Chemical Reviews最新文献_第7页

Folding and Oligomerization of CLC Channels and Transporters CLC通道和转运蛋白的折叠和寡聚化。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-12 Epub Date: 2026-07-14 DOI: 10.1021/acs.chemrev.6c00294

Janice L. Robertson

{"title":"Folding and Oligomerization of CLC Channels and Transporters","authors":"Janice L. Robertson","doi":"10.1021/acs.chemrev.6c00294","DOIUrl":"10.1021/acs.chemrev.6c00294","url":null,"abstract":"Regarded as one of the most complex membrane proteinfolds, CLCsform a large family of membrane proteins that function as anion channelsand secondary active anion/proton transporters. Despite low sequencesimilarity, available structures are remarkably similar, maintainingthe same inverted topology and fold, with subunits assembled as dimersin wild-type structures. Because of these strong structural features,CLC-ec1, a prokaryotic homologue from E. coli, hasbecome a highly valuable model system for studying membrane proteinfolding and oligomerization assembly. Associating via a membrane-embeddeddimerization interface, the subunits participate in a dynamic equilibriumbetween monomers and dimers in lipid bilayers, enabling investigationof the physical driving forces underlying the formation of stablemembrane complexes. Like soluble protein assembly, studies indicatethat CLC-ec1 dimerization is driven by a solvophobic force arisingfrom the free energy gained by burying lipid bilayer defects. Dimerizationstability is influenced by lipid composition and pH, which, in turn,provide a mechanism for functional regulation through oligomerization.In this review, I provide an overview of how the exploration of CLCfolding and oligomerization advances our understanding of membraneprotein self-assembly in general and the role of oligomerization inregulating function.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 15","pages":"8853–8880"},"PeriodicalIF":64.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional Infrared Spectroscopy as a Bioanalytical Technique 多维红外光谱作为生物分析技术。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-12 Epub Date: 2026-07-16 DOI: 10.1021/acs.chemrev.6c00244

Sander Woutersen, Neil T. Hunt

{"title":"Multidimensional Infrared Spectroscopy as a Bioanalytical Technique","authors":"Sander Woutersen, Neil T. Hunt","doi":"10.1021/acs.chemrev.6c00244","DOIUrl":"10.1021/acs.chemrev.6c00244","url":null,"abstract":"Since its inception at the end of the last century, 2D-IRspectroscopyhas undergone continuous development into an established method forstudying the structure, dynamics and intermolecular interactions ofbiomolecules. Thanks to parallel advances in lasers and related technology,2D-IR data sets can now be acquired in minutes, using minimal samplequantities and under physiologically relevant conditions. This progresshas opened the door for 2D-IR spectroscopy to play a role as an analyticaltool, making measurements that characterize samples and inform decisionsin arenas ranging from drug design to biomedical diagnostics. Here,we briefly review the pioneering developments that have brought aboutthis scenario before discussing the current state of the art in analyticalapplications of 2D-IR spectroscopy. We consider the implementationof 2D-IR spectroscopy to measure label free protein structure, biomolecularinteractions and the use of 2D-IR to interrogate complex mixturesand biological tissues. We include strategies that have extended thereach of 2D-IR spectroscopy through advances in measurement sensitivityand data quality and highlight the potential impact that emergingmethods such as machine learning could have on the development of2D-IR. Finally, we look ahead to the challenges and opportunitiesfacing 2D-IR on its path toward a robust and widely used bioanalyticaltool.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 15","pages":"8743–8767"},"PeriodicalIF":64.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical Self-Assembly, Nanoarchitectonics, and Emerging Functionalities of Chiral π-Amphiphiles 手性π-两亲化合物的层次自组装、纳米结构和新功能

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-12 Epub Date: 2026-07-23 DOI: 10.1021/acs.chemrev.6c00011

