EAS Journal of Pharmacy and Pharmacology最新文献_第2页

Regulatory Status of Probiotics in India: A Current Scenario 印度益生菌的监管状况:现状

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-06-08 DOI: 10.36349/easjpp.2023.v05i03.005

Yogesh Soni, Preeti Sangwan, N. Sharma, Priyanka Ahirwar, Sahdev Kamboj

引用次数: 0

Role of Hospital Pharmacist in Infection Prevention and Control 医院药师在感染防控中的作用

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-05-26 DOI: 10.36349/easjpp.2023.v05i03.004

M. Amer, Zubariya Tamkeen

引用次数: 0

Formulation and Characterization of Solid Dispersion of Oxcarbazepine 奥卡西平固体分散体的制备及表征

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-05-26 DOI: 10.36349/easjpp.2023.v05i03.003

N. Sharma, Priyanka Ahirwar

引用次数: 0

Neurotoxic Effects of Manganese Chloride on the Cerebellar Cortex of Adult Wistar Rats 氯化锰对成年Wistar大鼠小脑皮质的神经毒性作用

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-05-23 DOI: 10.36349/easjpp.2023.v05i03.002

Opoola S. S, Ajibade A. J

{"title":"Neurotoxic Effects of Manganese Chloride on the Cerebellar Cortex of Adult Wistar Rats","authors":"Opoola S. S, Ajibade A. J","doi":"10.36349/easjpp.2023.v05i03.002","DOIUrl":"https://doi.org/10.36349/easjpp.2023.v05i03.002","url":null,"abstract":"Manganese is a naturally occurring element and an essential nutrient. It is an essential trace metal that is involved in bone formation, brain development and in the metabolism of carbohydrates, cholesterol and amino acids. Excessive exposure of humans to manganese can result in a neurologic and psychological disorder called Manganism. This study assesses the effect of Manganese on the cerebellar cortex of adult wistar rats. Thirty-six (36) adult wistar rats were picked at random and divided into 4 groups with 9 animals each. Group A which was the control received distilled water, group B, group C and Group D received orally 0.3 mg/kg, 0.6 mg/kg and 0.8 mg/kg body weight of Manganese Chloride respectively for 29 days. Experimental Animals were sacrificed on the 30th day by cervical dislocation. The cerebellum were collected after sacrifice, weighted and fixed in 10% formol calcium and subsequently processed for histological observation using Hematoxylin and Eosin staining principle. Part of the cerebella cortex was homogenized for MDA, NO and SDH analysis. The result shows that the mean body weights decreased significantly in the manganese- treated groups when compared to the control. The mean brain weight of the Manganese Chloride treated groups B, C and D Insignificantly Increased compared with the control. Biochemical analysis of the MDA (Lipid Peroxide), NO (Nitric Oxide) and SDH (Succinate Dehydrogenase) Increased Significantly (P<0.05) in the Manganese treated group compare with the control. Histological analysis showed loss and degenerated neurons particularly the Purkinje cells in the cortical layers of the Manganese treated groups compare with normal Cerebella histoarchitecture in the control. This study concluded that Wistar rats treated with Manganese Chloride demonstrated neurodegenerative changes in the cerebella cortical layers, which may adversely affect some cerebella functions in the Wistar rats investigated.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126681489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Potential and Underlying Mechanistic of Phenolic Component from Ziziphus jujuba Fruit: A Molecular Docking Validation 酸枣果实酚类成分的抗炎作用及其机制:分子对接验证

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-05-11 DOI: 10.36349/easjpp.2023.v05i03.001

A. Maurya, J. Malik

引用次数: 0

Characterization of Mistletoe Leaves Growing on Fig Plant Found in NISLT, Samonda, Ibadan Premises 在NISLT，萨蒙达，伊巴丹处所发现的无花果植物上生长的槲寄生叶的特征

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-04-26 DOI: 10.36349/easjpp.2023.v05i02.005

Ikokoh, P. P. A, M. M, Imohiosen, J. J, Idenyi, E. O, Aribo, T, Gbadegesin Y. H, D. Bwai

