Intracerebral hemorrhage associated COVID-19 patient with normal coagulation profile after ECMO treatment: A case report

IF 1.3 Q4 CLINICAL NEUROLOGY

Brain Hemorrhages Pub Date : 2023-06-01 DOI:10.1016/j.hest.2022.08.002

Wael Osman Amer , Hussein Awad El gharieb , Hossam Ibrahim , Ahmed Alanazi , Mostafa Meshref

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引用次数: 4

Abstract

Objective

Coronavirus disease 2019 (COVID-19) is a novel coronavirus-caused infectious acute respiratory disease that can progress to severe acute respiratory distress syndrome (ARDS). For severe cases, extracorporeal membrane oxygenation (ECMO) is an excellent treatment option. ECMO had a number of side effects, including bleeding. Intracerebral hemorrhage can occur in COVID patients due to a variety of mechanisms, including covid's effect on ACE-2 receptors and subsequent hypertension, coagulopathy, DIC, or medication, such as anticoagulant use.

Case presentation

We present a case of a 53-year-old male COVID-19 patient who developed multiple, massive, severe intracerebral hemorrhages (ICH) despite a normal coagulation profile after ECMO treatment.

Conclusion

COVID-19 can progress to severe acute respiratory distress syndrome (ARDS), necessitating the use of extracorporeal membrane oxygenation (ECMO). Although ICH is not a common complication in patients with COVID-19 disease, it is unknown why this patient had a lower threshold of ICH despite having a normal coagulation profile.

Abstract Image

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ECMO治疗后凝血情况正常的COVID-19脑出血相关患者1例

目的2019冠状病毒病（coronavirus disease 2019，新冠肺炎）是一种新型冠状病毒引起的传染性急性呼吸道疾病，可发展为严重急性呼吸窘迫综合征（ARDS）。对于重症病例，体外膜肺氧合（ECMO）是一个很好的治疗选择。ECMO有许多副作用，包括出血。COVID患者可能发生脑出血，原因多种多样，包括新冠肺炎对ACE-2受体的影响，以及随后的高血压、凝血障碍、DIC或药物治疗，如抗凝药物的使用。病例介绍我们介绍一例53岁男性新冠肺炎患者，他在ECMO治疗后出现多发性、大量、严重的脑出血（ICH），尽管凝血情况正常。结论COVID-19可发展为严重急性呼吸窘迫综合征（ARDS），需要使用体外膜肺氧合（ECMO）。尽管ICH不是新冠肺炎疾病患者的常见并发症，但尚不清楚为什么该患者尽管具有正常的凝血特征，但ICH阈值较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Hemorrhages Medicine-Surgery

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

22 days