Chemical Reviews最新文献_第5页

Insights into the Life Cycle and Therapeutic Agents for Monkeypox Virus Infection 猴痘病毒感染的生命周期和治疗剂研究

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-14 DOI: 10.1021/acs.chemrev.6c00118

Qiuyu Zhong, Shulei Hu, Xiong Xie, Xiaofei He, Jinlin Wang, Haowen Shou, Wenhao Dai, Hong Liu

{"title":"Insights into the Life Cycle and Therapeutic Agents for Monkeypox Virus Infection","authors":"Qiuyu Zhong, Shulei Hu, Xiong Xie, Xiaofei He, Jinlin Wang, Haowen Shou, Wenhao Dai, Hong Liu","doi":"10.1021/acs.chemrev.6c00118","DOIUrl":"10.1021/acs.chemrev.6c00118","url":null,"abstract":"Since the first confirmed case in 1970, the monkeypoxvirus (MPXV)has emerged as a significant threat to global public health. The WorldHealth Organization (WHO) has declared it a Public Health Emergencyof International Concern (PHEIC) on two occasions. Despite decadesof research, only tecovirimat has been approved by the European MedicinesAgency (EMA) for the treatment of MPXV infection. The genome and structureare similar between MPXV and other orthopoxviruses (OPXVs), suggestingthat the strategies used for other OPXVs may be applicable to MPXV.This review systematically summarizes the genome, structure, and criticalstages in the life cycle of OPXVs, especially MPXV. A variety of antiviralagents against MPXV and other OPXVs are discussed according to theirdistinct mechanisms of action: 1) blocking viral entry and fusion,2) inhibiting DNA replication and processing, 3) disrupting transcriptionand mRNA processing, 4) preventing virion assembly, maturation andrelease, 5) modulating immune responses, and 6) mechanism unknown.Overall, this article provides a systematic review of current researchprogress on potential therapeutic targets and agent for MPXV, aimingto offer innovative insights and strategies for the development ofeffective therapeutic agents against mpox.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9307–9356"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrical Properties in Biological Materials 生物材料的电学特性

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-04 DOI: 10.1021/acs.chemrev.5c00925

Han Kim, Seung-Wuk Lee

{"title":"Electrical Properties in Biological Materials","authors":"Han Kim, Seung-Wuk Lee","doi":"10.1021/acs.chemrev.5c00925","DOIUrl":"10.1021/acs.chemrev.5c00925","url":null,"abstract":"Bioelectricphenomena in biological materials arise from intricatemolecular structures and hierarchical organizations, resulting indiverse electrical properties. Understanding the structure–functionrelationship at each hierarchical level is crucial for elucidatingthese mechanisms. A multidisciplinary approach combining advancedexperimental tools and computational simulations helps bridge thegap between observation and theory. Crystallographic studies highlightthe importance of lattice symmetry in classifying electrical characteristics,playing a significant role in understanding bioelectricity. Investigatingthe electrical properties of biological building blocks, includingamino acids, peptides, proteins, tissues, and viruses, reveals significantinsights. These biological components exhibit diverse electrical behaviorsdue to their unique structural arrangements. Understanding these phenomenafrom the nanoscale to the macroscale is essential for comprehendingbioelectricity and developing biomedical and wearable devices. Thisreview provides insights into bioelectricity by discussing the bioelectricalproperties of biological building blocks, categorizing their hierarchicalstructures, and analyzing their underlying mechanisms. Our reviewwill clarify the relationship between fundamental structures and bioelectricalproperties, and provide insights for designing novel biotechnologiesand future applications.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9006–9049"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148692367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational Mass Spectrometry Imaging in the Era of AI: Focus Review AIFocus时代的计算质谱成像综述

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-05 DOI: 10.1021/acs.chemrev.6c00098

Timothy J. Trinklein, Mithunjha Anandakumar, Hsi-Chun Chao, Marisa Asadian, Dharmeshkumar Parmar, Jonathan V. Sweedler, Fan Lam

{"title":"Computational Mass Spectrometry Imaging in the Era of AI: Focus Review","authors":"Timothy J. Trinklein, Mithunjha Anandakumar, Hsi-Chun Chao, Marisa Asadian, Dharmeshkumar Parmar, Jonathan V. Sweedler, Fan Lam","doi":"10.1021/acs.chemrev.6c00098","DOIUrl":"10.1021/acs.chemrev.6c00098","url":null,"abstract":"Mass spectrometry imaging (MSI) is a tool-of-choice formappingand understanding the spatial organization of biomolecules, includingsmall metabolites, lipids, peptides, and many others. As the MSI instrumentand spatial biology inquiries evolve, researchers and practitionersare constrained by the inherent trade-offs in spatial resolution,chemical detail, and acquisition time. Here, we review how the rapidlygrowing interplay between MSI and machine learning/artificial intelligence(ML/AI)-powered computational approaches is addressing these issues.We begin by highlighting key steps in MSI experiments and summarizingmajor ML/AI paradigms in the context of MSI data, providing a foundationto review how ML/AI impact each step in the MSI workflow, startingwith methods to accelerate data acquisition. We then discuss emergingapplications of dimensionality reduction, segmentation, and varioussupervised/unsupervised learning approaches to extract useful chemicalinsights from high-dimensional MSI data. Approaches to leverage multimodalimaging to guide the acquisition process or provide a more informativeintegrated analysis are discussed. We conclude with a forward-lookingdiscussion on the state of computation and MSI, spanning ML-enabledinstrumentation, scaling measurements to 3D and large cohorts, andthe integration of MSI with other spatial omic data.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9272–9306"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148692371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perovskite Radiation Detectors: Emerging Applications, Testing Protocols, and Radiation Hardness 钙钛矿辐射探测器：新兴应用，测试协议和辐射硬度