{"title":"Characterization of Mistletoe Leaves Growing on Fig Plant Found in NISLT, Samonda, Ibadan Premises","authors":"Ikokoh, P. P. A, M. M, Imohiosen, J. J, Idenyi, E. O, Aribo, T, Gbadegesin Y. H, D. Bwai","doi":"10.36349/easjpp.2023.v05i02.005","DOIUrl":"https://doi.org/10.36349/easjpp.2023.v05i02.005","url":null,"abstract":"This study investigates the chemical composition of mistletoe leaves growing on fig tree. The mistletoe leaves and the fig leaves used for this research were harvested from Fig plant. Proximate analyses, phytochemical screening, Elemental and antioxidant analysis were done on both leaves. This study has provided a scientific justification that both the Fig leaves and Mistletoe leaves contained relevant phyto constituents such as alkaloids, saponins, flavonoid, and steroids; whereas antraquinones, tannins, phenols, resins and terpenoids were completely absent. Nutritionally relevant inorganic minerals like, Calcium, magnesium and potassium were the most abundant element in both plants. Proximate constituents like carbohydrates, lipids and proteins were present in varied amounts in both leaves. Result of inhibition of free radicals in fig leave extract increases with increase in concentration of the extract. The inhibition is closely comparable with that of the standard (Vitamin C) at the same concentration. The inhibition by the extracts of mistletoe grown on fig tree is low when compared with that of Fig and that of standard. This suggests that some of the chemical characteristics of mistletoe are conferred to them by their host trees.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115676226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peperomia pellucida (L.) Kunth Piperaceae has the Expected Reproductive Toxicity of Antimalarial Drugs? 透明胡椒(L.)昆特胡椒科抗疟药是否具有预期的生殖毒性?

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-04-18 DOI: 10.36349/easjpp.2023.v05i02.004

G. Alade, Blessing O. Ariri, T. Alade, K. Ajibesin

{"title":"Peperomia pellucida (L.) Kunth Piperaceae has the Expected Reproductive Toxicity of Antimalarial Drugs?","authors":"G. Alade, Blessing O. Ariri, T. Alade, K. Ajibesin","doi":"10.36349/easjpp.2023.v05i02.004","DOIUrl":"https://doi.org/10.36349/easjpp.2023.v05i02.004","url":null,"abstract":"In folklore medicine, Peperomia pellucida (L.) Kunth (Piperaceae), has demonstrated a good activity in malaria treatment and this has also been proven pharmacologically. Most antimalarial agents have demonstrated negative effects on spermatogenesis. For effective development and formulation of this plant resource into a dosage form that will be well tolerated by humans, the leaf extract of the plant was therefore evaluated for reproductive toxicity associated with antimalarial drugs in male Wistar rats at 250, 500 and 1000mgkg-1 doses for it effect on the sperm characteristics as well as the histology of the testes. Rats, divided into three groups (n=6) administered with 250, 500 and 1000mgkg-1 doses of the extract and a fourth one which was the control (administered with distilled water), were used for a period of twenty days following standard procedure. The result indicated, although the normal sperm morphology was not significantly affected, a significant reduction of sperm count and active motility by 93 and 71 (p<0.05) observed at 1000 mg/kg and interstitial necrosis of the testes at 500 which became severe at 1000 mg/kg. The extract was however safe at 250 mg/kg. The usual spermatotoxicty of antimalarials was therefore indicated at 500 and 1000mg/kg. The study has proven that P. pellucida leaf educed the usual antimalarial spermatotoxicity.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"294 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132698910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of Analgesic Efficacy of Ziziphus jujube Hydroalcholic Fruit Extract 红枣水醇果提取物的镇痛效果评价

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-04-05 DOI: 10.36349/easjpp.2023.v05i02.003

