Chemical Reviews最新文献

{"title":"Core–Shell Magnetic Particles: Tailored Synthesis and Applications","authors":"Yidong Zou,&nbsp;Zhenkun Sun,&nbsp;Qiyue Wang,&nbsp;Yanmin Ju,&nbsp;Nianrong Sun,&nbsp;Qin Yue,&nbsp;Yu Deng,&nbsp;Shanbiao Liu,&nbsp;Shengfei Yang,&nbsp;Zhiyi Wang,&nbsp;Fangyuan Li,&nbsp;Yanglong Hou*,&nbsp;Chunhui Deng*,&nbsp;Daishun Ling* and Yonghui Deng*,&nbsp;","doi":"10.1021/acs.chemrev.4c0071010.1021/acs.chemrev.4c00710","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00710https://doi.org/10.1021/acs.chemrev.4c00710","url":null,"abstract":"<p >Core–shell magnetic particles consisting of magnetic core and functional shells have aroused widespread attention in multidisciplinary fields spanning chemistry, materials science, physics, biomedicine, and bioengineering due to their distinctive magnetic properties, tunable interface features, and elaborately designed compositions. In recent decades, various surface engineering strategies have been developed to endow them desired properties (e.g., surface hydrophilicity, roughness, acidity, target recognition) for efficient applications in catalysis, optical modulation, environmental remediation, biomedicine, etc. Moreover, precise control over the shell structure features like thickness, porosity, crystallinity and compositions including metal oxides, carbon, silica, polymers, and metal–organic frameworks (MOFs) has been developed as the major method to exploit new functional materials. In this review, we highlight the synthesis methods, regulating strategies, interface engineering, and applications of core–shell magnetic particles over the past half-century. The fundamental methodologies for controllable synthesis of core–shell magnetic materials with diverse organic, inorganic, or hybrid compositions, surface morphology, and interface property are thoroughly elucidated and summarized. In addition, the influences of the synthesis conditions on the physicochemical properties (e.g., dispersibility, stability, stimulus-responsiveness, and surface functionality) are also discussed to provide constructive insight and guidelines for designing core–shell magnetic particles in specific applications. The brand-new concept of “core–shell assembly chemistry” holds great application potential in bioimaging, diagnosis, micro/nanorobots, and smart catalysis. Finally, the remaining challenges, future research directions and new applications for the core–shell magnetic particles are predicted and proposed.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 2","pages":"972–1048 972–1048"},"PeriodicalIF":51.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143086510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Data Machine Learning Approaches in Molecular and Materials Science","authors":"Siddarth K. Achar, John A. Keith","doi":"10.1021/acs.chemrev.4c00957","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00957","url":null,"abstract":"This article has not yet been cited by other publications.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"73 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity","authors":"Katia D’Ambrosio,&nbsp;Anna Di Fiore,&nbsp;Vincenzo Alterio,&nbsp;Emma Langella,&nbsp;Simona Maria Monti,&nbsp;Claudiu T. Supuran* and Giuseppina De Simone*,&nbsp;","doi":"10.1021/acs.chemrev.4c0027810.1021/acs.chemrev.4c00278","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00278https://doi.org/10.1021/acs.chemrev.4c00278","url":null,"abstract":"<p >Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the hydration of CO₂ to bicarbonate and a proton. Currently, 15 isoforms have been identified, of which only 12 are catalytically active. Given their involvement in numerous physiological and pathological processes, hCAs are recognized therapeutic targets for the development of inhibitors with biomedical applications. However, despite massive development efforts, very few of the presently available hCA inhibitors show selectivity for a specific isoform. X-ray crystallography is a very useful tool for the rational drug design of enzyme inhibitors. In 2012 we published in Chemical Reviews a highly cited review on hCA family (<contrib-group><span>Alterio, V.</span></contrib-group> et al. <cite><i>Chem Rev.</i></cite> <span>2012</span>, <em>112</em>, 4421−4468), analyzing about 300 crystallographic structures of hCA/inhibitor complexes and describing the different CA inhibition mechanisms existing up to that date. However, in the period 2012–2023, almost 700 new hCA/inhibitor complex structures have been deposited in the PDB and a large number of new inhibitor classes have been discovered. Based on these considerations, the aim of this Review is to give a comprehensive update of the structural aspects of hCA/inhibitor interactions covering the period 2012–2023 and to recapitulate how this information can be used for the rational design of more selective versions of such inhibitors.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 1","pages":"150–222 150–222"},"PeriodicalIF":51.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143084990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Conduction Channels in Memristors","authors":"Kyung Seok Woo,&nbsp;R. Stanley Williams and Suhas Kumar*,&nbsp;","doi":"10.1021/acs.chemrev.4c0045410.1021/acs.chemrev.4c00454","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00454https://doi.org/10.1021/acs.chemrev.4c00454","url":null,"abstract":"<p >Since the early 2000s, the impending end of Moore’s scaling, as the physical limits to shrinking transistors have been approached, has fueled interest in improving the functionality and efficiency of integrated circuits by employing memristors or two-terminal resistive switches. Formation (or avoidance) of localized conducting channels in many memristors, often called “filaments”, has been established as the basis for their operation. While we understand some qualitative aspects of the physical and thermodynamic origins of conduction localization, there are not yet quantitative models that allow us to predict when they will form or how large they will be. Here we compile observations and explanations of channel formation that have appeared in the literature since the 1930s, show how many of these seemingly unrelated pieces fit together, and outline what is needed to complete the puzzle. This understanding will be a necessary predictive component for the design and fabrication of post-Moore’s-era electronics.