Chemical Reviews最新文献_第6页

Introduction: Neuromorphic Materials 简介：神经形态材料

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-28 DOI: 10.1021/acs.chemrev.5c0034010.1021/acs.chemrev.5c00340

A. Alec Talin*, and , Bilge Yildiz*,

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IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-28

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Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy 分子金纳米团簇用于高级NIR-II生物成像和治疗

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-28 DOI: 10.1021/acs.chemrev.4c0083510.1021/acs.chemrev.4c00835

Ani Baghdasaryan, and , Hongjie Dai*,

{"title":"Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy","authors":"Ani Baghdasaryan,  and , Hongjie Dai*, ","doi":"10.1021/acs.chemrev.4c0083510.1021/acs.chemrev.4c00835","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00835https://doi.org/10.1021/acs.chemrev.4c00835","url":null,"abstract":"<p >Small thiolate-protected gold molecular clusters have gained significant interest in research due to their unique size-dependent properties. Their molecular to nanoscale sizes lead to distinctive quantum confinement effects, resulting in a discrete electronic energy band gap structure and molecule-like properties, including HOMO–LUMO electronic transitions, enhanced photoluminescence, and intrinsic magnetism and chirality. Near-infrared II (NIR-II, 1000–3000 nm) emissive gold clusters have emerged as a fascinating class of nanomaterials that are well-suited for biomedical applications. The unique combination of stability, biocompatibility, and tunable emission properties position them as valuable tools for high-resolution and deep-tissue imaging, with potential real-world applications ranging from disease diagnostics and prognosis to therapeutics. In this review, we focus on the NIR-II photoluminescence properties of gold molecular clusters for preclinical in vivo NIR-II imaging of vasculature, brain, kidney, liver, and gastrointestinal organs, and molecular targeted tumor imaging and theranostic treatment. The imaging capabilities combined with fast excretion and a high safety profile make molecular gold clusters highly promising for clinical translation.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 11","pages":"5195–5227 5195–5227"},"PeriodicalIF":51.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.4c00835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-28

Michelle C. Quan, and , Danielle J. Mai*,

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Computer-Aided Drug Discovery for Undruggable Targets. 不可药物靶标的计算机辅助药物发现。

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-05-27 DOI: 10.1021/acs.chemrev.4c00969

Qi Sun,Hanping Wang,Juan Xie,Liying Wang,Junxi Mu,Junren Li,Yuhao Ren,Luhua Lai

{"title":"Computer-Aided Drug Discovery for Undruggable Targets.","authors":"Qi Sun,Hanping Wang,Juan Xie,Liying Wang,Junxi Mu,Junren Li,Yuhao Ren,Luhua Lai","doi":"10.1021/acs.chemrev.4c00969","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00969","url":null,"abstract":"Undruggable targets are those of therapeutical significance but challenging for conventional drug design approaches. Such targets often exhibit unique features, including highly dynamic structures, a lack of well-defined ligand-binding pockets, the presence of highly conserved active sites, and functional modulation by protein-protein interactions. Recent advances in computational simulations and artificial intelligence have revolutionized the drug design landscape, giving rise to innovative strategies for overcoming these obstacles. In this review, we highlight the latest progress in computational approaches for drug design against undruggable targets, present several successful case studies, and discuss remaining challenges and future directions. Special emphasis is placed on four primary target categories: intrinsically disordered proteins, protein allosteric regulation, protein-protein interactions, and protein degradation, along with discussion of emerging target types. We also examine how AI-driven methodologies have transformed the field, from applications in protein-ligand complex structure prediction and virtual screening to de novo ligand generation for undruggable targets. Integration of computational methods with experimental techniques is expected to bring further breakthroughs to overcome the hurdles of undruggable targets. As the field continues to evolve, these advancements hold great promise to expand the druggable space, offering new therapeutic opportunities for previously untreatable diseases.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"3 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Phase-Change Memory for In-Memory Computing 用于内存计算的相变存储器

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-22 DOI: 10.1021/acs.chemrev.4c0067010.1021/acs.chemrev.4c00670

Ghazi Sarwat Syed*, Manuel Le Gallo and Abu Sebastian,

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Advancing Covalent Ligand and Drug Discovery beyond Cysteine 推进半胱氨酸以外的共价配体和药物发现

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-05-22 DOI: 10.1021/acs.chemrev.5c00001