Jyoti Pethari, R. Saxena

{"title":"Assessment of Analgesic Efficacy of Ziziphus jujube Hydroalcholic Fruit Extract","authors":"Jyoti Pethari, R. Saxena","doi":"10.36349/easjpp.2023.v05i02.003","DOIUrl":"https://doi.org/10.36349/easjpp.2023.v05i02.003","url":null,"abstract":"Pain is a term that refers to a spectrum of sensations of varying types and intensities, ranging from unpleasant to intolerable. The struggle to relieve pain began with the advent of mankind. Analgesics can be defined as drugs that reduce the sensation of pain without losing consciousness. Analgesics act in different ways on the peripheral and central nervous systems. They differ from anesthetics in that they reversibly eliminate sensation, acetaminophen [known in the US as acetaminophen, or simply APAP], non-steroidal anti-inflammatory drugs [NSAIDs] such as salicylates, morphine and opioids such as opiates. When choosing an analgesic, the severity and response to other drugs determine drug choice. World Health Organization [WHO] pain ladder. Herbal medicines have less side effects and less harm, so they have a higher market value. The nutritious jujube fruit (Ziziphus jujube Mill.) is a member of the Rhamnaceous family and grows mainly in inland areas of Europe, southern and eastern Asia, Australia and especially northern China. Jujubes have a long history as fruit and medicinal. The main bioactive components are vitamin C, phenols, flavonoids, triterpenoids and polysaccharides. Recent phytochemical studies of jujube fruit have highlighted the following biological effects: B. Anticancer, anti-inflammatory, anti-obesity, immunostimulatory, antioxidant, hepatoprotective and gastrointestinal protective activity in macrophages and inhibition of foam cell formation. Further focus on clinical trials and phytochemical definitions of jujube fruit will be essential for future research efforts. In this study, an attempt was made to evaluate the analgesic potential of Ziziphus jujube hydroalcoholic fruit extract.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116733696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Herbal Medicines as Remedies against COVID-19 草药治疗COVID-19的疗效

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-03-03 DOI: 10.36349/easjpp.2023.v05i02.001

Abdullateef A. Raji, Ruqayyah Abdullateef, R. A. Aladodo, Muhammed M. Abdul- Lateef, Hassanat Jimoh

{"title":"Efficacy of Herbal Medicines as Remedies against COVID-19","authors":"Abdullateef A. Raji, Ruqayyah Abdullateef, R. A. Aladodo, Muhammed M. Abdul- Lateef, Hassanat Jimoh","doi":"10.36349/easjpp.2023.v05i02.001","DOIUrl":"https://doi.org/10.36349/easjpp.2023.v05i02.001","url":null,"abstract":"Objective: Coronaviruses belong to the order Nidovirales, family Coronaviridae, and four genera, namely: alpha, beta, gamma, and delta. In December 2019, a novel coronavirus was first officially reported in Wuhan City of China. Consequently, on February 11, 2020, the CSG named the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); it causes the disease dubbed Covid-19. The virus was officially declared pandemic by WHO, on March 11, 2020. Up till date, no drug, including the existing ones, has been approved for covid-19 treatment. The objective of this work, is to carry out a review on proven herbal extracts and the phyto-compound contents, for possible antiviral properties against SARS-CoV-2, and thus, as potential candidates for Covid-19 vaccine. Materials and Methods: Investigation into proven plant species against respiratory tract diseases was carried out between 1st to 30th of July, 2020 via: (a) Conduction of interview with traditional herbal healers and users, in south-western Nigeria on efficacies and history of use of identified plant species; (b) Search to confirm active phyto-compounds in the traditionally identified plant species via: (i). the free ELSEVIER repositories at the ‘COVID-19 RESOURCE CENTRE’ hosted on ELSEVIER Connect. (ii). Unrestricted resources in the PubMed domain. (iii). Unrestricted publicly funded repositories, such as the WHO COVID-19 database. Results: Findings revealed herbal extracts of: (i). Zingiber officinale, (ii). Psidium guayava, (iii). Nigella sativa, and (iv). Hibiscus sabdariffa; are highly rich in phyto-compounds with potent antiviral properties, and therefore suit as a potential remedy against Covid-19. Conclusion: Identified plant species possess phyto-compounds with antiviral activities, thus projecting them as potential candidates for development of Covi-19 vaccine.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123607616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intravenous Antibacterial Consumption at Sahloul University Hospital from 2018 to 2021 2018 - 2021年沙浩大学医院静脉抗菌药物使用情况

EAS Journal of Pharmacy and Pharmacology Pub Date : 2023-02-08 DOI: 10.36349/easjpp.2023.v05i01.003

C. Amine, Belhajmbarek Imen, Mhiri Asma, Jardak Maroua, Kacem Balsam

引用次数: 0