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-10 DOI: 10.1021/acs.chemrev.5c00927

Sailesh Bataju, Rongbo Ji, Mahdi Montazeri, Lei Pan, Lei R. Cao, Hsinhan Tsai, Wanyi Nie

{"title":"Perovskite Radiation Detectors: Emerging Applications, Testing Protocols, and Radiation Hardness","authors":"Sailesh Bataju, Rongbo Ji, Mahdi Montazeri, Lei Pan, Lei R. Cao, Hsinhan Tsai, Wanyi Nie","doi":"10.1021/acs.chemrev.5c00927","DOIUrl":"10.1021/acs.chemrev.5c00927","url":null,"abstract":"Halide perovskitesare emerging semiconductor materials that canbe synthesized from solution at a low cost. Recently, they have garneredsignificant attention for radiation detection applications owing totheir incorporation of high atomic number elements, which enable efficientattenuation of photons and particles. Substantial progress has beenmade in leveraging perovskite semiconductors for radiation detectionand imaging, although significant challenges remain. This Review uniquelyaddresses current gaps by providing a comprehensive analysis of characterizationprotocols, radiation-induced damage mechanisms, and self-healing behaviorsin perovskite-based detectors. We critically evaluate the impact ofbeam calibration, ion migration, and air ionization artifacts on performancemetrics such as sensitivity and detection limits, factors that haveoften been overlooked in prior reviews. Furthermore, we explore theradiation hardness of perovskite architectures under high-energy photonand particle exposure, offering insights into their operational reliabilityin extreme environments. To overcome current limitations, we highlightemerging material systems, including hybrid metal chalcogenides, MXenes,and metal–organic frameworks, which demonstrate enhanced stability,reduced toxicity, and multifunctionality. By integrating these perspectives,this Review establishes a foundation for advancing perovskite radiationdetectors toward robust, scalable, and application-ready technologies.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9050–9107"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148718218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern Higher-Order Cycloadditions 现代高阶环加法

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-04 DOI: 10.1021/acs.chemrev.5c01109

Anne Kristensen, Karl Anker Jørgensen

引用次数: 0

New Particle Formation and Growth in Urban Atmospheres: From Observations to Molecular-Level Understanding 城市大气中新粒子的形成和生长：从观察到分子水平的理解

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-07-27 DOI: 10.1021/acs.chemrev.5c00684

Runlong Cai, Xiaoxiao Li, Rujing Yin, Bin Zhao, Chao Yan, Juha Kangasluoma, Xiuhui Zhang, Jun Zheng, Hong-Bin Xie, Veli-Matti Kerminen, Kebin He, James N. Smith, Lin Wang, Markku Kulmala, Jingkun Jiang

{"title":"New Particle Formation and Growth in Urban Atmospheres: From Observations to Molecular-Level Understanding","authors":"Runlong Cai, Xiaoxiao Li, Rujing Yin, Bin Zhao, Chao Yan, Juha Kangasluoma, Xiuhui Zhang, Jun Zheng, Hong-Bin Xie, Veli-Matti Kerminen, Kebin He, James N. Smith, Lin Wang, Markku Kulmala, Jingkun Jiang","doi":"10.1021/acs.chemrev.5c00684","DOIUrl":"10.1021/acs.chemrev.5c00684","url":null,"abstract":"Aerosol particles, profoundly influenced by human activities,playpivotal roles in air quality and climate. The formation and growthof new atmospheric particles is a leading source of high-concentrationaerosol particles in urban environments and also the largest sourceof uncertainties in global climate predictions. Recent advances inexperimental and theoretical research have dramatically improved ourunderstanding of urban new particle formation (NPF), showing thatthe abundant anthropogenic pollutants in complex urban atmospheresenable the fast formation of new particles that are highly selectivetoward the gaseous precursors and chemical processes. The uniquenessof urban atmospheres causes the underrepresentation of urban NPF inregional and global models, while the evolving urban environmentscomplicate the prediction of future environmental and climate effectsof NPF. In this review, we link the latest molecular-level chemicalmechanisms and implications on climate predictions and air pollutioncontrol by assessing the methodology to investigate urban NPF, sortingout the latest mechanistic findings, and discussing their implementationin three-dimensional models.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"8881–8956"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Modifications for Cellular Protein Delivery 细胞蛋白质传递的蛋白质修饰