Guanghui Ouyang, Minghua Liu

{"title":"Hierarchical Self-Assembly, Nanoarchitectonics, and Emerging Functionalities of Chiral π-Amphiphiles","authors":"Guanghui Ouyang, Minghua Liu","doi":"10.1021/acs.chemrev.6c00011","DOIUrl":"10.1021/acs.chemrev.6c00011","url":null,"abstract":"Rational design of functional building blocks and precisecontrolover their hierarchical self-assembly form the cornerstones of supramolecularchemistry and materials science. Amphiphilic molecules, with theirinherent hydrophilic–hydrophobic duality, serve as criticalbuilding blocks across several disciplines. Integrating additionalfunctionalities such as π-conjugation and chirality significantlyexpands the design space and utility of common amphiphiles, givingrise to a new class of building blocks: chiral π-amphiphiles.Typically, a synthetic chiral π-amphiphile consists of two functionallydistinct segments, i.e., a hydrophobic π-extended chromophoreand a hydrophilic chiral unit, covalently linked via common chemicallinkers. The integration of chirality, functional π-systems,and amphiphilicity offers distinct advantages, such as chirality-guideddirectional π-stacking and superior chiroptical properties arisingfrom their hierarchical chiral architectures in both organic and aqueousphases. Emerging chiral functions of chiral π-amphiphiles includingcircularly polarized luminescence, chiral recognition and separation,chiral biomedicine, and spin electronics have witnessed groundbreakingprogress in recent years, which we believe will contribute to thedevelopment of novel chiral materials through molecular self-assemblyapproaches. This review systematically summarizes and discusses thedefinition, molecular design strategies, classification, nanostructures,applications, and future perspectives of chiral π-amphiphiles,aiming to help scientists evaluate the cutting-edge field of chiralityscience via diverse supramolecular technologies and systematic molecularengineering.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 15","pages":"8358–8435"},"PeriodicalIF":64.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases 信号传导中配体偏倚的机制和表现：以受体酪氨酸激酶为中心。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-12 Epub Date: 2026-07-30 DOI: 10.1021/acs.chemrev.6c00023

Ryan J. Schuck, Tanaya Roy, Ana-Nicoleta Bondar, Pavel Krejci, Kalina Hristova

{"title":"Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases","authors":"Ryan J. Schuck, Tanaya Roy, Ana-Nicoleta Bondar, Pavel Krejci, Kalina Hristova","doi":"10.1021/acs.chemrev.6c00023","DOIUrl":"10.1021/acs.chemrev.6c00023","url":null,"abstract":"The development oforganisms and the maintenance of tissue homeostasisdepend on complex intercellular signaling networks that govern basiccell functions. Because cells are typically exposed to many diverseligands simultaneously, distinct intracellular mechanisms of cellsignaling have evolved, allowing cells to accurately sense and respondto their environment. Here, we discuss the concept of ligand bias,which describes the ability of different ligands to preferentiallyactivate specific signaling pathways, and thus produce divergent responsesthrough the same receptor. Although bias can be challenging to identifyand quantify, protocols have been established to (i) determine whetherpreferences exist and (ii) quantify these preferences. We review theseprotocols and their utility in studies of signaling by RTKs, the largestfamily of single-pass membrane receptors. We summarize the literaturesuggesting that RTKs engage in biased signaling and discuss the utilityof signaling bias in therapeutics design. We discuss parallels withGPCR biased signaling, and lessons that have been learned after yearsof GPCR signaling research. Finally, we propose that RTK ligand biasappeared in evolution to diversify the morphogen signaling pathwaysthat direct the development of tissues and organs in the mammalianbody.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 15","pages":"8487–8516"},"PeriodicalIF":64.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Materials and Device Engineering for Efficient, Stable, and Scalable Monolithic Perovskite/Silicon Tandem Photovoltaics 高效，稳定和可扩展的单片钙钛矿/硅串联光伏的材料和器件工程。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-07-10 DOI: 10.1021/acs.chemrev.5c01014

Lorenzo Mardegan, Ahmed Ali Said, Anil R. Pininti, Thomas Allen, Anand S. Subbiah and Stefaan De Wolf*,

{"title":"Materials and Device Engineering for Efficient, Stable, and Scalable Monolithic Perovskite/Silicon Tandem Photovoltaics","authors":"Lorenzo Mardegan, Ahmed Ali Said, Anil R. Pininti, Thomas Allen, Anand S. Subbiah and Stefaan De Wolf*, ","doi":"10.1021/acs.chemrev.5c01014","DOIUrl":"10.1021/acs.chemrev.5c01014","url":null,"abstract":"Rapid advances in photovoltaic technology have driven its exponential global deployment, establishing solar power as a central pillar of future electricity generation. Among next-generation photovoltaic concepts, perovskite/silicon tandem solar cells offer a compelling pathway to surpass the ∼29.4% efficiency limit of conventional crystalline-silicon devices at manufacturing scale. Laboratory demonstrations have already exceeded this threshold, enabled by innovations in perovskite composition engineering, additive incorporation, interfacial passivation, optimized charge-selective contacts, and improved silicon bottom-cell architectures. This Review provides an integrated overview of perovskite material fundamentals and device-engineering strategies that have propelled these rapid efficiency gains. Emphasis is placed on the interplay between performance, stability, and manufacturability of monolithic perovskite/silicon tandems, outlining key challenges and opportunities that will determine their progression from laboratory prototypes to commercially viable photovoltaic technologies.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 14","pages":"7959–8015"},"PeriodicalIF":64.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conditional Transmembrane Peptides as Allosteric Modulators: Thermodynamic and Functional Perspectives in Membrane Protein Regulation 条件跨膜肽作为变构调节剂：膜蛋白调控的热力学和功能观点。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-07-08 DOI: 10.1021/acs.chemrev.6c00122

