Formulation and Characterization of Solid Dispersion of Oxcarbazepine

The purpose of the current study was to use the solid dispersion approach to improve the solubility of the medication oxcarbazepine, which is only moderately water soluble. The antiepileptic medication oxcarbazepine is used to treat seizures. Due to its high permeability and low water solubility, it falls under BCS class II. To prevent issues of this nature, it was imperative to increase the solubility of oxcarbazepine in accordance with British Pharmacopoeia (BP) solubility criteria since pure oxcarbazepine falls under the category of being only very slightly soluble. Solid dispersion technique has been used to try and increase the solubility of pure oxcarbazepine. Oxcarbazepine is also extensively metabolized by the liver. Attempt has been made to formulate solid dispersions containing oxcarbazepine to improve its solubility and dissolution rate to avoid first pass metabolism; to avoid difficulty.