Volume 3: Biomedical and Biotechnology Engineering最新文献

{"title":"Design of Metacarpophalangeal Single-Piece Joint Prosthesis to Increase Motion in Abduction/Adduction","authors":"Nathaniel Millard, Raymond K. Yee","doi":"10.1115/imece2019-11005","DOIUrl":"https://doi.org/10.1115/imece2019-11005","url":null,"abstract":"\u0000 One of the leading causes of disability is rheumatoid arthritis (RA), especially that of the hand, the metacarpophalangeal (MCP) joint being affected the most. Current single piece prostheses are designed to allow for motion in flexion and extension, but little effort is put towards motion in abduction and adduction. The objective of this study is to determine the effects of web (hinge) joint cross-sectional geometry on stress, strain, shear strain, strain energy, and reaction moment magnitude for an MCP joint that is subject to not only flexion and extension but also abduction and adduction. Using finger bone dimensions from the literature, geometry was produced in ANSYS finite element software. The geometry was assigned a hyperelastic material constitutive model, making the analysis nonlinear. The cross-sectional shape of the hinge was controlled by ellipse dimensions, one for thickness and one for width. Motion boundary conditions were applied to the distal portion of the model resulting in bending at the hinge. The study showed that for flexion/extension motion the von Mises (equivalent) stress, shear strain, and equivalent strain are linearly proportional to the thickness but inversely proportional to the width. The reaction moment and strain energy are linearly proportional to the thickness but exponentially proportional to the width. For motion in abduction and adduction the behavior is opposite; the width acting as the thickness does in flexion/extension motion and the thickness acting as the width does in flexion/extension motion. It was also seen that high levels of shear strain develop on the palmer side of the model, indicating that failure has the most potential to occur in that area.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115160342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration Protocol of Different Measurement Methods for the Analysis of the Physiological and Biomechanical Efficiency of a Professional Athlete","authors":"M. Milani, L. Montorsi, L. Fontanili, Salvatore Rossini, R. Citarella","doi":"10.1115/imece2019-11774","DOIUrl":"https://doi.org/10.1115/imece2019-11774","url":null,"abstract":"\u0000 The paper focuses on the methodology for the analysis of the physiological and biomechanical efficiency of a professional athlete for integrating the standard preparation routine. The proposed methodology combines an in-house developed prototype of multiple uniaxial force plates for the measurement of the vertical component of ground reaction forces during movement and an infrared motion capture technique is adopted for measuring accurately the body motion.\u0000 The procedure is applied on a top level professional volley player and integrates the working routines used for the training over an entire season. The dynamic performance of the athlete is measured in terms of fatigue threshold and the aerobic workload. The proposed methodology demonstrates to be an accurate and reliable instrument for quantifying, for both slow and fast movements, the efficiency with which the athlete reaches the defined training targets and the precision achieved in developing an exercises’ routine. Furthermore, the dynamic response of the athlete is also measured by evaluating the position of the body during the workload as well as the speed of the movements and the corresponding interaction with the ground. This analysis verifies if an asymmetrical loading of the lower limbs and the power exerted during the impulsive contact phase with the ground. The measurements carried out during the analysis provide a map of the athlete performances during an entire season training and the mono- and bi-podalic movements could be associated with the time evolution of the athletic results, such as jumping length and height, speed, precision. Therefore, inefficiencies in the postural and technical aspects during the training can be measured and thus corrected leading to an improvement of the performance and to a reduction of the possibility for injuries onset.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"412 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124406959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Electro-FSI Model of Trabecular Network in the Brain Sub Arachnoid Space","authors":"Khashayar Teimoori, A. Sadegh, Bhaskar Paneri","doi":"10.1115/imece2019-10529","DOIUrl":"https://doi.org/10.1115/imece2019-10529","url":null,"abstract":"\u0000 The brain is encased in the skull and suspended and supported by a series of three fibrous tissue layers: Dura mater, Arachnoid and Pia matter, known as the Meninges. Arachnoid trabeculae are strands of collagen tissues located in a space between the arachnoid and the pia matter known as the subarachnoid space (SAS). The SAS trabeculae play an important role in damping and reducing the relative movement of the brain with respect to the skull. The SAS is filled with cerebrospinal fluid (CSF), which is a colorless fluid that surrounds all over the brain inside the subarachnoid spaces. This fluid stabilizes the shape and position of the brain during head movements.\u0000 To address normal and pathological SAS functions, under conditions where an electrical stimulation is applied, this study proposes a novel fully-coupled electro-Fluid-Structure Interaction (eFSI) modeling approach to investigate the response of the system of SAS-CSF under the applied electric current, which is provided by the transcranial Direct Current Stimulation (tDCS) technique according to the following steps. First, a two-dimensional channel model of the brain SAS with several trabecular morphologies is numerically simulated using the finite element (FE) method. The channel model is then subjected to a specific electric field intensity by applying a 1∼2mA direct current. COMSOL Multiphysics v. 5.3a software is used to perform the coupled eFSI numerical simulation in order to investigate the effects of the applied electric field on the flow of the CSF, thereby showing the deflection of the trabeculae inside the channel model.