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 1","pages":"294–325 294–325"},"PeriodicalIF":51.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143085376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-Free Gene Expression: Methods and Applications","authors":"Andrew C. Hunt, Blake J. Rasor, Kosuke Seki, Holly M. Ekas, Katherine F. Warfel, Ashty S. Karim, Michael C. Jewett","doi":"10.1021/acs.chemrev.4c00116","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00116","url":null,"abstract":"Cell-free gene expression (CFE) systems empower synthetic biologists to build biological molecules and processes outside of living intact cells. The foundational principle is that precise, complex biomolecular transformations can be conducted in purified enzyme or crude cell lysate systems. This concept circumvents mechanisms that have evolved to facilitate species survival, bypasses limitations on molecular transport across the cell wall, and provides a significant departure from traditional, cell-based processes that rely on microscopic cellular “reactors.” In addition, cell-free systems are inherently distributable through freeze-drying, which allows simple distribution before rehydration at the point-of-use. Furthermore, as cell-free systems are nonliving, they provide built-in safeguards for biocontainment without the constraints attendant on genetically modified organisms. These features have led to a significant increase in the development and use of CFE systems over the past two decades. Here, we discuss recent advances in CFE systems and highlight how they are transforming efforts to build cells, control genetic networks, and manufacture biobased products.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"24 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity","authors":"Katia D’Ambrosio, Anna Di Fiore, Vincenzo Alterio, Emma Langella, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone","doi":"10.1021/acs.chemrev.4c00278","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00278","url":null,"abstract":"Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the hydration of CO₂ to bicarbonate and a proton. Currently, 15 isoforms have been identified, of which only 12 are catalytically active. Given their involvement in numerous physiological and pathological processes, hCAs are recognized therapeutic targets for the development of inhibitors with biomedical applications. However, despite massive development efforts, very few of the presently available hCA inhibitors show selectivity for a specific isoform. X-ray crystallography is a very useful tool for the rational drug design of enzyme inhibitors. In 2012 we published in Chemical Reviews a highly cited review on hCA family (<contrib-group person-group-type=\"allauthors\"><span>Alterio, V.</span></contrib-group> et al. <cite><i>Chem Rev.</i></cite> <span>2012</span>, <em>112</em>, 4421−4468), analyzing about 300 crystallographic structures of hCA/inhibitor complexes and describing the different CA inhibition mechanisms existing up to that date. However, in the period 2012–2023, almost 700 new hCA/inhibitor complex structures have been deposited in the PDB and a large number of new inhibitor classes have been discovered. Based on these considerations, the aim of this Review is to give a comprehensive update of the structural aspects of hCA/inhibitor interactions covering the period 2012–2023 and to recapitulate how this information can be used for the rational design of more selective versions of such inhibitors.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"24 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-Free Gene Expression: Methods and Applications","authors":"Andrew C. Hunt,&nbsp;Blake J. Rasor,&nbsp;Kosuke Seki,&nbsp;Holly M. Ekas,&nbsp;Katherine F. Warfel,&nbsp;Ashty S. Karim and Michael C. Jewett*,&nbsp;","doi":"10.1021/acs.chemrev.4c0011610.1021/acs.chemrev.4c00116","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00116https://doi.org/10.1021/acs.chemrev.4c00116","url":null,"abstract":"<p >Cell-free gene expression (CFE) systems empower synthetic biologists to build biological molecules and processes outside of living intact cells. The foundational principle is that precise, complex biomolecular transformations can be conducted in purified enzyme or crude cell lysate systems. This concept circumvents mechanisms that have evolved to facilitate species survival, bypasses limitations on molecular transport across the cell wall, and provides a significant departure from traditional, cell-based processes that rely on microscopic cellular “reactors.” In addition, cell-free systems are inherently distributable through freeze-drying, which allows simple distribution before rehydration at the point-of-use. Furthermore, as cell-free systems are nonliving, they provide built-in safeguards for biocontainment without the constraints attendant on genetically modified organisms. These features have led to a significant increase in the development and use of CFE systems over the past two decades. Here, we discuss recent advances in CFE systems and highlight how they are transforming efforts to build cells, control genetic networks, and manufacture biobased products.