性脑微循环障碍的有益影响

Brain Hemorrhages Pub Date : 2024-04-01 DOI: 10.1016/j.hest.2023.10.006

Hidenori Suzuki , Hideki Nakajima , Tomonori Ichikawa , Ryuta Yasuda , Takeshi Okada , Fuki Goto , Shota Ito , Yasutaka Horiuchi , Yotaro Kitano , Hirofumi Nishikawa , Masashi Fujimoto , Naoki Toma

{"title":"Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage","authors":"Hidenori Suzuki , Hideki Nakajima , Tomonori Ichikawa , Ryuta Yasuda , Takeshi Okada , Fuki Goto , Shota Ito , Yasutaka Horiuchi , Yotaro Kitano , Hirofumi Nishikawa , Masashi Fujimoto , Naoki Toma","doi":"10.1016/j.hest.2023.10.006","DOIUrl":"10.1016/j.hest.2023.10.006","url":null,"abstract":"<div><h3>Objective</h3><p>This retrospective study aimed to analyze the prospectively collected data of computed tomography (CT) perfusion imaging and to examine if clazosentan add-on administration prevented post-subarachnoid hemorrhage (SAH) delayed cerebral microcirculatory dysfunctions.</p></div><div><h3>Methods</h3><p>A total of 36 consecutive patients with non-mild SAH due to ruptured anterior circulation aneurysms and no significant cardiopulmonary dysfunctions (mean age, 67.9 years; and admission World Federation of Neurological Surgeons grades IV–V, 66.7 %) underwent aneurysmal obliteration up to day 3 post-SAH, followed by our conventional treatment (fasudil hydrochloride, cilostazol and perampanel administrations; n = 20; January 2020 to May 2022) or add-on administration of clazosentan (10 mg/hr) to the conventional treatment (n = 16; June 2022 to May 2023).</p></div><div><h3>Results</h3><p>Clazosentan add-on treatment significantly affected perioperative fluid management, which appeared to have no effects on the finding of CT perfusion imaging performed a median of 6.5 to 7.0 days post-SAH. However, cerebral blood flow and mean transit time were better in patients receiving add-on administration of clazosentan, although angiographic vasospasm frequencies and cerebral blood volume values were similar between the two treatment groups.</p></div><div><h3>Conclusion</h3><p>The findings suggest that clazosentan add-on treatment has beneficial effects against post-SAH angiographic vasospasm-unrelated delayed cerebral microcirculatory dysfunctions possibly by improving blood flow in smaller resistance arteries or arterioles.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X2300044X/pdfft?md5=dad888183e2d60ce0d53b778fa82a984&pid=1-s2.0-S2589238X2300044X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136128936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clazosentan, first approval in Japan: Has perioperative management of subarachnoid hemorrhage changed? 日本首次批准使用氯唑生坦：蛛网膜下腔出血的围手术期管理是否发生了变化？

Brain Hemorrhages Pub Date : 2024-04-01 DOI: 10.1016/j.hest.2023.12.004

Hidenori Suzuki

引用次数: 0