\u0000 The results of this study demonstrate that the induced electric field causes less deflection of the trabeculae by exacerbating the velocity profile of the cerebrospinal fluid flow and decreasing the flow pressure applied on each trabecula inside the trabecular SAS channel. This electro-mechanostructural modeling approach is significant because of the applied current on the channel walls that can directly affect the CSF flow. In fact, the results of this study can open up a new horizon for future research on disorders like hydrocephalus, which involves an unusual production rate of the CSF inside the brain. This disorder may be controlled by applying an electric current in the brain, using one of the available brain stimulation techniques, i.e. tDCS. By using an electrical stimulation technique, one might control the dynamics of brain function and, therefore, regulate dysfunctionality through the first eFSI multiphysics modeling approach proposed in this study. Briefly, the brain SAS may be considered as a novel region for electrotherapeutic and electromechanical neuromodulation.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121063823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Modeling of Polymer Saturation in Porous 3D Printed Matrix","authors":"Adam Mihalko, R. J. Michael, D. Piovesan","doi":"10.1115/imece2019-10988","DOIUrl":"https://doi.org/10.1115/imece2019-10988","url":null,"abstract":"\u0000 Due to the accuracy, speed, and ability to produce controllable complex geometries, additive manufacturing has gained traction in the medical industry. Additive manufacturing based on powder binder-jetting allows fabricating composite ceramic artifacts to mimic the physical properties of cortical bone. Given the porous nature of the artifacts their physical properties can be manipulated based on the percentage of solid matrix and adhesive binder. It has been demonstrated that a reduction of porosity via infiltration greatly increases the mechanical properties of the artifact. In this paper experiments are presented investigating the post processing of porous materials using different adhesives to infiltrate the artifact. The resulting saturation and porosity profiles of the produced composite are analyzed.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125521960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject-Specific Models of the Head and Neck for Reproducing Experimentally Obtained Head Impacts in OpenSim","authors":"Jonathan D Mortensen, M. Homayounpour, A. Merryweather","doi":"10.1115/imece2019-11932","DOIUrl":"https://doi.org/10.1115/imece2019-11932","url":null,"abstract":"\u0000 Simulating impacts to the head that are likely to cause concussion contributes knowledge to inform efforts to reduce head injury risk in sports. Previous studies used generic models and potentially missed subject-specific factors, which when combined with experimental data may offer additional insights about an individual’s risk. This study details methods for creating more subject-specific OpenSim models of the head and neck, which can be used in future studies to evaluate head injury risk during impacts. A generic model was scaled to match subject height and weight using data available from the literature. Muscle strength and passive properties were also scaled in order to reproduce experimental data obtained during safe impacts to the head. The average error between experimental and simulation kinematic values was under 15% for all but one of the subject-models.\u0000 By applying the methods presented in this study, future work could include using subject-specific models to assess individual athletes and generate personalized training protocols to help prevent injury. Future work could also include subject-specific models to investigate the effects of posture, startle response, and auditory warnings on head injury metrics.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125653004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical Evaluation of Recalling Elasticity due to Surface Roughness by Finite Element Modeling of Human Skin","authors":"Tomohisa Yamamoto, A. Sakuma","doi":"10.1115/imece2019-11881","DOIUrl":"https://doi.org/10.1115/imece2019-11881","url":null,"abstract":"\u0000 Among human sensations, tactile perception has an important role in physics and in living comfortably. It is already known that surface roughness greatly affects the feel of solid objects, but the mechanics of the relationship between feeling and physics, as well as their effects, are difficult to determine. This study, aims to clarify the numerical relationship between elastic tactile perception and surface roughness of a rigid body by designing various products with surfaces comfortable to touch. The finite element method (FEM) has been adopted for this clarification, and a numerical model of human skin with 3 layers, epidermis, dermis, and subcutaneous, has been developed to discuss the mechanical effects of touch movement. This skin model is used to evaluate the distribution of skin deformations during the process of touch movement, and the analysis of the tactile perception is done by discussing the distribution change due to touching objects. The change in distribution of deformation is mainly discussed in terms of pressure under the epidermis, and various patterns of distribution are inspected by changing the diameters and pitch ratio of a uniformly spread ball used as a plain surface. By comparing the relationship between distributions of rigid and elastic surfaces, similar distributions of pressure in the skin model were observed, and the relationships of the distribution are summarized to solve the mechanics of touch feeling. In this summarization, the maximum pressure and the maximum gradient of pressure distribution are adopted as parameters for the analysis. The analysis shows that it is numerically possible to represent the elasticity recalled by the rigid surface from its relationship with the elastic surface when they have the same maximum pressure and maximum inclination of pressure. The importance of maximum inclination of pressure for touch feeling is also shown here.