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-13 DOI: 10.1021/acs.chemrev.6c00267

Jan Vincent V. Arafiles, Jonathan Franke, Palina Dubatouka, Luise Franz, Christian P.R. Hackenberger

引用次数: 0

Cycloaddition-Based Retrosynthetic Logic for the Diversification and Molecular Editing of Polycyclic Aromatic Hydrocarbons 基于环加成的多环芳烃多样化和分子编辑反合成逻辑

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-11 DOI: 10.1021/acs.chemrev.6c00372

Sajan Pradhan, Rikuou Tanase, Kazuma Amaike, Taichi Koike, Hiroshi Masai, Kenichiro Itami

{"title":"Cycloaddition-Based Retrosynthetic Logic for the Diversification and Molecular Editing of Polycyclic Aromatic Hydrocarbons","authors":"Sajan Pradhan, Rikuou Tanase, Kazuma Amaike, Taichi Koike, Hiroshi Masai, Kenichiro Itami","doi":"10.1021/acs.chemrev.6c00372","DOIUrl":"10.1021/acs.chemrev.6c00372","url":null,"abstract":"Expanding the chemical and structural diversity of polycyclicaromatichydrocarbons (PAHs) represents a significant aspirational goal inorganic chemistry, materials science, and chemical biology, as itenables precise modulation of their molecular properties for a widerange of applications. Conventional approaches to PAH diversificationtypically rely on lengthy multistep sequences involving prefunctionalizedaromatic substrates and strong oxidants, which limits efficiency andsubstrate generality. In contrast, retrosynthetic disconnection strategiesbased on cycloaddition–cycloreversion (retro-cycloaddition)or cycloaddition–rearomatization processes offer a conceptuallydistinct and streamlined approach to PAH construction and modification.These methods enable atom- and step-economical transformations directlyfrom simple, unfunctionalized PAH templates, thereby circumventingthe need for preinstalled functional groups. Recent advances havedemonstrated that such disconnection strategies enable diverse transformations,including regioselective PAH growth via bay-, M- and L-region annulative π-extension(APEX) reactions, K-region aza-APEX reactions, formalC–H amination, ring-expansion through dearomative atom insertion,and π-extension via two-carbon fragment exchange.This review summarizes these developments and highlights the emergingpotential of cycloaddition-based retrosynthetic logic as a unifyingplatform for the diversification and molecular editing of PAHs.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9525–9562"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148718466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manganese Biomineralization by a Multicopper Oxidase Protein Complex 多铜氧化酶蛋白复合物对锰的生物矿化作用

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-26 Epub Date: 2026-08-10 DOI: 10.1021/acs.chemrev.6c00213

Alexandra V. Soldatova, Bradley M. Tebo, Thomas G. Spiro

{"title":"Manganese Biomineralization by a Multicopper Oxidase Protein Complex","authors":"Alexandra V. Soldatova, Bradley M. Tebo, Thomas G. Spiro","doi":"10.1021/acs.chemrev.6c00213","DOIUrl":"10.1021/acs.chemrev.6c00213","url":null,"abstract":"In oxic environments, the stable form of manganese isan insolubleMnO2 mineral. However, the uncatalyzed oxidation of solubleMn(II) is very slow. Consequently, this oxidation, a key part of theglobal manganese cycle, is largely under biological control, beingcarried out by bacteria and fungi. Dormant spores of many Bacillus species employ multicopper oxidase enzymes (MCOs)that use oxygen directly to oxidize Mn(II) and form MnO2 minerals. This presents a biochemical conundrum, because MCOs workthrough single electron transfers from their substrates, whereas conversionof Mn(II) to MnO2 is a 2-electron oxidation, involvingone-electron steps with high kinetic barriers due to high reductionpotentials. How is this accomplished? Expression and purificationof the first bacterial manganese oxidizing MCO complex Mnx createda new chapter in the field of inorganic biochemistry: protein-controlledmanganese biomineralization. This review documents the history ofgenetic studies in Bacillus sp. that led to productionof the enzymatic complex Mnx responsible for Mn biomineralization.Biochemical and cryoelectron microscopy structural studies then showedhow Mnx has solved the problem of high kinetic barriers to Mn oxidationby exploiting the stabilizing effect of hydroxo- and oxo-bridgingin binuclear Mn complexes in all three oxidation states, II, III,and IV. We offer an outlook for future directions of manganese biomineralizationresearch, connecting it to broader quests in the fields of geochemistryand geomicrobiology.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"126 16","pages":"9441–9459"},"PeriodicalIF":64.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148718467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Polyoxometalate Nanoelectronics 迈向多金属酸氧纳米电子学

IF 64.2 1区化学

Chemical Reviews Pub Date : 2026-08-12 Epub Date: 2026-07-31 DOI: 10.1021/acs.chemrev.6c00120

Dominique Vuillaume, Anna Proust

引用次数: 0