Gibae Kim, R. Justin Grams, Ku-Lung Hsu

{"title":"Advancing Covalent Ligand and Drug Discovery beyond Cysteine","authors":"Gibae Kim, R. Justin Grams, Ku-Lung Hsu","doi":"10.1021/acs.chemrev.5c00001","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00001","url":null,"abstract":"Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Covalent chemistry has emerged as a powerful solution for accessing protein sites in difficult to ligand regions. By leveraging activity-based protein profiling (ABPP) and LC-MS/MS technologies, academic groups and industry have identified cysteine-reactive ligands that enable selective targeting of challenging protein sites to modulate previously inaccessible biological pathways. Cysteines within a protein are rare, however, and developing covalent ligands that target additional residues hold great promise for further expanding the ligandable proteome. This review highlights recent advancements in targeting amino acids beyond cysteine binding with an emphasis on tyrosine- and lysine-directed covalent ligands and their applications in chemical biology and therapeutic development. We outline the process of developing covalent ligands using chemical proteomic methodology, highlighting recent successful examples and discuss considerations for future expansion to additional amino acid sites on proteins.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"35 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase-Change Memory for In-Memory Computing 用于内存计算的相变存储器

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-05-22 DOI: 10.1021/acs.chemrev.4c00670

Ghazi Sarwat Syed, Manuel Le Gallo, Abu Sebastian

引用次数: 0

Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores 单细胞纳米包封：人工壳内细胞孢子的化学合成

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-05-22 DOI: 10.1021/acs.chemrev.4c00984

Hyeong Bin Rheem, Nayoung Kim, Duc Tai Nguyen, Ghanyatma Adi Baskoro, Jihun H. Roh, Jungkyu K. Lee, Beom Jin Kim, Insung S. Choi

{"title":"Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores","authors":"Hyeong Bin Rheem, Nayoung Kim, Duc Tai Nguyen, Ghanyatma Adi Baskoro, Jihun H. Roh, Jungkyu K. Lee, Beom Jin Kim, Insung S. Choi","doi":"10.1021/acs.chemrev.4c00984","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00984","url":null,"abstract":"Nature has evolved adaptive strategies to protect living cells and enhance their resilience against hostile environments, exemplified by bacterial and fungal spores. Inspired by cryptobiosis in nature, chemists have designed and synthesized artificial “cell-in-shell” structures, endowed with the protective and functional capabilities of nanoshells. The cell-in-shells hold the potential to overcome the inherent limitations of biologically naı̈ve cells, enabling the acquisition of exogenous phenotypic traits through the chemical process known as single-cell nanoencapsulation (SCNE). This review highlights recent advancements in the development of artificial spores, with sections organized based on the categorization of material types utilized in SCNE, specifically organic, hybrid, and inorganic types. Particular emphasis is placed on the cytoprotective and multifunctional roles of nanoshells, demonstrating potential applications of SCNEd cells across diverse fields, including synthetic biology, biochemistry, materials science, and biomedical engineering. Furthermore, the perspectives outlined in this review propose future research directions in SCNE, with the goal of achieving fine-tuned precision in chemical modulation at both intracellular and pericellular levels, paving the way for the design and construction of customized artificial spores tailored to meet specific functional needs.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"140 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perovskite Solar Cells and Light Emitting Diodes: Materials Chemistry, Device Physics and Relationship 钙钛矿太阳能电池与发光二极管：材料化学、器件物理及其关系

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-05-21 DOI: 10.1021/acs.chemrev.4c0066310.1021/acs.chemrev.4c00663

Ligang Yuan, Qifan Xue, Feng Wang, Ning Li, Geoffrey I. N. Waterhouse, Christoph J. Brabec, Feng Gao* and Keyou Yan*,

{"title":"Perovskite Solar Cells and Light Emitting Diodes: Materials Chemistry, Device Physics and Relationship","authors":"Ligang Yuan, Qifan Xue, Feng Wang, Ning Li, Geoffrey I. N. Waterhouse, Christoph J. Brabec, Feng Gao* and Keyou Yan*, ","doi":"10.1021/acs.chemrev.4c0066310.1021/acs.chemrev.4c00663","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00663https://doi.org/10.1021/acs.chemrev.4c00663","url":null,"abstract":"<p >Solution-processed perovskite solar cells (PSCs) and perovskite light emitting diodes (PeLEDs) represent promising next-generation optoelectronic technologies. This Review summarizes recent advancements in the application of metal halide perovskite materials for PSC and PeLED devices to address the efficiency, stability and scalability issues. Emphasis is placed on material chemistry strategies used to control and engineer the composition, deposition process, interface and micro-nanostructure in solution-processed perovskite films, leading to high-quality crystalline thin films for optimal device performance. Furthermore, we retrospectively compare the device physics of PSCs and PeLEDs, their working principles and their energy loss mechanisms, examining the similarities and differences between the two types of devices. The reciprocity relationship suggests that a great PSC should also be a great PeLED, motivating the search for interconverting photoelectric bifunctional devices with maximum radiative recombination and negligible non-radiative recombination. Specific requirements of PSCs and PeLEDs in terms of bandgap, thickness, band alignment and charge transport to achieve this target are discussed in detail. Further challenges and issues are also illustrated, together with prospects for future development. Understanding these fundamentals, embracing recent breakthroughs and exploring future prospects pave the way toward the rational design and development of high-performance PSC and PeLED devices.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 11","pages":"5057–5162 5057–5162"},"PeriodicalIF":51.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0