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132126781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Photoactivated Cross-Linking Compound on Mechanical Properties of Porcine Carotid Arteries Post-Angioplasty","authors":"Farshad Mogharrabi, Jonathan Kuhlenhoelter, Blake Anderson, K. Kauser, K. Monson","doi":"10.1115/imece2019-11661","DOIUrl":"https://doi.org/10.1115/imece2019-11661","url":null,"abstract":"\u0000 Percutaneous transluminal angioplasty (PTA) is a medical procedure performed on patients with severe atherosclerosis to open up stenosed blood vessels by inflating a balloon at the narrowing location. In many cases of PTA, restenosis occurs post-surgery due either to elastic behavior of the artery, also known as elastic recoil in medical literature, or to plaque reformation within the lumen. For that reason, stents are commonly deployed to keep the arterial lumen open. Stent deployment causes problems in some cases; for example, the presence of stents in arteries with frequent movements and large deformations can cause ruptures in the arterial wall.\u0000 Recent studies on 1,8-Naphthalimide organic compounds have shown that when these compounds are activated using a certain wavelength of light, it causes cross-linking between the components of the extracellular matrix. This observation has led to studies with the goal of developing a method to utilize this process to replace stents for cases with limiting conditions for stent deployment.\u0000 In this study we focused on measuring and quantifying the effects of this compound on the mechanical properties of treated arteries undergoing PTA under a variety of loading conditions.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130479415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature Regulated Sleeve for Leg Prosthesis","authors":"R. Grubbs, Matthew G. Yough, Olivia L Rose, Anthony Lee, Teresa Sicree, S. Tiari, D. Piovesan","doi":"10.1115/imece2019-10984","DOIUrl":"https://doi.org/10.1115/imece2019-10984","url":null,"abstract":"\u0000 This paper presents the findings of the research and design of a heat generating thermal prosthetic sleeve. The goal of the project was to get the sleeve to be designed in a way that keeps a comfortable temperature of the amputation site. Heat transfer analysis as well as comfort tests were used to select the optimal materials for the body of the sleeve. A series of electrical tests using multimeters were used to determine which heating element should be used, as well as in which orientation they should be connected. A microcontroller system had also to be selected to give the sleeve some adjustability.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"301 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131794825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Evaluation of a Blood-Contacting Medical Device for Improving Functionality and Durability of Vascular Anastomosis","authors":"Gurjap Singh, M. Esmaeilpour, J. Bhama, A. Ratner","doi":"10.1115/imece2019-10922","DOIUrl":"https://doi.org/10.1115/imece2019-10922","url":null,"abstract":"\u0000 An example of vascular anastomosis is coronary artery bypass grafting (or CABG), which is the most common open-heart surgery in the United States today. It is used to treat people with coronary heart disease. Although it generally produces good outcomes, it is not without risk of failure. Due to rotation-related fluid stress on the graft at the point of attachment, possibility of clots forming at extraction and perfusion sites is high. The possibility of endothelialization at the suture joints carries a further risk of flow obstruction. Present research proposes a new blood contacting medical device that is attached to both ends of a vascular graft, and aids in flow rotation at the points of blood extraction and perfusion, thereby alleviating the possibility of clotting at those sites. It also shifts the suture lines such that the endothelialization causes minimal flow obstruction compared to current techniques. Simplified 3D models of both the current grafting technique and the proposed device are evaluated with periodic rectified sine pulse acting as a surrogate for human blood pulse. For both perfusion and extraction, better outcomes were observed for vascular anastomosis with the proposed blood contacting medical device.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133644980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Velocity Distribution Estimation Using Blood Pressure Data Based on the Coupled Wave Theory of Elastic Pipes and Fluids","authors":"Takeshi Tokunaga, K. Mori, H. Kadowaki, Takashi Saito","doi":"10.1115/imece2019-10548","DOIUrl":"https://doi.org/10.1115/imece2019-10548","url":null,"abstract":"\u0000 Cardiovascular disease that is one of Non-Communicable Disease accounts for about 25% of death in Japan. Prevention of arteriosclerosis that is a main cause of cardiovascular disease is important. Since an early lesions of arteriosclerosis progress as functional change of an endothelial cell that is uniformly distributed on the luminal surface of a blood vessel, an accurate evaluation of the endothelial cell function is important as prevention of the arteriosclerosis. Although Flow-Mediated Dilation (FMD) is widely used as a diagnosis of the endothelial cell function in clinic, it is an evaluation method that uses a static diameter of a blood vessel. Moreover, it isn’t possible to take into account individual difference of a wall shear stress on the endothelial cell. In previous study, it is found that an evoked hyperemic wall shear stress is a major correlate of %FMD. In order to accurately measure the endothelial cell function, it is necessary to simply assess the hyperemic shear stress during FMD. However, it is difficult to non-invasively measure the hyperemic shear stress on the endothelial cell in clinic. In this study, we focused on a blood pressure data that is obtained non-invasively and formulated a relationship between the pressure and a flow velocity based on the coupled wave theory. And we estimated a hyperemic shear stress by using a blood pressure data that is obtained by a tonometry method in experiment that simulate FMD. As a result of estimating the hyperemic shear stress, it reflected characteristics of blood flow in clinic. It may be necessary to consider the hyperemic pressure fluctuation that is waves including low frequency components. Moreover, the hyperemic pressure fluctuation should not be treated as a waveform that has individually different a static pressure in estimation of the hyperemic wall shear stress.","PeriodicalId":332737,"journal":{"name":"Volume 3: Biomedical and Biotechnology Engineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128897367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}