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 1","pages":"91–149 91–149"},"PeriodicalIF":51.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.4c00116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143085545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Conduction Channels in Memristors","authors":"Kyung Seok Woo, R. Stanley Williams, Suhas Kumar","doi":"10.1021/acs.chemrev.4c00454","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00454","url":null,"abstract":"Since the early 2000s, the impending end of Moore’s scaling, as the physical limits to shrinking transistors have been approached, has fueled interest in improving the functionality and efficiency of integrated circuits by employing memristors or two-terminal resistive switches. Formation (or avoidance) of localized conducting channels in many memristors, often called “filaments”, has been established as the basis for their operation. While we understand some qualitative aspects of the physical and thermodynamic origins of conduction localization, there are not yet quantitative models that allow us to predict when they will form or how large they will be. Here we compile observations and explanations of channel formation that have appeared in the literature since the 1930s, show how many of these seemingly unrelated pieces fit together, and outline what is needed to complete the puzzle. This understanding will be a necessary predictive component for the design and fabrication of post-Moore’s-era electronics.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"113 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Dimensional Organic–Inorganic van der Waals Hybrids","authors":"Fucai Cui, Víctor García-López, Zhiyong Wang, Zhongzhong Luo, Daowei He, Xinliang Feng, Renhao Dong, Xinran Wang","doi":"10.1021/acs.chemrev.4c00565","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00565","url":null,"abstract":"Two-dimensional organic–inorganic (2DOI) van der Waals hybrids (vdWhs) have emerged as a groundbreaking subclass of layer-stacked (opto-)electronic materials. The development of 2DOI-vdWhs via systematically integrating inorganic 2D layers with organic 2D crystals at the molecular/atomic scale extends the capabilities of traditional 2D inorganic vdWhs, thanks to their high synthetic flexibility and structural tunability. Constructing an organic–inorganic hybrid interface with atomic precision will unlock new opportunities for generating unique interfacial (opto-)electronic transport properties by combining the strengths of organic and inorganic layers, thus allowing us to satisfy the growing demand for multifunctional applications. Here, this review provides a comprehensive overview of the latest advancements in the chemical synthesis, structural characterization, and numerous applications of 2DOI-vdWhs. Firstly, we introduce the chemistry and the physical properties of the recently rising organic 2D crystals (O2DCs), which feature crystalline 2D nanostructures comprising carbon-rich repeated units linked by covalent/noncovalent bonds and exhibit strong in-plane extended π-conjugation and weak interlayer vdWs interaction. Simultaneously, representative inorganic 2D crystals (I2DCs) are briefly summarized. After that, the synthetic strategies will be systematically summarized, including synthesizing single-component O2DCs with dimensional control and their vdWhs with I2DCs. With these synthetic approaches, the control in the dimension, the stacking modes, and the composition of the 2DOI-vdWhs will be highlighted. Subsequently, a special focus will be given on the discussion of the optical and electronic properties of the single-component 2D materials and their vdWhs, which will be closely relevant to their structures, so that we can establish a general structure–property relationship of 2DOI-vdWhs. In addition to these physical properties, the (opto-)electronic devices such as transistors, photodetectors, sensors, spintronics, and neuromorphic devices as well as energy devices will be discussed. Finally, we provide an outlook to discuss the key challenges for the 2DOI-vdWhs and their future development. This review aims to provide a foundational understanding and inspire further innovation in the development of next-generation 2DOI-vdWhs with transformative technological potential.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"33 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covalent Proximity Inducers","authors":"Nir London*,&nbsp;","doi":"10.1021/acs.chemrev.4c0057010.1021/acs.chemrev.4c00570","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00570https://doi.org/10.1021/acs.chemrev.4c00570","url":null,"abstract":"<p >Molecules that are able to induce proximity between two proteins are finding ever increasing applications in chemical biology and drug discovery. The ability to introduce an electrophile and make such proximity inducers covalent can offer improved properties such as selectivity, potency, duration of action, and reduced molecular size. This concept has been heavily explored in the context of targeted degradation in particular for bivalent molecules, but recently, additional applications are reported in other contexts, as well as for monovalent molecular glues. This is a comprehensive review of reported covalent proximity inducers, aiming to identify common trends and current gaps in their discovery and application.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 1","pages":"326–368 326–368"},"PeriodicalIF":51.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.4c00570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143085164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}