Jennifer A. Rybak, and , Francisco N. Barrera*,

{"title":"Conditional Transmembrane Peptides as Allosteric Modulators: Thermodynamic and Functional Perspectives in Membrane Protein Regulation","authors":"Jennifer A. Rybak,  and , Francisco N. Barrera*, ","doi":"10.1021/acs.chemrev.6c00122","DOIUrl":"10.1021/acs.chemrev.6c00122","url":null,"abstract":"Membrane proteins participate in most cellular processes from sensing the cellular environment to regulating gene expression. The fundamental unit in eukaryotic membrane proteins is the transmembrane (TM) helix, which in addition to anchoring the protein to the lipid bilayer, often plays a central functional role. We review here advances in our understanding of the factors underpinning the thermodynamic stability of TM helices in cellular membranes. Interestingly, a class of TM sequences exists that has the ability to, when isolated as a peptide, be stable both in solution and in the membrane. This Review covers such conditional TM peptides, including their discovery in the form of the pHLIP peptide, the factors that determine their membrane insertion, and the basis for their use in cancer theranostics. We also discuss how this knowledge has been the conceptual basis for the design of sequences that partition into lipid bilayers and target membrane proteins. These peptides act as both positive and negative allosteric regulators of their membrane targets. Such TM allosteric conditional peptides (TMACs) additionally constitute tools that can advance our understanding of the activity and regulation of membrane proteins.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 14","pages":"8089–8105"},"PeriodicalIF":64.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148401421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-Dependent Polysaccharide Monooxygenases: Mechanism and Function 铜依赖的多糖单加氧酶：机制和功能。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-06-29 DOI: 10.1021/acs.chemrev.6c00006

Allison E. Batka, and , Michael A. Marletta*,

引用次数: 0

Ink Design for Printing Perovskite Solar Cells and Modules 打印钙钛矿太阳能电池和组件的油墨设计。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-06-30 DOI: 10.1021/acs.chemrev.5c00980

Yongrui Yang, Zhaokai Liu, Weifu Zhang, Jingjing Wu, Kun Zhang, Yang Wang, Lei Meng, Mingjian Yuan, Yali Qiao* and Yanlin Song*,

{"title":"Ink Design for Printing Perovskite Solar Cells and Modules","authors":"Yongrui Yang, Zhaokai Liu, Weifu Zhang, Jingjing Wu, Kun Zhang, Yang Wang, Lei Meng, Mingjian Yuan, Yali Qiao* and Yanlin Song*, ","doi":"10.1021/acs.chemrev.5c00980","DOIUrl":"10.1021/acs.chemrev.5c00980","url":null,"abstract":"Printed metal halide perovskite photovoltaics combine high device performance with low-cost manufacturing, which have become one of the most promising candidates for next-generation photovoltaic technologies. With the rapid development of printing methods for scalable film deposition, printed perovskite solar cells have already achieved a power conversion efficiency (PCE) exceeding 26%. However, the PCE of commercial-size perovskite solar modules remains near 21%, indicating that the key bottleneck is no longer the intrinsic optoelectronic potential of the absorber but the translation of precursor inks into uniform, scalable, and durable films. During the printing process, ink design governs precursor solvent coordination, intermediate-phase evolution, colloidal stability, rheology, crystallization kinetics, wet-film stability, and ultimately large-area film quality. This Review summarizes perovskite precursor inks from a solution chemistry to manufacturing perspective and discusses the influences of chemical composition, solvent selection, mixed-solvent interactions, solvent–perovskite intermediates, crystallization control, solvent extraction methods, and rheological regulation on the film morphology during the scalable printing process. We further highlight industrially relevant metrics that increasingly determine viable ink systems, including shelf life, ambient air tolerance, coating-speed window, defect suppression, reproducibility, solvent toxicity, and compatibility with module integration and encapsulation. By linking ink formulation to film formation, scalable deposition, and module performance, this Review provides direction for printable ink design and identifies the critical challenges that should be addressed to realize reproducible, low-waste, high-throughput, and durable printed perovskite solar modules.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 14","pages":"7878–7958"},"PeriodicalIF":64.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis 生物或非生物：人工光合作用的生物杂交系统。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-06-29 DOI: 10.1021/acs.chemrev.5c00963

Yifat Cohen, Oren Bachar, Roy Cohen, Matan M. Meirovich and Omer Yehezkeli*,

{"title":"To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis","authors":"Yifat Cohen, Oren Bachar, Roy Cohen, Matan M. Meirovich and Omer Yehezkeli*, ","doi":"10.1021/acs.chemrev.5c00963","DOIUrl":"10.1021/acs.chemrev.5c00963","url":null,"abstract":"Biotic-abiotic interfaced configurations hold great promise for application in renewable energy and artificial photosynthesis systems. Recent advances in synthetic biology, computational, and visualization techniques, along with enhanced high-resolution characterization, have enabled a deeper fundamental understanding of the interface, which, in turn, has improved electron transfer processes and the design architecture. These developed configurations open new routes to mimic the photosynthetic apparatus or add new applications based on biotic and abiotic catalytic reactions. Aiming to surpass natural systems, researchers have examined methods to reconfigure these block sets into new designs. This review focuses on the advances in artificial photosynthesis and coupled biotic-abiotic biohybrid systems. The work presents the development of artificial photosynthesis configurations aimed at generating light-induced energy or fuels. The use of natural photosynthetic proteins, inorganic photocatalysts, and advanced biohybrid materials is presented and discussed, aiming to enable future biotic-abiotic design and the ambitious goal of developing real-world applications.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 14","pages":"7804–7877"},"PeriodicalIF":64.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.5c00963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Single-Atom Catalysts for Thermal-Catalytic C1 Chemistry 用于热催化C1化学的先进单原子催化剂。

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-07-22 Epub Date: 2026-06-30 DOI: 10.1021/acs.chemrev.6c00203

Tao Zhou, Ningqiang Zhang, Zizhen Xiao, Wenjian Zhang, Zhaohui Li, Yu Zhang, Haofan Lei, Wenlong Wu, Hongliang Li, Han Yan* and Jie Zeng*,

{"title":"Advanced Single-Atom Catalysts for Thermal-Catalytic C1 Chemistry","authors":"Tao Zhou, Ningqiang Zhang, Zizhen Xiao, Wenjian Zhang, Zhaohui Li, Yu Zhang, Haofan Lei, Wenlong Wu, Hongliang Li, Han Yan* and Jie Zeng*, ","doi":"10.1021/acs.chemrev.6c00203","DOIUrl":"10.1021/acs.chemrev.6c00203","url":null,"abstract":"Thermal-catalytic conversion of one-carbon (C1) molecules into fuels and value-added chemicals represents a cornerstone of heterogeneous catalysis, driven by its profound implications for energy sustainability and environmental protection. The pursuit of high catalytic performance has spurred the rise of single-atom catalysts (SACs) with maximized metal utilization efficiency and atomic dispersion configuration. In this review, we first elucidated the critical role of the coordination environment in SACs for regulating catalytic performance. Furthermore, recent progress in SACs for the thermal catalytic conversion of key C1 molecules, including carbon monoxide, carbon dioxide, methane, methanol, formaldehyde, and formic acid, was systematically summarized. Based on these discussions, the common reaction mechanism in C1 chemistry and the design principle of SACs have been proposed. Furthermore, the inherent limitations, in terms of activity, selectivity, and stability, were also examined. Building upon the insights, the recent developments in ensembled structures derived from SACs, including single-atom–nanoparticle synergistic catalysts, dual-atom catalysts, “nano-island”-structured SACs, and single-atom alloy catalysts, were highlighted. Finally, future directions for SACs in C1 chemistry were discussed, focusing on key aspects including AI-driven rational design of SACs, regulating the microenvironment of SACs, stabilizing high-density SACs, characterizing SACs under operando conditions, and promoting the industrial application of SACs.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 14","pages":"8106–8201"},"PeriodicalIF":64.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0